Patents Represented by Attorney, Agent or Law Firm Patrick M. Ryan
  • Prostaglandin product
    Patent number: 6235781
    Abstract: A pharmaceutical product comprising an aqueous prostaglandin formulation and a polypropylene container are disclosed. Aqueous prostaglandin formulations are more stable in polypropylene containers than polyethylene containers.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: May 22, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Alan L. Weiner, Subhash C. Airy, Cody Yarborough, Julia A. Clifford, William E. McCune
  • Compositions containing histamine H2 agonists and methods of use in treating allergy and inflammation
    Patent number: 6225332
    Abstract: Compositions containing histamine H2 agonists and methods of use for treating allergy and inflammation of the eye are disclosed.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 1, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Steven T. Miller, Daniel A. Gamache, John M. Yanni
  • Compounds which inhibit human conjunctival mast cell degranulation for treating ocular allergic-type complications
    Patent number: 6225327
    Abstract: Composition and methods for treating ocular allergic reactions are disclosed. In particular, the invention is directed to compounds which inhibit human conjunctival mast cell degranulation.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: May 1, 2001
    Assignees: Alcon Laboratories, Inc., Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Steven T. Miller, Mark R. Hellberg, John M. Yanni
  • Bicomposite intraocular lens and method for its preparation
    Patent number: 6210438
    Abstract: Bicomposite intraocular lenses having an anterior surface material different from a posterior surface material are disclosed. The posterior surface material reduces the risk of posterior capsule opacification.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: April 3, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: John W. Sheets, Jr., Albert R. Leboeuf, Anilbhai S. Patel, Mutlu Karakelle, Stephen J. Van Noy
  • Preservative system for topically administrable pharmaceutical compositions
    Patent number: 6211238
    Abstract: Anionic surfactants are used in conjunction with an antifungal acid and a chelating agent to preserve topically administrable pharmaceutical compositions without the need for a conventional preservative such as benzalkonium chloride.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: April 3, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Ernesto J. Castillo, Steven Howard Gerson, Wesley Wehsin Han
  • Topical use of &kgr; opioid agonists to treat ocular pain
    Patent number: 6191126
    Abstract: The present invention relates to the pharmaceutical treatment of pain. In particular, the present invention relates to the topical use of kappa opioid receptor agonists and partial agonists for the prevention or alleviation of pain in the eye.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: February 20, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventor: Daniel A. Gamache
  • Intraocular lens coating compositions
    Patent number: 6187042
    Abstract: Intraocular lens coating compositions for reducing the risk of posterior capsule opacification are disclosed. The coating materials, which differ from the substrate material, consist essentially of at least two aryl acrylic hydrophobic monomers of the formula wherein: X is H or CH3; m is 0-10; Y is nothing, O, S, or NR wherein R is H, CH3, CnH2n+1 (n=1−10) iso OC3H7, C6H5, or CH2C6H5; Ar is any aromatic ring which can be unsubstituted or substituted with CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5, or CH2C6H5.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: February 13, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: John W. Sheets, Jr., Albert R. Leboeuf, Anilbhai S. Patel, Mutlu Karakelle, Stephen J. Van Noy
  • Chilled temperature polishing method for soft acrylic articles
    Patent number: 6186868
    Abstract: A method of polishing articles comprising soft acrylic materials is disclosed. The method includes a polishing step and a cleaning step. In the polishing step a receptacle is charged with polishing beads of various sizes, alumina, sodium hydroxide, water, a surfactant, and the articles to be polished, and agitated for a period of time and at a speed sufficient to remove surface irregularities. The polishing step is completed below the glass transition (Tg) point of the acrylic article being polished but above 0° C. Following the polishing step, the polished articles are cleaned by rinsing them with water for a period of time to clean the surface of the polished articles.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: February 13, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bryan L. Cremeans, Teresa L. Pickett, Jennia Tucker
  • In vivo polymerizable ophthalmic compositions and methods of using
    Patent number: 6180687
    Abstract: In vivo polymerizable intraocular lens compositions which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends. The compositions are preferably cured by UV photoinitiation and are useful in repairing torn or detached retinal tissue or forming intraocular lenses in situ.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: January 30, 2001
    Assignees: Alcon Laboratories, Inc., University of Southern Mississippi
    Inventors: Mark E. Hammer, Steven T. Charles, John C. Lang, Robert Y. Lochhead, Lon J. Mathias
  • Gelling ophthalmic compositions containing xanthan gum
    Patent number: 6174524
    Abstract: Ophthalmic drug delivery vehicles which are administrable as a liquid and which gel upon contact with the eyes are disclosed. The vehicles contain xanthan gum.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rajan Bawa, Rex E. Hall, Bhagwati P. Kabra, James E. Teague
  • Method of inhibiting cytokine release from human ocular cells
    Patent number: 6174914
    Abstract: Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: John M. Yanni, Daniel A. Gamache, Lori K. Weimer
  • Topical use of kappa opioid agonists to treat otic pain
    Patent number: 6174878
    Abstract: Compositions and methods for treating otic pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists locally for the prevention or alleviation of otic pain.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: January 16, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Use of carbon dioxide and carbonic acid to clean contact lenses
    Patent number: 6171404
    Abstract: Simple, efficacious, easily manufacturable, convenient to use and cost-effective contact lens care cleaning compositions comprising carbon dioxide and carbonic acid as cleansing agents are disclosed. The compositions do not require abrasive agents such as polymeric beads, nor ocularly irritating agents such as enzymes or surfactants in order to effectively clean proteinaceous and nonproteinaceous deposits from the surface of contact lenses. Also disclosed is a one-step cleaning and disinfecting regimen, whereby an effervescent tablet composition capable of generating carbon dioxide and carbonic acid is dissolved in a disinfecting solution or rinsing/disinfecting/storage solution.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: January 9, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rajkumar Bhatia, Alok K. Kulshreshtha, Geoffrey R. Owen, Yusuf Ali
  • Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
    Patent number: 6146622
    Abstract: Anionic amino acid based surfactants are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as carboxyvinyl polymers, xanthan gum, polystyrene sulfonic acid polymers and cationic exchange resins.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: November 14, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Ernesto J. Castillo, Steven Howard Gerson, Wesley Wehsin Han
  • Articles coated with in vivo polymerizable ophthalmic compositions
    Patent number: 6124037
    Abstract: Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: September 26, 2000
    Assignees: Alcon Laboratories, Inc., University of Southern Mississippi
    Inventors: Mark E. Hammer, Steven T. Charles, John C. Lang, Robert Y. Lochhead, Lon J. Mathias
  • Polishing method for soft acrylic articles
    Patent number: 6095901
    Abstract: A method for polishing articles comprising soft acrylic materials is disclosed. The method includes a polishing step and a cleaning step. In the polishing step, a receptacle is charged with polishing beads of various sizes, alumina, a swelling agent and the articles to be polished, and agitated for a period of time and at a speed sufficient to remove surface irregularities. Following the polishing step, the polished articles are cleaned by agitating them with a cleaning slurry comprising cleaning beads of various sizes, alumina, a solvent and a surfactant for a period of time and at a speed sufficient to clean the surface of the polished articles. Agitation is preferably accomplished by a tumbling machine.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: August 1, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stephanie Robinson, Kevin Lewellen
  • Method of preparing 16.alpha., 17.alpha.-dialkylated steroids
    Patent number: 6040468
    Abstract: 16.alpha., 17.alpha.-dialkylated steroids are prepared by reacting a 16.alpha.-alkyl-17(20)-enyl-20-silyl ether with an alkylating agent and an enol silyl ether cleaving agent in a suitable solvent.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: March 21, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventor: Raymond E. Conrow
  • Myeloperoxidase assay of endotoxin-induced inflammation
    Patent number: 6022699
    Abstract: An improved model of endotoxin-induced inflammation is obtained by eliminating the interference in the biochemical assay of myeloperoxidase caused by endogenous reductants and cellular constituents containing free thiol functional groups. The interference was eliminated by 1) extensively diluting soluble, interfering substances and 2) blocking tissue sulfhydril functional groups during tissue homogenization. The improved model can be used to assess the therapeutic potential of anti-inflammatory agents. For example, the model can be used to evaluate topically administrable ophthalmic anti-inflammatory agents in Lewis rats.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: February 8, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gustav Graff, Mark R. Hellberg
  • Method of preparing foldable hydrophilic ophthalmic device materials
    Patent number: 6015842
    Abstract: Foldable, hydrophilic, ophthalmic device materials are cured by exposure to blue light using a benzoylphosphine oxide photoinitiator.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: January 18, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Albert R. LeBoeuf, Mutlu Karakelle
  • Storage-stable prostaglandin compositions
    Patent number: 6011062
    Abstract: The use of polyethoxylated castor oils in prostaglandin compositions enhances the prostaglandin's chemical stability.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: January 4, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: L. Wayne Schneider, Rajan Bawa, Alan L. Weiner