Patents Represented by Attorney R. Brent Olson
  • Patent number: 4751244
    Abstract: The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: ##STR1## wherein: R.sup.1 =HO or HOOC(CH.sub.2).sub.x CHR.sup.2 NH--;R.sup.2 =H, lower alkyl, benzyl or --CH.sub.2 OH;x=0 or 1;A=--(CH.sub.2).sub.n -- or ##STR2## n=1 to 5; and Y=H, Cl or OCH.sub.3Z=H or Clm=0 or 1R=lower alkyl;with the proviso that where R.sup.1 =OH, Y is H or Cl and m is 1, n is 4 or 5.The present invention is also directed to an antisickling pharmaceutical carrier and an antisickling agent of the general formula (I) (without the proviso) and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 30, 1987
    Date of Patent: June 14, 1988
    Assignees: Merck & Co., Inc., The University of Pittsburgh
    Inventors: Donald J. Abraham, Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr.
  • Patent number: 4685918
    Abstract: The instant invention is directed to a lipid osmotic pump, comprising:(A) a core, comprising:(i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid wettable;(ii) a sufficient amount of at least one water immiscible lipid carrier, which is liquid at the temperature of intended use, to dissolve and/or suspend said active agent; and(iii) a sufficient amount of at least one osmotic agent to ensure release of said lipid carrier from the pump; and(B) surrounded by a water insoluble wall:(i) having a thickness of about 1 to 1000 microns;(ii) which is preferentially wetted by said lipid carrier over an aqueous solution of said osmotic agent;(iii) having a water permeability of about 1.times.10.sup.-18 to 4.times.10.sup.-15 cm.sup.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: August 11, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Gordon L. Amidon, Takeru Higuchi, Jennifer B. Dressman
  • Patent number: 4655815
    Abstract: The present invention is directed to a synergistic antimicrobial admixture comprising 2-bromo-2-bromomethylglutaronitrile and a formaldehyde donor.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: April 7, 1987
    Assignee: Calgon Corporation
    Inventor: John A. Jakubowski
  • Patent number: 4640793
    Abstract: The instant invention is directed to an admixture, and its use in inhibiting scale and corrosion in aqueous systems, comprising:(a) a water-soluble polymer having a weight average molecular weight of less than 25,000, as determined by low angle laser light scattering, comprising an unsaturated carboxylic acid and an unsaturated sulfonic acid, or their salts, having a ratio of 1:20 to 20:1, and(b) at least one compound selected from the group consisting of water-soluble polycarboxylates, phosphonates, phosphates, polyphosphates, metal salts and sulfonates.The instant invention is also directed to a method of inhibiting the formation of insoluble alluvial, metal oxide and metal hydroxide deposits in an aqueous system, comprising adding to the system at least 0.
    Type: Grant
    Filed: May 9, 1985
    Date of Patent: February 3, 1987
    Assignee: Calgon Corporation
    Inventors: Leonard J. Persinski, Jerry L. Walker, Bennett P. Boffardi
  • Patent number: 4639366
    Abstract: The instant invention is directed to a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units.The instant invention is also directed to a controlled release device which comprises:(A) a polymer with at least one labile backbone bond per repeat unit and at least one pendant acid functionality per thousand repeat units; and(B) a beneficial substance incorporated within or surrounded by the matrix of said polymer.
    Type: Grant
    Filed: June 6, 1984
    Date of Patent: January 27, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Jorge Heller
  • Patent number: 4618448
    Abstract: The instant invention is directed to a process for inhibiting corrosion and the formation and deposition of scale and iron oxide in aqueous systems, comprising adding to the system at least 0.1 ppm of a water-soluble polymer having an intrinsic viscosity of 0.05 to 2.5 dl/g, prepared from:(a) 35 to 90%, by weight, of an unsaturated carboxylic acid, or its salt;(b) 5 to 40%, by weight of an unsaturated sulfonic acid, or its salt; and(c) 5 to 40%, by weight, of an unsaturated, polyalkylene oxide compound, the total of (a), (b) and (c) being 100% weight of the polymer.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: October 21, 1986
    Assignee: Calgon Corporation
    Inventors: Charles Y. Cha, Richard G. Varsanik, Shih-Ruey T. Chen
  • Patent number: 4613481
    Abstract: The present invention is directed to a composition useful for inhibiting the corrosion of copper and copper alloy metals in an aqueous system comprising mercaptothiazoline and ferrous ions.The present invention is also directed to a method of inhibiting the corrosion of copper and copper alloy metals in an aqueous system comprising maintaining in the aqueous system at least about 1 ppm (parts per million) of mercaptothiazoline, preferably in combination with ferrous ions.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: September 23, 1986
    Assignee: Calgon Corporation
    Inventors: Jasbir S. Gill, Arthur J. Friedman
  • Patent number: 4612328
    Abstract: The instant invention is directed to synergistic antimicrobial admixtures comprising 2-bromo-2-bromomethylglutaronitrile and methylene bis(thiocyanate) and its use in inhibiting microbial growth.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: September 16, 1986
    Assignee: Calgon Corporation
    Inventor: John A. Jakubowski
  • Patent number: 4604405
    Abstract: The instant invention is directed to synergistic antimicrobial admixtures comprising 2-bromo-2-bromomethylglutaronitrile and 2,2-dibromo-3-nitrilopropionamide and its use in inhibiting microbial growth.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: August 5, 1986
    Assignee: Calgon Corporation
    Inventor: John A. Jakubowski
  • Patent number: 4604212
    Abstract: The instant invention is directed to a process for inhibiting corrosion and the formation and deposition of scale in aqueous systems comprising adding to the system at least 0.1 ppm. of a water soluble polymer, having an intrinsic viscosity of 0.05 to 2.5 dl/g, prepared from:(A) 50 to 95%, by weight, of an unsaturated carboxylic acid, or its salt, and(B) 5 to 50%, by weight, of a betaine-containing monomer selected from the group consisting of: ##STR1## wherein R, which may be the same or different, is hydrogen, a straight or branched, alkyl or an aryl or alkylaryl group of from 1 to 20 carbon atoms;R.sup.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: August 5, 1986
    Assignee: Calgon Corporation
    Inventor: Gary F. Matz
  • Patent number: 4596661
    Abstract: The instant invention is directed to a method of settling fine calcium carbonate solids from a suspension comprising water and calcium carbonate, comprising adding to said suspension an effective amount of an admixture comprising: (a) an anionic polyelectrolyte; and (b) an anionic surfactant, wherein said polyelectrolyte/surfactant ratio ranges from 10:1 to 1:5, by weight.
    Type: Grant
    Filed: February 4, 1985
    Date of Patent: June 24, 1986
    Assignee: Calgon Corporation
    Inventors: Jasbir S. Gill, Richard G. Varsanik
  • Patent number: 4594268
    Abstract: The instant invention is directed to a method for suppressing dust comprising contacting the material being treated with an aqueous emulsion of a methacrylate polymer or a composition comprising a hydrophobic liquid and a methacrylate polymer. These emulsions and compositions may further comprise a wetting/penetrating surfactant.
    Type: Grant
    Filed: March 29, 1985
    Date of Patent: June 10, 1986
    Assignee: Calgon Corporation
    Inventor: Ross C. Kirwin
  • Patent number: 4593033
    Abstract: Novel substituted indeno[2,1-c] pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: June 3, 1986
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Wasyl Halczenko, Steven D. Young
  • Patent number: 4589985
    Abstract: The instant invention is directed to a method of inhibiting the precipitation and deposition of alkaline earth metal scales in an aqueous system, comprising adding to said system an effective amount of (a) an anionic polyelectrolyte; and (b) an anionic surfactant, wherein said polyelectrolyte/surfactant ratio ranges from 1000:1 to 1:10, by weight.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: May 20, 1986
    Assignee: Calgon Corporation
    Inventor: Monica A. Yorke
  • Patent number: 4561897
    Abstract: The instant invention is directed to an aqueous stable magnesium hydroxide suspension which is dispersible in oil, comprising a mixture of:(a) a 33 to 60, preferably 50 to 60, percent, by weight, aqueous slurry or paste of magnesium hydroxide; and(b) an alkyl benzene sulfonate emulsifier.The instant invention is also directed to a process for the preparation of an aqueous stable magnesium hydroxide suspension which is dispersible in oil, comprising mixing:(a) a 33 to 60, preferably 50 to 60, percent, by weight, aqueous slurry of magnesium hydroxide; and(b) an alkyl benzene sulfonate emulsifier.The instant invention is also directed to a process for inhibiting corrosion in fuel burning boilers comprising adding to the fuel a corrosion inhibiting amount of an aqueous stable magnesium hydroxide suspension which is dispersible in oil, comprising a mixture of:(a) a 33 to 60 percent, by weight, aqueous slurry or paste of magnesium hydroxide; and(b) an alkyl benzene sulfonate emulsifier.
    Type: Grant
    Filed: August 16, 1984
    Date of Patent: December 31, 1985
    Assignee: Calgon Corporation
    Inventors: John D. Zupanovich, John G. Myers
  • Patent number: 4552665
    Abstract: The instant invention is directed to a process for inhibiting the precipitation of dissolved manganese ion and its reaction products in aqueous solutions, comprising adding to the aqueous solution 0.1 to 20 ppm of a copolymer of an unsaturated carboxylic acid or salt selected from the group consisting of acrylic acid and methacrylic acid and an unsaturated sulphonic acid or salt selected from the group consisting of 2-acrylamido-2-methylpropylsulphonic acid and 2-methacrylamido-2-methylpropylsulphonic acid.
    Type: Grant
    Filed: May 4, 1984
    Date of Patent: November 12, 1985
    Assignee: Calgon Corporation
    Inventors: Paul H. Ralston, Sandra L. Whitney
  • Patent number: 4549010
    Abstract: The instant invention is directed to a bioerodible poly(ortho ester) thermoplastic elastomer prepared from:(A) a diketene diacetal;(B) a long-chain non-polar, flexible diol containing 4 to 22 carbon atoms; and(C) a diol selected from the group consisting of:(i) diols containing at least one functional group which produces hydrogen bonding or other association, and(ii) rigid symmetrical diols.
    Type: Grant
    Filed: June 27, 1984
    Date of Patent: October 22, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Randall V. Sparer, Stefano A. Pogany
  • Patent number: 4544488
    Abstract: The instant invention is directed to a process for removing volatile and nonvolatile organic chemicals from water comprising: (1) passing said water through an induced draft air stripper; and (2) passing the effluent of said induced draft air stripper through a carbon adsorption bed.
    Type: Grant
    Filed: July 5, 1984
    Date of Patent: October 1, 1985
    Assignee: Calgon Corporation
    Inventor: Robert P. O'Brien
  • Patent number: 4544639
    Abstract: The instant invention is directed to a process for determining the amount of organic phosphonate present in an aqueous solution, comprising the steps of:(a) adding 1000 to 20,000 ppm of a strong oxidizing agent and 8 ppb to 5000 ppm silver ion to the aqueous solution;(b) allowing the organic phosphonate present in said solution to react to form orthophosphate;(c) precipitating any excess silver in said solution by the addition of 1000 to 50,000 ppm of a reducing agent or at least an equimolar amount of a halide, based on the silver ion added in Step (a), and removing any precipitate formed;(d) adding to said solution 5 to 30 percent, by volume, of an acid solution containing 500 to 2000 ppm of ions selected from the group consisting of molybdate ion and vanadate ion, and if a halide was used in Step (c), adding 1000 to 50,000 ppm of a reducing agent;(e) measuring the absorbance of said solution at 625 to 880 nanometers and determining the orthophosphate concentration from a calibration curve of orthophosphate
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: October 1, 1985
    Assignee: Calgon Corporation
    Inventor: Robert J. Faust
  • Patent number: 4540678
    Abstract: The instant invention is directed to a process for the continuous manufacturing of carbon molecular sieves having average effective pore diameters of from 2 to 15 Angstroms which comprises continuously feeding a charred naturally occurring substrate to a means for heating said substrate and heating said substrate under non-activation conditions, without the use of an externally added pore blocking substance, at a temperature range of about 900.degree. F. (482.degree. C.) to 2000.degree. F. (1093.degree. C.) for a time period of about 5 to 90 minutes.The instant invention is also directed to a carbon molecular sieve, useful for separating gas or liquid mixtures containing components of at least two different molecular diameters, molecular weights or molecular shapes which has the following physical characteristics:(a) an apparent density of from 0.60 to 0.70 g/cc,(b) an oxygen diffusivity (.times.10.sup.-8) of from 500 to 900 cm.sup.2 /sec,(c) an oxygen/nitrogen selectivity ratio of from 5.0 to 8.
    Type: Grant
    Filed: December 13, 1983
    Date of Patent: September 10, 1985
    Assignee: Calgon Carbon Corporation
    Inventor: Robert F. Sutt, Jr.