Patents Represented by Attorney Michael C. Sudol
  • Patent number: 4272537
    Abstract: This invention relates to 3-amino-5-substituted-6-halo-N-(4,4-disubstituted-6-substituted-1,3,5-tria zin-2-yl)-2-pyrazinecarboxamides and processes for preparing same. The compounds are eukalemic/saluretic agents useful in the treatment of edema and hypertension.
    Type: Grant
    Filed: July 2, 1980
    Date of Patent: June 9, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Otto W. Woltersdorf, Jr., S. Jane deSolms, Robert L. Smith
  • Patent number: 4265645
    Abstract: An injector type cooling apparatus is disclosed wherein multiple flat liquid sprays are directed into a conduit of uniform cross-section to draw cooling air into and through the conduit for mixture with and heat transfer from the liquid. The discharge end of the conduit is fitted with mist eliminators, in addition, holes or slots fitted with mist eliminators are provided in the conduit roof or sides downstream of the liquid sprays. These holes or slots cause increased air flow which results in improved cooling apparatus performance.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: May 5, 1981
    Assignee: Baltimore Aircoil Co., Inc.
    Inventor: Richard P. Merrill
  • Patent number: 4257745
    Abstract: The invention is a unique combination of a pressure switch, a temperature switch, and a check valve which act to automatically control the on-off operation of a centrifugal pump in response to an external flow demand.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: March 24, 1981
    Assignee: Baltimore Aircoil Co.
    Inventors: Gerry W. Thur, Timothy A. Moore
  • Patent number: 4256758
    Abstract: Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: March 17, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • Patent number: 4249021
    Abstract: Substituted 1-oxo-2,2-disubstituted-5-indanacetic acids and their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: February 3, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Haydn W. R. Williams, Otto W. Woltersdorf, Jr.
  • Patent number: 4246406
    Abstract: The case involves novel heterocyclic substituted pyrazinoylguanidines and a process for preparing same. The heterocyclic pyrazinoylguanidines are eukalemic agents possessing diuretic and natriuretic properties.
    Type: Grant
    Filed: March 27, 1979
    Date of Patent: January 20, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr., Susan J. DeSolms
  • Patent number: 4237130
    Abstract: The invention relates to 2,3-dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids and derivatives thereof having diuretic-saluretic, uricosuric and antihypertensive pharmacological activity.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., William F. Hoffman
  • Patent number: 4237144
    Abstract: This invention relates to 2,3-dihydro-2,6,7-trisubstituted-5-acylbenzofurans, derivatives thereof and processes for their preparation. The novel benzofurans described herein have diuretic-saluretic, uricosuric and antihypertensive pharmacological activity.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., William F. Hoffman
  • Patent number: 4233452
    Abstract: Novel derivatives of glycolic and glyoxylic acid are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate urolithiasis (calcium oxalate kidney and bladder stone disease).
    Type: Grant
    Filed: May 3, 1979
    Date of Patent: November 11, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Haydn W. R. Williams, Edward J. Cragoe, Jr., Clarence S. Rooney
  • Patent number: 4224447
    Abstract: The case involves novel pyrazinecarboxamide compounds and processes for preparing same. The pyrazinecarboxamides are eukalemic agents possessing diuretic and natriuretic properties.
    Type: Grant
    Filed: March 27, 1979
    Date of Patent: September 23, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Otto W. Woltersdorf, Jr., Susan J. deSolms
  • Patent number: 4208413
    Abstract: The case involves novel N-pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same. The compounds are excellent eukalemic agents possessing diuretic and natriuretic properties.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: June 17, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
  • Patent number: 4207329
    Abstract: Novel derivatives of glycolic and glyoxylic acid are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate urolithiasis (calcium oxalate kidney and bladder stone disease).
    Type: Grant
    Filed: October 11, 1978
    Date of Patent: June 10, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Haydn W. R. Williams, Edward J. Cragoe, Jr., Clarence S. Rooney
  • Patent number: 4196292
    Abstract: N-amidino-3,5-diamino-6-substituted-2-pyrazinecarboxamides and a process for their synthesis.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: April 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Otto W. Woltersdorf, Jr., Susan J. deSolms, Edward J. Cragoe, Jr.
  • Patent number: 4196157
    Abstract: A counterflow evaporative heat exchanger comprises a vertical conduit in which a coil assembly is positioned. A fluid to be cooled or condensed passes through the coil assembly while water is sprayed downwardly over it and air is blown upwardly through it. The coil assembly comprises a plurality of tubes which at each level in the assembly are spaced apart from each other in the horizontal direction by an amount greater than the diameter of the tubes. This has been found to improve heat transfer in comparison to counterflow evaporative heat exchangers using closely packed coil assemblies.
    Type: Grant
    Filed: July 6, 1978
    Date of Patent: April 1, 1980
    Assignee: Baltimore Aircoil Company, Inc.
    Inventor: Edward N. Schinner
  • Patent number: 4190655
    Abstract: A novel salt of amiloride particularly amiloride citrate has been discovered. Because of its inherent insolubility and less bitter taste, it would lend itself to be more easily formulated into oral liquids, sustained release formulations and chewable tablets than would amiloride hydrochloride.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: February 26, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Joseph DeMarco, Gerald S. Brenner
  • Patent number: 4189496
    Abstract: 2,3-Dihydro-6,7-disubstituted-5-thienylmethyl or furylmethyl benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
    Type: Grant
    Filed: February 16, 1978
    Date of Patent: February 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., William F. Hoffman, Otto W. Woltersdorf, Jr.
  • Patent number: 4187315
    Abstract: N-Alkyl and N-cycloalkyloxamic acid derivatives are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate urolithiasis (kidney and bladder stone disease).
    Type: Grant
    Filed: October 11, 1978
    Date of Patent: February 5, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Frederick C. Novello, Walfred S. Saari
  • Patent number: 4182764
    Abstract: [1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acid, derivatives thereof, their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. Also disclosed are processes for the preparation of such [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids, pharmaceutical compositions comprising therapeutically effective amounts of such compounds and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: January 8, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
  • Patent number: 4181727
    Abstract: 2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
    Type: Grant
    Filed: January 27, 1978
    Date of Patent: January 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
  • Patent number: D254149
    Type: Grant
    Filed: July 12, 1977
    Date of Patent: February 5, 1980
    Assignee: Baltimore Aircoil Company, Inc.
    Inventor: John Engalitcheff, Jr.