Abstract: This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate salts. More particularly, it concerns orotate salts of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. The orotate salts are equally efficacious in inhibiting the SCCAKI-1 kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HCl suggests a reduction in toxicity induced by free radical generation by the anthracyclines.

Abstract: An ergonomically constructed dynamic bra includes smart combo cups designed with multilayered materials, a modern neckline silhouette, supporting armhole and a cut-out tear drop area to achieve a soft and quiet bust point. A sling is built into the cup for breast support, to construct different ergonomic, bra designs, including i) a semi-demi ergonomic bra design with or without straps, with a plunging neckline and including at the sides telescope boning, support frame and back strap ending in a soft-seal and cushioned back fastener, ii)—a full coverage ergonomic bra designed as the semi-demi ergonomic bra including a pair of pressure releasing cushioned front straps, and iii) a cross-over strap bra design including pressure releasing cushioned front straps designed to cross-over in -the back and fastened to the opposite side of a back frame. The ergonomic bra is constructed to facilitate interaction between the breasts and the body.

Abstract: The present invention relates generally to the method of increasing the oral bioavailability, reducing chemotherapy induced toxicity and side effects, and improving the effectiveness of pharmaceutical agents that are poorly absorbed from the gastrointestinal tract. Specifically, the invention relates to poorly absorbed pharmaceutical drugs and converting them to orotate salts. The orotate salts of the drugs can be dosed at lower doses to provide the efficacy benefits of a higher dose, while reducing the drugs' toxic effects at lower doses. Additionally, the orotate salts of pharmaceutical agents have better clearance and reduce the potential for drug-induced hepatic toxicity. Therefore, an especially useful formulation of the orotate salt of the pharmaceutical agent can provide rapid and consistent action using a lower dose while reducing drug interactions and side-effects.

Abstract: The present invention is directed to compositions of fetal hematopoietic stem and progenitor cells and stromal (mesencymal) cells derived from second trimester (16-20 weeks gestation) miscarriages, that are isolated, processed and cryopreserved, and the therapeutic uses of such stem and progenitor cells upon application. Such compositions may be useful for hematopoietic reconstitution and/or replacement in patients with various diseases and metabolic disorders. The invention also relates to methods for collecting, isolating, processing and cryopreserving of the fetal stem and progenitor cells of the invention. Importantly, the invention meets an urgent need in regenerative medicine while at the same time ensures utility of the product compositions because it utilizes fetal materials from second trimester (16-20 weeks of gestation) spontaneously lost pregnancies which are free of moral or ethical burdens.

Abstract: Method and composition of Carboxyamidotriazole orotate for treating age-related macular degeneration and other angiogenesis-dependent diseases.

Abstract: This invention is in the field of chemical restructuring of antimetabolite agents known to have poor oral bioavailability and to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the methotrexate and trimetrexate, that are found to improve the oral bioavailability and clearance compared with their respective forms—methotrexate and trimetrexate, currently in use.

Abstract: The present invention provides unique technology, systems and methods of cultivating different types of seaweeds, including, but not limited to, Porphyra (Nori), Laminaria, Undaria, Eucheuma, Gracillaria, Ulva, Sargassum, Codium, Cladophora, Ascophyllum, Palmaria, Furcellaria, Fucus or Enteromorpha, in land-based seawater ponds having a climatically suitable and nutrient controlled environment. These land-based ponds may be built in any part of the world with structural engineering and architectural modifications. The land based units for cultivation of seaweeds comprise phycological laboratory facilities, U-shaped sleeves, to allow the maturation of the sporelings; growth tanks, U-shaped cultivation tanks, a plurality of small inoculation tanks aerated with air, and a harvesting unit.

Abstract: This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. There orotate derivatives are equally efficacious in inhibiting the SCCAKI-1 kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HCl suggests a reduction in toxicity induced by free radical generation by the anthrracyclines.

Abstract: A specimen collecting, processing and analytical assembly, designed for testing small volumes of body fluids, substances and secretions, said assembly comprising a one piece barrel assembly with a volumetrically graduated capillary tube having an open end, and optionally coated internally with an anticoagulant, a stabilizer or a preservative. The barrel assembly includes a filter membrane fitted above the capillary end at the junction of the barrel assembly and the capillary tube, a support means at the barrel's second open end, and an analytical testing means disposed there between. The invention also provides a sealed vial containing an analytical testing reagent, the vial being substantially airtight and sealed with a pierceable material, a first tip cap for closing the open end of the capillary tube, a second cap to close sealably the second open end of the barrel container and a lancet to induce capillary skin punctures.

Abstract: This invention discloses circularly knit undergarments, said under garments having an anterior tummy region, a posterior stretching from the waist to the gluteal region, and two outer-regions corresponding to the outer thigh region, each of said regions includes knit-in support panels to minimize appearance of undesirable bulges. The posterior region further includes a plurality of derriere cups to slim and shape the lower half of the body to a younger tone and to provide a natural appearance to the derriere, hips and tummy. In a preferred embodiment the body of the undergarment is made with material that is seamlessly woven, for example, light weight micro fiber nylon or LYCRA spandex, and includes a gusset that is made of cotton and micro fiber nylon to prevent moisture build up between the legs. The under garments are finished in ribbing located at their terminal ends.

Abstract: The present invention relates generally to compression devices and, more particularly to a method using air flow to close the exhaust valve in each sleeve, allows air to fill the sleeve to a pretuned pressure, and finally deflating the sleeve by letting the air flow through the outlet valve. This creates a pressure gradient and a pneumatic cycle means that facilitates the massaging movement on the limb towards direction of the heart. The magnetic force in valves is uniquely adapted for controlling low-pressure compression. A magnetically adjustable valve is adapted for use in a compression device to control and regulate low to very low pressures and comprising of a movable magnetic part and a metal part, defining an air gap there between.

Abstract: The present invention relates generally to the field of generating genetically modified C57 mice. More particularly, the present invention pertains to 1) blastocyst-derived mouse embryonic stem cell (ES) cell lines including, but not limited to, the IC1, IC2, IAC1, IAC2, IAC3, IAC4, IAC5, IAC6, IAC7 or IAC8 ES cell line, 2) to efficient methods of making genetically modified C57 mice by introducing the modified C57 ES cells into the mouse blastocysts of either the same mouse strain and/or color of albino C57 strain, or other C57 strain, to generate genetically modified novel, useful and hereto unknown models of C57 mice, and to methods for identifying the chimerism of chimeras which can be not known by coat color.

Abstract: The present invention provides unique technology, systems and methods of cultivating different types of seaweeds, including, but not limited to, Porphyra (Nori), Laminaria, Undaria, Eucheuma, Gracillaria, Ulva, Sargassum, Codium, Cladophora, Ascophyllum, Palmaria, Furcellaria, Fucus or Enteromorpha, in land-based seawater ponds having a climatically suitable and nutrient controlled environment. These land-based ponds may be built in any part of the world with structural engineering and architectural modifications. The invention provides methods of designing different stages of growth, and defining the special conditions to optimize each of the different stages in controlled environments. The technology includes techniques of enriching the seaweeds with desired nutrients and ingredients for the production of high quality products that are free of marine pollutants, in addition to generating maximum yields under optimum, clean, temperature controlled and stable environmental conditions.

Abstract: This invention provides women's apparel including camisoles, tankinis or dresses, each having a unique and improved maternity and/or nursing breast support and enables the wearer to comfortably unsecure and secure a flap on a bra cup upon completion of nursing. The main inventive feature is a dynamic non-continuous or hanging bra support system made with a plurality of fabric members triangular in shape to allow a sizeable opening in each brassiere cup. The fabric members in each cup are joined at the upper end and create vertically oriented openings for maximum breast exposure that allow access to the breast and at the same time leave room for expansion of the breasts. The upper edges of the triangular cups are diagonally oriented, and the cups are attached only partially, at the lower portion to narrow regions of a stretchable band and/or laterally, to the side, thus providing flexibility, support and comfort for the wearer.

Abstract: The CHAOS holistic game of this invention comprises an N sided dice with N distinct and different educational graphics one for each side and a plurality of portable bases equal to (P?1)×N where P is the number of players. In this holistic total immersion game the players constitute the game pieces. It can be played indoors as well outdoors and is educational and entertaining both for children and adults. It engages, challenges, involves and benefits body mind and spirit of each player. Almost any educational subject can be taught through this game as the medium of instruction in a fun loving way.

Abstract: The present invention describes novel, cost-effective and rapid processes suitable for recycling and degradation of specially designed plastics, which are instantly degradable synthetic polymeric plastics having the characteristics and properties of conventional forms of plastics. These novel plastic products are made from a variety of compositions of polymers and their compatible nontoxic modifiers. The resulting novel instant degradable plastic products retain latent solubility properties which are triggered upon mild chemical processes of the present invention, thus enabling cost effective and facile recycling of plastic refuge.

Abstract: This invention provides women's apparel having a unique and improved maternity and/or nursing breast support and enables the wearer to comfortably unsecure and secure a flap on a bra cup upon completion of nursing. The main inventive feature is a dynamic non-continuous or hanging bra support system made with a plurality of fabric members triangular in shape to allow a sizeable opening in each brassiere cup. The fabric members in each cup are joined at the upper end and create vertically oriented openings for maximum breast exposure that allow access to the breast and at the same time leave room for expansion of the breasts. The upper edges of the triangular cups are diagonally oriented, and the cups are attached only partially, at the lower portion to narrow regions of a stretchable band and/or laterally, to the side, thus providing flexibility, support and comfort for the wearer.

Abstract: The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR complex in the prevention and/or treatment of thrombolytic disorders. The invention further relates to combination compositions and/or therapy regimens, comprising the cross-linked scuPA/suPAR complex or tcuPA/suPAR and one or more currently used plasminogen activators to achieve improved therapeutic efficacy and/or reduce side effects.

Abstract: A device for the treatment of objects using an effective amount of ozone, the device comprising at least two sealed treatment chambers into which a person inserts at least one object to be treated, each treatment chamber being hermetically sealed by a sealing means to provide a complete seal, a distribution means for delivering the ozone-oxygen to each of the treatment chambers, a control system being designed to produce a static mode operation wherein there is no ozone flow into or out of the treatment chamber except during testing periods when a negative pressure is produced in each treatment chamber. The inventions also pertains to an improved device for treating wound, ulcers, burns, skin and immune system disorders, thrombotic diseases, and disorders of blood platelets, diabetes or peripheral vascular diseases.