Abstract: A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an inhibitorily effective amount of reversible cholinesterase inhibitor selected from the group consisting of pyridostigmine and physostigmine followed by administration of an inhibitorily effective amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form.

Abstract: A heat developing apparatus for developing a heat-processable photo-sensitive material having a supply unit provided with a loading section for loading the heat-processable photo-sensitive material, an exposure unit for forming a latent image based on an image signal or on a predetermined signal for density measurement, a developing unit for heat development, a device for gaining density information of the heat-processable photo-sensitive material developed, and a controller for conducting a correction for a density of the heat-processable photo-sensitive material based on a desired density and the density information, by controlling at least one of the exposure unit and the developing unit, wherein, the controller conducts the correction according to the density information when a predetermined condition is satisfied after a new package incorporating the heat-processable photo-sensitive material has been loaded on the loading section.

Abstract: An ink-jet recording medium including a support having thereon an ink receptive layer, wherein the support includes a white-colored substrate and a blue-colored substrate laminated with each other.

Abstract: The invention concerns a proton exchange membrane comprising a perfluorosulfonic acid having silica particles embedded therein in a concentration by weight comprised between 0.01 and 50% by weight and dimensions comprised between 0.001 and 10 micrometers, characterized in that said membrane comprises both an amorphous and a crystalline phase and the ratio thereof is adjusted by means of a controlled thermal treatment at a temperature higher than the glass transition temperature, controlled by an X-ray spectrometer. The invention further concerns an electrochemical cell using said membrane, in particular a fuel cell and the method of operating the same.

Abstract: The fixing device having therein the heating member for heating a toner image, the pressure applying member arranged to face the heating member for performing a pressure contact to the heating member, an urging means which urges the pressure applying means, and a changeover means which changes the condition of the pressure applying member from the pressure contact condition to the heating member to the pressure contact released condition by controlling the urging means, wherein urging power by the urging means under the pressure contact released condition is lower than that under the pressure contact condition.

Abstract: This invention relates to an image forming apparatus including a fixing unit which includes a heat section having a resilient body and a release layer that covers the resilient body, and a press section having a resilient body and a release layer that covers the resilient body and pressed by the heat section, and which heats and fixes a transfer medium at a nip portion as a press contact portion of the two sections. This fixing unit satisfies at least one of the following three conditions: (a) the tensile strength of the resilient body of the heat section upon a lapse of an arbitrary use time is higher than its initial tensile strength or is not lower than the initial tensile strength by 0.

Abstract: The present invention relates to novel pyrido-thieno-diazepines, their preparation process and the pharmaceutical compositions containing them.

Abstract: The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a polymeric residue; Z is one of: and B is a residue of a biologically active amine-containing moiety or a hydroxyl-containing moiety.

Abstract: An image forming apparatus includes an image reading unit, document convey unit, display/operating portion, and hinge. The image reading unit has a slit glass plate for conveying and scanning a document, and a platen glass plate for fixing and scanning the document. The document convey unit is set above glass surfaces of the slit glass plate and platen glass plate. The display/operating portion is provided to one side of the glass surfaces. The hinge is provided to the other side of the glass plates and serves to attach the document convey unit to be openable and closeable with respect to the glass surfaces. The hinge has an angle stopper with which the document convey unit can be opened at one desired open angle selected from at least two different open angles with respect to the glass surfaces.

Abstract: The present invention relates a composition promoting the growth, and increasing preservative capability of human body, animals and plants. The composition of the present invention maximizes physiological activity of human body, animals and plants. In addition, the present invention relates a producing method of the composition composed of the following steps: 1) preparing a composition containing kaoline (white soil) 30-40 wt %, potassium sulfate 15.0-20.0 wt %, sodium sulfate 13.0-17.0 wt %, feldspar 12.0-16.0 wt %, talc 12.0-16.0% and ferric oxide 0.5-1.5 wt %; and 2) mixing the above-mentioned composition using a compressed molding method; and 3) heating the mixed composition at 1000-1300° C. The composition of the present invention can be used in whole fields of industries, and will cause the original changes in the field of industrial matters, and promote the welfare of human beings such as improvement of health and life of human.

Abstract: A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically withdrawing groups to modify the cinnamate moiety's electric properties as well as photo reactivities for the purpose of achieving a proper hydrolysis rate of the acyl bond between the biologically active molecule moiety and the cinnamic acid backbone. The biologically active molecule can be any biologically active agent or diagnostic, for example, a chemotherapeutic such as a paclitaxel, campotothecin, doxorubicin, amethopterin, etoposide, or fluconazole. The prodrug composition can be modified to add a carrier moiety on the prodrug composition for targeting or to facilitate uptake of the drug. The prodrug compositions can be activated with an energy source to release the drug at the desired site.

Abstract: In an eccentric bearing arrangement for a pump shaft (2) comprising an eccentric ring (4) that is fixedly attached thereto, and further comprising a needle roller bearing that is arranged on an outer peripheral surface of the eccentric ring, a stop washer (12) is retained in a circumferential groove (13) of the needle roller bushing (9) and is surrounded radially by the adjoining flange (11) of the needle roller bushing (9), and the stop washer (12) comprises an axially inward open annular groove (15) in which the cage (6) is guided.

Abstract: Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to produce 7,8-dihydro-1,7-dihydroxy-3-hydroxymethyl-xanthenone-8-carboxylic acid methylester which inhibits VEGF-induced proliferation of HUVEC, angiogenesis in CAM assay, and tumor growth. The novel compound can be effectively used for the medical treatment of anigiogenic diseases, including cancers, rheumatoid arthritis, and diabetic retinopathy.

Abstract: A seat adjustment mechanism is provided and includes an arm defining a first locking shoulder, a sector plate rotatably supported by the arm and defining a second locking shoulder having a lock recess, a locking member selectively engaging at least one of the first and second locking shoulders, a quadrant rotatably supported by the arm and slidably supporting the locking member for locking the quadrant in one of a first and second position relative to the arm and a cam plate rotatably supported by the quadrant for selectively engaging the locking member for locking the quadrant in one of the first and second positions. In the first position the locking member is biased against the first locking shoulder and in the second position the locking member is biased into the lock recess. A gear assembly is preferably provided and operably supported by the quadrant for actuation of the cam plate.

Abstract: The invention concerns a rotary piston adjuster for adjusting the angular position of the camshaft of an internal combustion engine, said adjuster comprising an outer rotor having at least one hydraulic chamber, and an inner rotor comprising at least one pivoting vane that can pivot hydraulically in the hydraulic chamber between a retard stop position and an advance stop position. A locking device suitable for detachably connecting the outer and inner rotors to each other and at least one compression spring acting in opposition to the frictional torque of the camshaft are arranged between the two rotors. A liberal design of the compression spring and a low-wear operation with this spring are enabled by the fact that the compression spring (27, 27′) is arranged in an attachment (4) that is connected to the rotary piston adjuster, and the components of the attachment have a wear-resistant configuration and support the compression spring (27, 27′) at least pointwise over its entire length.

Abstract: The invention concerns DNA polymerase inhibitors, namely mikanolide and dihydromikanolide and dihydromikanolide-enriched extracts. Said compounds or mixtures can be used for preparing medicines designed to treat proliferative diseases, in particular cancer, viral diseases or parasitic diseases provoked by protozoae (for example malaria) or protists (for example, diseases caused by amoebae).

Abstract: The builder's square aids in cutting sheet material, such as full sheets of plywood, and in particular reduces the time required for cutting. The square comprises a short leg and a long leg connected in an L-shape. The short leg is of greater height than the long leg so that it can bear against one edge of the sheet of plywood to be cut. There is a clamping member at the distal end of the long leg so that the square can be clamped to the plywood. The builder's square also provides improved accuracy and safety for the user.

Abstract: The present invention is directed to a method of in vivo and ex vivo gene delivery, for a variety of cells. More specifically, it relates to a novel carrier system and method for targeted delivery of nucleic acids to mammalian cells. More specifically, the present invention relates to carrier system comprising single-chain polypeptide binding molecules having an a region rich in basic amino acid and having the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. The basic amino acid rich region can comprise oligo-lysine, oligo-arginine or combinations thereof. Such preparations of modified single chain polypeptide binding molecules also have ability to bind nucleic acids at the region rich in basic amino acid residues. These properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications including gene therapy.

Abstract: An image forming material is disclosed, comprising a support having thereon an image forming layer containing a light-insensitive organic silver salt and a reducing agent and a protective layer in that order, wherein the image forming layer or the protective layer contains a binder having a structure unit represented by the following formula in which Z is a divalent linkage group, R1 is a hydroxyl group, an alkyl group containing a hydroxyl group or an aryl group containing a hydroxyl group.

Abstract: An ink jet recording sheet comprising a non-water absorptive support having thereon an ink absorptive layer comprising polyvinyl alcohol, a cationic polymer, and a compound containing a zirconium or aluminum atom other than zirconium oxide and aluminum oxide, wherein a surface pH of the ink absorptive layer is 4 to 6 measured 30 minutes after receiving a water based ink of pH range 6 to 9 jetted from an ink jet printer in an amount of 20 ml/m2.