Patents Represented by Law Firm Pennie & Edmonds
  • Patent number: 6704657
    Abstract: The present invention comprises an apparatus and a method for measuring the first arrival time of seismic waves from detonation in seismic explorations, comprising a or several detectors for measuring seismic waves and converting them into electrical signals and a signal processing means for calculating an average energy of the electrical signals to determine the first arrival time of seismic waves and using a smooth filtering method to compute accurately the first arrival time backwards from the first maximum valve in the average energy curve.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: March 9, 2004
    Assignee: China Petroleum & Chemical Corporation
    Inventors: Shulin Peng, Weiwei Zhao, Lixin Wang, Xiaoxi Liu
  • Patent number: 6703422
    Abstract: The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: March 9, 2004
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Patent number: 6704891
    Abstract: A method of generating and verifying a memory test is disclosed. A simulator is used to verify that the sequence of time-ordered commands complies with a set of operating constraints for the memory. A packer may thereafter be used to optimize run time of the verified test.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: March 9, 2004
    Assignee: Rambus Inc.
    Inventors: Steven Cameron Woo, John Philip Privitera, Mark Alan Horowitz
  • Patent number: 6703489
    Abstract: The present invention relates to nucleotide sequences of Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the Serrate protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Serrate which comprise one or more domains of the Serrate protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, cysteine rich domain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing. Antibodies to Serrate, its derivatives and analogs, are additionally provided. Methods of production of the Serrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: March 9, 2004
    Assignees: Yale University, Imperial Cancer Research Technology, Ltd.
    Inventors: David Ish-Horowicz, Domingos Manuel Pinto Henrique, Julian Hart Lewis, Anna Mary Myat, Robert J. Fleming, Spyridon Artavanis-Tsakonas, Robert S. Mann, Grace E. Gray
  • Patent number: 6703362
    Abstract: This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: March 9, 2004
    Assignees: Cytogen Corporation, Elan Corporation, PLC
    Inventors: Vernon L. Alvarez, Daniel J. O'Mahony, Imelda J. Lambkin, Catherine A. Patterson, Judith Singleton, Benjamin A. Belinka, Jr., John M. Carter, Gerard M. Cagney
  • Patent number: 6704907
    Abstract: A digital contents editing method performs an editing operation of digital contents with a plurality of computers connected via a network. A digital contents editing apparatus or server accumulates the initial data of the digital contents and the editing operation information which is digitized, and transfers the editing operation information to clients which are involved in the editing operation. Each client then performs an editing operation of the digital contents by creating the editing operation information, in which the editing operation of the digital contents is digitized, and communicates only the editing operation information to other clients via the server and the network.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: March 9, 2004
    Assignee: Nippon Telegraph and Telephone Corporation
    Inventors: Masakatsu Aoki, Ken Tsutsuguchi, Yasuhiko Watanabe, Noboru Sonehara
  • Patent number: 6703491
    Abstract: The present invention relates to Drosophila genes and methods for their use. The invention provides nucleotide sequences of Drosophila genes, amino acid sequences of the encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of proteins which comprise one or more domains of a Drosophila protein. Antibodies to Drosophila proteins, and derivatives and analogs thereof, are also provided. Also provided herein are vectors and host cells comprising such nucleic acids. Methods of production of a Drosophila protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Chimeric polypeptide molecules comprising polypeptides of the invention fused to heterologous polypeptide sequences are provided. Methods to identify the biological function of a Drosophila gene are provided, including various methods for the functional modification (e.g.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: March 9, 2004
    Assignee: Exelixis, Inc.
    Inventors: Sheila Akiko Homburger, Allen James Ebens, Jr., Catherine Sue Erickson, Helen Louise Francis-Lang, Jonathan Scott Margolis, Bindu Priya Reddy, David Andrew Ruddy, Andrew Roy Buchman
  • Patent number: 6701446
    Abstract: A memory device with multiple clock domains. Separate clocks to different portions of the control circuitry create different clock domains. The different domains are sequentially turned on as needed to limit the power consumed. The turn on time of the domains is overlapped with the latency for the memory access to make the power control transparent to the user accessing the memory core. The memory device can dynamically switch between a fast and a slow clock depending upon the needed data bandwidth. The data bandwidth across the memory interface can be monitored by the memory controller, and when it drops below a certain threshold, a slower clock can be used. The clock speed can be dynamically increased as the bandwidth demand increases.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: March 2, 2004
    Assignee: Rambus Inc.
    Inventors: Ely K. Tsern, Richard M. Barth, Craig E. Hampel, Donald C. Stark
  • Patent number: 6699249
    Abstract: The invention relates to a bone fixation device which includes a pair of bone plates and a longitudinal carrier. The longitudinal carrier can be used to permit the bone plates to telescope with respect to one another, such as in a direction parallel to the longitudinal axis of the vertebral column. A joint also may be used to permit swivelling of the plates with respect to each other.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: March 2, 2004
    Assignee: Synthes (U.S.A.)
    Inventors: Fridolin J. Schläpfer, Martin Hess
  • Patent number: 6699699
    Abstract: A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more amino acid substitutions selected from M73T, G79E, V275I, L277K, C281Y, G300V, N304K, I305L and I305M.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: March 2, 2004
    Assignee: Synmax Biochemical Co., Ltd.
    Inventors: Yang Yunn-Bor, Wei Chia-Li, Hsu Jyh-Shing, Tsai Ying-Chieh
  • Patent number: 6701391
    Abstract: A method and apparatus for transferring optical data from a DVD in response to a request from a host. When a data request is issued, a portion of the request containing the target ID for the target data block is used by a comparator circuit to locate the target data block. Another portion of the request containing the number of data blocks requested is used by a monitoring circuit to monitor data block transfer from a DVD to a data buffer once the target data block is located. The monitoring circuit stops data transfer when all of the requested data blocks have been transferred. Each data block is transferred into a data buffer containing areas separated by pointers. In a scratch area of the data buffer, the data block is error corrected, error checked and descrambled.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: March 2, 2004
    Assignee: Oak Technology, Inc.
    Inventors: Mehran Ayat, Nedi Nadershahi
  • Patent number: 6699910
    Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: March 2, 2004
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Patent number: 6697458
    Abstract: Voice messages are stored in both a user's voice mailbox in a voice mail system and an e-mail box in an e-mail system distinct from the voice mail system. When a voice message is stored in a user's voice mailbox in the voice mail system, a corresponding e-mail message is sent to and stored in an e-mail system with the voice message located in an attachment to the e-mail message. Information identifying the voice mail system and the voice mail message are included in a predefined portion of the email message, such as a particular field of the header. At predetermined times the user's voice mailbox and e-mail box are synchronized.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: February 24, 2004
    Assignee: Ulysses ESD, Inc.
    Inventor: Shreesha Kunjibettu
  • Patent number: 6696255
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, oligonucleotide probes containing hairpin structures, or arrays of such oligonucleotide probes immobilized on a solid support, that are suitable for hybridization analysis are provided. Methods for nucleic acid hybridization analysis using the probes or array of immobilized probes are also provided.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: February 24, 2004
    Assignee: Applied Gene Technologies, Inc.
    Inventor: Nanibhushan Dattagupta
  • Patent number: 6694568
    Abstract: A hinge that has a first mounting base for attachment to a first hinged object. The hinge also has first and second hinge members pivotally connected together. The first hinge member and the first base are configured and dimensioned for cooperatively positioning and aligning the first hinge member in a plurality of mounted positions along the base length. At least one first locking member is associated with the first hinge member and the first base for locking the first hinge member to the first base in one of the mounted positions. The hinge may also be segmented. A positioning tool may be connected to at least the first base with an attachment portion and configured for positioning the first base and attachment portion on a first hinged object at a predetermined distance from the second hinge member.
    Type: Grant
    Filed: April 21, 2003
    Date of Patent: February 24, 2004
    Inventor: Austin R. Baer
  • Patent number: 6695894
    Abstract: The present invention provides a method and apparatus for removing trace contaminants from a gas stream or flue gas. In one embodiment, the present invention an apparatus for removing a trace contaminant from a gas stream, comprising a gas duct configured to receive a gas stream comprising a trace contaminant; a plurality of substrates disposed within the gas duct; a trace contaminant sorbent disposed on at least a portion of each of the substrates; an isolation device for separating the portion of each of the substrates from the gas stream; and a regenerator for regenerating the trace contaminant sorbent. In another embodiment, the present invention provides a method for removing a trace contaminant from a gas stream.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: February 24, 2004
    Assignee: Electric Power Research Institute, Inc.
    Inventors: Ramsay Chang, Sharon Sjostrom
  • Patent number: 6696498
    Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative-immuno-suppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect NF-kB inhibitory activity.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 24, 2004
    Assignee: Consiglio Nazionale Della Richerche
    Inventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
  • Patent number: 6695808
    Abstract: The present invention is an apparatus for treating a selected patient tissue or organ region, at the surface of such region. The apparatus has an accessing tool for accessing the patient region, the tool having a distal end, and a proximal end at which the tool can be manipulated to place the distal end adjacent to the patient region. The apparatus also has a probe carried on the distal end and defining a contact surface that may be urged against the patient region thereby creating contact pressure. A pressure transducer is operatively coupled to the probe and is capable of producing a measurable response to the contact pressure. A monitoring device is operatively connected to the pressure transducer, for determining the contact pressure. An effector is operatively disposed on the probe for producing a given effect on the patient region when the effector is activated, and an activator operatively connected to the effector, by which the effector can be activated.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: February 24, 2004
    Assignee: SciMed Life Systems, Inc.
    Inventor: Curtis P. Tom
  • Patent number: 6697707
    Abstract: An architecture for robot intelligence enables a robot to learn new behaviors and create new behavior sequences autonomously and interact with a dynamically changing environment. Sensory information is mapped onto a Sensory Ego-Sphere (SES) that rapidly identifies important changes in the environment and functions much like short term memory. Behaviors are stored in a DBAM that creates an active map from the robot's current state to a goal state and functions much like long term memory. A dream state converts recent activities stored in the SES and creates or modifies behaviors in the DBAM.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: February 24, 2004
    Assignee: Vanderbilt University
    Inventor: Richard Alan Peters, II
  • Patent number: D487113
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: February 24, 2004
    Assignee: BIC Corporation
    Inventor: Michael Kent