Abstract: The present invention relates to compounds and uses of compounds which interact with chitinase enzymes, in particular the inhibition of those enzymes.

Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.

Abstract: There is provided a vehicle body reinforcing structure capable of improving the structural durability of a side body against a load applied from the front and capable of connecting a front body and the side body more firmly to each other.

Abstract: A conductor termination system for use with an electrical power transmission conductor includes a termination assembly and a connector. The termination assembly includes an end member and an integral retainer mechanism. The end member includes a receiver portion configured to receive a segment of the conductor. The retainer mechanism includes a moveable keeper member on the end member. The retainer mechanism is operable to selectively clamp a segment of the conductor in the receiver portion to the end member and to apply a retention load to the conductor segment. The connector is adapted to be applied to the end member and the conductor to securely clamp the conductor segment to the end member.

Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates useful for implementing the inventive methods.

Abstract: The invention provides a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. Also provided are compositions comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention also discloses methods of making a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against Yersinia pestis.

Abstract: The present invention provides methods of forming a phase-change material layer including providing a substrate and a chalcogenide target including germanium (Ge), antimony (Sb) and tellurium (Te) at a temperature wherein tellurium is volatilized and antimony is not volatilized, and performing a sputtering process to form the phase-change material layer including a chalcogenide material on the substrate. Methods of manufacturing a phase-change memory device using the same are also provided.

Abstract: An MRI-compatible patch for identifying a location includes a flexible base layer, a flexible substrate and at least one of MRI-visible fiducial element. The flexible base layer is mountable on and substantially conformable to a patient's body surface. The base layer has opposed upper and lower primary surfaces. The flexible substrate is releasably attached to the upper primary surface of the base layer and substantially conformable to the patient's body surface. The at least one MRI-visible fiducial element is defined by or secured to the flexible substrate. The patch may include a plurality of the MRI-visible fiducial elements arranged in a defined pattern.

Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a bivalent radical, a —(CH2)t- bivalent radical, or a covalent bond; and where part (T) is a -Y-L-Z- radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for their preparation of these compounds in a combinatorial manner, is also disclosed.

Abstract: Provided are methods of forming a phase change memory device. A semiconductor device having a lower electrode and an interlayer insulating layer may be prepared. The lower electrode may be surrounded by the interlayer insulating layer. Source gases, a reaction gas and a purge gas may be injected into a process chamber of a semiconductor fabrication device to form a phase change material layer on a semiconductor substrate. The source gases may be simultaneously injected into the process chamber. The phase change material layer may be in contact with the lower electrode through the interlayer insulating layer. The phase change material layer may be etched to form a phase change memory cell in the interlayer insulating layer. An upper electrode may be formed on the phase change memory cell.

Abstract: A sealant-filled enclosure for environmentally sealing a connection includes a first cover member and a second cover member. The first cover member defines a first cavity having a first bottom. The second cover member is pivotally connected to the first cover member for movement between an open position and a closed position. The second cover member defines a second cavity having a second bottom. A first sealant is positioned in the first cavity and extends up to a first level relative to the first bottom without a connection disposed in the first cavity. A second sealant is positioned in the second cavity and extends up to a second level relative to the second bottom without a connection disposed in the second cavity. The first and second levels together exceed a height from the first bottom to the second bottom in the closed position. The first and second sealants may be gels.

Abstract: The invention provides the crystalline imidazole-5-carboxylic acid derivative (I, the chemical name: 2-butyl-4-chloro-1-[2?-(1H-tetrazol-5-yl) 1,1?-biphenyl-methyl]-imidazole-5-carboxylic acid, 1-[(isopropoxy)-carbonyloxy]methyl ester), its preparation method and uses thereof.

Abstract: A payload delivery unit for protecting and delivering a payload submerged in a submersion medium comprises a container including a pressure resistant shell and a resilient seal device. The shell defines a containment chamber and includes first and second shell members having opposed first and second sealing faces, respectively. The seal device engages and is interposed between the first and second sealing faces.

Abstract: Polypeptides and fusion proteins that bind to eukaryotic viruses, in particular, eukaryotic single-stranded DNA (ssDNA) viruses are provided. The polypeptides and fusion proteins bind to the replication initiation proteins (Rep) of ssDNA viruses and optionally inhibit viral replication and/or viral infection. The virus can be a plant pathogen or animal pathogen. Consensus sequences used to identify polypeptides that bind to eukaryotic viruses are also provided.

Abstract: An asparagine-linked ?2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked ?2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose in N-acetylglucosamine on the nonreducing terminal side of an asparagine-linked oligosaccharide wherein the asparagine has amino group protected with a lipophilic protective group, and a process for producing these compounds.

Abstract: A surgical marking tool for marking a location on a patient includes a cutting head and a handle. The cutting head includes a screw thread. The handle is coupled to the cutting head to rotate the cutting head. The screw thread is configured to progressively embed in the patient to mark the location when the cutting head is placed in contact with the patient and rotated with respect to the patient using the handle.

Abstract: In a radio access network (10) comprising a radio network controller node (26) and a base station node (28), a code tree has spreading codes which are allocatable between high speed downlink shared (HS-DSCH) channels and dedicated (DCH) channels. According to one aspect of the technology, use of the spreading codes of the code tree is monitored and an HS-DSCH channel is allocated a free spreading code which is non-adjacent to a spreading code already allocated to the HS-DSCH channels. In some example implementations, the free, non-adjacent spreading code is allocated so that more than one high speed channel user can use the spreading codes. In other example implementations, the free, non-adjacent spreading code is allocated so that one user uses the spreading codes by using more than one HS-SCCH channel. Preferably the non-adjacent spreading code is released from the HS-DSCH channel when the non-adjacent spreading code is needed for use by a DCH channel.

Abstract: A contamination analysis unit and method for inspecting pollutants remaining on a target side of an inspection object such as a reticle after cleaning the object is provided. After steeping the target side in a solution, a sampling liquid may be abstracted therefrom after a predetermined time and may be analyzed.

Abstract: A memory device is configured to operate in first and second data input/output modes. The memory device includes a first electrode pad, a second electrode pad, a clock signal line, a first switching unit, and a second switching unit. The clock signal line is configured to transmit a clock to an integrated circuit inside the memory device. The first switching unit switches to electrically connect the first electrode pad and the clock signal line in response to a control signal occurring for the first data input/output mode. The second switching unit switches to electrically connect the second electrode pad and the clock signal line in response to an inverse signal of the control signal occurring for the second data input/output mode.