Abstract: The invention provides a class of dopamine transporter inhibitors of formula (I) (DAT inhibitors), packaged pharmaceuticals comprising such inhibitors, and their uses in treating, or manufacturing medicaments for treating disease conditions including Parkinson's disease, when assessed by one or more of Hoehn and Yahr Staging of Parkinson's Disease, Unified Parkinson Disease Rating Scale (UPDRS), and Schwab and England Activities of Daily Living Scale. Related business methods such as marketing the inhibitors to healthcare providers are also provided.

Abstract: An apparatus and method include a transmission line carrying a propagating signal between an inlet port and an outlet port. The propagating signal can include a forward traveling wave and optionally a backward traveling wave. A feedback stage samples a the propagating signal at the outlet port, generates a feedback signal the includes a time translation and a gain translation in the feedback energy, and routes the feedback signal to the inlet port such that the gain translation constructively interferes with the forward traveling wave and thereby increases the amplitude of the forward traveling wave.

Abstract: A computer readable storage medium includes executable instructions to identify a user of a website, retrieve one or more keywords describing content on the website, and search for reports corresponding to the one or more keywords. The reports are filtered based on data access permissions associated with the user. A highly ranked report is displayed on the website.

Abstract: A vehicle with front and rear steering is disclosed. The vehicle can be a cycle. The cycle includes a front wheel steered by a front hand-steering mechanism, and two back wheels steered by a back hand-steering mechanism. The back wheels are dual inclined casters with full rotational movement. A drive train forward of the front wheel drives the front wheel, while a rider is inclined in a seat in a recumbent orientation. The front and rear steering provides unlimited maneuverability and turning capabilities.

Abstract: A device to produce electricity by a chemical reaction without the addition of liquid electrolyte comprises an anode electrode, a polymer membrane electrolyte fabricated to conduct hydroxyl (OH—) ions, the membrane being in physical contact with the anode electrode on a first side of the membrane, and a cathode electrode in physical contact with a second side of the membrane. The anode electrode and cathode electrode contain catalysts, and the catalysts are constructed substantially entirely from non-precious metal catalysts. Water may be transferred to the cathode side of the membrane from an external source of water.

Abstract: A spinal implant prosthesis includes a pair of end plates for affixation to adjacent vertebral bone structures and respectively defining inter-engaged convex and concave articulatory surfaces of elliptical profile. These elliptical articulatory surfaces are elongated in an anterior-posterior direction, and are comparatively shorter in a medial-lateral direction. With this configuration, in response to angular displacement and/or axial rotation, the elliptical surfaces displace in a manner increasing the distance between the adjacent vertebral bone structures, thereby tensioning the prosthesis and producing counteracting forces which urge the components back toward a substantially centered or neutral position. In addition, in the preferred form, the anterior-posterior length of the concave articulatory surface in incrementally greater than the anterior-posterior length of the convex articulatory surface to accommodate a limited range of anterior-posterior translation.

Abstract: A computer readable storage medium comprises executable instructions to receive user-created data for user-specified positions in an OLAP hierarchy. The OLAP hierarchy is reorganized according to the user-created data. Data manipulation statements are generated to evaluate a set of members of the OLAP hierarchy according to the user-specified positions.

Abstract: The present invention provides methods for treating Acquired Immunodeficiency Syndrome (AIDS) and other viral diseases and Human Immunodeficiency Virus (HIV) related infections by administering one or more compounds of formula I: wherein: the dotted line represents a single or a double bond; and R1 and R2 are the same or different and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3 or a group represented by the formula: or salts or hydrates thereof in a carrier which minimizes micellar formation or van der Waals attraction of molecules of said compound. The invention also provides S enantiomeric forms of such compounds which possess the ability to inhibit cell growth while being of low toxicity to such cells and methods of making such compounds.

Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.

Abstract: A system and method for building segmented scorecards for a population is presented. A model of the population is built using a model builder computer, and one or more variables used by the model builder to build the model is stored in a repository. A scorecard is generated for each segment of the population based on the model and using an adaptive random tree computer program. Next, the scorecard for each segment is enhanced using a integer non-linear programming computer program to determine optimal score weights associated with the variables used by the model builder to build the model, and to generate an enhanced segmented scorecard for the population.

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein each of Ring A, Ring B, T, R2, R2?, and RA is as defined and described herein and methods for treating subjects or patients with a disease, disorder, or condition.

Abstract: An aquatic exercise device (100) includes a cuff strap (102) for fastening a plurality of fins (106) to a user's leg. The cuff strap (102) is configured to position the plurality of fins (102) to extend outwardly form an interior of the cuff strap (102) when the cuff strap (102) is fastened to an ankle area of the user's leg. The plurality of fins (106) provide resistance in a direction opposite to the direction of motion of the user's foot when the aquatic exercise device (100) is moved through water.

Abstract: A method of generating procedural language code for extracting data from a data warehouse comprising the steps of accepting a declarative specification and generating procedural language code to execute the declarative specification.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A cloud broker receives a request for processing resources from one of a plurality of cloud management infrastructures (each of which correspond to one of a plurality of clouds). The cloud broker selectively enables access to the clouds associated with each cloud management infrastructure. The clouds each comprise segregated computing environments having at least one server for executing tasks and a data store for data persistency attached to the at least one server. The cloud management infrastructures selectively starts and stops services executed by the corresponding cloud. After receiving the request, the cloud broker identifies which of the plurality of clouds coupled to the cloud broker has processing capacity to fulfill the request. Subsequently, the cloud broker enables access to at least one of the identified clouds having capacity to fulfill the request. Related apparatus, systems, techniques and articles are also described.

Abstract: A dry powder suitable for inhalation n a dry powder inhaler, the powder comprising a carrier, an active agent and at least 0.5% by weight of magnesium stearate, the powder being further characterized in that the less than 10% of the surface of the carrier material is covered with particles of magnesium stearate. The invention is also directed to a method of making dry powders by blending together the ingredients mentioned in a diffusion blender for a period of time that is less than 60 minutes.

Abstract: A method for updating filters, at a Packet Data Serving Node, with a care-of-address associated with at least one of a mobile station or a correspondent node. The method includes the steps of implementing a soft filtering rule at a Packet Data Serving Node and receiving, by the Packet Data Serving Node, a care-of-address that is associated with at least one the mobile station and a correspondent node. The method also includes updating, by the Packet Data Serving Node, filters with the care-of-address to correctly identify flows belonging to a particular session during Mobile IP use. The method further includes filtering, by the Packet Data Serving Node, packets including a care-of-address that is associated with one of the mobile station and the correspondent node.

Abstract: The present invention is directed generally to stable formulations of a TLR agonist preferably a TLR7 or a TLR8 agonist, for use in the treatment of cancer, preferably solid tumors and lymphomas. Specifically, the present invention is directed to stable formulations of up to 50 mg/ml of a TLR agonist which comprise a cyclodextrin.

Abstract: Disclosed are devices, systems and methods including a wireless terminal adapted to perform a detach of the wireless terminal when registered to a telecommunication network by associating an identification for the wireless terminal, deriving a signature for the identification, and allocating a pair containing the identification and the signature to the wireless terminal. The wireless terminal includes a transceiver adapted to send a detach request including the identification and the identification signature from the wireless terminal to the network in response to detection of a predetermined state of the wireless terminal. The predetermined state includes one or more of, for example, a power off state, a low battery state, and/or a removal of a subscriber identity module from the wireless terminal.

Abstract: A system and method for drawing directed acyclic graphs is disclosed. In particular, an algorithm, as implemented in a method and system, to aesthetically layout directed acyclic graphs is presented. The algorithm includes methods to reduce the number of edge crossings and increase the number of straight edges in such drawings. The algorithm keeps short and straight edges wherever possible and gives preference to vertical edges. It also provides an edge-crossing reduction heuristic to refine the layout obtained after standard median heuristic layout, and further provides a method to focus on important paths in the graph through layout.