Abstract: A process for isolating selected polypeptides from biological specimens. The process employs a guanidinium salt to treat frozen biological specimens from which selected polypeptides are to be obtained. The process is useful in reducing proteolytic modification of the selected polypeptides.

Abstract: Enkephalin-like compounds having opiate agonist activity and useful as analgesic agents are extracted from bovine adrenal glands.

Abstract: p-Tert. butylbenzaldehyde is manufactured by the electrochemical oxidation of p-tert. butyltoluene, an intermediate for the production of e.g. .alpha.-methyl-.beta.-(p-tert. butylphenyl)-propionaldehyde.

Abstract: Tumor associated antigens are disclosed in both crude and pure form which are specific to human breast cancer. The antigens are designated BCA. Antisera, radiolabeled antigens and antisera, as well as methods for the detection of circulating BCA are also disclosed. Methods for the extraction of BCA also form part of the invention. A diagnostic kit for the detection of circulating BCA, especially one suitable for use in as radioimmunoassay is also disclosed.

Abstract: The invention relates to a process for producing 1.alpha.-hydroxydehydroepiandrosterone by fermenting or reacting dehydroepiandrosterone or a derivative thereof with microorganisms of the species Penicillium oxalicum or Aspergillus terreus or mycelium or extracts therefrom obtained when the microorganisms are in a stationary phase of growth. The invention process produces steroid compounds which are pharmacologically valuable substances.

Abstract: 1-(p-methoxybenzoyl)-2-pyrrolidinone and intermediates useful in its preparation are described. The 1-(p-methoxybenzoyl)-2-pyrrolidinone is useful in the prevention of cerebral insufficiency.

Abstract: 1-substituted 2-pyrrolidinones and pharmaceutical compositions containing same are described. The pharmaceutical compositions are useful in counteracting cerebral insufficiency or improving intellectual capacity.

Abstract: An improved radioimmunoassay for the polypeptidic thymic hormone thymosin.alpha..sub.1 is described. The assay employs a radiolabelled [Tyr.sup.1 ]-thymosin.alpha..sub.1 or [Tyr.sup.1 ]-desacetylthymosin.alpha..sub.1 as probe and an affinity purified thymosin.alpha..sub.1 antibody of improved selectivity.

Abstract: Pharmaceutical preparations containing glycerol alkyl ethers as the solvent.

Abstract: Dibenzothiophenes of the formula ##STR1## wherein R, R.sub.1 and R.sub.2 are as hereinafter described, prepared, inter alia, from the correspondingly substituted thiophenol and haloketocyclohexane are described. The dibenzothiophenes of the invention are useful antiinflammatory, analgesic and antirheumatic agents.

Abstract: Optically active pyrimidines of the formula ##STR1## wherein Z is --(CH.sub.2).sub.n -- or --(CH.sub.2).sub.n --O-- wherein n is an integer of 1 to 4 and each of the symbols X is a nitrogen atom and each of the symbols Y is --CH-- or each of the symbols Y is a nitrogen atom and each of the symbols X is --CH--,useful for electro-optical purposes, as well as liquid crystalline mixtures for electro-optical purposes containing compounds of the formula Ia and/or Ib, are described.The compounds of formulas Ia and Ib are useful for electro-optical purposes, for example, in electro-optical apparatuses.

Abstract: Human fibroblast interferon has been purified to homogeneity by use of a novel procedure combining affinity chromatography and high pressure liquid chromatography (HPLC).

Abstract: An improved process for purifying proteins, particularly proteins having molecular weights in excess of 12,000 involves novel applications of high performance liquid chromatography on a preparative scale to provide homogeneous end product in excellent yield. In an embodiment of the process, human interferon is produced as a homogeneous protein.

Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-6 -alkyl, R.sup.3 is C.sub.1-3 -alkyl and R.sup.4 is methylene or C.sub.2-4 -alkylidene and physiologically compatible acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.In yet another aspect, the invention relates to intermediates for the preparation of the compounds of formula I.

Abstract: Heterocyclic compounds characterized by the formula ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and z are as hereinafter set forth, prepared, inter alia, by reacting a compound characterized by the formula ##STR2## with an amine characterized by the formula ##STR3## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are as hereinafter set forth, are described. The end products are useful as fungicidal agents.

Abstract: Nitroimidazoles of the formula ##STR1## wherein R.sup.1 and R.sup.2 are as hereinafter set forth, are described. The nitroimidazoles are useful as hypoxic-cell radiosensitizers, as well as being useful as antiprotozoal agents.

Abstract: 1-Substituted 2-pyrrolidinones and pharmaceutical compositions containing same are described. The pharmaceutical compositions are useful in counteracting cerebral insufficiency or improving intellectual capacity.

Abstract: Pyrrolidine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as hereinafter described, prepared inter alia from the corresponding pyrrolines, are described. The compounds are useful as analgesic agents.

Abstract: Thiobenzamides of the formula ##STR1## wherein X' is bromine, fluorine, iodine, trifluoromethyl or C.sub.3-4 alkyl prepared from N-(2-aminoethyl)-morpholine and a compound of the formula ##STR2## wherein X' is as hereinbefore set forth and;Y is methoxy or ethoxy are described. The end products, including p-chloro-N-(2-morpholinoethyl)-thiobenzamide, are useful in the treatment of depressive conditions, that is, are useful as antidepressants.

Abstract: Dibenzothiophenes of the formula ##STR1## wherein R, R.sub.1 and R.sub.2 are as hereinafter described, prepared, inter alia, from the correspondingly substituted thiophenol and haloketocyclohexane are described. The dibenzothiophenes of the invention are useful antiinflammatory, analgesic and antirheumatic agents.