Patents Represented by Attorney, Agent or Law Firm Millen, White, Zelane, & Branigan, P.C.
  • Patent number: 6399611
    Abstract: Aralkylpyridazinone derivatives of the formula I and their physiologically acceptable salts in which R1, R2, R3, R4, R5 and Q have the meanings indicated in claim 1, show inhibition of phosphodiesterase IV and can be employed for the treatment of inflammatory processes and of allergies, asthma and autoimmune disorders.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: June 4, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Rochus Jonas, Michael Wolf, Norbert Beier
  • Patent number: 6342279
    Abstract: The invention relates to an electrooptical liquid-crystal display having a realignment layer for realigning the liquid crystals, where the field thereof has a significant component parallel to the liquid-crystal layer, containing a liquid-crystalline medium having positive dielectric anisotropy, where the medium comprises at least one mesogenic compound which contains a group of the formula I and at least one compound of formula II wherein L1 is H or F; R1 R2 are H, an alkyl or alkenyl radical having 1 to 15 carbon atoms which may be substituted; Q is a radical of the formula —(O)q (CH2)r—(CF2)s— in which q is 0 or 1; r is 0 or an integer of 1 to 6, and s is an integer of 0 to 6; X is F or Cl, and in the case where s ≠0, is alternatively H, and A1 and A2 are each, independently of one another, a 1,4-cyclohexenylene or trans-1,4-cyclohexylene which may be substituted; 1,4-phenylene in which may be substituted, 1,4-bicyclo[2.2.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: January 29, 2002
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Kazuaki Tarumi, Andreas Beyer, Anja Huth, Eike Poetsch, Michael Kompter
  • Patent number: 6225490
    Abstract: For the continuous hydrolysis of organochlorosilane, a reaction system comprising at least three stages of hydrolysis is used. Each stage includes a reactor and a phase separator wherein hydrolysis is effected to form a hydrolysis mixture which is separated into a hydrolyzate and a hydrogen chloride-containing aqueous medium. The separated aqueous medium is circulated to the reactor. The hydrolyzate is conveyed to the reactor of the subsequent stage. The organochlorosilane is fed into the first stage reactor, the aqueous medium containing an amount of water corresponding to the consumption in one stage is fed into one stage reactor from the subsequent stage, and an amount of water corresponding to the consumption in the overall reaction system is fed in the last stage. Then the entire amount of hydrogen chloride generated in multiple stages of hydrolysis is recovered as anhydrous hydrogen chloride from the first stage.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: May 1, 2001
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Hiroshi Nakayama, Naoyuki Ida, Hiroyuki Kobayashi, Yukinori Satoh, Yoshihiro Shirota, Masaaki Furuya
  • Patent number: 6179058
    Abstract: A system for displacing instruments in a pipe including a portion that is greatly inclined to the vertical. The system includes a set of instruments mechanically linked, by means of an extension, to a first end of electrically-powered displacement device. The extension is a section of a composite, semi-rigid rod that can be wound around a drum and comprises at least one electric conductor. The present invention also relates to a method for implementing the system. Application is to greatly inclined oil wells and to lateral holes.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: January 30, 2001
    Assignee: Institut Francis du Petrole
    Inventor: Christian Wittrisch
  • Patent number: 6143278
    Abstract: The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical administration of an opioid analgesic agent, e.g., morphine sulfate, in admixture with a skin- or mucosal-specific penetration enhancer, to produce a localized analgesic effect in inflamed or non-inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of opioid agent, e.g., into the systemic circulation.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: November 7, 2000
    Inventor: George F. Elkhoury
  • Patent number: 6140524
    Abstract: A mixture of short-chain polysulfide silanes of the formula: (RO).sub.3 SiC.sub.3 H.sub.6 S.sub.n C.sub.3 H.sub.6 Si(OR).sub.3 wherein R is methyl or ethyl and n is a positive number having a distribution whose average falls in the range: 2.2.ltoreq.n.ltoreq.2.8 is prepared by reacting metal polysulfides, typically Na.sub.2 S.sub.n with a halogenopropyltrialkoxysilane of the formula: (RO).sub.3 SiC.sub.3 H.sub.6 X wherein X is halogen.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: October 31, 2000
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Shoji Ichinohe, Hideyoshi Yanagisawa
  • Patent number: 6107295
    Abstract: Arylalkanoylpyridazine derivatives of the formula I ##STR1## and the physiologically acceptable salts thereof in whichR.sup.1, R.sup.2, R.sup.3, R.sup.4, Q and B have the meanings given in claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases and AIDS.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: August 22, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Jonas Rochus, Norbert Beier, Franz-Werner Kluxen, Michael Wolf
  • Patent number: 6106144
    Abstract: A process for gravimetric production of test gas by re-weighing includes a series of sequential process steps, the first of which is weighing an evacuated gas container on a scale and then connecting a gas feed line to a control valve that is connected to the gas container by a controllable adjustment element connected to the scale. The controllable valve is automatically opened to fill a first test gas component, with the amount placed in the first test gas component being automatically monitored by weighing the gas container. After a selected quantity of test gas is provided, the controllable valve is closed. The connection between the gas feed line and controllable valve is accomplished by an adjustable fluid cylinder which automatically disconnects the gas feed line from the scale. The gas container is then reweighed and the process repeated for each subsequent test gas component placed in the gas container.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: August 22, 2000
    Assignee: Linde Technische Gase GmbH
    Inventor: Helmut Schon
  • Patent number: 6096670
    Abstract: An alkali metal-free aluminoborosilicate glass is described which has the following composition (in % by weight based on oxide):SiO.sub.2 57-60; B.sub.2 O.sub.3 6.5-9.5; Al.sub.2 O.sub.3 14-17.5; MgO 5-8; CaO 1-4; SrO 5-8; BaO 0-3.5; with MgO+CaO+SrO+BaO 15-17; ZrO.sub.2 0.4-1.5; TiO.sub.2 0.4-1.5; CeO.sub.2 0.1-0.5; SnO.sub.2 0.2-1.The glass is particularly suitable for use as a substrate glass in display technology.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: August 1, 2000
    Assignee: Schott Glaswerke
    Inventors: Gerhard Lautenschlager, Klaus Schneider, Thomas Kloss, Peter Brix
  • Patent number: 6090966
    Abstract: Alkylhalosilanes are produced by first fluidizing a metallic silicon powder with an inert gas, preheating the silicon powder at a temperature between C. and a steady reaction temperature while keeping the silicon powder fluidized, adding a copper catalyst to the preheated silicon powder to form a contact mass, and feeding an alkyl halide into the contact mass whereby the alkylhalosilanes are formed by direct synthesis. This process prevents the copper catalyst from being sintered by thermal hysteresis and activates a high catalysis on the contact mass at the start of reaction. The desired dialkyldihalosilane can be produced at a high selectivity.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: July 18, 2000
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Tetsuo Nakanishi, Tetsuya Inukai, Kazumasa Tsukioka, Hiroshi Nakayama, Yukinori Satoh
  • Patent number: 6077966
    Abstract: Water-soluble organic silicon compounds are prepared by effecting co-hydrolysis of (A) 1-30 parts of an alkyltrialkoxysilane of R.sup.1 Si(OR.sup.2).sub.3 or a partial hydrolyzate thereof, (B) 70-90 parts of an alkoxy-containing siloxane of R.sup.3.sub.a (OR.sup.2).sub.b SiO.sub.(4-a-b)/2, and (C) 1-20 parts of an amino-containing alkoxysilane of R.sup.4 R.sup.5 NR.sup.6 --SiR.sup.7.sub.n (OR.sup.2).sub.3-n or a partial hydrolyzate thereof in the presence of an organic or inorganic acid. R.sup.1 is a C.sub.7 -C.sub.18 alkyl group, R.sup.2 is a C.sub.1 -C.sub.4 alkyl group, R.sup.3 is a C.sub.1 -C.sub.6 alkyl group, R.sup.4 and R.sup.5 are a hydrogen atom, C.sub.1 -C.sub.15 alkyl or aminoalkyl group, R.sup.6 is a divalent C.sub.1 -C.sub.18 hydrocarbon group, and R.sup.7 is a C.sub.1 -C.sub.4 alkyl group. Letters a and b are 0.75.ltoreq.a.ltoreq.1.5, 0.2.ltoreq.b.ltoreq.2, and 0.95<a+b<3.4.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: June 20, 2000
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Kazuyuki Matsumura, Mitsuo Asai, Shoji Ichinohe
  • Patent number: 6063361
    Abstract: Cascade polymer complexes having a complexing ligand with at least two different reproduction units and having a complexing agent which is a macrocyclic group having an amide grouping or a linear DTPA-type group having a linkage to the polymer through the central nitrogen.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: May 16, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Andreas Muhler, Thomas Frenzel
  • Patent number: 6063456
    Abstract: Supertwist liquid-crystal displays (SLCDs) with outstanding properties are obtained if the nematic liquid-crystal mixtures used therein comprise at least one compound selected from the formulae 1A and 1B ##STR1## and at least one compound of the formula 1C ##STR2## in which R.sup.a is alkyl, alkoxy, alkenyl or alkenyloxy having 1 to 12 carbon atoms,R.sup.b is alkyl or alkoxy having 1 to 5 carbon atoms,Z is --COO--, --CH.sub.2 CH.sub.2 -- or a single bond, andL.sup.a, L.sup.b, L.sup.c, L.sup.d, L.sup.e, L.sup.f, L.sup.g, and L.sup.h in each case independently of one another are H or F,with the proviso that the 1,4-phenylene rings carry not more than 2 fluorine atoms per ring,R.sup.3 is an alkenyl group having 2 to 7 carbon atoms,R.sup.4 is R.sup.a or R.sup.3 andc is 0 or 1.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: May 16, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Harald Hirschmann, Sven Schupfer, Volker Reiffenrath, Sabine Schoen
  • Patent number: 6060504
    Abstract: The invention relates to a novel heat-stable form of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diph enylacetamide and to a process for the preparation and isolation of this compound in this novel form and to use for the production of medicaments which contain this compound and/or one of its physiologically acceptable salts.
    Type: Grant
    Filed: August 26, 1996
    Date of Patent: May 9, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Inge Stein, Holger Beeres, Klaus Beschmann, Steffen Neuenfeld, Andrew Barber
  • Patent number: 6054518
    Abstract: In a silicone rubber composition comprising an organopolysiloxane, reinforcing silica, and a curing agent, an ester wax, typically having a melting point of C., is blended as an abherent. When the composition is molded in a mold, the flow of the composition in the mold and the parting of the cured silicone rubber from the mold are significantly improved.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: April 25, 2000
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Osamu Hayashida
  • Patent number: 6043281
    Abstract: The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: March 28, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Claude Lardy, Jaques Barbanton, Herve Dumas, Francois Collonges, Philippe Durbin
  • Patent number: 6034922
    Abstract: A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examination area to be acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.
    Type: Grant
    Filed: January 12, 1999
    Date of Patent: March 7, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Volkmar Uhlendorf, Thomas Fritzsch, Joachim Siegert
  • Patent number: 6018951
    Abstract: A refrigerating and shipping container for refrigerated goods, whereby said container is made heat-insulated, with a door or a cover and with a refrigeration supply. According to the invention, a wall of the container has an indentation into which a cold finger of a refrigeration supply fits.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: February 1, 2000
    Assignee: Linde Aktiengesellschaft
    Inventor: Horst Rudiger
  • Patent number: 6019959
    Abstract: Oligomeric compounds that contain perfluoroalkyl of general formula IA--R.sup.F (I)in whichA is a molecule portion that contains 2-6 metal complexes that are connected directly or via a linker to a nitrogen atom of an annular skeleton chain, andR.sup.F is a perfluorinated, straight-chain or branched carbon chain with formula --C.sub.n F.sub.2n E, in which E represents a terminal fluorine, chlorine, bromine, iodine, or hydrogen atom and n stands for numbers 4-30,are valuable compounds for diagnosis, especially as in-vivo contrast media.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: February 1, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 6017469
    Abstract: Supertwist liquid crystal displays with outstanding properties are obtained when the nematic liquid crystal mixture contains at least one compound of the formula (I): ##STR1## where the variables are as defined in the disclosure.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: January 25, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Volker Reiffenrath, Bernhard Rieger, Michael Junge, Martina Schmidt, Christine Pfister