Abstract: The present invention is an apparatus for intermittently providing oral medications to a patient being fed through a feeding tube, the apparatus having a dosage vessel, which preferably can be capped or sealed, and a secure fluid path to a tubing connector for connecting to the indwelling feeding tube.

Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4methyl-3-(Z)-alkoxyiminopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.

Abstract: The present invention relates to novel 3-nitropyridine derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same as active ingredients. Methods of preparing the derivatives and pharmaceutical compositions containing the same are also disclosed. The 3-nitropyridine derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as therapeutic agents as well as preventive agents for hepatitis B and acquired immune deficiency syndrome (AIDS).

Abstract: The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

Abstract: The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

Abstract: A next textile treatment where the present method can be used to remove contaminants from the textile concerns rewashing. As already observed above, after dyeing textile with reactive dyestuffs, a considerable amount of dyestuff, particularly hydrolyzed dyestuff, is left behind on the textile. Because the hydrolyzed dyestuff is not fast to washing, it should be removed to provide a textile with sufficient washing fastness. In a rewashing treatment of textile dyed with reactive dyestuff, the textile is first rinsed with water to remove alkali and salt. Thereupon, it is rewashed, with the fructan polycarboxylic acid being metered in the form of a 25-40% solution in an amount of 1-3 g/l of water. Rewashing preferably takes place at a temperature of 95-100° C. for a period of 10-30 minutes. After rewashing, the textile is again rinsed with water to remove residues of the hydrolyzed reactive dyestuff.

Abstract: A compound of Formula I, providing tetrapartate prodrugs is provided wherein: L1 is a bifunctional linking moiety; D is a moiety that is a leaving group, or a residue of a compound to be delivered into a cell; Z is covalently linked to [D]y, wherein Z is selected from the group consisting of: a moiety that is actively transported into a target cell, a hydrophobic moiety, and combinations thereof, Y1, Y2, Y3 and Y4 are each independently O, S, or NR12; R11 is a mono- or divalent polymer residue; R1, R4, R9, R10 and R12 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls and substituted C1-6 heteroalkyls; R2, R3, R5 and R6 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C1-6 alkoxy, phenoxy, C1-8 heteroalkyls, C1-8 heteroalkoxy, substituted C1-6 alkyls, C3-8 cycloalkyls, C

Abstract: The present invention is directed to a method of in vivo and ex vivo gene delivery, for a variety of cells. More specifically, it relates to a novel carrier system and method for targeted delivery of nucleic acids to mammalian cells. More specifically, the present invention relates to carrier system comprising single-chain polypeptide binding molecules having an a region rich in basic amino acid and having the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. The basic amino acid rich region can comprise oligo-lysine, oligo-arginine or combinations thereof. Such preparations of modified single chain polypeptide binding molecules also have ability to bind nucleic acids at the region rich in basic amino acid residues. These properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications including gene therapy.

Abstract: The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

Abstract: This invention relates to an image forming apparatus that can correct a curl of a transfer medium correctly and smoothly. This image forming apparatus includes a curl correcting mechanism, including a rotatable sponge roller and a fixed press member which presses the sponge roller while biting into part of the outer surface of the sponge roller, and provided downstream of a fixing processing unit, and a regulating unit, provided immediately before the curl correcting means, so as to guide the leading end of the transfer medium to that position on the outer surface of the sponge roller which is tilted, within the range of 5° to 10° (both inclusive) from a reference line that connects the center of the sponge roller and the press start position of the press member with respect to the sponge roller, to a direction opposite to the rotating direction of the sponge roller.

Abstract: A picture hanger with a height adjustable hook allows the height of the picture to be adjusted from time to time. The hanger uses a back plate on which two opposed crenelated tracks are positioned. Two spring biased crenelated cars are housed in a frame and move on the tracks. The hook is attached to the frame. The frame is either a traveling plate which moves between the tracks and the back plate or a traveling block which is slidably mounted in a channel in the back plate and on a rod positioned in the channel of the back plate.

Abstract: There is described a liquid treatment installation including a tank which defines a substantially vertical flow channel of circular cross section. Disposed coaxially in the flow channel there is a spiral separator plate pack 20 which comprises one or more conical helical plates which define at least one helical flow passage between axially facing surfaces of the plate or plates. The conical helical plate or plates of the separator plate pack 20 consist of a plurality of platelets 10, which have dimensions that allow them to pass through an opening 21 which runs axially through the centre of the spiral separator. The invention also relates to a method of constructing the above liquid treatment installation and to a method for assembling the spiral separator plate pack 20.

Abstract: The portable dispenser has individual supply chambers that communicate with a mixing chamber. Each of the supply chambers has a doser to move fluid compositions from the supply chamber to the mixing chamber. The mixing chamber has a mixer to allow it to form a homogeneous mix of the individual compositions. An applicator is used to output the homogeneous mix.

Abstract: A silver halide color graphic material is disclosed, comprising a support having on one side thereof a red-sensitive layer unit, a green-sensitive layer unit, a blue-sensitive layer unit and a light-insensitive layer, wherein an oil-soluble organic basic compound exhibiting a pKa value of 5.5 to 8.5, and a cationic starch are used in combination.

Abstract: A method for processing a silver halide light-sensitive material employing an automatic processing machine is disclosed. A developer comprises compounds represented by the formula (1), and a fixer comprises thiosulfate salts, water-soluble aluminum salts, and at least one type of crystallization retarding agents and substantially comprises no boron compound. wherein Q represents —CH2CH2— or —CH2CH(J)—, wherein J represents a hydrogen atom or an alkyl group. x+y+Z is between 2.8 and 3.2, and R represents the group described below. Staining of the water washing tank and processing unevenness caused by a decrease in the replenishment rate of a fixer, are minimized during photographic processing employing an automatic processing machine.

Abstract: This invention relates to a method for preparing a coloring pigment, wherein an anionic or cationic clay, which clay contains substantially no agglomerates of clay sheets, is subjected to an ion exchange with an organic dye. The invention further relates to a coloring pigment and the use thereof for coloring substrates.

Abstract: There are described methods for making polyhydroxyalkanoate and its copolymers, by culturing a host cell transformed with a vector comprising a polyhydroxyalkanoate biosynthesis-related DNA fragment isolated from Alcaligenes latus. The DNA fragment comprises genes that encode for polyhydroxyalkanoate synthase, &bgr;-ketothiolase, and acetoacetyl-CoA reductase.

Abstract: An image processing system provided with a receiving circuit to receive image selecting information and output environment information; a memory to memorize plural image data and plural image processing conditions being applied to the image data; a selector to select a specific image processing condition from the plural image processing conditions memorized in the memory on the basis of the received output environment information; an image processing circuit to select image data from the plural image data on the basis of the image selecting information and to process the selected image data on the basis of the selected image processing condition; and a transmitting circuit to transmit the processed image data.

Abstract: Methods of preparing amino acid-substituted taxanes such as: using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a secondary amine thus substantially avoiding base-catalyzed hydrolysis of amino acid from the taxane. The preferred amino acid-taxanes are useful as intermediates in the production of polymer conjugated therapeutic compositions or as part of pharmaceutically acceptable formulations.

Abstract: A method of applying a coating to a surface of a substrate, comprising the steps of: introducing a substrate into an atmosphere which consists of at least one chemically reactive compound, water and at least one of nitrogen and argon, and thereafter using a corona discharge on the surface of the substrate to form a coating from the reactive compound having an inhibiting effect on the permeability to vapor and/or gas.