Patents Represented by Attorney Michael J. DiVerdi

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  • Bicyclic derivatives as modulators of ion channels
    Patent number: 7745629
    Abstract: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 29, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas Termin, Nicole Zimmermann, Tara Leanne Knoll, Gabriel Martinez-Botella, Esther Martinborough
  • Modulators of ATP-binding cassette transporters
    Patent number: 7741321
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: June 22, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Target ligand generation
    Patent number: 7716030
    Abstract: Methods of identifying potential ligands for macromolecular targets are disclosed herein. The methods comprise providing models of three dimensional structural information for ligands or a ligand:macromolecule complex, mapping spatial relationships between the models, and identifying one or more pairs of matching bonds. Databases and apparatuses are also provided.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: May 11, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Albert Pierce, Guy Bemis
  • Modulators of ATP-binding cassette transporters
    Patent number: 7691902
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: April 6, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney
  • Biphenyl derivatives as modulators of voltage gated ion channels
    Patent number: 7683083
    Abstract: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: March 23, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Danielle Lehsten, Timothy Neubert, Aarti Sameer Kawatkar, Nicole Zimmermann, Andreas Termin
  • Isoquinolines useful as modulators of ion channels
    Patent number: 7683066
    Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: March 23, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas Termin, Dean Wilson, Pramod Joshi
  • Modulators of ATP-Binding Cassette transporters
    Patent number: 7671221
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: March 2, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Brian Bear, Jason McCartney, Peter D. J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 7659268
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 9, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida-Ruah, Matthew Hamilton, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou, Frederick van Goor