Patents Represented by Attorney Michael P. Morris

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  • Hydrates and polymorphs of 4-[[(7)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy--(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
    Patent number: 8034816
    Abstract: Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: October 11, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Peter Sieger, Gerd F. Kraemer, Rolf Herter, Matthias Hoffmann, Werner Rall, Rolf Schmid
  • Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
    Patent number: 8034809
    Abstract: Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X? may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: October 11, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Philipp Lustenberger, Ingo Konetzki, Peter Sieger
  • Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 8034941
    Abstract: The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 11, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Norbert Hauel, Elke Langkopf, Frank Himmelsbach, Iris Kauffmann-Hefner, Mohammad Tadayyon, Michael Mark
  • Viral polymerase inhibitors
    Patent number: 8030309
    Abstract: An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: October 4, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Youla S. Tsantrizos, Catherine Chabot, Pierre Beaulieu, Christian Brochu, Martin Poirier, Timothy A. Stammers, Bounkham Thavonekham, Jean Rancourt
  • PCV2 immunogenic compositions and methods of producing such compositions
    Patent number: 8025888
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time-consuming extraction procedures required to separate and recover the recombinant protein from within the cells.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: September 27, 2011
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • Antibodies to
    Patent number: 8021663
    Abstract: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test kit for diagnosing Lawsonia intracellularis infections.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: September 20, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Malik Merza
  • Method for the administration of an anticholinergic by inhalation
    Patent number: 8022082
    Abstract: An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1 ?{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 ?m, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 ?m to 500 ?m, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 ?{square root over (kPa)} min/L containing the inhalable powder.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: September 20, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventor: Bernd Zierenberg
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 8017771
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: September 13, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • gM-negative EHV-mutants
    Patent number: 8017317
    Abstract: This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: September 13, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Knut Elbers, Nikolaus Osterrieder, Christian Seyboldt
  • Antibodies to
    Patent number: 8007802
    Abstract: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test kit for diagnosing Lawsonia intracellularis infections.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: August 30, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Malik Merza
  • Method for preparing tiotropium salts
    Patent number: 8008495
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: August 30, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ralf Lock, Werner Belzer, Rainer Hamm, Monika Hofmann
  • Indazole compounds as CCR1 receptor antagonists
    Patent number: 8008327
    Abstract: Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: August 30, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Darren DiSalvo, Daniel Kuzmich, Can Mao, Hossein Razavi, Christopher Ronald Sarko, Alan David Swinamer, David Smith Thomson, Qiang Zhang
  • Antibodies to
    Patent number: 8007801
    Abstract: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test kit for diagnosing Lawsonia intracellularis infections.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: August 30, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Malik Merza
  • Substituted prolinamides, the preparation thereof and the use thereof as pharmaceutical compositions
    Patent number: 8003639
    Abstract: The present invention provides new substituted prolinamides of the general formula (I) in which D, L, E, G, J, M, R3, R4, R5, and R13 are defined as in claim 1, their tautomers, their enantiomers, their diastereomers, their mixtures and their salts, more particularly their physiologically tolerated salts with organic or inorganic acids or bases, which exhibit valuable properties.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: August 23, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Georg Dahmann, Kai Gerlach, Herbert Nar, Roland Pfau, Annette Schuler-Metz, Wolfgang Wienen
  • Capsule for taking an active substance which can be inhaled
    Patent number: 8001965
    Abstract: The invention relates to a novel capsule for receiving an active substance to be administered by inhalation, which is preferably intended for use in a powder inhaler operating on the Bernoulli principle.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 23, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Heinrich Kladders, Burkhard Metzger, Dieter Hochrainer
  • Dihydropteridinone compounds
    Patent number: 8003786
    Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: August 23, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Matthias Hoffmann, Matthias Grauert, Martin Steegmaier, Anke Baum, Jens Juergen Quant, Flavio Solca, Florian Colbatzky, Gisela Schnapp
  • Dual chamber container and process for its filling up
    Patent number: 8002734
    Abstract: A double chamber container for holding and combining a solid lyophilizate and a liquid reconstituting medium, comprising a cylindrical body with a closure at each of the two ends, an upper displaceable closure at the reconstituting medium end, and a lower closure at the lyophilizate end, a separating stopper that can be pushed in the cylindrical body and act as a seal between the upper chamber and the lower chamber, and a bypass arranged underneath the separating stopper, with a length L that is preferably greater than the height H of the separating stopper, wherein at the upper end in the wall of the cylindrical body or in the separating stopper means are provided that allow partial connection of the interior of the cylindrical body to the environment during the lyophilization.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: August 23, 2011
    Assignee: Boehringer Ingelheim International Gmbh
    Inventors: Stefan Bassarab, Alexander Bauer, Nicole Denkinger, Patrick Garidel, Markus Hemminger, Hans-Hoachim Kern, Andreas Langer, Ingo Presser
  • Antibodies to
    Patent number: 8003107
    Abstract: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test kit for diagnosing Lawsonia intracellularis infections.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: August 23, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Malik Merza
  • Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
    Patent number: 7998949
    Abstract: The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb and Rc are defined as in claim 1, their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids and bases, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: August 16, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Birgit Jung, Ralf Lotz, Markus Ostermeier
  • Hybridoma producing antibodies to
    Patent number: 7993649
    Abstract: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test kit for diagnosing Lawsonia intracellularis infections.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: August 9, 2011
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Malik Merza