Patents Represented by Attorney Quine Intellectual Property Law Group
  • Patent number: 7897750
    Abstract: The invention provides methods for screening compound or chemical libraries by analyzing expressed RNA samples from biological samples treated with members of a compound library in a high throughput format.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: March 1, 2011
    Assignee: Althea Technologies, Inc.
    Inventor: Joseph Monforte
  • Patent number: 7892554
    Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: February 22, 2011
    Assignee: The Regents of the University of California
    Inventors: James D. Marks, Marie Alix Poul
  • Patent number: 7888063
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: February 15, 2011
    Assignee: The Scripps Research Institute
    Inventors: Alexander Deiters, T. Ashton Cropp, Jason W. Chin, J. Christopher Anderson, Peter G. Schultz
  • Patent number: 7883880
    Abstract: The present invention relates to the identification and isolation of a DNA polymerase and uses of this polymerase. In particular, the present invention describes the nucleotide sequence of the human gene for DNA polymerase lambda (Pol ?), the amino acid sequence of Pol ?, and the amino acid sequence of several isoforms derived from alternative splicing of its mRNA. The association of some of these isoforms with tumour samples makes Pol ? a marker for the diagnosis, prognosis and evolution of tumoral processes.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: February 8, 2011
    Assignee: Consejo Superior de Investigaciones Cientificas
    Inventors: Luis Blanco Dávila, Antonio Bernad Miana, Orlando Domínguez López, Miguel García Díaz
  • Patent number: 7870481
    Abstract: Methods and systems for providing display of information over a network or communications medium or at a kiosk or other display site by accessing an original presentation comprising two or more items and using an automatic summary module to automatically create a layout and a view comprising an arrangement items by analyzing a total number and relative number of each type or amount of media items.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: January 11, 2011
    Inventors: Victor Zaud, Hans Larsen
  • Patent number: 7838730
    Abstract: The enzymes of the ACC synthase family are used in producing ethylene. Nucleotide and polypeptide sequences of ACC synthases are provided along with knockout plant cells having inhibition in expression and/or activity in an ACC synthase and knockout plants displaying a staygreen phenotype, a male sterility phenotype, or an inhibition in ethylene production. Methods for modulating staygreen potential in plants, methods for modulating sterility in plants, and methods for inhibiting ethylene production in plants are also provided.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: November 23, 2010
    Assignees: Pioneer Hi-Bred International Inc., The Regents of the University of California
    Inventors: Daniel R. Gallie, Robert Meeley, Todd Young, Timothy George Helentjaris
  • Patent number: 7834159
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: November 16, 2010
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Patent number: 7824856
    Abstract: The invention provides novel compositions and methods for the analysis of gene expression (e.g., expression profiling) using microarray-based technology. In some embodiments of the invention, the novel methods use gene-specific as well as universal amplification primers during sample preparation, and the methods permit the simultaneous analysis of multiple samples on the same microarray. Furthermore, some embodiments of the invention incorporate barcode sequences into the amplified products, thereby permitting the use of generic arrays and generic labeled probes.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: November 2, 2010
    Assignee: Althea Technologies, Inc.
    Inventor: Joseph Monforte
  • Patent number: 7824893
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthoghonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing alkynyl amino acids, and cellular translation systems.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: November 2, 2010
    Assignee: The Scripps Research Institute
    Inventors: Alexander Deiters, Peter G. Schultz
  • Patent number: 7825226
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 2, 2010
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Patent number: 7811801
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: October 12, 2010
    Assignee: The Scripps Research Institute
    Inventors: Lital Alfonta, Peter G. Schultz, Zhiwen Zhang
  • Patent number: 7807411
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: October 5, 2010
    Assignee: The Scripps Research Institute
    Inventors: Jiangyun Wang, Jianming Xie, Peter G. Schultz
  • Patent number: 7803541
    Abstract: Methods of detecting two or more nucleic acids in a multiplex branched-chain DNA assay are provided. Different nucleic acids are captured through cooperative hybridization events on different, identifiable subsets of particles or at different selected positions on a spatially addressable solid support. Compositions, kits, and systems related to the methods are also described.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: September 28, 2010
    Assignee: Panomics, Inc.
    Inventors: Yuling Luo, Wen Yang
  • Patent number: 7794978
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: September 14, 2010
    Assignee: The Scripps Research Institute
    Inventors: Jason W. Chin, T. Ashton Cropp, J. Christopher Anderson, Peter G. Schultz
  • Patent number: 7790847
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid phenylselenocysteine and translation systems. The invention further provides methods for producing modified proteins (e.g., lipidated proteins) through targeted modification of the phenylselenocysteine residue in a protein.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: September 7, 2010
    Assignee: The Scripps Research Institute
    Inventors: Jiangyun Wang, Peter G. Schultz
  • Patent number: 7790378
    Abstract: A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived from a sample of cells, the sequence from the cDNA library varying within the cell library; contacting the library of cells with a plurality of agents which may affect protein degradation rates; for each agent, selecting cells in the library which express short-lived proteins based on whether the cells have different reporter signal intensities than other cells in the library, the difference being indicative of the selected cells expressing shorter lived fusion proteins than the fusion proteins expressed by the other cells in the library; and characterizing the fusion proteins expressed by the selected cells for each agent.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: September 7, 2010
    Assignee: Panomics, Inc.
    Inventors: Xianqiang Li, Xin Jiang
  • Patent number: 7778448
    Abstract: An on-line method for issuing a certificate of authenticity for a collectible to a collector who has personally witnessed the collectible being signed and a verification system for authenticating a suspected signature on an object by scanning the suspected signature and transmitting to a central computer where the suspected signature is compared with a set of authentic reference signatures based on input as to the shape of the object. In embodiments, the collector provides information on the collectible via the Internet to a central computer which stores the information for future reference by potential purchasers of the collectible. The collector must sign a statement on the certificate of authenticity that declares, under penalty of perjury, the information that the collector provided regarding the collectible is correct. Subsequent purchasers can access the central computer via the Internet.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: August 17, 2010
    Assignee: AuthenticSig, Inc.
    Inventor: Dan C. Morgan
  • Patent number: 7776758
    Abstract: Methods for forming or patterning nanostructure arrays are provided. The methods involve formation of arrays on coatings comprising nanostructure association groups, formation of arrays in spin-on-dielectrics, solvent annealing after nanostructure deposition, patterning using resist, and/or use of devices that facilitate array formation. Related devices for forming nanostructure arrays are also provided, as are devices including nanostructure arrays (e.g., memory devices).
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: August 17, 2010
    Assignee: Nanosys, Inc.
    Inventors: Xiangfeng Duan, Chao Liu
  • Patent number: 7771989
    Abstract: This invention relates to a micromachined microfluidics diagnostic device that comprises one or multiple assaying channels each of which is comprised a sample port, a first valve, a reaction chamber, a second valve, a fluid ejector array, a third valve, a buffer chamber, a capture zone and a waste chamber. Each of these device components are interconnected through microfluidic channels. This invention further relates to the method of operating a micromachined microfluidic diagnostic device. The flow of fluid in the microchannels is regulated through micromachined valves. The reaction of sample analytes with fluorescent tags and detection antibodies in the reaction chamber are enhanced by the micromachined active mixer. By ejecting reaction mixture onto the capture zone through micromachined fluid ejector array, the fluorescent tagged analytes bind with capturing antiodies on capture zone. The fluid ejector array further ejects buffer fluid to wash away unbound fluorescent tags.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: August 10, 2010
    Assignee: Micro Point Bioscience, Inc.
    Inventor: Yunlong Wang
  • Patent number: 7763773
    Abstract: The enzymes of the ACC synthase family are used in producing ethylene. Nucleotide and polypeptide sequences of ACC synthases are provided along with knockout plant cells having inhibition in expression and/or activity in an ACC synthase and knockout plants displaying a staygreen phenotype, a male sterility phenotype, or an inhibition in ethylene production. Methods for modulating staygreen potential in plants, methods for modulating sterility in plants, and methods for inhibiting ethylene production in plants are also provided.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: July 27, 2010
    Assignees: Pioneer Hi-Bred International Inc., The Regents of the University of California
    Inventors: Daniel R. Gallie, Robert Meeley, Todd Young