Patents Represented by Attorney, Agent or Law Firm Pillsbury Madison & Sutro
  • Patent number: 6222013
    Abstract: A process is disclosed for the esterification of an amino acid or peptide in which the amino acid or peptide is converted into the corresponding ester in the presence of a hydrosulphate have the general formula ROSO3H, where R represents an alkyl group, with the hydrosulphate being prepared, in the presence of the amino acid or peptide, from chlorosulphonic acid and an alcohol having the general formula ROH, where R has the same meaning as above. The chlorosulphonic acid to amino acid or peptide molar ratio preferably is between 0.8 and 2.0, in particular between 1.0 and 1.3. A primary alcohol, in particular methanol, is preferably used as alcohol. The amino acid used may be for example an &agr;-amino acid chosen from the group comprising p-hydroxyphenylglycine, phenylglycine, phenylalanine, tyrosine, proline and valine; L-alanyl-L-proline or an ester of L-aspartyl-L-phenylalanine, for example, may be used as peptide.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: April 24, 2001
    Assignee: DSM NV
    Inventors: Wilhelmus H. J. Boesten, Peter J. L. M. Quaedflieg
  • Patent number: 6220786
    Abstract: Apparatus for locally disturbing an underwater bed to enable the burial of an elongate member (39) comprises a mounting (30,31), resilient means (88-93) such as brush filaments coupled to the mounting, and means (9) for moving the resilient means with respect to the mounting. The resilient means is constructed such that on moving the mounting along the line of the elongate member while moving the resilient means with respect to the mounting, the underwater bed is disturbed by the resilient means to enable the elongate member to be buried.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: April 24, 2001
    Assignee: Cable & Wireless PLC
    Inventors: Andrew Stuart Ollason, Graham Peter Wallace, Kevin Clyde Peterson
  • Patent number: 6221865
    Abstract: Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2 is selected from (a) (b) —C(O)NH—CH(R14)—C(O)OR15, (d) —C(O)NH—CH(R14)—C(O)NHSO2R16, (e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and (g) —C(O)NH—CH(R14)—C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl,  and —P(W)RR3RR3′; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5—(d) —L4—L6—C(W)—N(R5)&md
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: April 24, 2001
    Assignee: University of Pittsburgh
    Inventors: Said M. Sebti, Andrew D. Hamilton, Kenneth J. Barr, Stephen A. Fakhoury, Stephen J. O'Connor, Saul H. Rosenberg, Wang Shen, Bryan K. Sorensen, Gerard M. Sullivan, James T. Wasicak, Kenneth J. Henry, Le Wang
  • Patent number: 6216691
    Abstract: A mounting body (10) for mounting a flow generator assembly (13) within an external housing. The body (10) is formed from a compliant material and is adapted to be fixed with respect to the housing. The body (10) also includes a recess of substantially complementary shape to the flow generator assembly (13) to receive and locate same. Also disclosed is an apparatus for providing breathable gas to a patient. The apparatus includes an external apparatus housing, the flow generator assembly (13) and the mounting body (10).
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: April 17, 2001
    Assignee: ResMed Limited
    Inventors: Barton John Kenyon, Alexander Virr, Marek Tomasz Sapula, Philip Rodney Kwok, Peter John Deacon Wickham
  • Patent number: 6218436
    Abstract: The carotenoids lutein and zeaxanthin are disclosed for pharmaceutical use in the treatment of advanced macular degeneration. High dosages are deployed to produce the high serum carotenoid levels needed to cause take-up by the macula.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: April 17, 2001
    Assignee: The Howard Foundation
    Inventors: Alan N Howard, John T Landrum, Richard A Bone
  • Patent number: 6217682
    Abstract: An energetic solid rocket motor propellant having one or more plateau regions of low operating pressure exponent is disclosed. The propellant is formulated from ingredients including an energetic polyoxetane, an effective amount of a plasticizer, an inorganic oxidizer in at least two discrete particle size ranges, and a refractory oxide burn rate modifier.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: April 17, 2001
    Assignee: Cordant Technologies Inc.
    Inventor: Carol Jean Campbell
  • Patent number: 6219544
    Abstract: A method of measuring radio path quality values (SQ) in a digital mobile telephone network (PLMN) comprising at least one mobile station (MS). In the method, co-ordinates (XY) of a measuring point are determined and transmitted to the mobile telephone network (PLMN). A mobile test device (TS) measures the radio path quality values (SQ) from a downlink transmission path. The mobile telephone network (PLMN) measures the radio path quality values (SQ) from an uplink transmission path. According to the invention, the mobile test device (TS) sends the results from said measurements to the mobile telephone network (PLMN) essentially without delay. The mobile telephone network (PLMN) receives the measurement results (SQ) sent by the mobile test device (TS) and combines them with its own measurement results (SQ) and with the co-ordinates (XY) of the measuring point essentially without delay.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: April 17, 2001
    Assignee: Nokia Telecommunications Oy
    Inventor: Jari Suutarinen
  • Patent number: 6218115
    Abstract: This invention relates to a novel protein having a high degree of homology to the amino acid sequence of the so-called cyclin box which is characteristic of cyclins: they are herein referred to as “human cyclin I” or “human cyclin I protein.” Further, the invention relates to a gene encoding their amino acid sequences and the protein: the gene is referred to as “gene encoding human cyclin I” or “human cyclin I gene.” Also, the invention relates to expression vector into which the human cyclin I gene is incorporated as well as to a transformant into which the vector is introduced. Still further, the invention relates to a recombinant protein obtained by growing the transformant. In addition, the invention relates to a novel neuron-marking method using an anitisense nucleotide of the gene as probe. Furthermore, the invention relates to method for screening cancer cell using the human cyclin I gene.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: April 17, 2001
    Assignee: Sumitomo Electric Industries, Ltd.
    Inventor: Takeshi Nakamura
  • Patent number: 6218552
    Abstract: A compound, 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione, which has a structure of crystals exhibiting the strongest peak at an angle of diffraction, 2&thgr;, of 4.7°, among peaks appearing within the range of not smaller than 3° of 2&thgr;, in an X-ray diffraction using a Cu-K&agr;-ray. The compound gives dyed or printed products having deep and brilliant tint of colors with excellent fastnesses, when applied to hydrophobic fiber materials, particularly, polyester fiber materials.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: April 17, 2001
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Junichi Sekihachi, Jun Yamamoto, Yasuyoshi Ueda
  • Patent number: 6213482
    Abstract: An add-on barrier for a wheelbarrow for expanding the volume capacity of the wheelbarrow, the barrier comprising a substantially rectangular baseless frame having substantially vertically disposed walls, the frame including a plurality of legs for mounting the frame over the wheelbarrow, the frame further including a plurality of integral hinged bag retainers for retaining a bag in an expanded volume formed by volume contributions of the wheelbarrow and the frame.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: April 10, 2001
    Assignee: ZAG Industries Ltd.
    Inventor: Zvi Yemini
  • Patent number: 6214959
    Abstract: The present invention describes a process for the making of a copolymer of the general formula (I) wherein A is a residue of at least one (meth)acrylate monomeric species, B is a residue of at least one monomeric species copolymerizable with A, R is a (meth)acrylate functionalized pendant ester group, X1 and X2 are terminal groups which may be the same or different, n and p are both at least one and are chosen such that the copolymer has a number average molecular weight of more than 2000.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: April 10, 2001
    Assignee: Imperial Chemical Industries PLC
    Inventors: Andrew Trevithick Slark, Michael Stephen Chisholm, Helen Harte
  • Patent number: 6214952
    Abstract: A propylene random copolymer and a film laminate thereof is described having excellent blocking resistance and transparency and substantially maintaining favorable low-temperature heat-sealing properties after corona discharge treatment. The propylene random copolymer of the invention includes a propylene component and an &agr;-olefin component having 4 to 10 carbon atoms, wherein the content of the &agr;-olefin component is in the range of about 6% to about 40% by weight, the intrinsic viscosity [&eegr;] measured in tetralin at 135° C. is not lower than about 0.45 dl/g and not higher than about 5.0 dl/g, and the melting point (Tm) measured by a differential scanning calorimeter and the content of 20° C. xylene soluble fraction (CSX) fulfill a relationship of Tm≦140−35.693 log10(CXS).
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: April 10, 2001
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Hajime Sadatoshi, Makoto Satoh, Naofumi Naga
  • Patent number: 6212900
    Abstract: The evaporator and the condenser are disposed in a duct. First bypass passage is disposed at the side of the condenser and first air mixing damper rotates to control air bypassing amount. Further second bypass passage is formed at the side of the evaporator and second mixing damper rotates to control air bypassing amount. Cooling rate at the evaporator and heating rate at the condenser are varied so that air adjusted in proper temperature is generated and discharged from each outlets into a room. An outside heat exchanger is disposed the outside of the duct. Refrigerant flow is randomly switched among the outside heat exchanger, the evaporator and the condenser so that cooling, heating, dehumidifying, dehumidified-heating and defrosting operations are performed.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: April 10, 2001
    Assignee: Nippendenso Co., Ltd.
    Inventors: Kunio Iritani, Shigeo Numazawa, Kenichi Fujiwara, Yasushi Yamanaka, Akira Isaji, Nobunao Suzuki
  • Patent number: 6214268
    Abstract: The blow-molded hose of a synthetic resin of the present invention is produced by blow-molding a single parison comprising a soft resin and a hard resin. The blow-molded hose comprises a monolayer (or single-layer) segment formed with either a soft resin layer or a hard resin layer and multilayer (laminating) segment formed with the soft resin layer and the hard resin layer, wherein, in the multilayer (laminating) segment, the thickness of the resin layer forming the monolayer segment is thinner than that of the other resin layer. Practically, the monolayer segment comprises the soft resin layer and forms the connection end (s) at the end (s) of the hose.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: April 10, 2001
    Assignee: Tigers Polymer Corporation
    Inventor: Masaaki Ogawa
  • Patent number: 6214874
    Abstract: A method for using nordihydroguiaretic acid derivatives, in particular tetramethyl nordihydroguiaretic acid and tetraglycinal nordihydroguiaretic acid, for the localized treatment of tumors induced by human papillomavirus.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: April 10, 2001
    Assignee: John Hopkins University
    Inventors: Ru Chih C. Huang, Jonathan D. Heller
  • Patent number: 6214272
    Abstract: A rotational molding method is provided consisting in a first method of spraying the inner mold area with an acrylic polyethylene alloy prior to loading the resin into the mold. The mold is then heated, rotated and cooled to form the molded part. The part is provided with a shinier and harder surface layer as compared to previous rotational molding methods. In a second method, in lieu of spraying, the acrylic polyethylene alloy is loaded into the mold with the resin. In the third and fourth methods, a drop box is provided for releasing resins into the mold. Other materials, in addition to acrylic polyethylene, can also be used with the various methods.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: April 10, 2001
    Assignee: Brunswick Corporation
    Inventors: Dave Gruenwald, Stephen Crane
  • Patent number: 6213119
    Abstract: Apparatus for the supply of breathable gas cyclically at an inspiratory pressure and a lower expiratory pressure substantially in synchronism with a patient's respiration. A flow generator coupled to a gas delivery system delivers breathable gas to the patient's airway. A motor controller receives a signal representing respiratory flow. The motor controller sends out a signal to control an electric motor and turbine to generate the desired inspiratory and expiratory pressures. The controller detects transitions between inspiration and expiration via a flow signal to discriminate between the respiratory phases of the patient. A counter counts a first time duration commencing from the last transition to inspiration and whereby if the first time duration elapses before a transition to expiration is detected, the controller initiates the supply of a given expiratory pressure.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: April 10, 2001
    Assignee: ResMed Limited
    Inventors: John William Ernest Brydon, Grant Willson
  • Patent number: 6215590
    Abstract: A stereoscopic image display apparatus having a light source that defines at least one right and left light-cells which provide plural pairs of right and left lights. A spatial modulator, spaced apart from the light source, spatially modulates the right and left lights from the light source so as to focus the right and left lights on the eyes of at least one viewer. A display mode changer is capable of automatically changing the display mode of the image display between a stereoscopic image display mode and a normal plane image display mode. The display is automatically changed in accordance with the location of the viewer or in response to an instruction from the viewer.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: April 10, 2001
    Assignee: Kabushiki Kaisha Toshiba
    Inventor: Hideaki Okano
  • Patent number: D440105
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: April 10, 2001
    Assignee: Cutting Edge Enterprises, Inc.
    Inventor: Mark S. Avery
  • Patent number: D440208
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: April 10, 2001
    Assignee: ResMed Limited
    Inventors: Susan Robyn Lynch, Zdzislaw Antoni Ziolkowski, Adrienne Mary Claire Walker