Abstract: Sterile, essentially crystalline cefazolin sodium for parenteral administration is prepared by a freeze-drying process wherein a C.sub.1 -C.sub.3 alcohol-water solution of cefazolin sodium containing about 10 percent by volume of the C.sub.1 -C.sub.3 alcohol is chilled slowly from room temperature to about -10.degree. C. over a 3-12 hour period and then rapidly cooled to -30.degree. to about -40.degree. C. and held for 1-2 hours before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents.

Abstract: Essentially crystalline cephalothin sodium for parenteral administration is prepared by a freeze-drying process wherein a (C.sub.1 -C.sub.3 alcohol or acetone)-water solution of cephalothin sodium containing from about 2 to about 10 percent of C.sub.1 -C.sub.3 alcohol or acetone by volume is chilled from room temperature to -20.degree. C., or below, preferably about -40.degree. C. over a 1-3 hour period and then warmed to from about -3.degree. C. to about -10.degree. C. and held for 3 hours or more, then cooled to -20.degree. C., or below, preferably about -40.degree. C., before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents. Alternatively, from about 2 to about 5 percent by weight of sodium bicarbonate, related to the amount of cephalothin sodium present, is added to the solution before freeze-drying.

Abstract: A refillable column for chromatography at elevated pressure is described comprised of a cylinder connected on both ends to a coupling having internal threads and an annular shoulder at the internal terminus of the threads. A plug having external threads is disposed in said coupling and sealed against the shoulder of the coupling. An axial hole communicates between the top and bottom of the plug. The column can be packed, emptied and repacked repeatedly.

Abstract: Passing a solution, buffered to a pH of from about 3.5 to about 4.5, of an alkali metal or ammonium salt of cefamandole through a bed of an adsorbent resin depending on van der Waals forces for adsorption followed by acidification to a pH of about 2.0 with a non-oxidizing inorganic acid yields pure crystalline cefamandole, which can be separated and dried, or partitioned into a preferential solvent from which crystalline sodium cefamandole can be recovered.

Abstract: Antibiotic A-4696, produced by Actinoplanes sp., strain ATCC 23342, under submerged aerobic conditions in a liquid culture medium isolated from the fermentation broth by adsorption on activated carbon, eluted therefrom with a 1% sulfuric acid solution in acetone, and purified over sulfuric acid-washed alumina has antibacterial and growth promotant activity.

Abstract: Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15.degree. C. in no more than 3 hours, the frozen solution is held between about <0.degree. C. and about -10.degree. C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.

Abstract: A pharmaceutical preparation is described which comprises nitroglycerin tablets stabilized against the migration of the active agent from tablet to tablet when such tablets are in contact with each other.A method is provided for stabilizing such nitroglycerin tablets.

Abstract: An automated sample changer, controlled by gas fluidic circuitry, integrated with a Nuclear Magnetic Resonance (NMR) spectrometer provides a means for sequentially transferring samples to and from such spectrometer without an attendant to control such transfer. Such a changer comprises a means for holding a series of samples, a robot arm cooperating with such holding means and disposed in alignment with the sample receiving tube of an NMR spectrometer, a gas fluidic circuit to sense the required action, and a second gas fluidic circuit integrated therewith to provide the energy to make the transfer.

Abstract: Compositions comprising certain 2-(substituted anilino)benzoxazoles, such as 2-[4-bromo-3-(trifluoromethyl)anilino]benzoxazole, and methods for using same as immunosuppressive agents, antifertility agents, for the prophylaxis of Marek's disease in chickens and as herbicides.

Abstract: Antibiotic A-4696, produced by Actinoplanes sp., strain ATCC 23342, under submerged aerobic conditions in a liquid culture medium isolated from the fermentation broth by adsorption on activated carbon, eluted therefrom with a 1% sulfuric acid solution in acetone, and purified over sulfuric acid-washed alumina has antibacterial and growth promotant activity.

Abstract: Novel Mono- and di-basic aluminum salts of 2-(3-phenoxyphenyl)-and 2-(3-phenylthiophenyl)alkanoic acids provide tasteless and practically water insoluble forms of said alkanoic acids, which have anti-inflammatory activity in mammals, for formulating pharmaceutical suspensions.

Abstract: Method of inhibiting the hydrolysis of acetylsalicyclic acid in the presence of d-propoxyphene hydrochloride in pharmaceutical compositions comprising admixing the hydrochloride of one of the 23 naturally occuring amino acids therewith, and compositions containing such amino acid hydrochloride, acetylsalicylic acid and d-propoxyphene hydrochloride.

Abstract: Method of killing microorganisms in the inside of a container which comprises directing an electromagnetic field into such container, inducing a plasma therein by focusing a single-pulsed, high-power laser beam into said field and exposing the inside of such container to said plasma for from about 1.0 millisecond to about 1.0 second by sustaining said plasma with said electromagnetic field.

Abstract: Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15.degree. C. in no more than 3 hours, the frozen solution is held between about <0.degree. C. and about -10.degree. C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.

Abstract: A pharmaceutical suspension for parenteral administration is provided which comprises finely divided crystals of cefazolin suspended in a vehicle composed of water, a pharmaceutically acceptable surfactant, lecithin and a viscosity adjusting agent or agents. Methods are also provided for preparing such a suspension.

Abstract: 5-Bromo-5-nitro-2-alkylsubstituted-1,3-dioxanes, such as 5-bromo-2-methyl-5-nitro-1,3-dioxane, novel antimicrobials with activity against both bacteria and fungi.

Abstract: A process is provided for treating spent antibiotic fermentation broth containing concentrations of up to about 12 percent fats and up to about 9.5 percent proteins which comprises acidifying such spent broth to coagulate the fats, impinging the coagulated fat on a coalescing strainer, basifying the effluent therefrom to coagulate the proteinaceous material, filtering the basified spent broth to remove the proteinaceous material, and passing the filtrate serially through anionic and cationic exchange resins, wherein the biological oxygen demand of the effluent therefrom is reduced to a level of less than 0.04 g. oxygen per liter.

Abstract: Sterile, essentially amorphous cefazolin sodium for parenteral administration, having an improved solubility on reconstitution, is prepared by a freeze-drying process wherein a sterile solution of from about 10 to about 25 percent (W/V) of cefazolin sodium is exposed to an environment wherein the temperature is held at from about minus 50.degree. C. to minus 55.degree. C. until the temperature of the solution (frozen) is reduced to minus 48.degree. C. to minus 55.degree. C. before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.

Abstract: A pharmaceutical suspension of titanium dioxide for use in admixing with gelatin solutions for the manufacture of empty opaque gelatin capsules is provided which comprises: titanium dioxide, glycerin, sodium lauryl sulfate, simethicone, sodium citrate and water. A process is also provided which entails the requirement for adding the sodium citrate as the final ingredient in the suspension.

Abstract: Novel Mono- and di-basic aluminum salts of 2-(3-phenoxyphenyl)-and 2-(3-phenylthiophenyl)alkanoic acids provide tasteless and practically water insoluble forms of said alkanoic acids, which have anti-inflammatory activity in mammals, for formulating pharmaceutical suspensions.