Abstract: Disclosed are 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles. Also disclosed are methods for making 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles, including those having the formulae. The methods include contacting a 4-substituted-6,7-dihydro indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, or benzothiazole compound or a 7-substituted-4,5-dihydro indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, or benzothiazole compound with a vinyldiazo compound in the presence of a dirhodium catalyst.

Abstract: Disclosed are compounds having the formula: wherein R21 is an alkyl, aryl, alkoxy, hydroxy, or amino group or a halogen atom; wherein R2 is hydrogen or an alkyl, aryl, alkoxy, or amino group; wherein R23 and R24 are independently selected from hydrogen, an alkyl, aryl, alkoxy, hydroxy, or amino group, and a halogen atom or wherein R23 and R24, taken together with the carbon atom to which they are bound, form a ring; wherein R25 is hydrogen, an alkyl, aryl, alkoxy, hydroxy, or O-silyl group or a halogen atom; wherein Z, taken together with the carbons to which it is bonded, forms a 5-12 membered ring; and wherein Y is an electron withdrawing group. These compounds can be used to prepare erogorgiaene congeners, such as erogorgiaene, pseudopterosin A, helioporin E, pseudopteroxazole, colombiasin A, elisapoterosin B, elisabethadione, p-benzoquinone natural products, ileabethin, sinulobtain B, sinulobtain C, and sinulobtain D.

Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid. 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.

Abstract: The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.

Abstract: Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus (“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.

Abstract: Disclosed are compounds having the following formula: in which Z11 is selected from a substituted or unsubstituted saturated adamantyl or other polycyclic group and a substituted or unsubstituted branched acyclic group containing at least 5 carbon atoms at least one of which is a tertiary carbon; and in which Z12 is a cyclic imide. Methods of using these compounds as chiral catalysts for carbenoid reactions and for enantioselective C—H aminations are also described.

Abstract: The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase.

Abstract: The invention provides a method of increasing expression of p21WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The invention further provides a method of treating or preventing an abnormal condition resulting from a defect in a tumor suppressor gene in a subject that results in decreased induction of p21WAF1/Cip 1 in the cells of the subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of PP5 protein in the cells of the subject.

Abstract: The present invention relates to free radical captors, especially to radical polymerization inhibitors or retarders which, characteristically, are immobilized on a solid support. The present invention also relates to a method of preparing said immobilized captors, and to a method of stabilizing, at least temporarily, molecules or mixtures of molecules which makes use of said immobilized captors.

Abstract: Disclosed is a method of preparing a stable composition of radically copolymerizable monomers, said composition containing firstly at least one monomer which has at least one urea function in its formula and secondly at least one monomer which does not have an isocyanate function in its formula, said method comprising preparing said monomer(s) having urea function(s) by reaction of two types of reagent: at least one radically copolymerizable monomer which has at least one isocyanate function in its formula with at least one amine selected from primary and secondary amines, and incorporating said monomer(s) which does(do) not have an isocyanate function in its(their) formula, prior to said reaction, together with one of said reagents, before adding the other of said reagents, and/or during the addition of said reagents, and/or after said reaction.

Abstract: The present invention is directed to electro-optico chromophore bridge compounds and donor-bridge compounds which can be used in the preparation of polymeric thin films for waveguide media.

Abstract: The present invention relates to novel naphthopyran-type compounds, annelated in position C5-C6 by an indene- or dihydronaphthalene-type carbocycle, which are of the formulae (I) and (II) given below: These compounds (I) and (II) have interesting photochromic properties. The invention also relates to their preparation, to their applications as photochromes, as well as to the compositions and (co)polymer matrices containing them.

Abstract: The present invention relates to novel compounds of the naphthopyran type which have an annelated carbocycle in position 5,6. These compounds are of formula (I) given below: in which A is an alicyclic ring which is optionally annelated with an aromatic ring and in which two adjacent R3 can together form at least one ring, for example a benzo group. These compounds (I) possess interesting photochromic properties. The invention also relates to the method of preparing these compounds (I), as well as their applications as photochromes and compositions and (co)polymer matrices comprising them.

Abstract: The present invention deals with a novel photochromic organic material, the use of at least one plasticizer for the preparation of said novel material, said preparation and photochromic articles constituted wholly or in part of said novel material. The intervening plasticizer, advantageously a phthalate, is according to a variant simply dispersed in the polymer matrix, or, according to another variant, chemically bound to said polymer matrix. Said novel material possesses remarkable photochromic properties together with interesting optical and mechanical properties.

Abstract: The invention relates to novel naphthopyran- and phenanthropyran-type compounds having a carbobicycle annelated in 5,6- position. These compounds have formula (I) given below: These compounds (I) have interesting photochromic properties. The invention also relates to their preparation, to their applications as photochromes, as well as to the compositions and (co)polymer matrices containing them.

Abstract: The present invention is directed to dicyanomethylenedihydrofuran-based electron acceptors which can be used in the preparation of polymeric thin films for waveguide media, and methods of making the same.

Abstract: The principal object of the present invention is organic lens molds, constituted wholly or in part of at least one specific inorganic glass, advantageously strengthened by a chemical tempering or a thermal tempering. Said glass has the following composition, expressed in percentages by weight: SiO2 56-66, Al2O3 2.5-10, B2O3 0.5-7, Li2O 0-3, Na2O 8-15, K2O 3-12, with Li2O+Na2O+K2O 12-20, ZnO 2-12, MgO 0-3, TiO2 0-0.5, ZrO2 1-9, CaO 0-1, BaO 0-2, SrO 0-2, with MgO+CaO+SrO+BaO 0-5, Cl 0-0.5, As2O3+sb2O3 0-1. The invention also deals with novel inorganic glasses which have the above composition with a single exception relative to the Al2O3 content: Al2O3 2.5-4.

Abstract: The invention relates to novel benzopyran-type compounds having an aromatic heterocycle annelated in position 7,8 and a carbocycle annelated in position 5,6. These compounds have the formula (I) given below: These compounds (I) have interesting photochromic properties. The invention also relates to their preparation, to their applications as photochromes, as well as to the compositions and (co)polymer matrices containing them.

Abstract: The invention relates to photochromic transparent organic materials particularly useful for the production of photochromic organic ophthalmic lenses. The material includes an optical-quality polymer matrix and at least one coloring agent giving photochromic properties to the matrix. The coloring agent is chosen from the group of the spirooxazins the spiropyrans, and the chromenes. The polymer of the matrix is chosen from the group of homopolymers of ethyoxylated bisphenol A dimethacrylate with formula I: in which R is H or CH3, and m and n independently represent 1 or 2, and of the copolymers of this dimethacrylate containing at most 30 wt % of an aromatic monomer with vinyl, acrylic or methacrylic functionality.

Abstract: For subject, the present invention has novel naphthopyran derivatives of formula: optionally substituted in position(s) 2, 3, 4, 6, 7, 8, 9 or/and 10; the substituent Z in position 5 being of formula —C(R1)(R2)(OR3). The invention also relates to compositions and (co)polymer matrices containing such derivatives. Said derivatives have interesting photochromic properties.