Patents Represented by Attorney Peter R. Shearer
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Patent number: 4218567Abstract: A process for the preparation of aromatic ethers by the bromination of a compound of the formula ##STR1## wherein R.sub.1, independently, is hydrogen, hydroxy, lower alkoxy, lower alkyl; m is an integer from 1-4, and A is --CHO, --COOR.sub.3 or lower alkyl, and subsequently treating the reaction product of the bromination step with an alkali metal alkoxide in the presence of cuprous halide or oxide, is described.Type: GrantFiled: May 30, 1978Date of Patent: August 19, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Percy S. Manchand, John M. Townsend
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Patent number: 4210754Abstract: Benzamides of the formula ##STR1## wherein X is halogen, trifluoromethyl or C.sub.3-4 -alkyl and Y is hydrogen, halogen or nitro,and N-oxides thereof, prepared inter alia from N-(2-aminoethyl)-morpholine and an acid of the formula ##STR2## wherein X and Y are as hereinbefore set forth, are described. The end products are useful in the treatment of depressive conditions, that is, are useful as antidepressants.Type: GrantFiled: October 20, 1978Date of Patent: July 1, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Willy Burkard, Pierre-Charles Wyss
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Patent number: 4203980Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-6 -alkyl, R.sup.3 isC.sub.1-3 -alkyl and R.sup.4 is methylene or C.sub.2-4 -alkylideneand physiologically compatible acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.Type: GrantFiled: April 26, 1978Date of Patent: May 20, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Ivan Kompis, Alexander E. Wick
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Patent number: 4202832Abstract: Thiocarbamoylthio fatty acid derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Y and n are as hereinafter set forth, are described. The compounds of formula I are useful as lipid-lowering agents.Type: GrantFiled: October 20, 1978Date of Patent: May 13, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Ulf Fischer, Ado Kaiser
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Patent number: 4202894Abstract: Heterocyclic compounds characterized by the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and z are as hereinafter set forth,prepared, inter alia, by reacting a compound characterized by the formula ##STR2## with an amine characterized by the formula ##STR3## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are as hereinafter set forth,are described. The end products are useful as fungicidal agents.Type: GrantFiled: November 18, 1977Date of Patent: May 13, 1980Assignee: Hoffmann-La Roche Inc.Inventor: Albert Pfiffner
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Patent number: 4191758Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-3 -alkyl, and R.sup.3 and R.sup.4, independently, are hydrogen or methyl,and physiologically acceptable acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.Type: GrantFiled: April 26, 1978Date of Patent: March 4, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Ivan Kompis, Alexander E. Wick
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Patent number: 4187303Abstract: Thienothiazine derivatives of the formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as hereinafter set forth, and their tautomers are described. The thienothiazine derivatives are useful as anti-inflammatory, analgesic, antirheumatic and antithrombotic agents.Type: GrantFiled: August 15, 1978Date of Patent: February 5, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Otto Hromatka, Dieter Binder, Paul Zeller, Rudolf Pfister
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Patent number: 4180475Abstract: Liquid crystal mixtures having positive anisotropy of the dielectric constants which comprise a nematogenic mixture with a clearing point above 60.degree. C. which is doped with an organic solvent or solvent mixture with a specific resistance of at least 10.sup.7 Ohm.cm. as well as a dipole moment along the longitudinal axis of the molecule of less than 3.5 Debye, or with a compound of the formula ##STR1## wherein R.sub.14 and R.sub.15 are straight-chain alkyl containing a total of not more than 14 carbon atoms or R.sub.14 is straight-chain alkyl and R.sub.15 is straight-chain alkoxy containing a total of not more than 8 carbon atoms,or a compound of the formula ##STR2## wherein R.sub.16 and R.sub.17 are straight-chain alkyl containing a total of not more than 6 carbon atoms,or a compound of the formula ##STR3## wherein R.sub.16 and R.sub.17 are straight-chain alkyl containing a total of not more than 6 carbon atoms,or mixtures thereof, are described.Type: GrantFiled: February 18, 1977Date of Patent: December 25, 1979Inventors: Martin Schadt, Hanspeter Scherrer, Arthur Boller
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Patent number: 4180662Abstract: Anti-inflammatory, analgesic, anti-rheumatic and anti-thrombotic thienothiazine derivatives having the formula ##STR1## wherein A together with the two carbon atoms forms the group ##STR2## and the dotted line indicates the double bond present in the first and last thieno structures above, R.sup.1 is lower alkyl, R.sup.2 is the radical of an aromatic heterocycle with 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl radical optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy, R.sup.3 is halogen and R.sup.3' is hydrogen or halogen,and pharmaceutically acceptable salts thereof are described.Type: GrantFiled: August 31, 1978Date of Patent: December 25, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Rudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
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Patent number: 4175085Abstract: Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.Type: GrantFiled: March 2, 1978Date of Patent: November 20, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Dieter Binder, Otto Hromatka, Rudolf Pfister, Paul Zeller
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Patent number: 4131602Abstract: Radiation curable acrylated polyurethane is porduced by (a) producing an isocyanate-terminated intermediate by coreacting an organic diisocyanate with a combination of organic tri/tetraol and organic diol, said combination being chosen from polyester tri/tetraol-polyether diol and polyether tri/tetraol-polyester diol combinations; (b) reacting the isocyanate-terminated intermediate with an hydroxyacrylate such as 2-hydroxyethyl acrylate. Unexpectedly, the oligomer has desirably low viscosity, yet cures upon exposure to radiation to a coating having good physical properties.Type: GrantFiled: September 29, 1977Date of Patent: December 26, 1978Assignee: Union Carbide CorporationInventors: Leonard E. Hodakowski, Charles H. Carder
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Patent number: 4130523Abstract: Aqueous polymer latexes having total solids contents of nearly 70 volume percent or more are produced by a process in which a portion of a forming latex in a reaction zone is continuously withdrawn from the reaction zone during formation of a stable seed latex and an intermediate latex, and the withdrawn latex is continuously fed back to the reaction zone during the formation of the final latex.Type: GrantFiled: July 18, 1977Date of Patent: December 19, 1978Assignee: Union Carbide CorporationInventors: Kenneth L. Hoy, Roland H. Peterson
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Patent number: 4126747Abstract: Unsaturated carbamoyloxy carboxylates having low color are produced by reacting hydroxyalkyl carbamates such as N-methyl 2-hydroxyethyl carbamate with acrylic or methacrylic acid in contact with a lower alkoxy substituted phenolic or alkylated alkoxyphenolic polymerization inhibitor at a critical low reaction temperature of 40.degree. C. to 80.degree. C. Novel unsaturated carbamoyloxy carboxylates are also disclosed.Type: GrantFiled: December 28, 1976Date of Patent: November 21, 1978Assignee: Union Carbide CorporationInventors: Frank G. Cowherd, III, Louis F. Theiling, Jr.
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Patent number: 4116786Abstract: Radiation curable coating compositions that contain an acrylate-capped polyether urethane, a low molecular weight polyfunctional acrylate, a monofunctional acrylate and, optionally, a photo-initiator are described. When cured, the coating compositions are sufficiently hard and flexible to serve as an overprint coating on sheet metal which is to undergo metal forming operations.Type: GrantFiled: June 8, 1976Date of Patent: September 26, 1978Assignee: Union Carbide CorporationInventor: Leonard Edward Hodakowski
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Patent number: 4113691Abstract: Novel compounds comprising poly(diphenylene ether) backbones having hydrolyzable organosilicon groups bonded thereto are useful in improving adhesion between resinous media and inorganic oxide surfaces.Type: GrantFiled: March 2, 1977Date of Patent: September 12, 1978Assignee: Union Carbide CorporationInventor: Robert James Ward
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Patent number: 4111876Abstract: A poly(vinyl chloride) resin composition comprised of an admixture of poly(vinyl chloride) resin and a clear or translucent polymeric material comprised of a non-uniform copolymer comprised of acrylonitrile, styrene and acrylate ester. The clear polymeric ASA material is a good impact modifier for PVC. The admixture contains from 3 to 15 percent by weight, based on the admixture, of the clear polymeric material. The clear polymeric material has a weight ratio of acrylonitrile and styrene acrylonitrile, styrene and acrylate ester which is between about 40 to 60 and about 60 to 40. The PVC resin combination, in dry form, can be conventionally hot processed or fabricated.Type: GrantFiled: March 30, 1976Date of Patent: September 5, 1978Assignee: Union Carbide CorporationInventors: Frederick Eugene Bailey, Joseph Victor Koleske
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Patent number: 4111769Abstract: Radiation curable pressure sensitive adhesive composition comprises: a polyoxyalkylene homo- or copolymer which is either a polyoxyethylene homopolymer or a poly (oxyethylene - oxypropylene) copolymer, or mixture thereof, having a molecular weight of from 1,700 to 90,000, in which at least 40 percent by weight of the oxyalkylene units are oxyethylene units; a liquid carbamyloxy alkyl acrylate; and, optionally, a photoinitiator.Type: GrantFiled: December 29, 1977Date of Patent: September 5, 1978Assignee: Union Carbide CorporationInventor: Kenneth Charles Stueben
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Patent number: 4093678Abstract: A highly crystalline non-uniform copolymer comprised of ethylene and acenaphthylene, which lacks the independent beta thermomechanical transition in the torsion pendulum loss-modulus curve possessed by known copolymers of ethylene. The non-uniform copolymer being photodegradable. A compatible blend of the polymeric material and high density polyethylene or the polymeric material and low density polyethylene has a higher use temperature than the particular polyethylene by itself.A though semi-crystalline, high-modulus, semi-elastic, non-uniform terpolymer comprised of ethylene, acenaphthylene and a different alpha-olefin, such non-uniform terpolymer being more elastic than polyethylene.Type: GrantFiled: April 26, 1976Date of Patent: June 6, 1978Assignee: Union Carbide CorporationInventors: Frederick Eugene Bailey, Werner Claus VON Dohlen
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Patent number: 4075152Abstract: When pigments which are to be dispersed in the polyol package of a two-package urethane coating are pre-treated by slurrying in an organic polyisocyanate, pigment flocculation is inhibited. Coating properties, such as gloss, weatherability, hardness and chemical resistance, are thereby improved.Type: GrantFiled: April 2, 1976Date of Patent: February 21, 1978Assignee: Union Carbide CorporationInventor: Robert Arthur Taller
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Patent number: 4066582Abstract: Addition of a small amount by weight of nitrocellulose to certain acrylate or methacrylate containing radiation curable coating compositions greatly inhibits penetration of the uncured compositions into porous substrates such as paper or paperboard.Type: GrantFiled: September 27, 1976Date of Patent: January 3, 1978Assignee: Union Carbide CorporationInventors: Gunther William Babian, Edward Bruce Harris