Patents Represented by Attorney, Agent or Law Firm Patrick M. Ryan
  • 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
    Patent number: 6750250
    Abstract: 11,12-Oxidoarachidonic acid derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: June 15, 2004
    Assignee: Alcon, Inc.
    Inventors: David B. Belanger, Peter G. Klimko
  • Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride
    Patent number: 6743439
    Abstract: Aqueous pharmaceutical solution compositions preserved with a cationic preservative and comprising a cationic drug and a sulfonated styrene/maleic anhydride copolymer are disclosed. The compositions are particularly well suited for topical ophthalmic use, but may also be used as topically administrable otic or nasal compositions.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: June 1, 2004
    Assignee: Alcon, Inc.
    Inventors: Ernesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Ronald F. Berry
  • Use of proteasome inhibitors to treat dry eye disorders
    Patent number: 6740674
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: May 25, 2004
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • Covalently-bound, hydrophilic coating compositions for surgical implants
    Patent number: 6723815
    Abstract: Covalently-bound, hydrophilic copolymer coatings for implants are disclosed. The copolymer coatings comprise a hydrophobic aryl acrylic monomer, a hydrophilic monomer selected from the group consisting of hydroxyalkyl (meth)acrylates, n-vinyl pyrrolidone and acrylamides, and a reactive plasticizer.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: April 20, 2004
    Assignee: Alcon, Inc.
    Inventors: Thomas A. Callaghan, Albert R. Leboeuf
  • Foldable intraocular lens optics having a glassy surface
    Patent number: 6703466
    Abstract: Foldable intraocular lenses having a reduced risk of posterior capsule opacification are disclosed. The foldable intraocular lenses have optics that are prepared such that their surface is glassy and their bulk is rubbery.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: March 9, 2004
    Assignee: Alcon, Inc.
    Inventors: Mutlu Karakelle, Joseph D. Menczel, Robert A. Scott, Charles Freeman
  • Use of NF-&kgr;B inhibitors to treat dry eye disorders
    Patent number: 6696453
    Abstract: NF-&kgr;B inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: February 24, 2004
    Assignee: Alcon, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Foldable ophthalmic and otorhinolaryngological device materials
    Patent number: 6653422
    Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: November 25, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Charles Freeman, Douglas C. Schlueter
  • Method of treating dry eye disorders
    Patent number: 6645994
    Abstract: Inhibitors of acyl-CoA synthetase are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: November 11, 2003
    Assignee: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac
    Patent number: 6646003
    Abstract: The topical use of certain flurbiprofen amide derivatives and ketorolac amide derivatives to treat ophthalmic angiogenesis-related and inflammatory disorders of the posterior segment of the eye is disclosed.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: November 11, 2003
    Assignee: Alcon, Inc.
    Inventors: Gustav Graff, Mark R. Hellberg, John M. Yanni
  • Covalently-bound, hydrophilic coating compositions for surgical implants
    Patent number: 6632905
    Abstract: Covalently-bound, hydrophilic copolymer coatings for implants are disclosed. The copolymer coatings comprise 2-phenylethyl (meth)acrylate, a hydrophilic monomer selected from the group consisting of hydroxyalkyl (meth)acrylates and acrylamides, and a reactive plasticizer.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: October 14, 2003
    Assignee: Alcon Universal Ltd.
    Inventor: Albert R. Leboeuf
  • Coating compositions and methods for reducing edge glare in implantable ophthalmic lenses
    Patent number: 6632887
    Abstract: Hydrophilic coatings for implantable ophthalmic lenses are disclosed. The coatings, which are applied to the edge surface of the ophthalmic lens, comprise a hydrophobic (meth)acrylic polymer and a hydrophilic polymer. When hydrated, the coatings reduce or eliminate edge glare.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: October 14, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Albert R. LeBoeuf, John W. Sheets, Jr.
  • Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
    Patent number: 6552084
    Abstract: Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: April 22, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Method of making high refractive index ophthalmic device materials
    Patent number: 6541572
    Abstract: Disclosed is a two-step method of making soft, high refractive index, acrylic ophthalmic device materials. In the first step, a copolymer containing pendant oxirane groups is formed by copolymerizing one or more aryl acrylic hydrophobic monomers with one or more compounds of the formula wherein X is H or CH3; and n is 1-4. In the second step, the copolymer containing pendant oxirane groups formed in the first step is reacted with a compound of the formula W—T—H wherein W is H, CH3(CH2)a, or Z(OCH2CH2)b; a is 0-3; b is 1-5; Z is H, or CH3(CH2)p; p is 0-3; and T is O, NH, S; provided that if T≠O, then W≠H.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: April 1, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Albert R. LeBoeuf
  • Foldable ophthalmic and otorhinolaryngological device materials
    Patent number: 6528602
    Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: March 4, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Charles Freeman, Douglas C. Schlueter
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6506802
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: January 14, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6500864
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 31, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Compositions containing a benzamide disulfide derivative for treating allergic diseases
    Patent number: 6492418
    Abstract: Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast cell stabilizing disulfide derivative as an active ingredient.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: December 10, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Steven T. Miller, Mark R. Hellberg, Zixia Feng
  • Toric intraocular lens material
    Patent number: 6491721
    Abstract: A method of selecting an intraocular lens material for toric lenses is disclosed. The method comprises determining the tack of the material.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 10, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Charles Freeman, Mutlu Karakelle, Michael J. Simpson
  • Disulfide derivatives useful for treating allergic diseases
    Patent number: 6492552
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: December 10, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Lens epithelial cell growth assay for intraocular lens materials
    Patent number: 6482230
    Abstract: A method for determining the propensity of an intraocular lens material to prevent posterior capsule opacification is disclosed. The method involves contacting a sample of an IOL material having the shape of an IOL optic with collagen to form a contact area, incubating the sample in a liquid composition comprising lens epithelial cells, determining whether lens epithelial cells grow on the collagen in the contact area.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 19, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Kwan Chan, John W. Sheets, Jr., Mutlu Karakelle