Abstract: The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula ##STR1## wherein R.sub.a to R.sub.c, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties.The compounds of the above formula I wherein R.sub.c denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein R.sub.c denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.
Type:
Grant
Filed:
February 2, 1999
Date of Patent:
September 5, 2000
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Uwe Ries, Norbert Hauel, Gerhard Mihm, Henning Priepke, Klaus Binder, Jean-Marie Stassen, Wolfgang Weinen, Rainer Zimmerman
Abstract: The present invention relates to new substituted 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indole derivatives, processes for preparing them and their use as pharmaceutical compositions.
Type:
Grant
Filed:
July 30, 1999
Date of Patent:
April 18, 2000
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Christoph Hoenke, Adrian Carter, Wolf-Dietrich Bechtel, Thomas Weiser, Rainer Palluk, Uwe Pschorn
Abstract: Milling/sizing apparatus which includes individual and/or nested sieves each of which may also include a quantity of beads, disks and/or other geometric or non-geometric shapes. The sieves can be rotated, vibrated or agitated in any and all combinations by various methods to achieve independently horizontal rotation and vertical reciprocation (similar to a merry-go-round) to efficiently segregate, size or mill cohesive and polydisperse powder particles to specific size ranges. The invention also contemplates a method for using the apparatus in the sizing and quantification of aggregated particles of cohesive disperse powders.
Type:
Grant
Filed:
December 9, 1998
Date of Patent:
March 14, 2000
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Abstract: Compounds of the formula ##STR1## which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
March 14, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Frank Himmelsbach, Franz Birke, Armin Fugner
Abstract: The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
March 7, 2000
Assignee:
Boehringer Ingelheim KG
Inventors:
Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
Abstract: Pharmacologically active novel esters and amides of di-substituted 1,4 piperidine as 5-HT.sub.4 antagonists of formula (I) ##STR1## wherein A, X, Y and R have the meanings specified in the description, and a process for their preparation, are disclosed.
Abstract: A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
Type:
Grant
Filed:
August 15, 1996
Date of Patent:
November 23, 1999
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Danny W. Chladek, David E. Gorcyca, Louis L. Harris
Abstract: The present invention relates to phenyl amidines of general formula (I), ##STR1## in which R.sup.1 to R.sup.5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases also having valuable pharmacological properties, preferably aggregation-limiting effects, producing them.
Type:
Grant
Filed:
December 17, 1997
Date of Patent:
September 28, 1999
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Frank Himmelsbach, Volkhard Austel, Gunther Linz, Helmut Pieper, Brian Guth, Johannes Weisenberger
Abstract: Precursors of anticholinergically active quaternary compounds can be synthesized from optically active tropic acid by acetylation, conversion into the acid chloride, reaction with amino alcohols of formula (I) ##STR1## (as the methanesulphonate; Q and R are explained in the specification), deacetylation and isolation of the reaction product.
Abstract: Disclosed herein is the use of epinastine for the treatment of pain, including migraine, Bing-Horton syndrome, tension headaches, muscle pain, inflammatory pain, and neuralgias. Epinastine may also be administered in combination with an additional analgesic for treating pain.
Type:
Grant
Filed:
June 9, 1998
Date of Patent:
August 24, 1999
Assignee:
Boehringer Indelheim KG
Inventors:
Birgit Jung, Christopher John Montague Meade, Michel Pairet
Abstract: The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.
Type:
Grant
Filed:
December 21, 1995
Date of Patent:
July 13, 1999
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Helmut Pieper, Volkhard Austel, Frank Himmelsbach, Gunter Linz, Brian Guth, Johannes Weisenberger
Abstract: The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein the group R.sup.2 is ##STR2## and R.sup.1, A, G, Y, Z and m have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
Type:
Grant
Filed:
May 27, 1997
Date of Patent:
July 13, 1999
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Brigit Jung, Erich Burger, Georg Speck
Abstract: The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.
Type:
Grant
Filed:
November 26, 1997
Date of Patent:
July 13, 1999
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Gunter Linz, Thomas Muller, Wolfgang Eisert, Johannes Weisenberger
Abstract: The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.
Type:
Grant
Filed:
May 28, 1997
Date of Patent:
March 9, 1999
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Frank Himmelsbach, Volkhard Austel, Gunter Linz, Helmut Pieper, Brian Guth, Thomas Muller, Johannes Weisenberger
Abstract: A multi-dose applicator comprising a bottle locking assembly wherein a supply bottle can be quickly and easily attached or removed from the applicator by rotating a locking ring a fraction of a turn and wherein the plunger is flexible to allow for misalignment.
Type:
Grant
Filed:
November 12, 1997
Date of Patent:
February 2, 1999
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Dean Doying, Sr., Tom Kennedy, Wayne Cole, W. L. Eidson, Jack Zupan