Patents Represented by Attorney Michael C. Sudol

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  • Use of a carboxylic functional polyampholyte to inhibit the precipitation and deposit of scale in aqueous systems
    Patent number: 4460477
    Abstract: The instant invention is directed to a method of inhibiting the precipitation and deposition of scale in an aqueous system comprising adding an effective amount, preferably at least 0.1 ppm, of a carboxylic functional polyampholyte, or the salt thereof, to said aqueous system.
    Type: Grant
    Filed: August 25, 1982
    Date of Patent: July 17, 1984
    Assignee: Calgon Corporation
    Inventors: Christine A. Costello, Gary F. Matz
  • Method of increasing oral absorption of glycosidic and related antibiotics
    Patent number: 4459295
    Abstract: A method and drug form are provided for increasing the oral absorption of glycosidic and related antibiotics such as macrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt thereof. The hydroxyaryl or hydroxyaralkyl acid or salt thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: July 10, 1984
    Assignee: INTERx Research Corporation
    Inventors: Takeru Higuchi, Toshiaki Nishihata
  • 4a-Substituted avermectin compounds
    Patent number: 4457920
    Abstract: There are disclosed novel avermectin compounds wherein the 4-methyl group is substituted with hydroxy or various groups connected through the hydroxy oxygen atom. The hydroxy compounds are prepared by oxidation of the 4-methyl group and the hydroxy substituents prepared by a substitution process selective for primary alcohols. The compounds have utility as antiparasitic agents and compositions for that use are also disclosed.
    Type: Grant
    Filed: August 4, 1982
    Date of Patent: July 3, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Helmut H. Mrozik
  • Ampholytic polymers for use as filtration control aids in drilling muds
    Patent number: 4455240
    Abstract: The instant invention is directed to an aqueous drilling fluid comprising an aqueous clay dispersion and a carboxylic functional polyampholyte, or the salt thereof. The instant invention is also directed to the use of the drilling fluid.
    Type: Grant
    Filed: December 15, 1981
    Date of Patent: June 19, 1984
    Assignee: Calgon Corporation
    Inventor: Christine A. Costello
  • Control of scale in sugar evaporation equipment
    Patent number: 4452703
    Abstract: The instant invention is directed to a method for preventing the formation of scale in sugar evaporation equipment comprising adding to the juice from 0.1 to 200 ppm of a polycarboxylic acid or its salt selected from the group consisting of polymaleic acid, amine adducts of maleic anhydride polymers, phosphonobutane tri-carboxylic acid, phosphinocarboxylic acids and copolymers of acrylic acid and an hydroxylated lower alkyl acrylate.
    Type: Grant
    Filed: May 24, 1983
    Date of Patent: June 5, 1984
    Assignee: Calgon Corporation
    Inventors: Paul H. Ralston, Sandra L. Whitney, Jerry L. Walker
  • Method of preparing 1,2-dibromo-2-cyano-(substituted)-alkane antimicrobial compounds
    Patent number: 4446076
    Abstract: Method of preparing antimicrobial compounds of the formula: ##STR1## comprising the following steps: (1) halogenating allyl halide to form 1,2,3-trihalopropane; (2) dehydrohalogenating the 1,2,3-trihalopropane to form 2,3-dihalo-1-propene;(3) treating the 2,3-dihalo-1-propene with a Grignard reagent of the formula R--MgHal, where R is as defined above, followed by treatment with magnesium, to form 3-(R-substituted)-2-magnesiumhalide)-1-propene;(4) treating the 3-(R-substituted)-2-(magnesiumhalide)-1-propene with cyanogen to form 3-(R-substituted)-2-cyano-1-propene; and(5) brominating the 3-(R-substituted)-2-cyano-1-propene to form the desired product.
    Type: Grant
    Filed: December 22, 1981
    Date of Patent: May 1, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Marshall R. Angeles
  • Prodrugs of 6-mercaptopurine and 6-mercaptopurine ribosides and therapeutic compositions and methods employing them
    Patent number: 4443435
    Abstract: Novel, transient prodrug forms of biologically active agents containing mercapto groups have (i) the structural formula (I): ##STR1## wherein X is O, S, or NR.sup.5 ;R.sup.1 S is the residue of any biologically active agent R.sup.1 SH;R.sup.
    Type: Grant
    Filed: November 12, 1981
    Date of Patent: April 17, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Nicholas S. Bodor, Kenneth B. Sloan, Stefano A. Pogany
  • Use of eucalyptol for enhancing skin permeation of bio-affecting agents
    Patent number: 4440777
    Abstract: Greatly enhanced delivery of a wide variety of bio-affecting agents is provided by formulations for topical application comprising at least one bio-affecting agent and eucalyptol. Optionally, the formulation can further comprise a non-toxic topical carrier and/or an additional penetration enhancer. The eucalyptol acts as a unique transport agent which readily delivers the active bio-affecting agent across the stratum corneum to the target area. Cosmetic and therapeutic dermatological agents as well as systemically effective therapeutic agents can be easily formulated with eucalyptol and effectively delivered through the skin to the desired site, i.e., to the underlying tissues of the epidermis and dermis or to the general circulation.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: April 3, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Jacob A. Zupan
  • .alpha.-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption
    Patent number: 4440740
    Abstract: A method and drug form enhancing the absorption of a rectally or orally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a drug form capable of being rectally and orally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the gastrointestinal area and an .alpha.-keto aldehyde or salts thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when administering the drug form to warm blooded animals.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: April 3, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joseph A. Fix, Stefano A. Pogany
  • Water and drug delivery system for suppository use
    Patent number: 4439194
    Abstract: A drug delivery system designed to deliver water and drug to the site of administration is composed of a core of an aqueous solubulizing system in a wax housing, which melts at body temperature, surrounded by a matrix of drug and water-dispersible excipients. The entire unit may also be coated with a semi-permeable membrane to modulate drug release.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: March 27, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Richard J. Harwood, Joseph V. Bondi
  • Osmotic drug delivery system
    Patent number: 4439196
    Abstract: An osmotic drug (or other beneficial substance) delivery system comprises a multi-chamber compartment formed by an external shell and one or more chamber-dividing walls each with a small orifice, of a microporous material and overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of the remaining chamber. Osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chambers covered by the semipermeable membrane, and external fluids that diffuse into those chambers form solutions and by osmotic pressure are forced through the orifice to the drug chamber to form a solution thereof and then through the exposed microporous shell to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.
    Type: Grant
    Filed: March 18, 1982
    Date of Patent: March 27, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Takeru Higuchi
  • Polyphosphoric acid as a scale and corrosion inhibitor
    Patent number: 4436628
    Abstract: The instant invention is directed to a process for the inhibition of scale and corrosion formation in an aqueous system, comprising adding to the system about 0.1 to 100 ppm, by weight based on the total aqueous content of said system, of 103 to 115% polyphosphoric acid, or neutral salts thereof.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: March 13, 1984
    Assignee: Calgon Corporation
    Inventors: Paul H. Ralston, Sandra L. Whitney
  • 4-[5(and 4)-Substituted-2-thienyl]-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
    Patent number: 4432992
    Abstract: Novel 4-[5(and 4)-substituted-2-thienyl]-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: February 21, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
  • Cationic polymers for reduction of viscosity of a magnesium hydroxide slurry
    Patent number: 4430248
    Abstract: The instant invention is directed to a method for reducing the viscosity of magnesium hydroxide aqueous slurries which comprises adding an effective amount of a cationic polymer to the magnesium hydroxide slurry. The instant invention is also directed to magnesium hydroxide aqueous slurries containing cationic polymer.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: February 7, 1984
    Assignee: Calgon Corporation
    Inventor: Paul A. Rey
  • [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa
    Patent number: 4426391
    Abstract: Novel prodrugs of methyldopa which are [(alkoxycarbonyl)oxy]alkyl esters of methyldopa are disclosed. Also, pharmaceutical compositions containing these compounds are disclosed. Upon administration to warm-blooded animals, these prodrugs liberate methyldopa along with innocuous side products.
    Type: Grant
    Filed: September 15, 1982
    Date of Patent: January 17, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Jose Alexander, Chung Shih
  • Photopolymerization using copper ions
    Patent number: 4415417
    Abstract: Photopolymerization of monomers by visible light using a photoreducible dye, a reducing agent and a controlled level of copper ions allows for high molecular weight polymer formation. The molecular weight is found to be proportional to the copper ion concentration. At 10 to 1,000 ppb copper ion concentration, the molecular weight of the polymer is optimum.
    Type: Grant
    Filed: July 19, 1982
    Date of Patent: November 15, 1983
    Assignee: Calgon Corporation
    Inventors: Lee W. Bush, Marie S. Chan, Gary P. Craun, William J. Erlanson, Wood E. Hunter, Wallace B. Ramsey
  • Aminomethylphosphonic acid and polymaleic anhydride combinations for treating corrosion
    Patent number: 4401587
    Abstract: A method of inhibiting corrosion of low carbon steel in an aqueous system comprising treating said system with 1.0 to 300 parts per million by weight of the total aqueous content of said system, of a composition comprising aminomethylphosphonic acid compounds and polymaleic anhydride or amine adducts thereof in a weight ratio of from 10:1 to 1:10.
    Type: Grant
    Filed: December 16, 1981
    Date of Patent: August 30, 1983
    Assignee: Calgon Corporation
    Inventor: Bennett P. Boffardi
  • Unit dose applicator
    Patent number: 4398909
    Abstract: A unit dose applicator for liquid ophthalmic medicaments in solution or suspension has an elongated housing for the medicament; at one end of the housing there is an opening for at least partially emptying the contents of the housing; at the other end of the housing is a second opening; and the second opening is capped by a diaphragm-like seal having a sufficient displacement potential to exude only 1 to 4 drops of the medicament.
    Type: Grant
    Filed: December 31, 1981
    Date of Patent: August 16, 1983
    Inventor: Joel B. Portnoff
  • Dispenser for fluid or semi-fluid materials
    Patent number: D271450
    Type: Grant
    Filed: June 18, 1981
    Date of Patent: November 22, 1983
    Assignee: Calgon Corporation
    Inventor: Gary B. Kleman
  • Dispenser for fluid or semi-fluid materials
    Patent number: D271544
    Type: Grant
    Filed: June 18, 1981
    Date of Patent: November 29, 1983
    Assignee: Calgon Corporation
    Inventor: Gary B. Kleman