Patents Represented by Attorney Peter R. Shearer
  • Patent number: 4218567
    Abstract: A process for the preparation of aromatic ethers by the bromination of a compound of the formula ##STR1## wherein R.sub.1, independently, is hydrogen, hydroxy, lower alkoxy, lower alkyl; m is an integer from 1-4, and A is --CHO, --COOR.sub.3 or lower alkyl, and subsequently treating the reaction product of the bromination step with an alkali metal alkoxide in the presence of cuprous halide or oxide, is described.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: August 19, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Percy S. Manchand, John M. Townsend
  • Patent number: 4210754
    Abstract: Benzamides of the formula ##STR1## wherein X is halogen, trifluoromethyl or C.sub.3-4 -alkyl and Y is hydrogen, halogen or nitro,and N-oxides thereof, prepared inter alia from N-(2-aminoethyl)-morpholine and an acid of the formula ##STR2## wherein X and Y are as hereinbefore set forth, are described. The end products are useful in the treatment of depressive conditions, that is, are useful as antidepressants.
    Type: Grant
    Filed: October 20, 1978
    Date of Patent: July 1, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Burkard, Pierre-Charles Wyss
  • Patent number: 4203980
    Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-6 -alkyl, R.sup.3 isC.sub.1-3 -alkyl and R.sup.4 is methylene or C.sub.2-4 -alkylideneand physiologically compatible acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.
    Type: Grant
    Filed: April 26, 1978
    Date of Patent: May 20, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Alexander E. Wick
  • Patent number: 4202832
    Abstract: Thiocarbamoylthio fatty acid derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Y and n are as hereinafter set forth, are described. The compounds of formula I are useful as lipid-lowering agents.
    Type: Grant
    Filed: October 20, 1978
    Date of Patent: May 13, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulf Fischer, Ado Kaiser
  • Patent number: 4202894
    Abstract: Heterocyclic compounds characterized by the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and z are as hereinafter set forth,prepared, inter alia, by reacting a compound characterized by the formula ##STR2## with an amine characterized by the formula ##STR3## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are as hereinafter set forth,are described. The end products are useful as fungicidal agents.
    Type: Grant
    Filed: November 18, 1977
    Date of Patent: May 13, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Albert Pfiffner
  • Patent number: 4191758
    Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-3 -alkyl, and R.sup.3 and R.sup.4, independently, are hydrogen or methyl,and physiologically acceptable acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.
    Type: Grant
    Filed: April 26, 1978
    Date of Patent: March 4, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Alexander E. Wick
  • Patent number: 4187303
    Abstract: Thienothiazine derivatives of the formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as hereinafter set forth, and their tautomers are described. The thienothiazine derivatives are useful as anti-inflammatory, analgesic, antirheumatic and antithrombotic agents.
    Type: Grant
    Filed: August 15, 1978
    Date of Patent: February 5, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Otto Hromatka, Dieter Binder, Paul Zeller, Rudolf Pfister
  • Patent number: 4180475
    Abstract: Liquid crystal mixtures having positive anisotropy of the dielectric constants which comprise a nematogenic mixture with a clearing point above 60.degree. C. which is doped with an organic solvent or solvent mixture with a specific resistance of at least 10.sup.7 Ohm.cm. as well as a dipole moment along the longitudinal axis of the molecule of less than 3.5 Debye, or with a compound of the formula ##STR1## wherein R.sub.14 and R.sub.15 are straight-chain alkyl containing a total of not more than 14 carbon atoms or R.sub.14 is straight-chain alkyl and R.sub.15 is straight-chain alkoxy containing a total of not more than 8 carbon atoms,or a compound of the formula ##STR2## wherein R.sub.16 and R.sub.17 are straight-chain alkyl containing a total of not more than 6 carbon atoms,or a compound of the formula ##STR3## wherein R.sub.16 and R.sub.17 are straight-chain alkyl containing a total of not more than 6 carbon atoms,or mixtures thereof, are described.
    Type: Grant
    Filed: February 18, 1977
    Date of Patent: December 25, 1979
    Inventors: Martin Schadt, Hanspeter Scherrer, Arthur Boller
  • Patent number: 4180662
    Abstract: Anti-inflammatory, analgesic, anti-rheumatic and anti-thrombotic thienothiazine derivatives having the formula ##STR1## wherein A together with the two carbon atoms forms the group ##STR2## and the dotted line indicates the double bond present in the first and last thieno structures above, R.sup.1 is lower alkyl, R.sup.2 is the radical of an aromatic heterocycle with 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl radical optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy, R.sup.3 is halogen and R.sup.3' is hydrogen or halogen,and pharmaceutically acceptable salts thereof are described.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: December 25, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
  • Patent number: 4175085
    Abstract: Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.
    Type: Grant
    Filed: March 2, 1978
    Date of Patent: November 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dieter Binder, Otto Hromatka, Rudolf Pfister, Paul Zeller
  • Patent number: 4131602
    Abstract: Radiation curable acrylated polyurethane is porduced by (a) producing an isocyanate-terminated intermediate by coreacting an organic diisocyanate with a combination of organic tri/tetraol and organic diol, said combination being chosen from polyester tri/tetraol-polyether diol and polyether tri/tetraol-polyester diol combinations; (b) reacting the isocyanate-terminated intermediate with an hydroxyacrylate such as 2-hydroxyethyl acrylate. Unexpectedly, the oligomer has desirably low viscosity, yet cures upon exposure to radiation to a coating having good physical properties.
    Type: Grant
    Filed: September 29, 1977
    Date of Patent: December 26, 1978
    Assignee: Union Carbide Corporation
    Inventors: Leonard E. Hodakowski, Charles H. Carder
  • Patent number: 4130523
    Abstract: Aqueous polymer latexes having total solids contents of nearly 70 volume percent or more are produced by a process in which a portion of a forming latex in a reaction zone is continuously withdrawn from the reaction zone during formation of a stable seed latex and an intermediate latex, and the withdrawn latex is continuously fed back to the reaction zone during the formation of the final latex.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: December 19, 1978
    Assignee: Union Carbide Corporation
    Inventors: Kenneth L. Hoy, Roland H. Peterson
  • Patent number: 4126747
    Abstract: Unsaturated carbamoyloxy carboxylates having low color are produced by reacting hydroxyalkyl carbamates such as N-methyl 2-hydroxyethyl carbamate with acrylic or methacrylic acid in contact with a lower alkoxy substituted phenolic or alkylated alkoxyphenolic polymerization inhibitor at a critical low reaction temperature of 40.degree. C. to 80.degree. C. Novel unsaturated carbamoyloxy carboxylates are also disclosed.
    Type: Grant
    Filed: December 28, 1976
    Date of Patent: November 21, 1978
    Assignee: Union Carbide Corporation
    Inventors: Frank G. Cowherd, III, Louis F. Theiling, Jr.
  • Patent number: 4116786
    Abstract: Radiation curable coating compositions that contain an acrylate-capped polyether urethane, a low molecular weight polyfunctional acrylate, a monofunctional acrylate and, optionally, a photo-initiator are described. When cured, the coating compositions are sufficiently hard and flexible to serve as an overprint coating on sheet metal which is to undergo metal forming operations.
    Type: Grant
    Filed: June 8, 1976
    Date of Patent: September 26, 1978
    Assignee: Union Carbide Corporation
    Inventor: Leonard Edward Hodakowski
  • Patent number: 4113691
    Abstract: Novel compounds comprising poly(diphenylene ether) backbones having hydrolyzable organosilicon groups bonded thereto are useful in improving adhesion between resinous media and inorganic oxide surfaces.
    Type: Grant
    Filed: March 2, 1977
    Date of Patent: September 12, 1978
    Assignee: Union Carbide Corporation
    Inventor: Robert James Ward
  • Patent number: 4111876
    Abstract: A poly(vinyl chloride) resin composition comprised of an admixture of poly(vinyl chloride) resin and a clear or translucent polymeric material comprised of a non-uniform copolymer comprised of acrylonitrile, styrene and acrylate ester. The clear polymeric ASA material is a good impact modifier for PVC. The admixture contains from 3 to 15 percent by weight, based on the admixture, of the clear polymeric material. The clear polymeric material has a weight ratio of acrylonitrile and styrene acrylonitrile, styrene and acrylate ester which is between about 40 to 60 and about 60 to 40. The PVC resin combination, in dry form, can be conventionally hot processed or fabricated.
    Type: Grant
    Filed: March 30, 1976
    Date of Patent: September 5, 1978
    Assignee: Union Carbide Corporation
    Inventors: Frederick Eugene Bailey, Joseph Victor Koleske
  • Patent number: 4111769
    Abstract: Radiation curable pressure sensitive adhesive composition comprises: a polyoxyalkylene homo- or copolymer which is either a polyoxyethylene homopolymer or a poly (oxyethylene - oxypropylene) copolymer, or mixture thereof, having a molecular weight of from 1,700 to 90,000, in which at least 40 percent by weight of the oxyalkylene units are oxyethylene units; a liquid carbamyloxy alkyl acrylate; and, optionally, a photoinitiator.
    Type: Grant
    Filed: December 29, 1977
    Date of Patent: September 5, 1978
    Assignee: Union Carbide Corporation
    Inventor: Kenneth Charles Stueben
  • Patent number: 4093678
    Abstract: A highly crystalline non-uniform copolymer comprised of ethylene and acenaphthylene, which lacks the independent beta thermomechanical transition in the torsion pendulum loss-modulus curve possessed by known copolymers of ethylene. The non-uniform copolymer being photodegradable. A compatible blend of the polymeric material and high density polyethylene or the polymeric material and low density polyethylene has a higher use temperature than the particular polyethylene by itself.A though semi-crystalline, high-modulus, semi-elastic, non-uniform terpolymer comprised of ethylene, acenaphthylene and a different alpha-olefin, such non-uniform terpolymer being more elastic than polyethylene.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: June 6, 1978
    Assignee: Union Carbide Corporation
    Inventors: Frederick Eugene Bailey, Werner Claus VON Dohlen
  • Patent number: 4075152
    Abstract: When pigments which are to be dispersed in the polyol package of a two-package urethane coating are pre-treated by slurrying in an organic polyisocyanate, pigment flocculation is inhibited. Coating properties, such as gloss, weatherability, hardness and chemical resistance, are thereby improved.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: February 21, 1978
    Assignee: Union Carbide Corporation
    Inventor: Robert Arthur Taller
  • Patent number: 4066582
    Abstract: Addition of a small amount by weight of nitrocellulose to certain acrylate or methacrylate containing radiation curable coating compositions greatly inhibits penetration of the uncured compositions into porous substrates such as paper or paperboard.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: January 3, 1978
    Assignee: Union Carbide Corporation
    Inventors: Gunther William Babian, Edward Bruce Harris