Patents Represented by Attorney, Agent or Law Firm R. P. Raymond
  • Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations
    Patent number: 5674878
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Fabric for the preparation of electrophoresis gels
    Patent number: 5672416
    Abstract: The invention relates to new fabrics with improved properties for the preparation of electrophoresis gels.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: September 30, 1997
    Assignee: Serva Feinbiochemica GmbH & Co.
    Inventors: Bertold Radola, Horst Schwall, Manfred Demharter
  • Apparatus for the surface culture of nucleated cells and cell culture dependent substances
    Patent number: 5672507
    Abstract: An improved bio-reactor with spiral or coil-shaped filling bodies is disclosed, the improvement comprising use of a gas diffusion tube through which air, oxygen or other gases can be bubbled through the fermentation medium.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: September 30, 1997
    Assignee: Boehringer Ingelheim Animal Health, Inc.
    Inventor: Walter Merk
  • Method for the preparation of 3-amino-2-chloro-4-methylpyridines
    Patent number: 5668287
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: September 16, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Cerebroprojection method
    Patent number: 5665729
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 9, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Antiherpes pentapeptides
    Patent number: 5648337
    Abstract: Disclosed herein are pentapeptide derivatives of the formula (SEQ ID NO: 24) XNR.sup.1 --CH(R.sup.2)--C(O)--NH--CH(R.sup.3 --C(O)--NR.sup.4 --CH(CH.sub.2 Y)--CO--NH--CH[CR.sup.5 (R.sup.6)--COOH]--C(W)--NH--CH(R.sup.7)--Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R.sup.1 is alkyl or phenylalkyl, R.sup.2, R.sup.3 and R.sup.7 are selected from the side chains of amino acid or derived amino acid residues, R.sup.4, R.sup.5, and R.sup.6 are hydrogen or lower alkyl, W is oxo or thioxo, Y is carboxy, carbamyl or 5-1H-tetrazolyl and Z is carboxy or 5-1H-tetrazolyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: July 15, 1997
    Assignee: Bio-Mega/Boehringer Ingelheim Research Inc.
    Inventors: Julian Adams, Pierre Louis Beaulieu, Pierre Lavallee, Raymond Plante, Sumanas Rakhit
  • Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
    Patent number: 5643919
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 1, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Controlled release of metered quantities of finely divided solids with a venturi nozzle and regulated control
    Patent number: 5624690
    Abstract: The invention relates to a process and apparatus for the controlled release of metered quantities of finely divided solids with one or more regulated venturi nozzles for the purpose of applying lubricant or separating compound to the stressed surfaces of pressing tools in tablet making machines or for applying finely divided solids to solid carrier materials particularly in the fields of pharmaceuticals, foodstuffs or catalysts.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 29, 1997
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Josef Boldis, Volker I. Glasel, Ekkehard Flaischlen, Gunther M. Voss
  • Process for preparing 1,3-dialkyl-5-hydroxyoxindoles and the ether derivatives thereof
    Patent number: 5614637
    Abstract: The invention is directed to a process for preparing a 1,3-dialkyl-5-hydroxyoxindole of formula 1: ##STR1## comprising heating an N-alkyl-p-alkoxy-(.alpha.-haloacyl)anilide of formula 2: ##STR2## wherein the substituents are as defined herein, in the presence of an anhydrous zinc halide to a temperature in the range from about 120.degree. C. to about 160.degree. C., and isolating the 1,3-dialkyl-5-hydroxyoxindole prepared.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: March 25, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Rainer Sobotta, Rainer Schwarz, Manfred Psiorz
  • Cyclic compounds and pharmaceutical compositions containing them
    Patent number: 5612335
    Abstract: The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: March 18, 1997
    Assignee: Karl Thomae GmbH
    Inventors: F. Himmelsbach, Helmut Pieper, Volkhard Austel, Gunter Linz, Brian Guth, Thomas Muller, Johannes Weisenberger
  • Useful for treating neurodegenerative diseases
    Patent number: 5607941
    Abstract: Novel benzomorphan derivatives of the formula ##STR1## wherein R.sup.1 -R.sup.8 are as defined herein. The benzomorphan derivatives are useful for treating cerebral ischaemia of various origins, epilepsy and neurodegenerative diseases.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 4, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Herbert Merz, Enzio Mueller, Werner Stransky, Ilse Streller
  • Substituted thiazoles and oxazoles and 2-hydroxy-morpholines
    Patent number: 5604225
    Abstract: Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: February 18, 1997
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Manfred Reiffen, Rudolf Hurnaus, Robert Sauter, Wolfgang Grell, Eckhard Rupprecht
  • Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5597825
    Abstract: The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: January 28, 1997
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, G unter Linz, Thomas M uller, Wolfgang Eisert, Johannes Weisenberger
  • Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
    Patent number: 5596000
    Abstract: The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR2## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: January 21, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Birgit Jung, Erich Burger
  • Pyrrolidine derivatives inhibitors of leukotriene biosynthesis
    Patent number: 5594008
    Abstract: 2-(1-pyrrolidino)-benzoxazoles of general formula ##STR1## are disclosed which are inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Kollol Pal, Mark Behnke, Julian Adams
  • Cyclic imino derivatives and pharmaceutical compositions containing them
    Patent number: 5591769
    Abstract: The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 7, 1997
    Assignee: Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Volkhard Austel, Helmut Pieper, Wolfgang Eisert, Thomas Mueller, Johannes Weisenberger, Guenter Linz, Gerd Krueger
  • Benzimidazolone derivatives
    Patent number: 5576318
    Abstract: Pharmacologically active benzimidazolone derivatives as 5-HT.sub.1A and 5-HT.sub.2 receptors, useful in the treatment of CNS disorders, of formula: ##STR1## wherein the substituents are defined herein.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: November 19, 1996
    Assignee: Boehringer Ingelheim Italia S.p.A.
    Inventors: Giuseppe Bietti, Franco Borsini, Marco Turconi, Ettore Giraldo, Maura Bignotti
  • Isosteric antiherpes peptide derivatives
    Patent number: 5574015
    Abstract: Disclosed herein are peptide derivatives of the formula A-B-D-CH.sub.2 CH{CH.sub.2 C(O)R.sup.1 }C(O)-NHCH{CR.sup.2 (R.sup.3)COOH}C(O)-E wherein A is a terminal group, for example an optionally substituted phenylalkanoyl, and B is a N-methyl amino acid residue; or A and B together form a saturated or unsaturated alkylaminocarbonyl; D is an amino acid residue; R.sup.1 is alkyl, cycloalkyl, a monosubstituted or a disubstituted amino; R.sup.2 is hydrogen or alkyl and R.sup.3 is alkyl, or R.sup.2 is hydrogen and R.sup.3 is phenylalkyl, or R.sup.2 and R.sup.3 are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: November 12, 1996
    Assignee: Bio-Mega/Boehringer Ingelheim Research Inc.
    Inventors: Pierre L. Beaulieu, Robert D eziel, Neil Moss, Raymond Plante
  • The treatment of HIV-1 infection using certain pyridodiazepines
    Patent number: 5571809
    Abstract: Disclosed are novel pyridodiazepines. These compounds, as well certain known 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-ones are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: November 5, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Process for preparing nevirapine
    Patent number: 5569760
    Abstract: A process for preparing nevirapine which comprises reacting 2-chloro-N-(2-chloro-4-methyl-3-pyridyl)-3-pyridine carboxamide with cyclopropylamine followed by cyclisation of the product, wherein the reaction with cyclopropylamine is carried out in the presence of an oxide or hydroxide of an element of the second main or sub-group of the periodic table of elements.
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: October 29, 1996
    Assignee: Boehringer Ingelheim KG
    Inventors: Heinrich Schneider, Albrecht Christmann