Abstract: Methods for the transport and hybridization of a nucleic acid on an electrode device by providing a low conductivity buffer with a reducing agent to the device. The low conductivity buffer may also contain a zwitterion. A current and voltage is applied to a location of the device to effect electrophoretic transportation of the nucleic acid towards the location. The nucleic acid is then hybridized to a nucleic probed located at the location. The reducing agent in the low conductivity buffer may also be acting as a chaotropic agent.

Abstract: A power supply comprises at least one power switch adapted to convey power between input and output terminals of the power supply, and a digital controller adapted to control operation of the at least one power switch responsive to an output measurement of the power supply. The digital controller comprises an analog-to-digital converter providing a digital error signal representing a voltage difference between the output measurement and a reference value, a digital filter providing a digital control output based on a sum of previous error signals and previous control outputs, an error controller adapted to modify operation of the digital filter upon an error condition, and a digital pulse width modulator providing a control signal to the power switch having a pulse width corresponding to the digital control output.

Abstract: An amplifying device comprises an electron gun emitting an electron beam, a collector spaced from the electron gun, the collector oriented to collect electrons of the electron beam emitted from the electron gun, and an interaction structure interposed between the electron gun and the collector. The interaction structure defines an electromagnetic path along which an applied electromagnetic signal interacts with the electron beam. The interaction structure further comprises a plurality of polepieces and a plurality of magnets, the polepieces each having an aligned opening to collectively provide an electron beam tunnel having an axis extending between the electron gun and the collector to define an electron beam path for the electron beam. The polepieces provide a magnetic flux path to the electron beam tunnel from the magnets. More particularly, the interaction structure further includes plural cavities defined therein interconnected to provide a coupled cavity circuit.

Abstract: A control and motor arrangement in accordance with the present invention includes a motor configured to generate a locomotive force for propelling the model train. The control and motor arrangement further includes a command control interface configured to receive commands from a command control unit wherein the commands correspond to a desired speed. The control and motor arrangement still further includes a plurality of detectors configured to detect speed information of the motor, and a process control arrangement configured to receive the speed information from the sensors. The process control arrangement is further configured and arranged to generate a plurality of motor control signals based on the speed information for controlling the speed of said motor. The control and motor arrangement yet still further includes a motor control arrangement configured to cause power to be applied to the motor at different times in response to the motor control signals.

Abstract: This invention pertains to the design, fabrication, and uses of an electronic system which can actively carry out and control multi-step and multiplex reactions in macroscopic or microscopic formats. In particular, these reactions include molecular biological reactions, such as nucleic acid hybridizations, nucleic acid amplification, sample preparation, antibody/antigen reactions, clinical diagnostics, combinatorial chemistry and selection, drug screening, oligonucleotide and nucleic acid synthesis, peptide synthesis, biopolymer synthesis, and catalytic reactions. A key feature of the present invention is the ability to control the localized concentration of two or more reaction-dependant molecules and their reaction environment in order to greatly enhance the rate and specificity of the molecular biological reaction.

Abstract: A control and motor arrangement in accordance with the present invention includes a motor configured to generate a locomotive force for propelling the model train. The control and motor arragement further includes a command control interface configured to receive commands from a command control unit wherein the commands correspond to a desired speed. The control and motor arrangement still further includes a plurality of detectors configured to detect speed information of the motor, and a process control arrangement configured to receive the speed information from the sensors. The process control arrangement is further configured and arranged to generate a plurality of motor control signals based on the speed information for controlling the speed of said motor. The control and motor arrangement yet still further includes a motor control arrangement configured to cause power to be applied to the motor at different times in response to the motor control signals.

Abstract: A smoke generating device for a model train that includes a smoke generating element supported by a support member. The smoke generating element can be wound around the support member is a generally helical pattern. The number of turns and the distance between turns can be varied to enhance the smoke generating properties of the device. The support member can be braided fiberglass. A length and cross-section of the support member can be varied to support smoke generating elements of different lengths. The length of the smoke generating element can be varied to produce smoke generating devices having different resistive values.

Abstract: Traffic information, including traffic flow information and traffic incident information, obtained through a traffic management system for providing and facilitating the exchange of traffic information between a remote location and a vehicle may be presented to a user on a user display in the vehicle. The traffic information may be presented to the user in several circumstances, either as cued by the user, or automatically presented by the traffic management system. The present invention discloses a vehicle navigation system for providing personalized traffic information to a user of the vehicle navigation system and methods for the same. The personalized traffic information is based at least in part on user preferences, either manually input by the user or automated by the vehicle navigation system.

Abstract: In a vehicular control object determination system, the position of an object detected by a radar device is stored by a detection position memory, and a predetermined area having the position of the object as the center is set as the determination region by a determination region setter. When the determination region set for one of two objects is passed through by the other object, the passing direction is determined by a passing direction determiner. During this process, the direction in which a fixed object or an object dropped on the road moves relative to a preceding vehicle is a direction in which the fixed object or the dropped object on the road approaches the subject vehicle with the preceding vehicle as a reference.

Abstract: A voltage regulator is configured to regulate an alternating current source provided to a model toy railroad layout. The voltage regulator delivers a substantially constant voltage level to the features and accessories drawing power from the third rail of the railroad layout. The voltage regulator comprises a load control unit having an output configured to be coupled to a load. The load control unit is responsive to a load control signal for controlling the delivery of current to the load during at least a portion of an alternating current waveform. A feedback unit is coupled to the output of the load control unit and is configured to produce a feedback signal indicative of an average voltage level of the alternating current source applied at the output. A controller is responsive to the feedback signal and is configured to generate the load control signal such that the average voltage level substantially corresponds to a predetermined reference voltage level.

Abstract: In an adaptive cruise control (ACC) region where vehicle speed V is greater than a predetermined third vehicle speed #V3, a decrease amount of a target inter-vehicle distance per predetermined unit vehicle speed decrease amount in a state where the vehicle speed V is less than a predetermined fourth vehicle speed #V4 is smaller than a decrease amount of the target inter-vehicle distance per predetermined unit vehicle speed decrease amount in a state where the vehicle speed V is greater than the predetermined fourth vehicle speed #V4. The decrease amount of the target inter-vehicle distance per predetermined unit vehicle speed decrease amount in a state where the vehicle speed V is less than a predetermined first vehicle speed #V1 is larger than a decrease amount of the target inter-vehicle distance per predetermined unit vehicle speed decrease amount in a state where the vehicle speed V is greater than the predetermined first vehicle speed #V1 and less than a predetermined second vehicle speed #V2.

Abstract: Methods and apparatus for treating disc herniation provide a conformable device which assumes a first shape associated with insertion and a second shape or expanded shape to occlude the defect which typically follows partial discectomy. The device may take different forms, including patches sized to cover the defect, plugs adapted to fill the defect, or a mesh screen collapsed into an elongated form for the purposes of insertion, thereby minimizing the size of the requisite incision while avoiding delicate surrounding nerves. Such a configuration also permits the use of instrumentation to install the device, including, for example, a hollow tube or sheath adapted to hold the collapsed screen and a push rod to expel the collapsed device out of the sheath for use in occluding the disc defect. A device may further include one or more anchors to assist in permanently affixing the device with respect to the defect.

Abstract: The present invention provides for reinforced and drug eluting stent-grafts and related methods of implanting and manufacturing the stent-grafts. A stent-graft of the present invention may include a tubular stent, a biocompatible covering surrounding the stent, and a supporting collar coupled to the proximal end of the stent-graft. A drug agent may be applied to a textured external surface layer of the biocompatible covering, or alternatively to a space between the textured external surface layer and a smooth luminal surface layer of the biocompatible covering, and allowed to elute over time into a wall of a body lumen after the stent-graft is deployed. The collar of the stent-graft absorbs pressure exerted on the stent-graft by fluid flow within the body lumen in order to minimize potential damage to the stent-graft, and may also include barbs to further secure the stent-graft to the body lumen.

Abstract: A connector for connecting a flexible elongate member having a sensor mounted thereon to a physiology monitor includes a housing, an electrical contact member disposed within the housing, the electrical contact member having a plurality of axially spaced contact members, a cable having a plurality of conductors being electrically connected to respective axially spaced contact members, and a sleeve having an opening therein which communicates with an internal passage of the housing. The sleeve is moveable between an open position and a closed position. An interlock mechanism may also be provided to prevent the sleeve from moving from the open position to the closed position.

Abstract: The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array by treating the surface with a linker by vapor deposition and providing a polymerization solution that includes at least one monomer having a polymerizable moiety, a modified streptavidin, a surfactant or porogen, and a cross-linking agent. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker.

Abstract: An apparatus and method for measuring output current and power in real-time is provided for a CPU core powered by a DC-to-DC power converter having active voltage positioning. In an embodiment of the invention, a switched mode power converter comprises at least one power switch operatively coupled to an input voltage source, an output filter operatively coupled to the at least one power switch to provide an output voltage and output current to a load, and a control circuit coupled to the at least one power switch. The control circuit activates the power switch with a duty cycle controlled to regulate at least one of the output voltage and the output current. The control circuit receives a first control signal defining a desired value for the output voltage, a second control signal defining a relationship between voltage input and current draw for the load, and a voltage sense signal corresponding to an actual value of the output voltage. The control circuit thereby provides a measurement of load current.

Abstract: The present invention is directed to devices and methods for carrying out and/or monitoring biological reactions in response to electrical stimuli. A programmable multiplexed active biologic array includes an array of electrodes coupled to sample-and-hold circuits. The programmable multiplexed active biologic array includes a digital interface that allows external control of the array using an external processor. The circuit may monitor, digitally control, and deliver electrical stimuli to the electrodes individually or in selected groups.

Abstract: A power supply for plural loads coupled in parallel comprises a voltage regulator, a plurality of current regulators, and an error control circuit. The voltage regulator provides a common output voltage to the plural loads. The voltage regulator comprises a sensor circuit providing a voltage sense signal corresponding to the output voltage, which provides feedback to regulate the output voltage at a selected level. The plurality of current regulators are coupled to respective ones of the plural loads. Each of the plurality of current regulators regulates current drawn by respective ones of the plural loads to within a desired regulation range. The plurality of current regulators each further provide a respective error signal corresponding to an ability to remain within the desired regulation range. The error control circuit is operatively coupled to the voltage regulator and to the plurality of current regulators.

Abstract: An apparatus for controlling operating features of a model train includes a plurality of selection devices, each of which corresponds to a respective operating feature of the train. The apparatus also includes a controller connected to the selection devices of the apparatus. The controller is operative to generate control signals such as digital messages or DC offset signals corresponding to the selection devices. The apparatus further includes a plurality of switches to control the form the control signals take, and a transmitter connected to the controller. The transmitter is operative to send the digital or DC offset messages that are generated by the controller to a receiver located on the train in order to carry out the desired functions. This invention provides for at least a single button output of complex messages.

Abstract: A power control system comprises at least one POL regulator, at least one auxiliary device, a serial data bus operatively connecting the POL regulator and the auxiliary device, and a system controller adapted to exchange digital data with the POL regulator and auxiliary device via the serial data bus. The auxiliary device may include a power regulation device, a switching device, a motor control device, a temperature control device, and/or a peripheral device. At least one auxiliary device controller may be operatively coupled between the auxiliary device and the serial data bus. The auxiliary device controller may be integrated with the system controller, or may be external to the system controller. The auxiliary device controller may further comprise at least one register adapted to store the programming data, with the programming data including at least one of turn-on delay, turn-off delay, polarity of input/output signals, fault configuration, and group membership.