Abstract: The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that has formed in the nucleus of tumor cells. Furthermore, the present invention relates to a method for causing the breakage of said proteinic complexes existing in the tumor cell lines in vitro. The present invention further relates to the use of said peptides for the preparation of a pharmaceutical composition for treating human tumors.

Abstract: An improved method for the formation of composite hydroxides or oxides comprising, on an oxide basis, Al2O3 and ZrO2, and optionally CeO2, La2O3, Nd2O3, Pr6O11, Sm2O3, Y2O3, and other rare earth oxides, comprising the steps of preparing an aqueous metal salt solution and forming a hydroxide precipitate slurry by combining the aqueous metal salt solution with an aqueous solution of a caustic alkali at a pH greater than 8.5 to precipitate out all the metal species. The variation in pH during the precipitation reaction is ±1. The invention also relates to composites formed by this method comprising 20-70 wt % Al2O3, 10-77 wt % ZrO2, 0-34 wt % CeO2 and 0-22 wt % REOs other than CeO2, and to composites per se comprising, on an oxide basis, 42-70 wt % Al2O3, 10-48 wt % ZrO2, 2-34 wt % CeO2 and 0-9 wt % REOs other than CeO2 and having the following properties after heating to 850° C. over four hours and holding at 850° C.

Abstract: An information terminal of the present invention aims at informing the user of an occurrence of an event during the reproduction of contents without an unexpected feeling. An information terminal of the present invention, includes a contents reproducing unit 10 for reproducing contents, a contents reproducing unit 20 for informing an occurrence of an event by reproducing the contents, a superposing unit 70 for superposing respective outputs of the contents reproducing unit 10, 20, and a controlling unit 50 for causing an information of the occurrence of the event and a superposition of respective outputs of the contents reproducing unit 10, 20 to execute in a previously set reproducing procedure.

Abstract: A system and device for spray painting using a flow of pressurised carrier fluid comprises a central source of the carrier fluid and one or more local elements for heating the fluid close to the point of use.

Abstract: Method for annealing at least one photovoltaic cell comprising a substrate based on silicon with a first type of conductivity, a layer doped with a second type of conductivity produced in the substrate and forming a front face of the substrate, an antireflection layer produced on the front face of the substrate and forming a front face of the photovoltaic cell, at least one metallization on the front face of the cell and at least on metallization on a rear face of the substrate. This method comprises at least the steps of: a) a first annealing of the photovoltaic cell at a temperature between around 700° C. and 900° C., b) a second annealing of the photovoltaic cell at a temperature between around 200° C. and 500° C., at ambient pressure and in ambient air, with hydrogen being diffused in the substrate during the process.

Abstract: A device for protection from accidents comprises a protective support (2) to be interposed between an operator and a tool (3) to be used by said operator; the protection device further comprises cutoff/switching off means adapted to be active on the tool (3) at a minimum distance between the protective support (2) and the tool (3).

Abstract: An object of the present invention is to provide an image processing apparatus capable of obtaining a sharp image having less noise, comprising: a horizontal edge strength calculating unit 22 for calculating an edge strength along a horizontal direction of a concerned pixel; and a prefilter 24 for carrying out a filter processing based on the horizontal edge strength, and performing noise reduction and edge enhancement, a vertical edge strength calculating unit 23 for calculating an edge strength along a vertical direction of the concerned pixel; and a prefilter 25 for carrying out a filter processing based on the vertical edge strength, and performing noise reduction and edge enhancement, thereby enabling to sharpen image data in the vicinity of the concerned pixel respectively along horizontal and vertical directions, and obtain an image having less noises as well as sharp for edge directions.

Abstract: Hinged connecting apparatus (1) for a lower limb prosthesis (2), the hinged connecting apparatus (1) comprising a first device (1000) intended to oppose a predetermined resistance during flexion of the prosthesis (2), this resistance being switched by said first device (1000) between two values which are a predetermined minimal value and a predetermined maximal value.

Abstract: A method comprising applying controlled flow cavitation apparatuses and holding tanks to a pretreatment process in order to reduce the free fatty acid content of a biodiesel feedstock. A feedstock comprising a high content of free fatty acids can be passed through controlled flow cavitation apparatuses and holding tanks at a velocity capable of generating hydrodynamic cavitation zones and subsequent dwell times where the free fatty acid content can be reduced to below 2%.

Abstract: The transport device comprises a screw conveyor (5), in a casing (5a) of which a propeller (5b) rotates. The device also comprises an elastic cradle (7), interposed between the casing (5a) of the screw and the propeller (5b), internally of which the propeller (5b) of the screw rotates.

Abstract: The present invention is for providing a radio terminal device having shock resistance and high rigidity capable of preventing breakage of the housing even in the case it is dropped from a hand, without the risk of deteriorating the performance of the stored antenna. The radio terminal device according to the invention comprises a printed board, a resin housing provided so as to cover one side surface of the printed board, a metal housing provided so as to cover the other side surface of the printed board, and an antenna provided on the one surface side of the printed board, wherein the resin housing and the metal housing are divided in a region elongating from the one side surface to the other side surface of the printed board.

Abstract: A spatial filtering adaptable for an interference wave that appears unsteadily can be implemented and also an interference canceling ability can be increased even in a condition that the interference wave does not steadily exist. At a time of non-active communication, the signals from a plurality of interference source radio communication devices 2 are received in advance by an interference signal receiving section 6 as the pre-process mode, then a resultant interference correlation matrix RI is stored in a storing section 7, and then an interference wave receiving antenna weight WI used to receive selectively the transmission signals from the interference source radio communication devices 2 is prepared based on the resultant interference correlation matrix RI.

Abstract: This invention relates to magnesium-based alloys particularly suitable for casting applications where good mechanical properties at room and at elevated temperatures are required. The alloys contain: 2 to 4.5% by weight of neodymium; 0.2 to 7.0% of at least one rare earth metal of atomic No. 62 to 71; up to 1.3% by weight of zinc; and 0.2 to 0.7% by weight of zirconium; optionally with one or more other minor component. They are resistant to corrosion, show good age-hardening behaviour, and are also suitable for extrusion and wrought alloy applications.

Abstract: The invention relates to blood processing apparatus comprising a cabinet (2) defining at least an interior housing (6) and presenting an aperture (6a) for allowing access from outside into said housing. The apparatus has a user interface (13) mounted in a movable manner on the cabinet between at least a first position, where the user interface is adjacent to the cabinet in correspondence of said aperture, and a second position, where the user interface is spaced apart from the aperture and opens the access to said housing.

Abstract: A patient end of a venous blood line (26) is connected to a discharge of a dialysis liquid preparation circuit by means of an auxiliary connector (23), and the patient end of an arterial blood line (25) is connected to a service line (32) located at the top of a venous expansion chamber (31). The filling and/or rinsing liquid is removed from the preparation circuit by backfiltering through a membrane (5) of a high-flux dialysis filter (2). The invention enables a blood circuit to be primed simply and rapidly.