Abstract: The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.

Abstract: A differential device differentially distributes a driving force to first and second axles. The differential device is comprised of a differential gear set configured to allow differential motion between the first and second axles, a casing rotatable about an axis, the casing housing and being drivingly coupled with the differential gear set and including a first end wall, a second end wall axially opposed to the first end wall, and a side wall disposed radially outward, which in combination with the first end wall and the second end wall defines a chamber configured to house the differential gear set, a clutch engageable with the differential gear set, a solenoid configured to drive the clutch, which is disposed adjacent to the first end wall, and a magnetic core fixed to the solenoid. The magnetic core is comprised of a sleeve portion snugly and slidably fitting around an outer periphery of the side wall to radially position the core and the solenoid in place.

Abstract: A holder for a position sensor of an electric machine. The holder includes a pocket for holding the position sensor, an abutment, and a biasing mechanism mountable to a fixture of the electric machine so as to bias the abutment relative to the fixture. Additionally, an electric machine that incorporates the holder, the electric machine including a stator against which the biasing mechanism biases the abutment.

Abstract: Cementitious compositions in which the cementitious properties of fly ash are carefully controlled are described. The cementitious compositions may be substantially free harsh acids and bases such as citric acids (?pH 2.2) and alkali metal activators including alkali hydroxides (?pH 12-14) and metal carbonates (?pH 11.6). The use of these harsh chemicals creates acid base reactions during use of the products. Instead of these harsh chemicals, a lactic acid salt based activator is be used as a reaction accelerator. Boric compounds may be used as a retarder in the compositions.

Abstract: A fan assembly for creating an air current includes an air outlet mounted on a stand. The stand includes a base and a body tiltable relative to the base. The fan assembly has a center of gravity located so that when the base is located on a substantially horizontal support surface, the projection of the center of gravity on the support surface is within the footprint of the base when the body is in a fully tilted position.

Abstract: A hand-held saw with a rigid saw frame is disclosed. The rigid frame of the hand-held saw allows a saw blade to remain highly tensioned during the cutting process. The rigid saw frame has a “C-shape,” is unbent, and contains openings that make up a truss-like structure, which distributes an external force that is focused on one portion of the saw frame across other portions of the saw frame.

Abstract: A method for manufacturing a polishing pad prevents slurry leaks and provides a pad that can be used to provide high optical detection accuracy. The method for manufacturing a polishing pad includes forming a groove for injecting a light-transmitting region forming material on the back surface of a polishing layer; injecting the light-transmitting region forming material into the groove and curing the material to form a light-transmitting region; and buffing the front surface of the polishing layer to expose the light-transmitting region on the front surface.

Abstract: A surface treating appliance includes a main body and a head rotatably connected to the main body about an axis, the main body and the head being provided with first and second electrical connectors, respectively. The first and second electrical connectors can be connected to provide an electrical connection between the main body and the head. One of the first and second electrical connectors is slideable within a channel. By providing an electrical connector within a channel, complicated and potentially unreliable arrangements such as slip-rings can be avoided while still providing an electrical connection between the head and the main body.

Abstract: A drying apparatus has a casing, a cavity formed in the casing for receiving an object, a fan located in the casing and creating an airflow, a motor arranged to drive the fan. At least one opening communicates with the fan and is arranged in the casing so as to direct an airflow transversely across the cavity. The motor and fan arrangement generate an airflow across the cavity, wherein, in use, the pressure of the airflow emitted through the opening is at least 8 kPa. The motor has a rotor which, in use, may rotate at a speed of at least 80,000 rpm. The high velocity, high pressure airflow provided by the apparatus is capable of drying an object efficiently and quickly and is suitable for use in a hand dryer.

Abstract: A nitride semiconductor light-emitting device includes an n type nitride semiconductor layer, a light-emitting layer formed on the n type nitride semiconductor layer, a first p type nitride semiconductor layer formed on the light-emitting layer, an intermediate layer formed on the first p type nitride semiconductor layer to alternately cover and expose a surface of the first p type nitride semiconductor layer, and a second p type nitride semiconductor layer formed on the intermediate layer. The intermediate layer is made of a compound containing Si and N as constituent elements.

Abstract: An image forming apparatus comprises a fixing part for fixing a toner image formed on a transfer material to the transfer material, a fan provided on the downstream side of the fixing part, for blowing air to the transfer material having passed through the fixing part, and an airflow control part for controlling the amount of air to be blown from the fan. When the basis weight of the transfer material is larger than a first threshold value, the airflow control part sets the amount of air to be blown to a value smaller than that in a case where the basis weight of the transfer material is smaller than the first threshold value.

Abstract: Register includes flip-flop circuits each constructed to retain data of n bit in synchronism with a clock pulse, the register retaining a multiplication result of a multiplier dividedly by the flip-flop circuits, n bit per flip-flop circuit. For each of a first and second numeric value data to be multiplied by the multiplier, a control circuit detects the number of consecutive zeros from the lowest-order bit of the data and performs control, on the basis of the detected number of the consecutive zeros and for each flip-flop circuit, as to whether or not the clock pulse should be supplied to the flip-flop circuit. The control circuit obtains an integral quotient value x by dividing by the number n the sum between the detected numbers for the first and second numeric value data, to stop the clock pulse supply to a particular number x of flip-flop circuit counted from the lowest-order.

Abstract: A wind turbine includes a rotor having adjustable rotor blades for driving a generator and an adjusting device for the rotor blades provided with an actuator that comprises at least an excitation winding. The adjusting device includes a torque-reducing device that automatically reduces drag torque of the actuator. The torque-reducing device includes a current divider that switches the current through the excitation winding in such a manner that the current flows completely through the excitation coil when the motor is in operation and the current only partly flows through the excitation coil when coasting (slip operation). As a result, when coasting, the magnetization of the excitation winding is reduced about the adjusting device, whereby the increase of the speed torque characteristic curve can be determined, thus improving the ratio of the adjusting device when coasting.

Abstract: The present invention provides orodispersable tablets and methods of using the same. The tablets and methods are useful, for example, for reducing first pass metabolism of orally administered active agents, enhancing bioavailability of active agents, and/or reducing the time it takes for an active agent to achieve maximal effect in a subject. The tablets, when taken orally, disintegrate or dissolve rapidly such that active agent included in the tablets is absorbed in the buccal cavity. The invention further provides methods of manufacturing any of the tablets disclosed herein and containers that include any of the tablets disclosed herein.

Abstract: A fixing device thermally fixes an unfixed image on a recording sheet by passing the recording sheet through a fixing nip. The fixing device has: a heat-generating endless belt; a first pressure member inside a running path of the endless belt; a second pressure member pressing the endless belt against the first pressure member from outside the running path to form the fixing nip, and a pair of power feeders. The endless belt includes: a circumferential resistive heat layer that generates heat upon receiving electric current; and a first electrode and a second electrode flanking a sheet passing area of the circumferential surface of the endless belt. Each electrode is composed of a pair of electrode layers, one on the inner and another on the outer circumferential surface of the resistive heat layer. Each power feeder is in contact with both the electrode layers of a different electrode.

Abstract: A semiconductor device includes a first circuit block connected between first and second power lines, a logic circuit that receives an output signal of the first circuit block that is connected between the first power line and a fourth power line or a third power line and the second power line, and a second circuit block that receives an output signal of the logic circuit that is connected between the third and fourth power lines. In an active state, a first potential is supplied and in a standby state, a second potential lower than the first potential is supplied between the first and second power lines. In any of the active state and the standby state, the first potential is supplied between the third and fourth power lines. With this configuration, speeding-up of a critical path can be realized while maintaining a subthreshold current low.

Abstract: A reset transistor is prevented from being deteriorated when power-down occurs during a programming operation or an erasing operation. It is made possible to protect the reset transistor as well as other transistors in a circuit to which a high voltage is applied when the power-down occurs during the erasing operation on an EEPROM, because the system is not reset all at once based only on a first reset signal POR of a power-on reset circuit, but is reset based on the first reset signal POR and a low voltage detection signal LD from a low voltage detection circuit so that the reset transistor is not turned on while the high voltage is applied to it.

Abstract: Systems and methods for treating disc herniation include surgical and endoscopic access and removal of disc tissue. The tissue removal devices that may be used include flexible elongate members, such as a cable, that may be inserted into a vertebral disc and rotated to pulverize the disc material and facilitate its removal.

Abstract: The present invention relates to the use of Parapoxviruses in combination with other agents for the treatment of viral diseases, and in particular HIV infections and AIDS. The invention also relates to methods for producing medicaments based on combinations of Parapoxviruses and other antiviral agents, and to such medicaments. In particular, the invention relates to the use of Parapoxviruses in combination with agents of the kind used for antiretroviral therapy and highly active antiretroviral therapy (HAART).