Abstract: The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.

Abstract: An improved percutaneous introducer device is provided that provides a splittable sheath having a flared lead in for the facile introduction of ancillary medical implements, such as small diameter catheters, guide wires and the like, and a hub member being shaped to matingly underlie the flared lead in. When the hub is separated, such as by wings being pulled apart radially to the sheath, the sheath is longitudinally split, allowing it to be easily removed from an in situ catheter.

Abstract: A bait casting reel enables a user to easily control rotation of the spool. The bait casting reel includes a frame, a spool rotatably supported by the frame, a lever externally disposed and movable by a user to a left-handed position and a right-handed position, and a click member coupled to and movable by the lever, the click member allowing rotation of the spool in a first direction and preventing rotation in a second direction when the lever is moved to the left-handed position. The click member allows rotation of the spool in the second direction and prevents rotation in the first direction when the lever is moved to the right-handed position. A click holder is provided inside of the cover of the bait casting reel. The click holder comprises a head contactably coupled with the gears of the spool, a tail contacting with bosses formed inside of the cover, and a click having a shoulder abutted on protrusions provided inside of the cover.

Abstract: A method for converting a kinetically stable multiester of a naphthoquinone and an o-quinone diazide sulfonyl halide to a thermodynamically stable compound. The method comprises the steps of dissolving a phenol having at least two free phenolic hydroxyl groups and an o-naphthoquinone diazide sulfonyl halide in an aprotic solvent in the presence of a strong base, there being at least one mole of said naphthoquinone diazide sulfonyl halide per mole of phenol, reacting said phenol with said o-napthoquinone diazide sulfonyl halide until essentially of said o-naphthoquinone diazide sulfonyl halide is reacted with said polyhydroxy phenol, and following completion of said reaction, permitting the reaction product to remain in said solvent for a period of time of at least 15 minutes before recovering said photoactive compound The photoactive compound formed by the process is suitable for the formation of photoresists and is less apt to precipitate from solution during storage.

Abstract: A method of treating a patient suffering from allergic diseases, comprises administering to said patient an effective amount of a pharmaceutical composition in dosage unit form comprising a dry powder of guava leaves.

Abstract: The present invention provides novel curing adhesive film composition useful to produce structural materials, such as decorative panels for aircraft interiors, and methods and articles of manufacture that comprise such compositions. A preferred adhesive film composition of the invention comprises a reactive polyurethane resin and an isocyanate that comprises a thermally labile blocking group wherein the isocyanate can be activated by exposure of a coating layer of the composition to a temperature of about 340.degree. F. for about one second or less.

Abstract: A long stroke spinning reel including a tubular traverse cam shaft to reciprocate a spool.

Abstract: A sheet is provided which can be applied to a planar base and onto which floor boards or tiles can laid, wherein the sheet comprises adhesive strips on its lower and upper sides. The adhesive strips are suitably applied in the longitudinal direction of the sheet. In an preferred aspect, two layers are fixedly connected to one another, a top layer comprising a foamed plastic having a high coefficient of sound insulation and a bottom layer comprising a vapor-tight material and an edge formed by a protruding bottom layer which may be provided on one longitudinal side.

Abstract: The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.

Abstract: The invention includes new hull systems and watercraft. In particular, the invention provides a watercraft hull that has a pivot axis forward of the hull waterline fore-aft center line. That pivot axis will be the deep water point of the hull and provides a fulcrum point around which the hull turns during a direction change. The forward pivot axis surprisingly imparts high maneuverability (i.e. the ability to execute turns of reduced radius) relative to prior systems, even at low speeds.

Abstract: Protein disulfide isomerase, which catalyzes the exchange reaction between sulfhydryl and disulfide in a protein for formation of the most stable natural type disulfide bonds, is useful for formation of natural type disulfide bonds in a protein which is produced in a prokaryotic cell.

Abstract: A peptide and veterinarily acceptable salts thereof are disclosed which comprise an amino acid sequence which is derived from foot-and-mouth disease virus (FMDV). The peptide is independent within the FMDV structure of a B-cell epitode and is capable of eliciting T-cell help in an animal susceptible to FMDV infection for production of antibody against an antigen. Optionally, an amino acid in the sequence may be replaced by another amino acid which does not affect the function of the sequence to elicit T-cell help.

Abstract: The semiconductor device of the invention includes: a substrate having an insulating surface; an active region formed on the insulating surface of the substrate, the active region being formed by a crystalline silicon film; and an insulating thin film formed on the active region. In the semiconductor device, the active region contains a catalyst element for promoting a crystallization of an amorphous silicon film by a heat treatment.

Abstract: A liquid crystal display apparatus having an input function includes a first substrate, a second substrate, and a third substrate; a display medium provided between the first substrate and the second substrate; a first electrode provided between the first substrate and the display medium; a second electrode provided between the second substrate and the display medium; spacers for supporting the second substrate and the third substrate with respect to each other; and at least two electrodes provided between the second substrate and the third substrate. The display medium includes a polymer projection and a liquid crystal region at least partially surrounded by the polymer projection, and the first, second and third substrates are each formed of a polymer material, at least one of the first, second and third substrates has a polarizing function, and at least one of the first, second and third substrates has a phase contrasting function.

Abstract: The present invention provides N,N'-diaryl substituted guanidines having therapeutic utility. The compounds of the present invention are represented by the formula: ##STR1## wherein R and R.sup.1 represent hydrogen or other group and Ar and Ar.sup.1 represent selected aryl groups, and at least one being acenaphthyl.

Abstract: Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.

Abstract: The present invention provides a nitrogen-containing cyclic compound represented by the formula (1): ##STR1## (wherein R.sup.1 represents an alkyl group; R represents a hydrogen atom or an alkyl group; X represents an oxygen or sulfur atom or NR.sup.3 ; Q.sup.1 represents a hydrogen atom, or an alkyl, cycloalkyl, alkenyl or alkynyl group, or a phenyl, naphthyl or heterocyclic group etc.; Q.sup.2 represents an alkyl, cycloalkyl or alkenyl group, or a phenyl or thienyl group etc.; A.sup.1 represents a carbon or nitrogen atom; A.sup.2 represents CR.sup.2 or NR.sup.2, or an oxygen or sulfur atom, or SO or SO.sub.2 ; A.sup.3 represents a single bond, or an oxygen or sulfur atom, or CR.sup.5 or NR.sup.5) and a herbicide comprising the same , which herbicide exhibits very high herbicidal activity at very low application rate and has selectivity against crops.

Abstract: The present invention provides a catalyst and method for purifying exhaust gases, having superior performance of NOx purification to exhaust gases containing oxygen and nitrogen oxides, particularly superior performance of NOx elimination to exhaust gases from lean-bum engines with excess oxygen, and a wider effective temperature range of NOx elimination, and also superior heat resistance at high temperature, said catalyst for purifying exhaust gases comprises, as indispensable contents, iridium and alkaline metal loaded on a carrier which is at least one selected from metal carbide and metal nitride, or these and at least one element selected from the group consisting of alkaline earth metal elements and rare earth metal elements, and said method using these catalyst.