Abstract: The invention relates to a process for the manufacture of enantiomerically enriched or pure compounds of formula I wherein R1, R2, R3, R6, R7 and Q are defined as in claim 1 as well as their crystalline forms for the treatment of proliferative diseases such as cancer.

Abstract: The invention relates to Glycoprotein VI (GPVI), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the use of GPVI, preferably recombinant GPVI, in the treatment of disorders and pathological events correlated directly or indirectly to blood coagulation disorders such as thrombotic and cardiovascular diseases. The extracellular recombinant protein can also be used for establishing screening assays to find potential inhibitors of the membrane bound GPVI in order to inhibit binding of thrombocytes and platelets, respectively, to collagen. Changes in GPIV can be used to monitor platelet age and exposure to thrombotic and cardiovascular diseases.

Abstract: The present invention relates to chemical compounds containing five or more benzene rings arranged in a linear manner and two bridging units between these rings, where at least one of these units represents a —CF2O— bridge. The invention additionally relates to liquid-crystalline media and to high-frequency components comprising these media, in particular antennae, especially for the gigahertz range.

Abstract: The present invention relates to a method of producing hydrogen of very high purity from a feed predominantly containing said hydrogen and a minor part of impurities mainly consisting of carbon dioxide, carbon monoxide, methane and heavier hydrocarbons. The purification method by hydrogen adsorption using a desorption stage at a lower pressure than the pressure of the feed, such as a PSA method for example, allows to produce the desorption stream and notably to recover the carbon dioxide under pressure and high-purity hydrogen, with a high yield. These performances are obtained by combining the successive stages of the method according to the invention with the use of a new family of adsorbent whose dynamic capacity at a high desorption pressure is greater than that of conventional adsorbents.

Abstract: This present invention disclosed the use of mesoprogestins, a new class of progesterone receptor modulators (PRMs), for the treatment and prevention of benign hormone dependent gynecological disorders: a) for the treatment of gynecological disorder such as endometriosis, uterine fibroids, postoperative peritoneal adhesions, dysfunctional bleeding (metrorrhagia, menorrhagia) and dysmenorrhea; b) for the prevention of gynecological disorders such as postoperative, peritoneal adhesions, dysfunctional uterine bleeding (metrorrhagia, menorrhagia) and dysmenorrhea; and c) a method of treatment and prevention of the above mentioned disorders in a female, preferably in a human female, in need of treatment or prevention of one or more of these disorders, with an effective amount of a mesoprogestin. Mesoprogestins are defined as compounds possessing both agonistic and antagonistic activities at the progesterone receptor (PR) in vivo.

Abstract: The present invention describes a method for measuring the concentrations of species present at one point of a separation unit functioning in simulated moving bed mode (SMB), using an immersing probe located at one point in the unit or on one of the streams entering or leaving said unit, and a thermocouple located in the vicinity of the immersing probe, in which a Raman spectrum obtained using a laser source functioning at a wavelength of 785 nm is utilized.

Abstract: The invention relates in particular to a housing for protecting and masking a toilet bowl whose top part is provided with a peripheral inwardly folded edge which delimits with the bowl a water distribution channel and which is characterized in that it consists of a body (30) and a cover part (32) which is open in the center thereof, is independent of said body (30) and is arrangeable on the body in such a way that it covers the peripheral edge (11) of the bowl, wherein the body (30) is provided with an anchoring part (5) interacting with the cover part (32) and said anchoring and cover (32) parts comprise complementarily shaped connecting means (51, 330).

Abstract: The present invention relates to a toilet in which the bowl (1) has at least one bearing (4) with an open cross section, preferably a curved wall, particularly in the general shape of a C, against which is rotatably engaged at least one part forming a pivot (20) attached to a moving part such as a flap forming a lid, a seat or a urinal, characterized in that said pivot (20) and said bowl each comprise means of mutual magnetic attraction (6) so arranged that said moving part (2) can be moved between a lowered position resting on the bowl (1) or roughly parallel to the upper plane of the bowl, and a raised position, wherein said pivot (20) is engaged in said bearing (4), and this pivot (20) can be separated from said bearing (4) provided said moving part (2) is pulled strongly enough to overcome the force of magnetic attraction.

Abstract: The present invention relates to novel crystalline forms of (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate and to pharmaceutical compositions containing said forms.

Abstract: The present invention relates to binders, to processes for the preparation thereof, and to the use thereof in formulations, surface coatings, inks and plastics.

Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Abstract: The present invention relates to 2-adamantylurea derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11?-HSD1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

Abstract: The invention relates to a method and device for producing packs of a food that comes in slices, in particular individually packaged processed cheese slices. The pack of food is put together from two uniform product stacks of food slices. The first product stack is transported via a first feed segment, and the second product stack is transported via a second feed segment, in each case horizontally by means of a transport means at transport speed. The feed segments are guided over one another in parallel in a collection area, and the upper feed segment ends at a sliding edge that defines a collection point, whereby means for synchronization are adjusted such that a product stack that arrives via the sliding edge is neatly placed onto the product stack that is transported to the lower feed segment.

Abstract: Novel 1,3-dihydroisoindole derivatives of the formula (I), in which R1-R3 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract: A container and associated dispenser for liquid is configured to dispense residual liquid from the container after the bulk of liquid has been dispensed from the container. This is accomplished by having a conical projection on the bottom of the container which causes residual liquid to flow into a gutter defined by the wall of the container and the surface of the conical projection. A dip-tube is connected to the dispenser and is rotatable in order to revolve the open free end of the dip-tube to access any circumferential location in the gutter in order to pick up residual liquid.

Abstract: The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11?-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

Abstract: A catalyst is described which comprises at least one zeolite with structure type EUO, at least one zeolite selected from IM-5 zeolite and zeolites with structure type MFI, MOR, BEA and MTW, at least one group VIII metal, at least one group IIIA metal and at least one porous mineral matrix. The catalyst of the invention is used in a process for isomerizing a feed comprising aromatic compounds containing 8 carbon atoms per molecule.

Abstract: Discloses are processes for preparing conductive glass-ceramics employ segregation or ion exchange.

Abstract: This invention provides a slide deck device, for a vehicle, which prevents a slide deck from rattling with respect to a floor surface of a vehicle even if an upward load is applied to the side deck in a state where the slide deck is completely drawn into the vehicle. The slide deck device is provided with a supporting member 30 provided on a floor surface 15 and supporting an undersurface of a slide deck 20, a floor contact-member 52 provided on the floor surface, and a slide deck contact-member 60 provided on the undersurface of the slide deck. When the slide deck is located at the accommodated position, the slide deck contact-member is in contact with the undersurface of the floor contact-member.