Abstract: A time-of-flight mass spectrometer includes a pulsed ion source that generates a pulse of ions from a sample to be analyzed. An ion lens focuses the pulse of ions into an ion beam. An ion deflector deflects the ion beam into a deflected ion beam path. An ion mirror is positioned in the deflected ion beam path so that a plane of constant ion flight time is parallel to an input surface of the ion mirror. The ion mirror decelerates and then accelerates ions so that ions of like mass and like charge exit the ion mirror in a reflected ion beam and reach an ion detector at substantially the same time. An ion detector is positioned in the path of the reflected ion beam so that a plane of constant ion flight time is substantially parallel to an input surface of the ion detector. The ion detector detects a time-of-flight of ions from the pulsed ion source to the ion detector that is substantially independent of a path traveled.

Abstract: The invention comprises apparatus and methods for rapidly and accurately determining mass-to-charge ratios of molecular ions produced by a pulsed ionization source, and for fragmenting all of the molecular ions produced and rapidly and accurately determining the intensities and mass-to-charge ratios of the fragments produced from each molecular ion.

Abstract: A strongly-ionized plasma generator includes a chamber for confining a feed gas. An anode is positioned inside the chamber. A cathode assembly is positioned adjacent to the anode inside the chamber. An output of a pulsed power supply is electrically connected between the anode and the cathode assembly. The pulsed power supply comprising solid state switches that are controlled by micropulses generated by drivers. At least one of a pulse width and a duty cycle of the micropulses is varied so that the power supply generates a multi-step voltage waveform at the output having a low-power stage including a peak voltage and a rise time that is sufficient to generate a plasma from the feed gas and a transient stage including a peak voltage and a rise time that is sufficient to generate a more strongly-ionized plasma.

Abstract: The TOF mass spectrometer disclosed places an even number of ion mirrors in close proximity to a MALDI ion source and a field-free drift space between the exit from the mirrors and an ion detector. This “reversed geometry” configuration may be distinguished from a conventional reflecting TOF analyzer employing a single ion mirror where a large fraction of the total drift space is located between the ion source and the mirror.

Abstract: An optical vector modulator includes an information generator that generates a plurality of N-bit streams at an output where each of the plurality of N-bit streams represents a desired modulation point in a signaling constellation. A memory look-up table having an N-bit address input retrieves a first and a second stored value that corresponds to the N-bit address input, where each of the first and the second stored value represent a respective one of a first and a second modulation vector of a desired modulation point in the signaling constellation. A first and a second digital-to-analog converter generates first and second analog signals, respectively, that correspond to respective ones of the first and second modulation vectors of the desired modulation points in the signaling constellation. A dual-drive interferometric modulator modulates the first and the second analog signals on the optical beam to obtain the desired modulation points in the signaling constellation.

Abstract: Methods and apparatus for generating a strongly-ionized plasma are described. An apparatus for generating a strongly-ionized plasma according to the present invention includes an anode and a cathode that is positioned adjacent to the anode to form a gap there between. An ionization source generates a weakly-ionized plasma proximate to the cathode. A power supply produces an electric field in the gap between the anode and the cathode. The electric field generates excited atoms in the weakly-ionized plasma and generates secondary electrons from the cathode. The secondary electrons ionize the excited atoms, thereby creating the strongly-ionized plasma.

Abstract: In an optical communications link, an optical system including: at least a first input port for delivering an optical signal travelling in the communications link, the optical signal including a plurality of wavelength channels, the channels being utilized for carrying optical information over an optical data link; a dispersive element for spatially separating the wavelength channels; an active optical-phase element; and a plurality of optical manipulation elements for directing the spatially separated channels between the dispersive element and the optical phase element wherein, the optical phase element independently modifies the phase of predetermined ones of the wavelength channel in a predetermined and decoupled manner for substantial compensation of signal degradation effects imparted to the wavelength channels by said communications link.

Abstract: Many applications in the study of metabolics and proteomics require measurements on peptides and small molecules with high resolving power and mass accuracy. These are often present in complex mixtures and sensitivity over a relatively broad mass range, speed of analysis, reliability, and ease of use are very important. The present invention is a time-of-flight mass spectrometer providing optimum performance for these and similar applications.

Abstract: A climbing wall includes a frame with a guiding channel. A plurality of panels slide in the guiding channel and present a climbing surface with protrusions for climbing. The frame includes a section where the plurality of panels pivot out of the guiding channel when loaded with a climber's weight. An actuator is engaged by torque generated when one of the plurality of panels pivots out of the guiding channel. A braking mechanism is coupled to the actuator. The braking mechanism applies an arresting force to the plurality of panels when the actuator is engaged.

Abstract: The present invention provides a time-of-flight (TOF) mass analyzer. The system includes an analyzer vacuum housing isolated from the evacuated ion source vacuum housing by a gate valve maintained at ground potential. A pulsed ion source is located within the ion source housing, and the gate valve is located in a first field-free region at ground potential. A second field-free drift space within the analyzer housing is biased at high voltage with opposite polarity to the voltage applied to the pulsed ion source. Novel ion detectors are provided with input surfaces in electrical contact with the second field-free drift space with output connected to an external digitizer at ground potential.

Abstract: The present invention is directed to ion source and vacuum housings for use in MALDI-TOF mass spectrometry which operates with any type of mass analyzer including linear, reflector, or tandem TOF-TOF instruments. By removing the requirement for the vacuum lock, the present invention allows operation of the ion source vacuum chamber at a pressure at least two orders of magnitude higher than conventional instruments. The present invention also requires only a single valve that isolates the ion source vacuum housing from the TOF analyzer vacuum housing. This is a significant improvement over vacuum locks in the art where the valve opening must be sufficiently large to allow the sample plate to pass through.

Abstract: A signal interface comprises a non-reciprocal device having a first port that accepts a first electrical signal and a second port that accepts a second electrical signal. The non-reciprocal device passes the second electrical signal through the first port without a phase shift and passes the first electrical signal through the second port with a 180 degrees phase shift. An optical modulator receives an optical signal at an optical input port, a second signal at a first and a second electrical input port, the first electrical signal at a third electrical input port, and the phase-shifted first electrical signal from the non-reciprocal device at a fourth electrical input port. The optical modulator transmits the second electrical signal to the first port of the non-reciprocal device without a phase shift and modulates the first electrical signal on the optical signal and providing the modulated optical signal at an optical output port of the optical modulator.

Abstract: An integrated laser device includes a pre-distortion circuit. The pre-distortion circuit receives an electrical modulation signal and generates a pre-distorted modulation signal. A laser is integral with the pre-distortion circuit. The laser includes an electrical modulation input that is connected to the output of the pre-distortion circuit. The laser modulates an optical signal with the pre-distorted modulation signal. The pre-distorted modulation signal causes at least some vector cancellation of distortion signals generated when the laser modulates the optical signal.

Abstract: A bi-directional signal interface includes a first waveguide that propagates a first traveling wave. The first waveguide has one end that is coupled to a RF input port that receives a RF transmission signal and another end that is coupled to a RF bi-directional port that receives a RF reception signal and that transmits the RF transmission signal. A second waveguide is positioned proximate to the first waveguide. The second waveguide has one end that is coupled to an output port that passes the received RF reception signal. A non-reciprocal coupler couples fields from the first waveguide to the second waveguide so that the RF reception signal from the bi-directional port couples from the first waveguide to the second waveguide in a substantially non-reciprocal manner and then passes through the output port, and the RF transmission signal from the RF input port passes through the first waveguide to the RF bi-directional port.

Abstract: In various aspects, the present teachings provide systems and methods for reducing chemical noise in a mass spectrometry instrument that use a neutral chemical reagent and one or more mass filters to reduce interfering chemical background ion signals that are generated by ionization sources of mass spectrometers. In various embodiments, the neutral chemical reagent belongs to the class of organic chemical species containing a disulfide functionality.

Abstract: A construction rule tape and a construction layout tool include a non-metallic material that conforms to a construction surface. The non-metallic material includes graduations that correspond to a combined thickness of at least one of a gap and an adhesive material used to secure the construction unit to other construction units and to the construction surface.

Abstract: In various aspects, ion sources, mass spectrometer systems, and a power supply circuit coupled to a feedback circuit are provided. A power supply is provided that includes at least the power supply circuit and is operable to transfer charge to a load. The feedback circuit is responsive to a DC component of an output voltage supplied by the power supply in a first feedback loop and an AC component of the output voltage in a second feedback loop to produce a feedback signal representative of at least one of: a value of the output voltage before a charge transfer from a capacitor of the power supply to a load; the value of the output voltage during the charge transfer from the capacitor of the power supply to the load; or the value of the output voltage after the charge transfer from the capacitor of the power supply to the load.

Abstract: An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

Abstract: In an optical system including an optical input port for projecting an input optical signal onto an optical phased matrix array, an optical phased matrix array including a plurality of individually addressable pixels thereon, each said pixel being drivable within a prescribed range of levels, and an optical output port for collecting a predetermined fraction of said optical signal received from said optical phased matrix array; a method of compensating for phase distortions including the steps of: (a) determining a plurality of transfer functions relating said level of each said pixel to the phase variation each said pixel introduces to light from said input optical signal which is incident thereon; and (b) controlling the level of selected ones of said pixels in accordance with a corresponding transfer function such that said fractional signal received at said output port is modified in phase to substantially compensate for optical phase distortions arising from said optical phased matrix array.

Abstract: In an optical communications link, an optical system including: at least a first input port for delivering an optical signal travelling in the communications link, the optical signal including a plurality of wavelength channels, the channels being utilized for carrying optical information over an optical data link; a dispersive element for spatially separating the wavelength channels; an active optical-phase element; and a plurality of optical manipulation elements for directing the spatially separated channels between the dispersive element and the optical phase element wherein, the optical phase element independently modifies the phase of predetermined ones of the wavelength channel in a predetermined and decoupled manner for substantial compensation of signal degradation effects imparted to the wavelength channels by said communications link.