Abstract: The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.

Abstract: A lancing device comprises a main housing, a movable housing and a pushbutton. The main housing encloses a portion of a lancing mechanism. The lancing mechanism includes a lancet holder attached to a shaft. The lancet holder receives a lancet and has a slot formed therein. The lancing mechanism moves between a rest position, a cocked position, and a puncture position. The movable housing is adjacent to the main housing. The movable housing moves from a rest position to a cocking position and a lancet-release position. The pushbutton allows the lancing mechanism to move from the cocked position to the puncture position upon depression of the pushbutton. The pushbutton includes a lancet-release tab that extends into the slot formed in the lancet holder and engages the lancet. The lancet is released from the lancet holder in response to the continued depression of the pushbutton and the movable housing is moved from the rest position to the lancet-release position.

Abstract: An organoruthenium complex represented by the general formula (1-1), bis(acetylacetonato)(1,5-hexadiene)ruthenium and bis(acetylacetonato)(1,3-pentadiene)ruthenium have low melting points, show excellent stability against moisture, air and heat, and are suitable for the film formation by a CVD method. (1-1) wherein X represents a group represented by the general formula (1-2); Y represent a group represented by the general formula (1-2) or a linear or branched alkyl group having 1 to 8 carbon atoms; Z represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and L represents an unsaturated hydrocarbon compound having at least two double bonds: (1-2) wherein Ra and Rb independently represent a linear or branched alkyl group having 1 to 5 carbon atoms.

Abstract: A container comprises a front panel including a stationary front portion and a removable front portion separated by a first line of weakness. The container comprises a rear panel including a stationary and a detachable rear portion separated by a second line of weakness. The container comprises a first and an opposing second side panel separated from the removable front portion by third and fourth lines of weakness. The container comprises a top front major flap extending from the removable front portion and hingedly coupled to the removable front portion by a first fold line. The container comprises a top rear major flap extending from the rear panel and hingedly coupled to the stationary rear portion and the detachable rear portion by a second fold line. The container is configured to be converted into a display configuration.

Abstract: Bandgap reference circuit, comprising a voltage generator (VG) designed to produce a voltage or a current proportional to absolute temperature, a supply circuit (SC), designed to produce a supply for operating the voltage generator (VG), comprising a bias element (BS) and a control element (CS), and a bias circuit (BC), designed to produce a bias for operating the voltage generator (VG), comprising a bias element (BB) and a control element (CB). At least one of the control element (CS) of the supply circuit (SC) and the control element (CB) of the bias circuit (BC) comprises a pseudomorphic high-electron-mobility transistor or a hetero-junction bipolar transistor and/or at least one of the bias element (BS) of the supply circuit (SC) and the bias element (BB) of the bias circuit (BC) comprises a long-gate pseudomorphic high-electron-mobility transistor or a resistor.

Abstract: A gaming system includes at least one display configured to display a plurality of symbols positions. The plurality of symbol positions are configured to display symbols indicative of a randomly selected outcome of a wagering game in relation to a plurality of paylines. The gaming system further includes a controller configured to award an award for any winning outcome occurring along a payline and to add a number of winning paylines to a counter configured to track a number of winning paylines. The controller is further configured, in response to a number of winning paylines in the counter exceeding a predetermined threshold number, to activate a game feature in which a second award is awarded.

Abstract: A gaming system comprises at least one wager input device, a plurality of gaming devices each displaying at least one primary wagering game, and a community display for displaying a community game. At least one controller is operative, in response to a triggering event, to (i) determine which of the plurality of gaming devices are eligible for participation in the community game, (ii) determine an individual award for each of the eligible gaming devices, (iii) determine a community award in the community game, (iv) select an individual award enhancement from a plurality of available individual award enhancements, (v) select one of the plurality of gaming devices to receive the selected individual award enhancement, and (vi) if the selected gaming device is eligible for participation in the community game, enhance the determined individual award for the selected gaming device with the selected individual award enhancement.

Abstract: An orthodontic implant structure including: an upper structure body having an insertion hole; a pair of bolts each having a head thread portion, a hexagonal locking portion, an engaging ring, and an embedding thread portion; and a base plate in which are formed a first locking hole and a second locking hole that lock with the hexagonal locking portions and having a projecting thread portion. Both bolts are embedded in bone, the first locking hole is locked on the hexagonal locking portion and a first nut is screwed onto the head thread portion, and the insertion hole is fitted over the projecting thread portion and a second nut is screwed onto the projecting thread portion.

Abstract: A fine powder of an alkaline earth metal carbonate selected from the group consisting of barium carbonate, strontium carbonate and calcium carbonate, in which a primary particle of the powder has a mean diameter of 30 to 90 nm, in which the mean diameter is measured on a circle obtained from a projected area of the primary particle, and in which an accumulated volume of micropores having a pore size in the range of 10 to 20 nm is not less than 5×10?2 cm3/g can be easily dispersed in an aqueous medium in the form of essentially primary particles by an industrially employable dispersing method.

Abstract: An audio and video production system and method, including a video production control switcher; and one or more computers connected through a network and configured for controlling the video production control switcher. The system is further configured for at least one of defining looks, including shot templates, that correspond to particular settings on the production control switcher or settings of parts of the production control switcher; defining sequences of the looks or assigning individual looks to control elements on a computer of the computers; transmitting the looks across the network; and translating of a single look into one or more standard editor commands, and transmitting the commands to the production control switcher.

Abstract: A method of playing a wagering game on a gaming terminal. The gaming terminal displays a plurality of indicia during the wagering game, which are then selected via player inputs. The selected indicia are revealed and arranged into groups corresponding to winning combinations. The arrangement is made so as to maximize at least one of the plurality of predefined winning combinations.

Abstract: A switchable capacitive element having an adjustable capacitance and an improved quality factor is specified. To this end, the characteristic variables of the switchable capacitive element are optimized in accordance with the equations cited in the description.

Abstract: Wagering game systems, gaming machines, and methods of changing the appearance of a gaming machine are presented herein. In one embodiment, a gaming machine for playing a wagering game is presented. The gaming machine includes a display for displaying the outcomes of the wagering game, and an input device for receiving wagers from players. The gaming machine also includes a cabinet with a mounting base integrated to the top of the cabinet. The mounting base is configured to support any of a plurality of different top-box mounted fixtures, such as tower lights, marquees, and other signage. In some embodiments, the gaming machine also includes at least one electrical connector that is accessible from the exterior of the cabinet. The electrical connector is configured to electrically couple the selected top-box mounted fixture to the cabinet.

Abstract: A dual ram assembly for a turret machine includes a first and second ram. The first ram comprises a first cam follower bracket and a first set of cam followers. An outer die tooling is connected to the first ram. The second ram comprises a second cam follower bracket and second set of cam followers. An inner knockout tooling is connected to the second ram. The first set of cam followers is configured to follow a first cam surface. The second set of cam followers is configured to follow a second cam surface. The first ram is connected to the second ram on a slide block. As the first and second sets of cam followers follow the first and second cam surfaces, the inner knockout tooling and the outer die tooling move toward or away from an article to be worked on.

Abstract: This method uses two sets of sensors to estimate certain characteristics of the movement of a device or a person or states, especially postures, they adopt. A first, abundant, set of sensors (1) is removed after a learning phase where it records with certainty the states obtained by interpreting first decisional rules. The measurements of a second set of sensors (2), much more restricted than the first, are correlated to the states reached during the learning period by second decisional rules automatically obtained by supplying a classifier. They are then interpreted to determine the new states reached by the wearer just by means of the second sensors. The results are good in spite of the low number of second sensors, thanks to the accuracy of the second decisional rules.

Abstract: An angled arrangement of a currency document handling device and a second unit and an angle arrangement of two currency document handling devices, components of the same, and methods of coupling and using the same. For example, a currency document processing system for processing currency documents including currency bills comprises a currency handling device, a first currency document receiving unit, and a first angular transport unit. The first currency document receiving unit is adapted to receive at least some bills processed by the currency handling device. The first angular transport unit is adapted to receive bills from the currency handling device and transport bills to the first currency document receiving unit. The angular transport unit is adapted to be coupled between the currency handling device and the first currency document receiving unit such that the currency handling device and the first currency document receiving units are angled relative to each other such as by ninety degrees (90°).

Abstract: The invention described herein is based, in part, on the discovery that thieno[3,2-c] pyridine derivatives prevent inflammation in the setting of inflammatory disorders, such as asthma. Described herein are methods for treating inflammatory disorders including, for example asthma, by administering a thieno[3,2-c] pyridine derivative compound to an individual in need thereof.

Abstract: In general, iPS cells are produced by delivery of stem cell-associated genes into adult somatic cells (e.g., fibroblasts). Described herein are methods for enhancing the efficiency and rate of induced pluripotent stem cell production by treating somatic cells with a transforming growth factor-beta receptor (TGF?R) inhibitor. Also described herein are iPS cell compositions made according to the methods described herein and iPS cell compositions comprising an iPS cell in an admixture with a TGF?R inhibitor. Further described herein are kits for producing iPS cells using a TGF?R inhibitor.

Abstract: Certain embodiments described herein include a memory system which can communicate with a host system such as a disk controller of a computer system. The memory system can include volatile and non-volatile memory and a controller which are configured such that the controller backs up the volatile memory using the non-volatile memory in the event of a trigger condition. In order to power the system in the event of a power failure or reduction, the memory system can include a secondary power source which is not a battery and may include, for example, a capacitor or capacitor array. The memory system can be configured such that the operation of the volatile memory is not adversely affected by the non-volatile memory or the controller when the volatile memory is interacting with the host system.