Abstract: Polypeptide and polynucleotide vaccines effective to treat or prevent infection of a mammal, such as a dog, a cat, or a human, by a protozoan. Methods of treatment and prevention are also provided, including therapeutic administration of the vaccine to an infected mammal to prevent progression of infection to a chronic debilitating disease state. Preferred embodiments of the polynucleotide vaccine contain nucleotide coding regions that encode polypeptides that are surface-associated or secreted by T. cruzi. Optionally the efficacy of the polynucleotide vaccine is increased by inclusion of a nucleotide coding region encoding a cytokine. Preferred embodiments of the polypeptide vaccine include immunogenic peptides that contain membrane transducing sequences that allow the polypeptides to translocate across a mammalian cell membrane.
Type:
Grant
Filed:
July 2, 2010
Date of Patent:
February 22, 2011
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A sensitive, multicomponent diagnostic test for infection with T. cruzi, the causative agent of Chagas disease, including methods of making and methods of use. Also provided is a method for screening T. cruzi polypeptides to identify antigenic polypeptides for inclusion as components of the diagnostic test, as well as compositions containing antigenic T. cruzi polypeptides.
Type:
Grant
Filed:
April 22, 2005
Date of Patent:
February 15, 2011
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Rick L. Tarleton, Ronald D. Etheridge, Jr.
Abstract: Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
Type:
Grant
Filed:
November 20, 2007
Date of Patent:
February 8, 2011
Inventors:
David S. Stephens, Seshu K. Gudlavalleti, Yih-Ling Tzeng, Anup K. Datta, Russell W. Carlson
Abstract: Photo booth systems and methods of using photo booth systems, such as those that provide photo booths and interaction between the photo booths and one or more user groups.
Abstract: An adapter apparatus includes a substrate having a plurality of openings defined therethrough. Further, a sleeve spring contact is mounted in each of the openings.
Type:
Grant
Filed:
February 26, 2009
Date of Patent:
January 25, 2011
Assignee:
Ironwood Electronics, Inc.
Inventors:
Mickiel P. Fedde, Ranjit Raghunath Patil
Abstract: Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
Type:
Grant
Filed:
June 29, 2007
Date of Patent:
January 25, 2011
Assignee:
Medtronic, Inc.
Inventors:
Julie A. Alkatout, Michael Eric Benz, Randall V. Sparer
Abstract: A convertible blower/vacuum for selectively blowing or vacuuming debris. The blower/vacuum may include a housing to which a blower/vacuum tube is coupled. The tube may be movable, relative to the housing, to allow a primary passageway of the tube to selectively communicate with either an air inlet of the housing or an air outlet. The blower/vacuum may further include a vacuum receptacle having an opening that selectively communicates with the air outlet when the passageway of the tube communicates with the air inlet.
Abstract: A medical device and displacement-based over-pressurization mechanism (OPM) for use with the same. The OPM may be positioned in or along a refill passageway of the device. It may include a valve plunger having a portion in biased, abutting contact with a reservoir surface that moves as the reservoir volume changes. The reservoir surface may move between a full position and a refill position. The OPM is preferably configured to close and occlude the refill passageway when the reservoir and reservoir surface reach the full position, e.g., before reaching an overfill position. A sensor may also be provided to detect a position of the valve plunger.
Abstract: Method and device for detection of analytes, particularly biohazards. A microarray containing immobilized sensing molecules captures complementary analytes on a redundant patterned substrate. Pattern analysis is performed using a computer algorithm.
Type:
Grant
Filed:
April 11, 2007
Date of Patent:
January 11, 2011
Assignee:
Purdue Research Foundation
Inventors:
Fred E. Regnier, Ronald George Reifenberger, Halina Dorota Inerowicz, Stephen Wayne Howell
Abstract: Methods and systems provide for incubating a plurality of eggs at least partially at a primary incubation location and then incubating the plurality of eggs (e.g., a plurality of single sex eggs sorted from the plurality of eggs) at least partially during transport to a secondary location.
Abstract: Devices and methods that may be used to reduce valve regurgitation are disclosed by locating a body across the regurgitant valve. When the valve closes, the body obliterates/ameliorates the regurgitant orifice in the valve, thereby reducing or preventing valve regurgitation. The body may be expandable. The devices may be implantable such that they can remain in place within a subject for extended periods of time.
Type:
Grant
Filed:
May 22, 2006
Date of Patent:
December 21, 2010
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be preformed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.
Abstract: A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.
Type:
Grant
Filed:
July 3, 2008
Date of Patent:
October 26, 2010
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Coating compositions containing coalescents and a latex polymer, wherein the coalescent has a volatile organic content of less than about 50% and is dispersible in the coating composition.
Type:
Grant
Filed:
May 27, 2004
Date of Patent:
October 12, 2010
Assignee:
Valspar Sourcing, Inc.
Inventors:
Larry B. Brandenburger, Bruce Sicklesteel, Mary Jane Hibben
Abstract: A walk-behind trenching vehicle incorporating a trenching boom with an endless trenching chain. The trenching boom may be connected to a forward end of the vehicle via a pivot joint that is offset from a drive axis of the trenching chain. The boom may be movable between an operating position and a transport position via a single actuator, e.g., hydraulic cylinder.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
October 5, 2010
Assignee:
The Toro Company
Inventors:
John P. Azure, Tanner L. Erickson, Glenn D. Liubakka
Abstract: A removable roller surface insert for use with a container of rollable liquid. The insert may, in one embodiment, include a roller surface having an upper edge, and an upper contact portion attached to the roller surface at or near the upper edge. The upper contact portion may be configured to contact an inner sidewall surface of the container at or near the upper rim. All, or substantially all, of the insert may be, when the insert is in a use position, located within a first half of the container, the first half defined by a vertical plane passing through a centerline of the container.
Abstract: Molecular targets are identified in T. cruzi suitable for use in diagnosis of Chagas disease, drug development, and vaccines, including live vaccines.
Type:
Grant
Filed:
July 14, 2006
Date of Patent:
August 24, 2010
Assignee:
University of Georgia Research Foundation, Inc.