Abstract: A device for positioning fitments in a perforated film. The device according to the invention includes a transporting member that brings the fitments into the vicinity of a perforated film, preferably below the latter, a member for positioning the fitments perpendicular to the perforations in the film, and an engaging member for pushing the ports through the perforations of the film so that at the exit of the device the film is equipped with fitments.

Abstract: A body fluid drainage device that includes a wedge-shaped reservoir evacuator which has a first sidewall and a second sidewall integrally formed and joined along a coextending common edge. A third collapsible bellows-shaped sidewall extends between the nonjoined edges and is sealed to the nonjoined edges of the first sidewall and second sidewall to enclose and form a fluid tight reservoir between the first, second and third sidewalls. An inlet port and outlet port are provided in fluid communication with the reservoir. A one-way valve is provided in the inlet port for permitting fluid flow into the reservoir but preventing fluid flow out of the inlet port. A spring element is provided for storing energy to force the first sidewall away from the second sidewall following compression of the first sidewall towards the second sidewall such that as the first sidewall moves away from the second sidewall a partial vacuum is created within the reservoir for drawing fluid into the reservoir.

Abstract: An infusion system includes fluid-delivery components for delivering a fluid from a separate source of the fluid into a patient, transducer components for producing a signal related to the pressure of the fluid in the fluid-delivery components, and identification components responsive to the signal for identifying pressure artifacts characteristic of patient activity. Gravity-fed infusion may be employed as well as infusion with a flow control device, and identification may be accomplished with a microprocessor for examining the waveform of the signal and identifying pressure artifacts characteristic of patient activity amidst pressure changes caused by fluid-delivery components so that site checking can be conducted during quiet periods, i.e., times of little patient acitivity.

Abstract: The present invention provides film structures for creating two identical webs of film. Preferably, the so created webs of film include a sterile surface. The webs of film are suitable for being processed into flexible containers.

Abstract: A device is described for accurately transferring multiple individual fluids from multiple source containers into a single receiving container. Fluid flows from the multiple source containers through individual fluid conduits to a chamber having a single fluid outlet conduit. The fluid outlet conduit is in fluid communication with a single receiving container. A pressure conduit is in communication with the chamber for alternately creating positive and negative pressures in the chamber to cause fluid to flow from the individual source containers into the chamber, and to cause fluid to flow from the chamber into the receiving container in response to commands from a control means in the device.

Abstract: The present invention provides a large volume flexible container capable of containing a fluid to be maintained under sterile conditions. The container comprises an inner liner constructed from a polyolefin that defines an interior of the container and an outer liner constructed from a three-layer laminate. The laminate includes an inner layer constructed from a polyolefin that will, upon the application of sufficient energy, bond to the polyolefin of the inner liner, a middle layer constructed from a barrier material, and an outer layer; the inner liner and outer liner being sealed together along edges of the container. At least one tube member, for accessing the container, extends from a face of the container, and includes an end that is secured to the container, a length of flexible tubing for defining a channel through which fluid can flow, and a connector at a second end. A structure for housing the container is also provided.

Abstract: A pivot pin bearing/seal especially adapted for supporting the rotor of a disposable filtration cartridge of a continuous-flow plasmapheresis blood separation system includes a lubricious plastic pivot pin injection molded with a recess at its end. The recess is surrounded by a sharp circular inside edge. A stainless steel eyelet, deep drawn from successive dies, is loosely inserted into the pin recess, a radial outer surface defined at the junction between the eyelet shank and the eyelet flange contacting the pin sharp edge. The eyelet rotates relative to the pin, the circular line path of rotational contact being defined by the smooth curved surface under the flange of the eyelet and the sharp inside edge surrounding the pin recess which quickly burnishes to a good rotational seal.

Abstract: An apparatus for sealing and severing a web of film. The apparatus includes a first jaw located on one side of the web of film and a second jaw located on a second side of the web of film. The first and second jaws cooperate to grip the web of film. Located within the first jaw is a heater member for sealing and severing the web of film. The heater member is secured so that the time and/or pressure at which the heater member engages the web of film may be varied independent of the first jaw.

Abstract: A parameter measuring apparatus includes a constant signal circuit incorporating a sensor having a known response to a given parameter for outputting a signal representing the parameter. The constant signal circuit further includes circuitry defining upper and lower limits of the parameter range. The parameter signal is provided to a sampling device such as current-to-frequency converter for providing an analog-to-pulse converted signal to a microprocessor. The apparatus further includes a switching arrangement coupled to and controlled by the microprocessor for switching into circuit the sensor or the circuitry defining the upper or lower parameter limits. The switching arrangement also eliminates internal switch resistance in the circuit for improved measurement accuracy.

Abstract: The present invention provides a stand-alone, in-line device and method for detecting whether a fluid is being properly supplied to a patient, including means for delivering a test pulse of the fluid through conduit means to the patient with the test pulse being distinguishable from the normal delivery pattern and with the test pulse creating a pressure wave response in the conduit means. The device and method also includes means for determining the area between a baseline and at least a portion of a pressure versus time curve representing the pressure wave response, and means responsive to the magnitude of the area for detecting whether the fluid is being improperly supplied by the conduit means to the patient. Preferably, the device and method also includes means for diverting and accumulating a predetermined volume of the upstream flow from the infusion source for use as the test pulse.

Abstract: A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.

Abstract: The invention consists of a device for welding and perforating a thermoplastic film folded back on itself. The device consists of a support for supporting two electrically heated welding strips and a perforation device. The perforation device is movably supported between the welding strips. The support is transversely movable with respect to the film. The welding strips consists of a non-heating portion and a heating portion. The non-heating portion is at least equal in length to the heating portion.

Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.

Abstract: An adherent cell culture flask is provided. The flask includes a body constructed from a first side wall and a second side wall, each side wall having an interior surface and an exterior surface. The first and second side walls are sealed together to define a chamber. The first side wall is constructed from flexible film and includes on its interior surface a charged surface for facilitating the attachment of cells thereto. The second side wall is constructed from flexible film and includes a non-smooth interior surface for preventing the first side wall interior surface from sticking to the second side wall interior surface.

Abstract: A cartridge for introducing a beneficial agent into a medical fluid conduit is disclosed. The cartridge includes a pierceable stopper having a hollow, open ended protrusion extending into the cartridge chamber and having the beneficial agent retained therein by a liquid pervious barrier. The hollow, open ended protrusion creates a directed flow path within the cartridge.

Abstract: A centrifugal processing system for cultured cellular suspensions comprises a reservoir for pooling a desired volume of the cellular suspension from a plurality of individual containers in which the cellular suspension have been cultured. A centrifugation chamber is provided operative in response to centrifugal force for separating the cellular suspension into a cellular component and a supernatant. Fluid is conveyed from the reservoir into the centrifugation chamber at a high flow rate exceeding 1 liter per minute. The cellular component and supernatant are collected from the centrifugation chamber.