Patents Represented by Attorney Michael P. Morris

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  • Carboxylic acid amides, the preparation thereof and their use as medicaments
    Patent number: 7947700
    Abstract: The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: May 24, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Kai Gerlach, Roland Pfau, Norbert Hauel, Iris Kauffmann-Hefner, Georg Dahmann, Herbert Nar, Sandra Handschuh, Wolfgang Wienen, Annette Schuler-Metz
  • Prevention and treatment of sub-clinical PCVD
    Patent number: 7943298
    Abstract: The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: May 17, 2011
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Vicky Fachinger, Knut Elbers, Marion Kixmoeller, Francois-Xavier Orveillon, Isabelle Von Richthofen, Axel Lischewski
  • Impaction nozzle for propellant driven metered dose aerosols
    Patent number: 7942146
    Abstract: Propellant gas inhaler fitted with a valve or valve system through which at least two clouds of aerosols or at least two jet streams are produced that travel towards one another at an angle from 0° to 180°, so that the individual aerosol particles at least partially impact with one another and lose kinetic energy thereby.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: May 17, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Georg Boeck
  • Inhibitors of human immunodeficiency virus replication
    Patent number: 7939545
    Abstract: Compounds of formula I: wherein a, b, c, X, R2, R3, R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: May 10, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Youla S. Tsantrizos, Michael Boes, Christian Brochu, Craig Fenwick, Stephen Mason, Marc Pesant, Eric Malenfant
  • Hepatitis C inhibitor compounds
    Patent number: 7939667
    Abstract: Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: May 10, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Montse Llinas-Brunet, Murray Bailey, Punit Bhardwaj, Josee Bordeleau, Pasquale Forgione, Elise Ghiro, Vida Gorys, Nathalie Goudreau, Sylvie Goulet, Teddy Halmos, Jean Rancourt
  • Enantiomeric pure beta agonists, manufacturing and use as a medicaments thereof
    Patent number: 7939658
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym? may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: May 10, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Ries, Peter Sieger
  • Compounds which modulate the CB2 receptor
    Patent number: 7935715
    Abstract: Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 3, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Angela Berry, Pier Francesco Cirillo, Eugene Richard Hickey, Doris Riether, David S. Thomson, Monika Ermann, James Edward Jenkins, Innocent Mushi, Malcolm Taylor, Christopher Francis Palmer, Nigel Blumire
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Patent number: 7932392
    Abstract: Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: April 26, 2011
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, Thomas A. Gilmore, Daniel Kuzmich, John Robert Proudfoot, David S. Thomson
  • 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl) phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as a medicament
    Patent number: 7932273
    Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: April 26, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rolf Schmid, Peter Sieger, Rainer Sobotta
  • Compounds which modulate the CB2 receptor
    Patent number: 7928103
    Abstract: Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: April 19, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Doris Riether, David Smith Thomson, Renee M. Zindell
  • Compounds which modulate the CB2 receptor
    Patent number: 7928123
    Abstract: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: April 19, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Angela Berry, Pier Francesco Cirillo, Doris Riether, David Thomson, Renee M. Zindell, Nigel Blumire, Chandana Chowdhury, Monika Ermann, James Edward Jenkins, Innocent Mushi, Christopher Francis Palmer, Malcolm Taylor
  • Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic
    Patent number: 7923455
    Abstract: The present invention relates to a method for the prevention or the treatment of heart failure comprising administration of a therapeutically effective amount of an anticholinergic 1, medicaments for the prevention or treatment of heart failure comprising one or more, preferably one anticholinergic 1, and methods for the preparation of these medicaments.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: April 12, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Steven Kesten, Klaus Viel
  • Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
    Patent number: 7923449
    Abstract: The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of premenstrual and other female sexual disorders.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: April 12, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Angelo Ceci
  • Self-replicating RNA molecule from hepatitis C virus
    Patent number: 7919312
    Abstract: A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV RNA in cell culture. This self-replicating polynucleotide molecule contains, contrary to all previous reports, a 5?-NTR that can be either an A as an alternative to the G already disclosed and therefore provides an alternative to existing systems comprising a self-replicating HCV RNA molecule. The G?A mutation gives rise to HCV RNA molecules that, in conjunction with mutations in the HCV non-structural region, such as the G(2042)C/R mutations, possess greater efficiency of transduction and/or replication. These RNA molecules when transfected in a cell line are useful for evaluating potential inhibitors of HCV replication.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: April 5, 2011
    Assignee: Boehringer Ingelheim (Canada) Ltd.
    Inventors: George Kukolj, Arnim Pause
  • Treatment of PRDC in pigs
    Patent number: 7914992
    Abstract: The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment, including a reduction in the severity of, duration of, and manifestations of, porcine respiratory disease complex (PRDC) in animals, preferably in pigs.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: March 29, 2011
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Vicky Fachinger, Knut Elbers, Marion Kixmoeller, Francois-Xavier Orveillon, Isabelle von Richthofen, Axel Lischewski
  • Apparatus for quantifying shear stress on a formulation comprising biomolecules
    Patent number: 7916289
    Abstract: The present invention relates to an apparatus for determining the shear sensitivity of particles in solutions and methods of determining the respective shear velocities or the respective shear stress.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: March 29, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Udo Heinzelmann, Patrick Garidel, Hans-Joachim Kern, Andreas Langer, Juergen Weber
  • Formulation for a metered dose inhaler using hydro-fluoro-alkanes as propellants
    Patent number: 7914770
    Abstract: An improved suspension formulation for use in a metered-dose inhaler having a hydro-fluoro-alkane propellant is described, the improvement being the controlled addition of a small quantity of water.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: March 29, 2011
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: George DeStefano, Linda Jean Kelash-Cannavo
  • PCV2 immunogenic compositions and methods of producing such compositions
    Patent number: 7910306
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time-consuming extraction procedures required to separate and recover the recombinant protein from within the cells.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: March 22, 2011
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
    Patent number: 7910731
    Abstract: The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: March 22, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank Himmelsbach, Birgit Jung, Flavio Solca
  • Imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions
    Patent number: 7906539
    Abstract: The present invention relates to imidazoles and triazoles of general formula wherein R1 to R4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: March 15, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Elke Langkopf, Leo Thomas, Mohammad Tadayyon