Patents Represented by Attorney, Agent or Law Firm Needle & Rosenberg
  • Patent number: 7824857
    Abstract: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: November 2, 2010
    Assignee: MUSC Foundation for Research Development
    Inventors: Michael Mitas, David J. Cole, William E. Gillanders, Michael Wallace
  • Patent number: 7434542
    Abstract: The small-animal mount assembly of the present invention can include a table member suitable for mounting a small animal. The table member can be selectively positionable into a desired table plane and can comprise at least one ECG pad and/or at least one grid of electronic heating elements disposed onto a top surface of the table pad. The assembly can also include a control apparatus electrically coupled to the at least one ECG pad and/or the at least one grid of electronic heating elements.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: October 14, 2008
    Assignee: VisualSonics Inc.
    Inventors: Leo Zan, James I. Mehi
  • Patent number: 7426904
    Abstract: The small-animal mount assembly of the present invention can include a table member suitable for mounting a small animal. The table member can be selectively positionable into a desired table plane and can comprise at least one ECG pad and/or at least one grid of electronic heating elements disposed onto a top surface of the table pad. The assembly can also include a control apparatus electrically coupled to the at least one ECG pad and/or the at least one grid of electronic heating elements.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: September 23, 2008
    Assignee: VisualSonics Inc.
    Inventors: Leo Zan, James I. Mehi
  • Patent number: 7427671
    Abstract: A DNA sequence which encodes a human type ? platelet derived growth factor receptor protein which preferentially binds to the AA homodimer and AB heterodimer forms of platelet derived growth factor and also binds the BB homodimer at high affinity, is described. Substantially pure human a platelet derived growth factor receptor protein and methods for recombinantly producing human ? platelet derived growth factor receptor protein are also described.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: September 23, 2008
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Toshimitsu Matsui, Stuart A. Aaronson, Jacalyn H. Pierce
  • Patent number: 7425818
    Abstract: The present invention provides a connector arrangement operative to connect a prime mover driven alternator to an alternating current circuit with an existing alternating current. For example, the connector arrangement may be used to connect an alternator driven by a Stirling engine to an alternating current mains electricity supply. The connector arrangement includes a circuit with an adjustable resonant frequency, adjustable between a first resonant frequency tuned to an initial operating frequency of the prime mover and a second resonant frequency detuned to the initial operating frequency. This adjustable resonant frequency is beneficial as it allows operation to be tailored to the exact operating conditions of the prime mover that is likely to have its own resonant frequency that may vary according to its operating condition.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: September 16, 2008
    Assignee: Microgen Energy Limited
    Inventors: Roger Stuart Silcock, Jonathan James Childs, Jarlath Michael McEntee
  • Patent number: 7419817
    Abstract: The present invention provides methods of purifying adeno-associated virus (AAV) particles. These AAV particles include AAV2, AAV4 and AAV5 particles. The present invention also provides AAV particles purified by the methods of the present invention.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: September 2, 2008
    Assignee: The United States of America as represented by the Secretary Department of Health and Human Services, NIH.
    Inventors: John A. Chiorini, Nikola A. Kaludov
  • Patent number: 7413683
    Abstract: A composition comprising particulate carbonaceous material and a sulfonated conducting polymer containing hetero atoms. The composition can further comprise a metal. Devices comprising the composition can be constructed including supported electrocatalysts, membrane electrode assemblies, and fuel cells. A method for preparing the composition comprises oxidatively polymerizing a monomer of a conducting polymer containing hetero atoms in the presence of a carbonaceous material and sulfonating the polymer or the monomer. The method grafts the sulfonated conducting polymer to the carbonaceous material. The method can further comprise metallizing the polymer-grafted carbonaceous material.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: August 19, 2008
    Assignee: Columbian Chemicals Company
    Inventor: Srinivas Bollepalli
  • Patent number: 7407699
    Abstract: Improved extruded polypropylene sheets containing a high level of beta crystallinity and A process for making such sheets are disclosed herein. The polypropylene sheets comprise a resinous polymer of propylene and an effective amount of beta spherulites. Uniaxially or biaxially oriented mesh structures produced from the disclosed sheets exhibit lower density, higher strength, and higher torsional rigidity than polypropylene meshes without beta spherulites. Thus, lighter weight mesh structures which meet all of the physical property requirements for end-use applications, such as reinforcing grids to stabilize concrete and soil in civil engineering and landfill applications, are produced. The lighter weight extruded beta-nucleated sheet can also be stretched at higher line speeds, thereby reducing manufacturing costs.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: August 5, 2008
    Assignee: Mayzo, Inc.
    Inventor: Philip Jacoby
  • Patent number: 7406818
    Abstract: The present invention is an apparatus and method of making yarn for carpet that exhibits a high degree of color pop. More specifically, in one aspect, the present invention comprises an apparatus and method that comprises supplying a plurality of yarns, false-twist the plurality of yarns, and passing the consolidated yarn through a downstream entangling assembly to tack at least a portion of the consolidated yarn. Another aspect of the present invention passes at least one of the plurality of yarns through one of a plurality of second entangling assemblies positioned upstream of the false-twist apparatus.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: August 5, 2008
    Assignee: Columbia Insurance Company
    Inventor: Kenneth H. Keith
  • Patent number: 7403562
    Abstract: A rate control algorithm for a predictive video encoder is provided to accurately control the coding rate while requiring a small complexity. The algorithm assumes the video encoder to consist of two processors, pre-processor and main processor, and the rate control located in main processor uses prediction cost and residual cost for each picture that are computed in pre-processor. Prediction cost represents the estimated number of bits needed to generate an error image, and residual cost describes the difficulty of encoding the resultant error image. Accurate and simple rate control is made possible by using a new rate model that adapts to the local characteristic of a video sequence, and by targeting to maintain the quantization parameter as constant as possible in a given set of pictures, GOP, instead of the conventional two step approach.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: July 22, 2008
    Assignee: EG Technology, Inc.
    Inventors: Kyeong Ho Yang, Hyung Joon Kim
  • Patent number: 7401855
    Abstract: A seat with a backrest and sitting surface, in particular for motor vehicles, wherein the backrest comprises a backrest frame and, disposed between it, elements forming an S-shaped backrest with a shoulder area that can be reconfigured in the forwards and backwards directions, and a lumbar spine area that can be reconfigured in the forwards and backwards directions, wherein the elements are swivel-mounted to rotate about an imaginary or real axis extending horizontally between the shoulder and lumbar spine areas and running through the backrest frame or parallel with it in such a way that, without changing an existing inclination setting of the backrest relative to the sitting surface, a reconfiguration of the lumbar area and/or the shoulder area in the forwards direction can be made automatically by reconfiguring the shoulder area and/or the lumbar area in the backwards direction.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: July 22, 2008
    Assignee: Grammer AG
    Inventors: Josef Kohl, Hermann Meiller
  • Patent number: 7403978
    Abstract: A method of determining a geographic location of an Internet user involves determining if the host is on-line, determining ownership of the host name, and then determining the route taken in delivering packets to the user. Based on the detected route, the method proceeds with determining the geographic route based on the host locations and then assigning a confidence level to the assigned location. A system collects the geographic information and allows web sites or other entities to request the geographic location of their visitors. The database of geographic locations may be stored in a central location or, alternatively, may be at least partially located at the web site. With this information, web sites can target content, advertising, or route traffic depending upon the geographic locations of their visitors. Through web site requests for geographic information, a central database tracks an Internet user's traffic on the Internet whereby a profile can be generated.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: July 22, 2008
    Assignee: Digital Envoy, Inc.
    Inventors: Sanjay M. Parekh, Robert B. Friedman, Neal K. Tibrewala, Benjamin Lutch
  • Patent number: 7393666
    Abstract: Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of enhancing apoptosis of neoplastic cells comprises inhibiting interaction of hepatitis B X-interacting protein (HBXIP) with Survivin.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: July 1, 2008
    Assignee: Burnham Institute for Medical Research
    Inventors: Ingo Tamm, John C. Reed
  • Patent number: 7390441
    Abstract: A composition comprising particulate carbonaceous material and a sulfonated conducting polymer containing hetero atoms. The composition can further comprise a metal. Devices comprising the composition can be constructed including supported electrocatalysts, membrane electrode assemblies, and fuel cells. A method for preparing the composition comprises oxidatively polymerizing with ozone a monomer of a conducting polymer containing hetero atoms in the presence of a carbonaceous material and sulfonating the polymer or the monomer. The method grafts the sulfonated conducting polymer to the carbonaceous material. The method can further comprise metallizing the polymer-grafted carbonaceous material.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: June 24, 2008
    Assignee: Columbian Chemicals Company
    Inventor: Srinivas Bollepalli
  • Patent number: 7392205
    Abstract: A buyer-seller matching system that uses incentives to verify commissions from matching the buyer with a seller. An item locator system that comprises a repository of information about items for purchase may be provided over a network for users to access information about items for purchase. Along with each item, the system presents an incentive that may be realized if that item is purchased from a designated third party seller. The user then executes the purchase with the seller, who pays the system the agreed upon fee and also issues a certification of purchase to the buyer. The user may then take the certification of purchase back to the central repository to redeem the incentive. The item locator system then checks to verify that it has received a fee or commission from the seller for bringing the seller a buyer of the item. The fee or commission may be based on the price of the item, such as if the item is a new house for sale and the seller is a new house builder.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: June 24, 2008
    Assignee: INest Realty, Inc.
    Inventor: David R. Forward
  • Patent number: 7392080
    Abstract: The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) the porator array comprising: i) a top surface, with a removable adhesive attached to the top surface, the top surface containing two concentric electrical contact rings for contacting the interface connection port at the anode and the cathode upon removal of the adhesive layer; ii) a bottom surface comprising a tissue interface membrane, the tissue interface membrane further comprising a substrate with at least one porator contained on or within the substrate, the bottom surface further comprising an adhesive layer for a
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: June 24, 2008
    Assignee: Altea Therapeutics Corporation
    Inventors: Jonathan Eppstein, Stuart McRae, Alan Smith
  • Patent number: 7384797
    Abstract: Biosensors including resonant optical cavities. The resonant optical cavities are shaped so as to generate whispering gallery modes, which increase the quality factors of the cavities and facilitate the detection of analytes in a sample with enhanced sensitivity. The sizes of the resonant optical cavities facilitate their use in biosensors that include arrays of sensing zones. Accordingly, the resonant optical cavities may be used in high-density sensing arrays that can be read in real-time and in parallel. Thus, the resonant optical cavities are useful for detecting small concentrations of samples in real-time and with high throughput. Different embodiments of the biosensors are also disclosed, as are methods for using the biosensors.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: June 10, 2008
    Assignee: University of Utah Research Foundation
    Inventor: Steven M. Blair
  • Patent number: 7378472
    Abstract: The use of a multimodal polyethylene composition comprising as comonomers to ethylene at least two C4-12 alpha olefins in injection molding.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: May 27, 2008
    Assignee: Borealis Technology Oy
    Inventors: Hans Jörg Fell, Philipp Walter
  • Patent number: D574500
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: August 5, 2008
    Assignee: Altea Therapeutic Corporation
    Inventors: Erin Melissa Koch, Mark James Fisher, Jeremiah Peter O'Leary, Stephen Wilson Braun, Uros Kascak, Loren J. Lantz, Zoran Novakovic
  • Patent number: D579833
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: November 4, 2008
    Inventor: Steven D. Acenbrak