Abstract: A computer mouse pad is heated for reducing repetitive motion stress for a user and for providing potential therapeutic treatment for the user's hand and wrist while operating a mouse thereon. The pad has a resistance-type heating element which is embedded in the rubber material of the pad. The mouse is either a stationary mouse or a conventional movably positioned mouse and is operated on the level section of the top surface of the pad. If a stationary mouse is utilized, the user's hand and wrist are support by an elevated section of the top surface of the pad. A non-skid surface is on the bottom of the pad. A conventional electric power outlet is utilized as the power source.

Abstract: Microsatellite nucleotide repeat sequences present in DNA isolated from a biological sample are used to determine the origin of a biological sample by a process including the steps of isolating nucleic acid from a biological sample, determining the interspersion pattern of repeats of a nucleotide sequence selected from the group consisting of di-, tri-, and tetra- microsatellite nucleotide repeat sequences in the DNA, and comparing the determined interspersion pattern with known interspersion patterns of the nucleotide sequence in selected mammalian species.

Abstract: The subject invention provides non-naturally occurring peptides capable of inhibiting growth factor-stimulated growth of cells. The peptide can be utilized to inhibit growth factor-stimulated growth, such growth factors including, for example, gonadotropins, peptide hormones, synthetic growth factors, and ligands, the ligand having a receptor that is a member of the steroid/thyroid hormone/vitamin receptor superfamily. Also provided are DNA sequences encoding the peptides and methods of producing and using the peptides.

Abstract: The present invention is directed to a heat-sensitive imaging material that comprises a support on which is formed a heat-sensitive imaging layer. This imaging layer comprises a color-forming amount of a substantially colorless, finally divided noble metal salt of an organic acid, an organic reducing agent that is capable of a color-forming reaction with the noble metal salt under heating conditions to produce a colored image, and a stabilizer compound of formula (I) that mitigates the formation of non-imaging background color in the imaging layer: ##STR1## In formula (I), Z.sub.1, Z.sub.2, and Z.sub.3 each independently represents hydrogen, an alkali metal ion, an alkyl group comprising 1 to about 8 carbon atoms, an aralkyl or cycloalkyl group comprising 5 to about 10 carbon atoms, or an aryl group comprising 6 to about 15 carbon atoms; or Z.sub.1 and Z.sub.

Abstract: The present invention is directed toward the 5 previously unknown genes, for subunits .delta., .delta.', .chi., .theta., and .psi., of the DNA polymerase III holoenzyme, and toward a unique man-made enzyme containing 5, preferably 6, protein subunits which shows the same activity as the naturally occurring 10 protein subunit DNA polymerase III holoenzyme.

Abstract: The ability to monitor the progression of human immunodeficiency virus (HIV) infection in patients is paramount to the study of HIV transmission, in predicting the onset and advancement of disease, and evaluating the clinical efficacy of therapeutics. Present methods available to the clinician for the study of HIV pathogenesis employ surrogate markers. Surrogate markers are biological indicators that tend to reflect, to varying extent, the gradual progression of the asymptomatic state to the development of acquired immune deficiency syndrome (AIDS). The most commonly used markers are CD4.sup.+ lymphocyte counts and HIV p24 antigen production. The use of markers to evaluate disease progression suffers from a number of limitations. No known marker consistently reflects disease progression in all patients and stages of disease. Moreover, an effective marker must rapidly reflect the changes associated with antiviral therapy.

Abstract: A composite material useful for removing heavy metal ions from solutions such as aqueous waste streams comprises a ceramic inorganic support such as silica gel which is covalently bonded, through a silane coupling agent, to a hydroxyquinoline ligand or such a support which has been reacted with a silylating agent and then on which is deposited a hydroxyquinoline ligand.

Abstract: A method for making titanium nitride whiskers comprising reacting titanium in the presence of nitrogen in a direct nitridation reaction, concurrently reacting titania in the presence of nitrogen in a carbothermal nitridation reaction, optionally in the presence of a transport species reaction under conditions necessary to make titanium nitride whiskers.

Abstract: The subject invention provides a platelet membrane glycoprotein, designated F11, which serves as a receptor for the monoclonal antibody M.Ab.F11. The purified platelet membrane glycoprotein has a deglycosylated molecular weight of about 29 kD. A partial sequence for the glycoprotein is also provided, as well as expression vectors and systems for producing the glycoprotein or fragments thereof.

Abstract: A reader for reading bar code symbols containing so called "fat bits" arranged on exposed film is described. A strip of film 10 which has one or more frames 11 has a boundary edge 13 with space in which zero, one, or two fat bits 14 is provided for each frame 11. A light source 28 directs light through the boundary edge 13 of the strip 10. A pair of optical sensors 25, 27 receives the light directed through the boundary edge 13. The sensors 25, 27 each output a signal corresponding to the presence or absence of a fat bit to a detector circuit 220. The detector circuit 220 outputs a signal corresponding to the fat bit to a controller 250 as the strip moves between the light source 28 and the sensors 25, 27. An encoder 230 measures the displacement of the strip 10 as it moves, and outputs pulse signals to the controller 250 representative of units of strip 10 displacement.

Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: ##STR1## wherein R.sub.1 is hydrogen or hydroxy;R.sub.2 is hydrogen;or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;R.sub.3 is --COOH or --COOR.sub.4 ;R.sub.4 has 1 to 6 carbon atoms;A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents.A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.

Abstract: A compound comprises a target cell-specific portion, such as an antibody specific to tumour cell antigens, and an inactivating portion, such as an enzyme, capable of converting a substance which in its native state is able to inhibit the effect of a cytotoxic agent into a substance which has less effect against said cytotoxic agent. The prolonged action of a cytotoxic agent at tumour sites is therefore possible whilst protecting normal tissues from the effects of the cytotoxic agent.

Abstract: The A-to-D converter 300 has an output buffer 320 with fourteen drivers each the same as driver 4100. Driver 4100 includes bipolar pull up pull down transistors 4102, 4103. Those transistors are both coupled to an output. Pull up transistor 4102 is coupled to a first reference voltage VDD; pull down transistor 4103 is coupled to a second or ground reference potential. A base drive circuit comprising a series connection between a resistor and a transistor 4121 to provide additional current to saturate the pull down transistor 4103 and thereby lower the collector-to-emitter voltage drop of transistor 4103 when transistor 4103 is turned on.

Abstract: An acceptor material for printing by ink-jet printers forms water-resistant, light-stable ink records with aqueous ink jet inks. The material comprises a support such as polyester film and a coating containing a water-soluble high molecular weight amino compound that forms insoluble compounds with and immobilizes the dyestuffs of the ink jet inks and a water managing polymer, preferably, hardened gelatin, which quickly renders the material dry-to-the-touch after contact with the aqueous ink.

Abstract: A semiconductor-on-diamond structure has a free-standing layer of diamond material that is thick enough to provide integrity for the integrated circuit and to insulate the circuit. The structure has a layer of diamond material 12 on a layer of silicon nitride 62. A device layer of semiconductor material 30 is positioned over the silicon nitride layer.

Abstract: The present invention relates to a method of imparting pathogen resistance to plants. This involves applying a hypersensitive response elicitor polypeptide or protein in a non-infectious form to a plant under conditions where the polypeptide or protein contacts cells of the plant. The present invention is also directed to a pathogen resistant plant and a composition for imparting pathogen resistance to plants.

Abstract: An integrated circuit 10 has a programmable Zener diode with diffusion regions 18 and 16 and metal contacts 34 and 32. A barrier metal 30 is disposed between one contact 32 and the substrate 12; another contact region 18 has no barrier metal on its surface. A polysilicon layer 22 is self-aligned with surface regions 18 and diffusion region 18. A silicide layer 128 may be used on the polysilicon layer 22 and on surface region 18.

Abstract: The present invention relates to an isolated gene fragment which confers disease resistance to plants by responding to an avirulence gene in plant pathogens. The gene fragment encodes for protein kinase, particularly serine/threonine kinase. The gene can be cloned into an expression vector to produce a recombinant DNA expression system suitable for insertion into cells to form a transgenic plant transformed with that gene fragment. Also disclosed is a process of conferring disease resistance to plants by growing plant host cells transformed with that expression system and expressing the gene conferring disease resistance to impart such resistance to the host cells.

Abstract: The present invention is directed to an isolated oligonucleotide having a nucleotide sequence which includes a sequence corresponding to SEQ ID NO:1, or which includes a sequence complementary to the sequence corresponding to SEQ ID NO:1. Methods for differentiating and/or identifying canine chromosomes using the isolated oligonucleotide are also provided. The invention further provides a method for differentiating and/or identifying canine chromosomes using a labeled repetitive probe, wherein the labeled repetitive probe is hybridized to canine chromosomes and the resulting hybrids are detected fluorescently. In one embodiment, the DNA sequence of the repetitive probe is provided in the recombinant plasmid designated pCfBE013/BH.

Abstract: A surface mountable integrated circuit and a method of manufacture are disclosed. A wafer 110 has a die with an integrated circuit 119 in one surface of the wafer. A via 130 extends to the opposite surface. The via has a sidewall oxide 131 and is filled with a conductive material such as metal or doped polysilicon. The metal may comprise a barrier layer and an adhesion layer. The second end of the via can be fashioned as a prong 233 or a receptacle 430. Dies with vias can be stacked on top of each other or surface mounted to printed circuit boards or other substrate.