Abstract: The invention relates to implants for the parenteral administration of an essentially uniform and continuous amount of a biologically active protein, peptide or polypeptide over an extended period of time which comprises a compacted, indented and partially coated composition containing from one to three layers of a homogeneous core mixture comprising about 20% to about 80% of a biologically active protein, a peptide or a polypeptide; about 10% to about 75% of a fat, a wax or a mixture thereof; 0% to about 25% of a buffer, a salt, a sugar or a mixture thereof; 0% to about 15% of a filler, on a weight basis of the total weight of the core mixture. The partial coating of a semipermeable material comprises about 5% to about 50%, on a weight basis of the total weight of the implant. The invention also relates to methods for increasing and maintaining elevated blood levels of biologically active proteins, peptides and polypeptides in animals by the administration of said implants.
Type:
Grant
Filed:
May 31, 1995
Date of Patent:
September 1, 1998
Assignee:
American Cyanamid Company
Inventors:
William David Steber, Susan Mancini Cady, David Farley Johnson, Theresa Rice Haughey
Abstract: There is provided a process for preparing intermediates having the structure ##STR1## from the corresponding aldehydes having the structure ##STR2##
Type:
Grant
Filed:
November 3, 1994
Date of Patent:
April 29, 1997
Assignee:
American Home Products Corporation
Inventors:
Robert F. Doehner, Jr., Jerry M. Barton, David G. Kuhn
Abstract: There is provided an effective and efficient, three step process for the manufacture of crop-selective, herbicidal 1-{[2-(cyclopropylcarbonyl)phenyl]sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl )urea compounds, and an intermediate for use therein.
Abstract: There are provided 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds, a method for the preparation thereof and the use thereof for the preparation of 5-(substituted methyl)-2,3-pylidinedicarboxylic acids.
Abstract: There is provided a stable herbicidal composition comprising 1-{[o-(cyclopropylcarbonyl)-phenyl]sulfamoyl}-3-(4,6-dimethoxy-2-pyrimidin yl)urea in combination with one or more low-melting or liquid herbicides and alkaline white carbon.
Abstract: There is provided a method for safening herbicides in crop plants by using substituted benzopyran or tetrahydronaphthalene compounds of formula I ##STR1## Further provided are compounds of formula II and compositions comprising a herbicide and an antidotally effective amount of a substituted benzopyran or tetrahydronaphthalene compound of formula I.
Abstract: This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LLF28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
Type:
Grant
Filed:
October 4, 1994
Date of Patent:
April 23, 1996
Assignee:
American Cyanamid Company
Inventors:
Guy T. Carter, Margaret J. Torrey, Michael Greenstein
Abstract: There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine. There is also provided a process for the manufacture of 3-alkoxymethylquinolines from 2-alkoxymethylacrolein.
Type:
Grant
Filed:
November 5, 1993
Date of Patent:
April 9, 1996
Assignee:
American CYanamid Company
Inventors:
Henry L. Strong, David A. Cortes, Zareen Ahmed
Abstract: There is provided a 6-heterocyclyl-1-(substituted phenyl)benzotriazole compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
Type:
Grant
Filed:
May 5, 1995
Date of Patent:
March 5, 1996
Assignee:
American Cyanamid Co.
Inventors:
Michael E. Condon, Alvin D. Crews, Jr., Mark C. Manfredi
Abstract: Methods and compositions utilizing 2-amino-5-thiazolyl thiocyanate compounds and their derivatives for the control of soilborne fungi and disease caused thereby are described.
Type:
Grant
Filed:
May 10, 1993
Date of Patent:
February 13, 1996
Assignee:
Eastman Kodak Company
Inventors:
V. James Spadafora, Thomas E. Brady, Masatoshi Motoyoshi
Abstract: There is provided an aryloxy-N-(substituted phenyl)benzotriazole compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.
Type:
Grant
Filed:
February 10, 1995
Date of Patent:
January 16, 1996
Assignee:
American Cyanamid Company
Inventors:
Michael E. Condon, Alvin D. Crews, Jr., Mark C. Manfredi
Abstract: There are provided substituted benzisoxazole and benzisothiazole compounds having the structural formula I ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
Abstract: The present invention provides a method for the purification of a 23-E isomer of a 23-imino derivative of a LL-F28249 compound having the structural formula I ##STR1##
Abstract: There is provided o-nitrophenyl cyclopropyl ketone, a key intermediate in the manufacture of the crop-selective, herbicidal agent 1-{[o-(cyclopropylcarbonyl)phenyl]sulfamoyl}-3-(4,6-dimethoxy-2-pyrimidiny l)urea and a method for the preparation of said ketone from dihydro-3-acetyl-2(3H)-furanone and o-nitrobenzoyl halide.
Type:
Grant
Filed:
August 9, 1994
Date of Patent:
September 26, 1995
Assignee:
American Cyanamid Co.
Inventors:
Marco P. Burello, Jeffrey G. Stack, David A. Cortes
Abstract: This disclosure is directed to certain substituted aryloxy benzotriazole compounds which are herbicidal agents. The structures of the compounds are represented by formulae I and II shown below: ##STR1## wherein M is C--X, N or N.sup.+ --O.sup.- ; W, X, Y and Z each independently represent hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 haloalkyl or C.sub.1 -C.sub.4 haloalkoxy;n is 0, 1 or 2;R is hydrogen, C.sub.1 -C.sub.4 alkyl, aryl or when taken together with R.sub.1, R and R.sub.1 may form a ring in which RR.sub.1 are represented by the structure --(CH.sub.2).sub.m -- where m is an integer of 2, 3, 4 or 5;R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 -C.sub.4 alkyl or when taken together R.sub.1 and R.sub.2 may form a ring in which R.sub.1 R.sub.2 are represented by the structure --(CH.sub.2).sub.m -- where m is an integer of 2, 3, 4 or 5;R.sub.3 is cyano, ##STR2## CH.sub.2 OR.sub.8 or CH(OR.sub.9).sub.2 ; Q is OH, OR.sub.4 or NR.sub.5 R.sub.6 ;A is O, NOR.sub.5, NCOR.sub.5, NNR.sub.5 R.
Abstract: There are provided aryloxybenzene compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
Abstract: 5-Heterocyclic 2-(2-imidazolin-2-yl)pyridine compounds which are effective for the control of undesirable plant species are described. Also described are a method for the herbicidal use of said compounds and a method for their preparation.
Abstract: An improved manufacturing procedure for the preparation and isolation of cyclopropylnitrile is provided. 4-Halobutyronitrile is reacted with an alkali metal base in the presence of an aprotic polar solvent, an inorganic salt and a catalytic amount of water at an elevated temperature. The reaction product cyclopropylnitrile is isolated by azeotropic distillation.
Abstract: This invention relates to methods and compositions for treating, controlling, preventing and protecting warm-blooded animals from infestation and infection by helminths, acarids and arthropod endo- and ectoparasites by administering or applying to the animals a nitropyrrole or pyrrole carbonitrile compound.
Abstract: There is provided o-nitrophenyl cyclopropyl ketone, a key intermediate in the manufacture of the crop-selective, herbicidal agent 1-{[o-(cyclopropylcarbonyl)phenyl]sulfamoyl}-3-(4,6-dimethoxy-2-pyrimidiny l)urea and a method for the preparation of said ketone from dihydro-3-acetyl-2(3H)-furanone and o-nitrobenzoyl halide.
Type:
Grant
Filed:
December 2, 1993
Date of Patent:
November 15, 1994
Assignee:
American Cyanamid Company
Inventors:
Marco P. Burello, Jeffrey G. Stack, David A. Cortes