Patents Represented by Attorney Nancy J. Harrison

Find this attorney in the Justia Lawyer Directory

  • A-21978 Antibiotics and process for their production
    Patent number: 4208403
    Abstract: Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-29178C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes; the A-21978C factors; and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.
    Type: Grant
    Filed: October 16, 1978
    Date of Patent: June 17, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn
  • Process for producing deoxynarasin antibiotics
    Patent number: 4204039
    Abstract: Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 20, 1980
    Assignee: Eli Lilly and Company
    Inventors: Walter M. Nakatsukasa, Gary G. Marconi, Norbert Neuss, Robert L. Hamill
  • Acylamino derivatives
    Patent number: 4187232
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 5-membered ring containing a single heteroatom, which may be oxygen, or sulphur, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: January 19, 1978
    Date of Patent: February 5, 1980
    Assignee: Lilly Industries Limited
    Inventors: Delme Evans, Michael R. J. Jolley, William J. Ross, Brian P. Swann
  • A-38533 Antibiotics and process for production thereof
    Patent number: 4180564
    Abstract: Antibiotic A-38533 complex, comprising microbiologically active, related factors A.sub.1, A.sub.2, B and C, is produced by submerged, aerobic fermentation of a new Streptomyces sp., NRRL 11298. The A-38533 antibiotics are closely related antibiotics. The individual A-38533 factors are separated by chromatography. The A-38533 factors are antibacterial agents which have a unique activity against Pseudomonas species.
    Type: Grant
    Filed: May 25, 1978
    Date of Patent: December 25, 1979
    Assignee: Eli Lilly and Company
    Inventors: Otis W. Godfrey, Ronald D. Johnson, Ralph E. Kastner
  • Antibiotic A-7413 and process for preparation thereof
    Patent number: 4174390
    Abstract: Antibiotic A-7413 complex, comprising a major microbiologically active factor A, and minor active factors B, C, and D, is produced by fermentation of Actinoplanes sp. NRRL 8122. The individual factors are isolated and separated by extraction and chromatography. The A-7413 antibiotics are antibacterial agents. The A-7413 complex and A-7413 antibiotic compounds are also useful as growth-promoting agents and in the control of dental caries and acne.
    Type: Grant
    Filed: August 11, 1978
    Date of Patent: November 13, 1979
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, W. Max Stark
  • Deoxynarasin antibiotics
    Patent number: 4174404
    Abstract: Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants. 20-Deoxynarasin and its salts are cardiotonic agents.
    Type: Grant
    Filed: October 27, 1978
    Date of Patent: November 13, 1979
    Assignee: Eli Lilly and Company
    Inventors: Walter M. Nakatsukasa, Gary G. Marconi, Norbert Neuss, Robert L. Hamill
  • Acylamino derivatives
    Patent number: 4166818
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucelus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: September 4, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Acylaminopyrazoles
    Patent number: 4166123
    Abstract: Acylamino pyrazolyl compounds of the formula: ##STR1## wherein Ar represents an optionally substituted pyrazolyl group, the acylamino group --NR.sup.1 COR.sup.2 being attached to a carbon atom of the pyrazolyl ring, which have anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: August 28, 1979
    Assignee: Lilly Industries Limited
    Inventors: Roger G. Harrison, William B. Jamieson, William J. Ross, John C. Saunders
  • Acylamino-1,2,4-oxadiazole or thiadiazole derivatives as anti-hypersensitivity agents
    Patent number: 4163048
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds having anti-allergy activity.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: July 31, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Method of obtaining streptomyces protoplasts capable of efficient cell regeneration
    Patent number: 4159226
    Abstract: A method of obtaining Streptomyces protoplasts which are able to regenerate viable cells with high efficiency is disclosed. The method involves growing Streptomyces cells to a particular physiological state, the transition phase between the exponential and stationary growth phases, and then forming protoplasts. The physiological state of the cells at the time of protoplast formation is crucial for efficient cell regeneration. Protoplasts obtained by this method enhance the use of protoplast-fusion techniques to effect genetic exchange within the genus Streptomyces, thereby facilitating the construction of hybrid or recombinant Streptomyces strains with useful properties.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: June 26, 1979
    Assignee: Eli Lilly and Company
    Inventor: Richard H. Baltz
  • Acylamino derivatives
    Patent number: 4158659
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: June 19, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Certain acylamino-oxa (or thia) diazoles in treatment of hypersensitivity conditions
    Patent number: 4152442
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: June 22, 1977
    Date of Patent: May 1, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Method of treating acne with antibiotic A201A
    Patent number: 4143141
    Abstract: A method for the topical treatment of acne with antibiotic A-201A and A-201A compositions for acne are disclosed.
    Type: Grant
    Filed: September 14, 1977
    Date of Patent: March 6, 1979
    Assignee: Eli Lilly and Company
    Inventors: Paul W. Ensminger, Robert L. Hamill
  • Deoxynarasin antibiotics
    Patent number: 4141907
    Abstract: Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants.
    Type: Grant
    Filed: October 20, 1977
    Date of Patent: February 27, 1979
    Assignee: Eli Lilly and Company
    Inventors: Walter M. Nakatsukasa, Gary G. Marconi, Norbert Neuss, Robert L. Hamill
  • Antibiotic A-32887 and process for production thereof
    Patent number: 4133876
    Abstract: Antibiotic A-32887 is produced by submerged aerobic fermentation of Streptomyces albus NRRL 11109. A-32887 is an antibacterial, antiprotozoal, anticoccidial, and insecticidal agent. A-32887 also increases feed-utilization efficiency in ruminants.
    Type: Grant
    Filed: May 31, 1977
    Date of Patent: January 9, 1979
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn
  • Antibiotic A-32887
    Patent number: 4132778
    Abstract: Antibiotic A-32887 is produced by submerged aerobic fermentation of Streptomyces albus NRRL 11109. A-32887 is an antibacterial, antiprotozoal, anticoccidial, and insecticidal agent. A-32887 also increases feed-utilization efficiency in ruminants.
    Type: Grant
    Filed: October 3, 1977
    Date of Patent: January 2, 1979
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn
  • Pleuromutilin glycoside derivatives
    Patent number: 4130709
    Abstract: Pleuromutilin glycoside derivatives which are useful agents against gram-positive and gram-negative bacteria, anaerobic bacteria, and mycoplasma.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: December 19, 1978
    Assignee: Eli Lilly and Company
    Inventor: Ramakrishnan Nagarajan
  • A-40104 antibiotics and process for production thereof
    Patent number: 4129721
    Abstract: A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors, A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: December 12, 1978
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • Antibiotic A-35512 and process for production thereof
    Patent number: 4122168
    Abstract: Antibiotic A-35512 complex, comprising microbiologically active, related factors A, B, C, E and H, is produced by submerged aerobic fermentation of Streptomyces candidus NRRL 8156. The individual A-35512 factors are separated and isolated by chromatography. The A-35512 antibiotics are antibacterial and growth-promoting agents and increase feed-utilization efficiency in animals. In addition, A-35512 factor B is useful in the treatment of dental caries and acne.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: October 24, 1978
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • Procedure for obtaining penicillium species mutants with improved ability to synthesize mycophenolic acid
    Patent number: 4115197
    Abstract: A procedure for efficiently obtaining higher mycophenolic-acid-producing mutants from mycophenolic-acid-producing strains of the genus Penicillium by selecting mutants which are resistant to polyene antibiotics.
    Type: Grant
    Filed: August 29, 1977
    Date of Patent: September 19, 1978
    Assignee: Eli Lilly and Company
    Inventors: Stephen W. Queener, Claude H. Nash, III