Patents Represented by Attorney Michael J. DiVerdi

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  • Heterocyclic derivatives as modulators of ion channels
    Patent number: 8343763
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: January 1, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • Modulators of ATP-binding cassette transporters
    Patent number: 8324207
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: December 4, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou, Fredrick van Goor
  • Modulators of ATP-binding cassette transporters
    Patent number: 8318733
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: November 27, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Sabina Hadida-Ruah, Matthew Hamilton, Mark Thomas Miller, Peter Diederik Jan Grootenhuis, Jinglan Zhou, Brian Richard Bear, Jason McCartney
  • Bicyclic derivatives as modulators of ion channels
    Patent number: 8314125
    Abstract: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: November 20, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas P. Termin, Nicole Hilgraf, Tara Leanne Hampton, Gabriel Martinez-Botella, Esther Martinborough
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 8309543
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: November 13, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Hilgraf
  • Piperidine and piperazine phenyl sulphonamides as modulators of ion channels
    Patent number: 8309587
    Abstract: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: November 13, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Ann Martinborough, Lev Tyler Dewey Fanning, Urvi Jagdishbhai Sheth, Dean Mitchell Wilson, Andreas P. Termin, Timothy Donald Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • Heteroaryl derivatives as CFTR modulators
    Patent number: 8299099
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: October 30, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida Ruah, Mark Miller, Jinglan Zhou, Brian Bear
  • Bicyclic derivatives as modulators of voltage gated ION channels
    Patent number: 8236829
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: August 7, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • Biphenyl derivatives as modulators of voltage gated ion channels
    Patent number: 8236833
    Abstract: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: August 7, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Danielle Lehsten, Timothy Neubert, Aarti Sameer Kawatkar, Nicole Hilgraf, Andreas Termin
  • Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters
    Patent number: 8232302
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: July 31, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Sara S. Hadida Ruah, Peter Diederik Jan Grootenhuis, Matthew Hamilton
  • Pyridyl derivatives as CFTR modulators
    Patent number: 8227615
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: July 24, 2012
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Sara Hadida-Ruah, Mark Miller, Jinglan Zhou, Brian Bear, Peter Grootenhuis
  • Heterocyclic derivatives for modulation of calcium channels
    Patent number: 8211935
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: July 3, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas P. Termin, Esther Ann Martinborough, Nicole Hilgraf, Charles J. Cohen, Corey Anderson
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 8202861
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: June 19, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E Gonzales, III, Andreas P Termin, Esther Martinborough, Nicole Zimmerman
  • Ion channel modulators and methods of use
    Patent number: 8193194
    Abstract: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: June 5, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Tim Neubert, Tara Whitney, Danielle Lehsten, Tara Hampton, Nicole Zimmermann, Andreas P. Termin
  • Pyrrolidinyl phenyl sulphonamides as modulators of ion channels
    Patent number: 8163720
    Abstract: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: April 24, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Lev T. D. Fanning, Urvi Sheth, Dean Wilson, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 8153655
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: April 10, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus Gonzalez, III, Andreas Termin, Esther Martinborough, Nicole Zimmermann
  • Heterocyclic derivatives as modulators of ion channels
    Patent number: 8143297
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 27, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • Derivatives for modulation of ion channels
    Patent number: 8129546
    Abstract: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: March 6, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Corey Anderson
  • Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
    Patent number: 8124781
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: February 28, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • Heterocyclic derivatives as modulators of ion channels
    Patent number: 8097636
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: January 17, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Stamos, Esther Martinborough, Nicole Zimmermann, Timothy Neubert, Mehdi Michel Djamel Numa, Tara Whitney, Tara Leanne Hampton