Abstract: This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract: Waveform data representative of singing voices of a singing music piece are analyzed to generate melody component data representative of variation over time in fundamental frequency component presumed to represent a melody in the singing voices. Then, through machine learning that uses score data representative of a musical score of the singing music piece and the melody component data, a melody component model, representative of a variation component presumed to represent the melody among the variation over time in fundamental frequency component, is generated for each combination of notes. Parameters defining the melody component models and note identifiers indicative of the combinations of notes whose variation over time in fundamental frequency component are represented by the melody component models are stored into a pitch curve generating database in association with each other.

Abstract: A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions.

Abstract: When a copy mode is set, all channel selecting switches on a control panel are set to valid for a parameter copy operation, in which, when an operation of the channel selecting switch is detected while the copy mode is set, (a) in a case where the operation of the channel selecting switch is determined to be a setting operation of a copy-source channel, the channel corresponding to the operated channel selecting switch is set as a copy-source channel and channel selecting switches corresponding to the channel of a different type from a type of the copy-source channel is set invalid so that only the channel selecting switch corresponding to the channel of the same type as of the copy-source channel is placed into a valid state, and (b) in a case where the operation of the channel selecting switch is determined to be the setting operation of a copy-destination channel, the channel corresponding to the channel selecting switch operated is set as a copy-destination channel.

Abstract: An electronic keyboard instrument with a hammer action, in which a circuit board for generating electronic musical tones can be disposed at a location for easy maintenance and for effective space utilization. Front and rear bars are bridged between side plates of an instrument main body so as to extend parallel to each other in the left-right direction and reinforce the instrument main body. A hammer action mechanism having hammers for respective keys is disposed rearward of a key-depression part of a keyboard and upward of a rear end portion of the keyboard, and a board tray is bridged between the front and rear bars. The board tray and the circuit board are located upward of the hammer action mechanism.

Abstract: The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and methods relate to removal of the occluding material from the blood vessels as well as other body lumens. The devices may include a catheter and a cutter assembly, where the cutter assembly has a distal cutter and a proximal cutter. The devices may also include a drive mechanism, a torque shaft, a deflecting mechanism and a torque control mechanism. The torque control mechanism may sweep the cutter assembly when the cutter assembly is deflected.

Abstract: A display device in which a pixel voltage is held at low power consumption without any influence from fluctuation in threshold voltage is provided. A liquid crystal capacitor element (Clc) is formed between a pixel electrode (20) and a counter electrode (80). A counter voltage (Vcom) is applied to the counter electrode (80). The pixel electrode (20), one ends of a first switch circuit (22) and a second switch circuit (23), and a first terminal of a second transistor (T2) form an internal node (N1). The other end of the first switch circuit (22) is connected to a source line (SL). The second switch circuit (23) has the other end connected to a voltage supply line (VSL) and is a series circuit of transistors (T1 and T2). A control terminal of the transistor (T1), a second terminal of the transistor (T2), and one end of the boost capacitor element (Cbst) form an output node (N2).

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.

Abstract: The verification system of this invention comprises an image forming apparatus 1 having verification function and a card reader 2 for reading a user ID from a card. The image forming apparatus 1 is capable of performing short-range radio communication with a portable instrument 3. The portable instrument 3 receives a polling command transmitted by the image forming apparatus 1 and sends back its own identification code if it is located near the image forming apparatus 1. The image forming apparatus 1 permits usage of all the functions thereof if it verifies that user is an officially permitted person according to user ID read by the card reader 2 and the identification code sent back from the portable instrument 3. Consequently, there is provided a verification system having a high security level and convenient for use or a verification system which permits usage of its apparatus and other related devices within an appropriate range depending on the security level of a verified method.

Abstract: The invention is directed to a positive airway pressure (PAP) system with a head mounted harness assembly with a housing and a head position sensor located within or secured to the housing that detects the position of a patient's head, and communicates this head position information to a controller of the system which may be disposed within the housing having the position sensor or a second housing. The controller varies the output pressure of the pressure source, e.g. a rotary compressor, based, at least in part, on the head position information provided by the head position sensor. In a preferred embodiment, the position sensor is an accelerometer.

Abstract: This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds of formula (I) are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract: A hybrid pepper designated E42.2346 is disclosed. The invention relates to the seeds of hybrid pepper E42.2346 to the plants of hybrid pepper E42.2346 and to methods for producing a hybrid plant, either inbred or hybrid, by crossing the hybrid E42.2346 with itself or another pepper plant. The invention further relates to methods for producing a pepper plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other pepper lines, cultivars or hybrids derived from the hybrid pepper E42.2346.

Abstract: A color printer of the invention is controlled to select DC motors needed to be newly activated according to a print mode when a print job occurs, determine an activation start time of each selected DC motor by sequentially going back activation times stored in relation to the selected DC motors from an image start reference time, activate one or ones of the DC motors to be activated according to the determined activation start times, measure an actual activation time of the activated DC motor and update a stored content about the activation time based on a measurement result of the actual activation time, and determine an activation start time of each DC motor based on the updated activation time. An image forming apparatus capable of preventing the motors from rotating more than necessary and effectively utilizing the life of components to be driven by the motors can be provided.

Abstract: A nitride semiconductor laser device with a reduction in internal crystal defects and an alleviation in stress, and a semiconductor optical apparatus comprising this nitride semiconductor laser device. First, a growth suppressing film against GaN crystal growth is formed on the surface of an n-type GaN substrate equipped with alternate stripes of dislocation concentrated regions showing a high density of crystal defects and low-dislocation regions so as to coat the dislocation concentrate regions. Next, the n-type GaN substrate coated with the growth suppressing film is overlaid with a nitride semiconductor layer by the epitaxial growth of GaN crystals. Further, the growth suppressing film is removed to adjust the lateral distance between a laser waveguide region and the closest dislocation concentrated region to 40 ?m or more.

Abstract: Apparatus and methods are disclosed for simultaneously tracking multiple finger and palm contacts as hands approach, touch, and slide across a proximity-sensing, multi-touch surface. Identification and classification of intuitive hand configurations and motions enables unprecedented integration of typing, resting, pointing, scrolling, 3D manipulation, and handwriting into a versatile, ergonomic computer input device.

Abstract: A user-space virtualization (USV) program to allow legacy applications in embedded systems to share resources without modification without compromising security is provided. A computer-implemented USV program may be characterized by a method in a user-space including retrieving a native code of an application, and identifying an instruction sequence. Further, identifying the instruction sequence includes, first, determining if executing the instruction sequence to perform processing is a possible security risk. If it is a possible security risk, then confirming that there is an execute authority for an active application. Execute authority may be confirmed by a security manager or a processor. If it is confirmed by the security manager that the active application has the execute authority for processing, then executing the instruction sequence with a processor. If the active application has no execute authority for processing, then not executing the instruction sequence.

Abstract: Provided is an optical pickup apparatus using a reduced number of parts. An optical pickup apparatus (26) of the present invention includes: a laser unit (108) for emitting a laser beam complying with the BD standards; a laser unit (106) for emitting a laser beam complying with the DVD standards and a laser beam complying with the CD standards; and a PDIC (10B) for receiving and detecting the laser beams complying with the respective standards. Because the laser beam complying with the DVD standards and the laser beam complying with the BD standards are received by one photo detector provided in the PDIC (10B), the number of parts needed for the optical pickup apparatus (26) can be reduced, and the costs of the apparatus can be decreased.

Abstract: The invention provides methods of modulating an immune response to a second antigen which entail administration of a first antigen and an immunostimulatory polynucleotide. Modulation of the immune response is generally manifested as stimulation of a Th1 response.

Abstract: The invention concerns a medical instrument disinfecting system (1) comprising a disinfecting chamber (4) adapted to implement a cycle for disinfecting the instruments. The invention is characterized in that each instrument (1) comprises identification data (5) and in that the chamber (4) is associated with means (6) for acquiring the identification data of the or each instrument (1) when it is introduced into or withdrawn from the chamber (4) at the start and at the end of a disinfecting cycle, with means (7, 8) for acquiring characterization data of the disinfecting cycle and with means (9, 10, 11, 12, 13) for associating the identification data of the or each instrument and the characterization data of the disinfecting cycle to generate traceability data of the disinfection of the or each instrument.

Abstract: An access control list, indicating contents of user operatable authorization, is set in an electronic file or folder stored in a document management server. The server receives from MFP a registering electronic file, location information of the electronic file and destination information including a notification destination user to which registration is notified. If no notification destination user is registered in ACL, the server transmits the notification of registration and the electronic file to PC of the notification destination user and receives a notification of electronic file reception from PC. The server sends the user in ACL a notification of notification destination user's reception of electronic file.