Abstract: Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.

Abstract: Systems and methods are provided for associating traceability codes on clamshells with unique identifiers on containers in which the empty clamshells are packed for later use. In various methods, the clamshells are marked with traceability codes and stacked together, one traceability code is read from one of the clamshells in each stack, a unique identifier is read from a container, and the stack is placed in the container. The traceability code is stored in association with the unique identifier for later retrieval. An exemplary table for making clamshell-to-container associations comprises a scanner for reading traceability codes and rails for positioning stacks of clamshells proximate to the scanner. The table can also comprise a second scanner positioned to read unique identifiers from containers placed proximate thereto. The table can further comprise a computing system to make and store the associations.

Abstract: Disclosed herein are methods and materials by which nanostructures such as carbon nanotubes, nanorods, etc. are bound to lectins and/or polysaccharides and prepared for administration to cells. Also disclosed are complexes comprising glycosylated nanostructures, which bind selectively to cells expressing glycosylated surface molecules recognized by the lectin. Exemplified is a complex comprising a carbon nanotube functionalized with a lipid-like alkane, linked to a polymer bearing repeated ?-N-acetylgalactosamine sugar groups. This complex is shown to selectively adhere to the surface of living cells, without toxicity. In the exemplified embodiment, adherence is mediated by a multivalent lectin, which binds both to the cells and the ?-N-acetylgalactosamine groups on the nanostructure.

Abstract: A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.

Abstract: Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.

Abstract: A client system receives a request for a set of unique security codes and also receives product data associated with a product on which the security codes are to be printed. The client sends at least some of the product data to a host system and receives a batch identifier from the host. The host stores received product data with the batch identifier. The client generates the set of security codes and then provides the codes to be printed on the product. After the products enter the stream of commerce, the host can receive an authentication request including a security code, and in response the host will verify that the security code is valid and return to the requestor the authentication result and at least part of the product data associated with the batch identifier.

Abstract: Systems and methods are provided for associating traceability codes on clamshells with unique identifiers on containers in which the empty clamshells are packed for later use. In various methods, the clamshells are marked with traceability codes and stacked together, one traceability code is read from one of the clamshells in each stack, a unique identifier is read from a container, and the stack is placed in the container. The traceability code is stored in association with the unique identifier for later retrieval. An exemplary table for making clamshell-to-container associations comprises a scanner for reading traceability codes and rails for positioning stacks of clamshells proximate to the scanner. The table can also comprise a second scanner positioned to read unique identifiers from containers placed proximate thereto. The table can further comprise a computing system to make and store the associations.

Abstract: A caster includes a housing, a rotating member, and a caster. The housing defines an accommodation space having an open bottom end. The rotating member is disposed within the housing, and is rotatable between first and second angular positions. The caster is co-rotatable with the rotating member. One of the housing and the rotating member has first and second engaging portions. The other one of the housing and the rotating member has a third engaging portion, which engages the first engaging portion so that the caster is unfolded and disposed outwardly of the housing when the rotating member is at the first angular position and which engages the second engaging portion so that the caster is folded and disposed at a folded position and within the accommodation space when the rotating member is at the second angular position.

Abstract: Disclosed is a method for making graphene nanoribbons (GNRs) by controlled unzipping of structures such as carbon nanotubes (CNTs) by etching (e.g., argon plasma etching) of nanotubes partly embedded in a polymer film. The GNRs have smooth edges and a narrow width distribution (2-20 nm). Raman spectroscopy and electrical transport measurements reveal the high quality of the GNRs. Such a method of unzipping CNTs with well-defined structures in an array will allow the production of GNRs with controlled widths, edge structures, placement and alignment in a scalable fashion for device integration. GNRs may be formed from nanostructures in a controlled array to form arrays of parallel or overlapping structures. Also disclosed is a method in which the CNTs are in a predetermined pattern that is carried over and transferred to a substrate for forming into a semiconductor device.

Abstract: This invention provides 1,1-bis(4-hydroxyphenyl)-1-phenylethane having a crystal form characterized by an X-ray diffraction pattern having one sharp and strong peak at 16.4° and three sharp peaks of intermediate intensity at each of 13°-16° and 17°-20.8° and at least three peaks of intermediate intensity at 22°-23° as a diffraction angle (2?) in an X-ray diffractometry with Cu—K ?-rays, and being capable of giving the storing stability of a colored image and a non-colored portion against heat, water or the like and the low-energy color-developing property suitable for high-speed color development.

Abstract: A method for determining ligand activation of receptors using cells expressing genetic constructs of a fusion protein of at least a binding domain of an auxiliary protein and a fragment of ?-galactosidase, a fusion protein of an endosome-associated protein and a complementary fragment of ?-galactosidase, and a wild-type receptor. The receptors are characterized by binding to the auxiliary protein-binding domain upon activation by an agonist and then endocytosing associated with an endosome to which the endosome-associated protein binds. Cells are incubated with a candidate ligand followed by lysis with a lysing medium comprising a substrate for the ?-galactosidase. The enzyme product is then detected as a measure of the activation of the receptor.

Abstract: A shelf code in a machine readable format, such as on a QR code on a printed card, is provided where bulk merchandise displayed in a bin. When the bin is stocked from a case bearing a case code, the case code is associated with the shelf code. Lot-specific and lot-independent information previously associated with the case code is then linked to the shelf code. Consumers scan the shelf code with a mobile device to establish a communication channel to access the linked information. Retailers and producers use the channel to reach the consumer, and to solicit feedback from the consumer at a known time and location. A mobile device can also be used to associate quality assessments of merchandise to the shelf code. Analysis of consumer ratings and quality inspection assessments that are tied to time and location can provide valuable insights to both producers and retailers.

Abstract: A low profile speaker that is designed to substantially eliminate wobble of the bobbin and voice coil during operation with two different electromagnetic motor designs. In each design there is an added feature to of a downward extension of the outer edge of the cone that bottoms out on the bottom surface of the frame before the bottom edge of the bobbin strikes the bottom of the air gap thus preventing damage to the bobbin and voice coil when the voice coil is overdriven downward. Additionally, there are two different bobbin and voice coil cooling feature for use with electromagnetic motors that utilize a Tyoke construction.

Abstract: Rolls of pre-printed case labels are distributed at a harvest for labeling cases of produce. The labels on each roll include sequential codes that each span a unique range. Part or all of each roll's range can be associated with harvest data, including picker and block identifications. The association can be made by placing a label from each roll on a harvest form bearing harvest data, or by entering harvest data into an electronic device and using the device to read a unique code from a label. Pickers then harvest produce, fill cases, and label the cases from their rolls. The association of ranges to pickers allows a subsequently read unique code from a filled case to be properly credited to the correct picker. The association of ranges to blocks allows subsequently obtained quality information to be correlated to specific blocks.

Abstract: Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes.

Abstract: Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK (SEQ ID NO: 1) and YRSRKYSSWY (SEQ ID NO: 2).

Abstract: A double-gate semiconductor device includes a MOS gate and a junction gate, in which the bias of the junction gate is a function of the gate voltage of the MOS gate. The breakdown voltage of the double-gate semiconductor device is the sum of the breakdown voltages of the MOS gate and the junction gate. The double-gate semiconductor device provides improved RF capability in addition to operability at higher power levels as compared to conventional transistor devices. The double-gate semiconductor device may also be fabricated in a higher spatial density configuration such that a common implantation between the MOS gate and the junction gate is eliminated.

Abstract: Systems and methods are provided for social networks that can verify that enrolled users are not misrepresenting facts about themselves such as age and gender. Verification can be performed, for example, by reference to biometric templates stored during the user enrollment process. The biometric templates can also be used to authenticate users logging into the social network to prevent user impersonation. The ability of some users to communicate to other users of the social network can be limited to only certified users, and even to those certified users that match a criterion, such as gender or age.

Abstract: Methods and compositions are provided for assaying for enzymes capable of releasing an enzyme donor fragment (ED) conjugated to a nucleic acid strand bonded to a surface. Conveniently, the beads are magnetic allowing segregation of the beads during the determination. Upon addition of enzyme acceptor fragment (EA) and substrate to the assay mixture, the method allows for discrimination between ED free in solution and ED bound to the bead. The complexing of ED and EA provides an active ?-galactosidase enzyme. The method permits the assay of any substance involved in a pathway that can result in a reaction releasing the ED.