Patents Represented by Attorney Mintz Levin Cohn Ferris Glovsky & Popeo, PC

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  • Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge
    Patent number: 7070260
    Abstract: Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: July 4, 2006
    Assignee: Labcyte Inc.
    Inventors: Mitchell W. Mutz, David Soong-Hua Lee, George McLendon
  • HDAC9 polypeptides and polynucleotides and uses thereof
    Patent number: 7063973
    Abstract: The present invention features substantially pure HDAC9, HDAC9a, HDAC9(?NLS), HDAC9a(?NLS), an HDRP(?NLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(?NLS), HDAC9a(?NLS), and HDRP(?NLS) nucleic acid sequences, and cells containing those vectors.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: June 20, 2006
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Victoria M. Richon, Xianbo Zhou, Richard A. Rifkind, Paul A. Marks
  • Probe for mass spectrometry
    Patent number: 7057165
    Abstract: The present invention relates to a probe for the analysis of one or more analytes, particularly proteins or compounds capable of binding or otherwise interacting therewith, by laser desorption/ionization mass spectrometry, more particularly MALDI MS. It also relates to a protein microarray, a method of producing a protein microarray and a method of analyzing a protein microarray. The probe comprises a support having an electroconductive target surface thereon characterized in that the target surface comprises a micro array having a plurality of discrete target areas presenting one or more analyte capture moieties. Each discrete target area has an area of less than 1000 ?m2, more preferably still less than 500 ?m2, and more preferably still less than 100 ?m2.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: June 6, 2006
    Assignee: Sense Proteomic Ltd.
    Inventors: Jens-Oliver Koopman, Jonathan M. Blackburn
  • Methods and compositions for the preparation and use of fixed-treated cell-lines and tissue in fluorescence in situ hybridization
    Patent number: 6995020
    Abstract: This invention relates to methods for the detection of one or more mRNA transcripts in paraffin-embedded tissue by “mRNA liberation in fixed-treated tissue or ‘MLIFTT’”. This method includes treating the tissue with ammonia-ethanol and sodium borohydride combined with pressure cooking of the tissue. The chemical treatments reduce the tissue autofluorescence and the physical treatments overcome the interference created by the fixation-induced chemical bonds. The methods of the present invention can be utilized to identify a plurality of mRNA transcripts in a microarray format.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: February 7, 2006
    Assignee: Aureon Laboratories, Inc.
    Inventors: Paola Capodieci, Jon Edelson
  • Prolonged efficacy of islet neogenesis therapy methods with a gastrin/CCK receptor ligand and an EGF receptor ligand composition in subjects with preexisting diabetes
    Patent number: 6992060
    Abstract: Compositions and methods are provided for achieving in vivo islet cell regeneration in subjects with preexisting diabetes. The methods comprise short term treatment with a composition having a gastrin/cholecystokinin receptor ligand and an EGF receptor ligand. Treatment with such a composition for a short term resulted in a prolonged period of increased insulin release, decreased fasting blood glucose, and improved glucose tolerance, the prolonged efficacy, the period being considered from the time of cessation of treatment.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: January 31, 2006
    Assignee: Waratah Pharmaceuticals, Inc.
    Inventor: Stephen J. Brand
  • Apparatus and method for repair of spinal cord injury
    Patent number: 6975907
    Abstract: An apparatus for stimulating regeneration and repair of damaged spinal nerves, comprising at least two electrodes placed intravertebrally near the site of spinal axon injury and delivering DC current thereto. A method for stimulating regeneration and repair of damaged spinal nervous tissue, comprising placing electrodes intravertebrally near the site of spinal cord injury and applying DC current at a level sufficient to induce regeneration and repair of damaged spinal axons but less than the current level at which tissue toxicity occurs.
    Type: Grant
    Filed: November 11, 2002
    Date of Patent: December 13, 2005
    Assignee: DynaMed Systems, LLC
    Inventors: Michael J. Zanakis, Philip A. Femano
  • Insoluble drug delivery
    Patent number: 6974593
    Abstract: Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: December 13, 2005
    Assignees: Jagotec AG, Board of Regents, The University of Texas System
    Inventors: Inge B Henriksen, Awadesh K. Mishra, Gary W. Pace, Keith P. Johnston, Simon Mawson
  • System and method for searching extended regular expressions
    Patent number: 6963876
    Abstract: A system and method for searching extended regular expressions. The system enables users to submit searches for extended regular expressions. The searches may be arbitrarily complex. Searches may also be performed for Unicode and ASCII strings. The system may parse the extended regular expression to be searched and search one or more object stores for extended regular expressions satisfying the search. The extended regular expressions located may then be presented to the user.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: November 8, 2005
    Assignee: International Business Machines Corporation
    Inventor: Robert Walter Schreiber
  • Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
    Patent number: 6960605
    Abstract: Provided are, among other things, compounds of formula I or IA, Also provided are methods of treatment with such compounds.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: November 1, 2005
    Assignee: Alteon, Inc.
    Inventors: Dilip Wagle, Sarah Vasan, Jack Egan
  • Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
    Patent number: 6956114
    Abstract: The present invention relates to the field of DNA recombinant technology. More specifically, this invention relates to fusion proteins comprising an ATP generating polypeptide joined to a polypeptide that converts ATP into a detectable entity. Accordingly, this invention focuses on sulfurylase-luciferase fusion proteins. This invention also relates to pharmaceutical compositions containing the fusion proteins and methods for using them.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: October 18, 2005
    Assignee: '454 Corporation
    Inventors: Maithreyan Srinivasan, Michael Reifler
  • Mutations associated with iron disorders
    Patent number: 6955875
    Abstract: The invention features a method of diagnosing an iron disorder, e.g., hemochromatosis, or a genetic susceptibility to developing such a disorder in a mammal by determining the presence of a mutation in exon 2 or in an intron of an HFE nucleic acid.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: October 18, 2005
    Assignee: Billups-Rothenberg, Inc.
    Inventors: Barry E. Rothenberg, Ritsuko Sawada-Hirai, James C. Barton
  • Use of interleukin-11 to prevent immune-mediated cytotoxicity
    Patent number: 6953777
    Abstract: The use of interleukin-11 to prevent, to ameliorate, and to treat an immune-mediated disease in a mammal in need of such treatment is disclosed.
    Type: Grant
    Filed: March 9, 2000
    Date of Patent: October 11, 2005
    Assignees: Genetics Indtitute LLC, Yale University
    Inventors: James Keith, Joseph M. Carroll, Jordan S. Pober
  • Method of treating cardio pulmonary diseases with no group compounds
    Patent number: 6945247
    Abstract: Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation comprises administering into the lungs as a gas compound with an NO group which does not form NO2/NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and/or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2/NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: September 20, 2005
    Assignee: Duke University
    Inventors: Jonathan S. Stamler, Eric J. Toone, Andrew J. Gow
  • Nucleic acid sequences encoding human slit-, megf-, and roundabout-like polypeptides
    Patent number: 6942992
    Abstract: This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to slit-, MEGF- or multiple epidermal growth factor, and roundabout-proteins. The nucleic acid sequence is 2341 nucleotides long and contains an open reading frame from nucleotides 215 to 2173. The encoded polypeptides of 653 residues are novel.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: September 13, 2005
    Assignee: CuraGen Corporation
    Inventor: Richard A. Shimkets
  • Hypoxia-mediated neurogenesis assay
    Patent number: 6924142
    Abstract: Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells can be subjected to hypoxic insult which induces the cells to express erythropoietin.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: August 2, 2005
    Assignee: Neuro Spheres Holdings Ltd.
    Inventors: Samuel Weiss, S. Todd Sorokan
  • Proteins and nucleic acids encoding same
    Patent number: 6903201
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: June 7, 2005
    Assignee: CuraGen Corporation
    Inventor: Muralidhara Padigaru
  • Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
    Patent number: 6902921
    Abstract: The present invention relates to the field of DNA recombinant technology. More specifically, this invention relates to fusion proteins comprising an ATP generating polypeptide joined to a polypeptide that converts ATP into a detectable entity. Accordingly, this invention focuses on sulfurylase-luciferase fusion proteins. This invention also relates to pharmaceutical compositions containing the fusion proteins and methods for using them.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: June 7, 2005
    Assignee: 454 Corporation
    Inventors: Maithreyan Srinivasan, Michael Reifler
  • Low cost, high performance, rodent resistant, flexible reinforcement for communications cable
    Patent number: 6897382
    Abstract: A low cost, high performance flexible, rodent resistant reinforcement member that can be used for both optical and copper communications cable. The reinforcement members made according to the preferred process are more rigid than known reinforcement members, but are less rigid than glass pultruded rods. Communications cables utilizing these members are lightweight and exhibit an improved combination of strength and flexibility compared to traditional communications cables. Further, these communication cables may then be installed into underground ducts using more economical and faster installation techniques.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: May 24, 2005
    Assignee: Neptco JV LLC
    Inventors: Thomas P. Hager, Richard N. Lehman, James R. Priest
  • Methods and compositions for neural progenitor cells
    Patent number: 6890724
    Abstract: The invention relates to methods and compositions for the isolation of neural progenitor cells.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: May 10, 2005
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Li-Ching Lo
  • Handbag
    Patent number: D513867
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: January 31, 2006
    Assignee: Celine
    Inventor: Nicole Stulman