Abstract: The present invention relates to salt forms of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazolin-6-yl}-acrylamide as exemplified by formula (I), methods of preparation thereof, pharmaceutical compositions comprising the same and their use thereof. The salt forms of the present invention, which possess excellent tumor inhibitory activity, good bioavailability and low toxicity in an animal body, are suitable for use of preparation of anti-tumor medicaments.

Abstract: The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

Abstract: Provided are a solid dosage form comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising an enteric solid dispersion comprising a poorly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 ?m and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising an enteric solid dispersion, the method comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 ?m and a specific surface area measured by BET method of at least 1.

Abstract: Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 ?m and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 ?m and a specific surface area measured by BET method of at least 1.

Abstract: A method for positioning a guide device for placement of an interventional object in a body, the guide device having a guide axis, includes: determining a target point in the body and a reference point, wherein the target point and the reference point define a planned trajectory line (PTL) extending through each; determining a visualization plane, wherein the PTL intersects the visualization plane at a sighting point; mounting the guide device relative to the body to move with respect to the PTL, wherein the guide device does not intersect the visualization plane; determining a point of intersection (GPP) between the guide axis and the visualization plane; and aligning the GPP with the sighting point in the visualization plane.

Abstract: A submersible object management (SOM) system for releasing and/or recovering a plurality of submersible objects within a body of liquid includes a hold and a deployment system. The hold is configured to store the plurality of submersible objects. The deployment system is selectively operable to controllably release at least one of the plurality of submersible objects from the hold into submersion in the body of liquid and/or selectively operable to controllably direct at least one of the plurality of submersible objects into the hold from submersion in the body of liquid. The deployment system includes a guide that is selectively extendable to direct the at least one submersible object, the guide including a plurality of extendable guide members configured to engage the at least one submersible object.

Abstract: The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

Abstract: Methods of applying cyclopropene amine derivatives and compositions thereof to inhibit ethylene receptors in plants and plant material are disclosed. Methods include applying to the plant an effective ethylene response-inhibiting amount of at least one cyclopropene amine compound or composition thereof. Cyclopropene amine compounds, enantiomers, stereoisomers or salts thereof are also provided.

Abstract: A covered cable assembly includes a cable and a sealing assembly. The cable includes a metal sheath and a cable core. The metal sheath has a sheath terminal edge defining a sheath opening. The cable core extends through the metal sheath. The cable core includes an electrical conductor and an oil-impregnated paper insulation layer surrounding the electrical conductor. An extended cable core section of the cable core extends through the sheath opening and beyond the sheath terminal edge. The sealing assembly includes an oil barrier tube, a sealing mastic and a pressure retention tape. The oil barrier tube surrounds the extended cable core section. The sealing mastic surrounds the cable about the sheath terminal edge and overlaps portions of the metal sheath and the oil barrier tube adjacent the sheath terminal edge to effect an oil barrier seal between the metal sheath and the cable core at the sheath opening. The pressure retention tape surrounds the sealing mastic to limit displacement of the sealing mastic.

Abstract: In an assist grip mounting structure, a pair of mounting parts 15 of an assist grip 10 are attached individually to a pair of mounted parts 5 on the roof side inner panel 2 side, and a coat hook part 20 projects from the one mounting part 15 side, a reinforcing plate 30 for reinforcing the coat hook part 20 overlaps a back surface 20U of the coat hook part 20.

Abstract: The present invention provides a process for recovering Li values from a sodium saturated brine. The process includes recovering Li values from a sodium saturated brine which contains LiX. The process includes concentrating the sodium saturated brine to at least 9000 mg/l LiX, passing the concentrated brine through a bed of polycrystalline hydrated alumina pellets until the pellets are loaded with LiX from the concentrated brine, displacing brine held-up in the bed by using concentrated NaX, unloading LiX from the pellets by flowing through the bed an aqueous solution of LiX which is not saturated, displacing the LiX from the bed using concentrated NaX, and repeating the steps at least one additional time to provide the Li values.

Abstract: To reduce the cogging torque of servomotors, electric power steering motors, and others, there is provided a permanent magnet motor comprising: a rotor 10 comprising a rotor yoke 11 and a plurality of permanent magnets (M1-M10); and a stator 20 comprising a stator yoke 22, salient magnetic poles 21, and armature windings 23, wherein at least one of the permanent magnets is disposed in an adjustment position that is displaced from a corresponding reference position in at least one of the circumferential, radial, and axial directions of the rotor yoke, and the plurality of permanent magnets excluding the permanent magnet disposed in the adjustment position is disposed in the reference positions, and wherein the adjustment position is set so that the permanent magnet motor in which at least one of the plurality of permanent magnets is disposed in the adjustment position has a smaller cogging torque than a permanent magnet motor in which all of the plurality of permanent magnets are disposed in the reference posi

Abstract: The present invention is related to a pair of oligonucleotide primers for the amplification of HSV nucleic acid comprising: a) an oligonucleotide, 10-50 nucleotides in length, preferably 10-35 nucleotides in length, comprising at least a fragment of 10 nucleotides of a sequence selected from the group consisting of: 5?-ACGTTCACCAAGCTGCTGCT-3?, or its complementary sequence and b) an oligonucleotide, 10-50 nucleotides in length, preferably 10-35 nucleotides in length, comprising at least a fragment of 10 nucleotides of a sequence selected from the group consisting of: 5?CCAGGGCCCTGGAGGTGCGG-3?, or its complementary sequence. The invention also relates to probes, method for amplifying an HSV DNA target, method of specific ou aspecific detection of HSV type 1 and 2 and test kit to do possible the detection of HSV. The present invention is especially useful in methods for practicing nucleic acid test.

Abstract: Provided is a method of preparing an SOI substrate having a backside roughened which the SOI substrate has a reduced number of defects in a silicon layer at the front surface in spite of sandblasting having been applied to the backside of the SOI substrate. Specifically provided is the method comprising the steps of: etching 10 nm or more of a surface of a silicon film of an SOI substrate; sandblasting a backside of the SOI substrate with protective tape attached to the etched surface of the silicon film, the back side being the other side of the SOI substrate from the etched surface; removing the protective tape after the sandblasting; and polishing and cleaning a silicon film surface from which the protective tape has been removed.

Abstract: A payload delivery system for protecting and delivering a payload submerged in a submersion medium includes a containment system. The containment system includes a container and a dehiscing system. The container includes a pressure-resistant shell defining a sealed containment chamber. The dehiscing system is operative to dehisce the shell to open the containment chamber to the submersion medium responsive to a prescribed event and/or a prescribed environmental condition.

Abstract: In one aspect, a mechanism is provided to resolve the Iub transport network congestion in the uplink direction by using the transmission window of the RLC to control the transfer rate of the flow. The RNC (110) detects the Iub TN congestion for the flow in the uplink. The EUL flow control running in the RNC (110) calculates the RLC transmission window size for the UE for the flow and the calculated RLC transmission window size is signaled to the peer RLC entity in the UE (130) through an RLC STATUS PDU.

Abstract: Semiconductor light emitting circuits include semiconductor light emitting diodes that are serially connected between a pair of input terminals. Four layer semiconductor devices, such as Shockley diodes and/or thyristors are also provided, a respective one of which is connected across a respective one of the semiconductor light emitting diodes. The four layer semiconductor devices can allow a string of light emitting diodes to continue to be lit if one light emitting diode fails.

Abstract: Wireless communications transceivers include a transmitter that is configured to selectively frequency shift and transmit portions of broadband information over multiple non-contiguous narrowband frequency bands/segments, each of which is too narrow to carry the broadband information. A receiver also is configured to receive and selectively frequency shift portions of broadband information from multiple non-contiguous narrowband frequency bands/segments, each of which is too narrow to carry the second broadband information. Broadband information thereby may be transmitted and received in a regulated communications environment, even though a given provider may only be assigned discontinuous frequency bands/segments, none of which is wide enough to carry the entire broadband information.

Abstract: There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein Ra represents an alkyl group, such as a C1-16 alkyl group, and preferably an isopropyl group; Rb represents an aryl group, preferably a 4-fluorophenyl group; Rc represents hydrogen, a protecting group or an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group; and Rd represents hydrogen, a protecting group or a SO2Re group where Re is an alkyl group, such as a C1-16 alkyl group, and preferably a methyl group.

Abstract: A protection system kit is provided for at least one vehicular window panel mounted in a window opening of a vehicle. The kit comprises a film unit supply assembly including a release liner and a multi-layer, self-adhesive film unit. The film unit includes a first film layer and a first adhesive layer releasably securing the first film layer to the release liner. The film unit further includes a second film layer secured to the first film layer on the release liner by a second adhesive layer. The second film layer is selectively removable from the first film layer by peeling the second film layer away from the first film layer. The first adhesive layer is adapted to secure the first film layer to a vehicular window panel in an associated window opening of a vehicle. The first and second film layers are pre-configured to fit the window opening.