Abstract: Methods and apparatus, including computer program products, for block compression of tables with repeated values. In general, value identifiers representing a compressed column of data may be sorted to render repeated values contiguous, and block dictionaries may be generated. A block dictionary may be generated for each block of value identifiers. Each block dictionary may include a list of block identifiers, where each block identifier is associated with a value identifier and there is a block identifier for each unique value in a block. Blocks may have standard sizes and block dictionaries may be reused for multiple blocks.

Abstract: A modular shoe system having interchangeable uppers and outsoles, comprising an internal support structure, a plurality of interchangeable first removable covers and a plurality of interchangeable second removable covers. The internal support structure includes a midsole, a heel counter and a toe box. The internal support structure has a front portion including the toe box and a rear portion including the heel counter. Each of the first removable covers includes a front upper and a front outsole. Each of the first removable covers is configured for being alternately removably attached to the front portion. Each of the second removable covers includes a rear upper and a rear outsole. Each of the second removable covers is configured for being alternately removably attached to the rear portion.

Abstract: Provided herein are compounds of the formula (I): were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract: The present invention provides methods of detecting cancer using biomarkers.

Abstract: The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells via S1P or LPA signaling. These methods are useful for reducing at least one symptom of the disorder.

Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.

Abstract: The invention relates to kits and methods for assessing skin health for a human and the human's susceptibility to skin disorders. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated disclosed herein and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kits for performing the methods.

Abstract: Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and chemical modifications.

Abstract: Systems and methods are provided for a two-way chat. In one aspect there is provided a system including a processor, which further includes a memory. The processor and memory provide a web client application. The system further includes a mobile wireless device and a centralized server. The centralized server provides a two-way chat between the web client application and the mobile wireless device.

Abstract: This invention relates to a method of routing for a message via an IMS system is disclosed. A message is received at an ICSCF. Address information is obtained for one of an application server, server or gateway for which said message is intended. The message is sent to said application server, server or gateway in accordance with said address information.

Abstract: A computer readable storage medium comprises executable instructions to provide a query interface for formulating continuous queries of multi-dimensional data streams. The query interface is populated to generate a plurality of continuous queries. The plurality of continuous queries are executed. The plurality of continuous queries are modified at run-time.

Abstract: Articles coated with a water-resistant coating that absorbs water to provide the water-resistant effect, and desorbs water when the coating is dried, and a method of providing water resistance and corrosion resistance to articles prepared with such coatings. The coating is formed by applying a composition comprising an aqueous solution of a superabsorbent water-soluble polymer precursor, optionally a viscosity modifying agent, and optionally a lubricant onto the surfaces of the article, and curing to form a coating comprising the superabsorbent polymer.

Abstract: A modular medical care system, housing a plurality of different modules providing different functions used in delivering healthcare to a patient, includes a plurality of different modules including: (a) a patient monitoring module for acquiring and processing signals derived from sensors suitable for attachment to a patient; and (b) a patient treatment module for delivering treatment to the patient. A processor processes signals derived from the plurality of different modules. A communication interface provides bidirectional communication between the processor and the plurality of different modules via a network.

Abstract: A system and method for monitoring activity of heterogeneous components of a business application are disclosed. A system includes a local event infrastructure within each of the heterogeneous components. The local event infrastructure includes an event manager to detect one or more events of the business application, and an event filter to filter the one or more events detected by the event manager. The system further includes a messaging platform to transmit messages indicative of filtered events from the local event infrastructure to a user interface of a central monitoring system, and a process log displayed in the user interface to generate and display a log of the one or more events.

Abstract: The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

Abstract: The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency comprising a finely powdered, carboxylic acid salt, a liquid block copolymer of ethylene oxide and propylene oxide, and a tocopherol.

Abstract: Methods and apparatus, including computer program products, are provided for debugging using dynamic compilers. The method may include receiving a first indication to grant access to a set of variables and to allow access to be inhibited to a set of remaining variables. The dynamic compiler may be allowed to optimize the set of remaining variables, while the set of granted variables is preserved. A second indication may be provided to acknowledge access to the set of granted variables and allow access to be inhibited to the set of remaining variables. In some variations, the set of granted variables is implemented as a set of live variables and the set of remaining variables is implemented as a set of dead variables. Related apparatus, systems, methods, and articles are also described.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for treating, immuno-allergical diseases, autoimmune diseases, and organ or tissue rejection following transplantation.

Abstract: Described herein are methods and devices for selectively applying fluids (particularly anesthetics) to a target tissue from within a blood vessel while minimizing the amount of fluid applied to non-target tissue. The injection catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter before extending the injector. The methods of selectively applying anesthetic to a target structure generally include the steps of inserting an injection catheter into a body vessel, positioning the injection catheter within the body vessel near the target structure, anchoring the injection catheter before extending a directional injector from the injection catheter, and applying anesthetic from the injection catheter to the target structure.