Patents Represented by Attorney Raymond M. Speer

Find this attorney in the Justia Lawyer Directory

  • 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
    Patent number: 5236899
    Abstract: Cyclosporin analogs containing a MeAla or MeAbu residue at the 6-position of the cyclic undecapeptide have been discovered to sensitize multidrug resistant cells to certain chemotherapeutic agents. These cyclosporin analogs have also been shown to increase the sensitivity of cells already susceptible to the chemotherapeutic agents. In addition, these cyclosporin A analogs lack the nephrotoxic and immunosuppressive activity of cyclosporin A.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: August 17, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Philippe L. Durette
  • Process for phosphate ester compounds of certain cyclohexapeptides
    Patent number: 5233023
    Abstract: A facile process for preparing a compound of the formula ##STR1## or a salt thereof, wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, X.sup.1 Y and Z are as defined in the specification, by direct phosphorylation of the corresponding phenolic compound with tetrabenzyl pyrophosphate in the presence of lithium hydroxide is described.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: August 3, 1993
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Mallory F. Loewe, David J. Mathre
  • Antimigraine alkyl indole
    Patent number: 5233050
    Abstract: An alkyl indole of the formula: ##STR1## is a useful antimigraine agent.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: August 3, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Robert P. Borris, Yiu-Kuen T. Lam, Lawrence Koupal
  • Antibiotic eicosenoic acids
    Patent number: 5233062
    Abstract: New antibiotic eicosenoic acids and a method of producing it are described. The acids have been found to have antifungal properties.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: August 3, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Wendy S. Horn, Myra B. Kurtz, Jerrold M. Liesch, Jack L. Smith, Isabel Martin, Francisca Vicente
  • Synergistic combination of sodium silicate and ortho-phosphate for controlling carbon steel corrosion
    Patent number: 5232629
    Abstract: An orthophosphate salt and sodium silicate, when used in a 3:1 ratio by weight, and in a concentration of 0.1 to 100 mg/L, are found to have a synergistic effect in controlling the corrosion of carbon steel in an aqueous system, e.g., a municipal water supply system. The synergistic combination is also useful in reducing lead solubility and leaching, and in stabilizing soluble iron and manganese and their reaction products.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: August 3, 1993
    Assignee: Calgon Corporation
    Inventor: Bennett P. Boffardi
  • Substituted azetidinones as anti-inflammatory and antidegenerative agents
    Patent number: 5229381
    Abstract: New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Conrad P. Dorn, Paul E. Finke, William K. Hagmann, Malcolm MacCoss, Shrenik K. Shah
  • .beta.-lactams useful in determining the amount of elastase in a clinical sample
    Patent number: 5229510
    Abstract: Disclosed are .beta.-lactams of formula I ##STR1## wherein X is a chromogenic or fluorogenic substituted aryl or heteroaryl, which are specific inhibitors of Human leukocyte elastase (HLE). Upon contact with HLE these compounds are cleaved to form a chromogenic or fluorogenic species which may be readily measured by the assay disclosed herein. The assay thus provides a means for direct measurement of the amount of active HLE in a body fluid or other sample.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Wilson B. Knight, William K. Hagmann, Alan L. Maycock
  • Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
    Patent number: 5229274
    Abstract: A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase enzyme of a recited sequence, the DNA encoding said enzyme, and expression thereof in a suitable host, e.g., Bacillus species under the control of a suitable promoter.
    Type: Grant
    Filed: January 13, 1992
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark S. Crawford, David B. Finkelstein, John A. Rambosek
  • Assay for evaluating inhibition of PMN elastase by N-substituted azetidinones
    Patent number: 5229267
    Abstract: N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with the enzyme. In the assay disclosed herein, the inhibitor-enzyme complex is advantageously hydrolyzed and specific product(s) of the hydrolysis are measured. The assays are useful in a clinical setting, for determining appropriate dosage and assessing the effectiveness of treatment.
    Type: Grant
    Filed: August 26, 1991
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William A. Hanlon, John L. Humes, Wilson B. Knight, Richard A. Mumford
  • Cyclic hexapeptide compounds
    Patent number: 5229363
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxyl; R.sub.2 is hydrogen; hydroxyl or methyl, R.sub.3 is hydrogen or hydroxyl; R.sub.4 is C.sub.5 -C.sub.23 alkyl, C.sub.5 -C.sub.23 alkenyl, aryl or substituted aryl; R.sub.5 is --CH.sub.2 OH, --CH(CH.sub.3)OH, --CH(CH.sub.2 CONH.sub.2)OH; R.sub.6 is --CH.sub.2 OH or --CH(CH.sub.3)OH; R is --CH.sub.2 OH or --CH(CH.sub.3)OH; provided that when R.sub.4 is --(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)C.sub.2 H.sub.5, R.sub.5 is --CH.sub.2 OH or --CH(CH.sub.3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.
    Type: Grant
    Filed: February 19, 1991
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, James V. Heck, Robert A. Zambias
  • Immunosuppressive fluorinated cyclosporin analogs
    Patent number: 5227467
    Abstract: New immunosuppressive cyclosporin analogs are disclosed having one or more fluorinated amino acids. These analogs may also have a "C-9 amino acid" wherein the double bond is replaced by a heteroatom such as sulfur or oxygen.
    Type: Grant
    Filed: April 29, 1991
    Date of Patent: July 13, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Arsenio A. Pessolano, Janos Kollonitsch
  • Controlling deposits in the calcination of fluxed iron ore pellets
    Patent number: 5221320
    Abstract: A stable aqueous suspension of a mixture of magnesium hydroxide and copper oxychloride, together with a suspending agent, is used to reduce deposits in kilns or furnaces used to make iron ore agglomerates, known as pellets, during a calcination process in which iron ore fines mixed with fluxing materials having a phosphate content of less than 1% by weight of the total flux and iron ore weight, are heated to from about 900.degree. to about 1400.degree. C. in order to create the hardened iron ore pellets, called flux pellets, one of the chief raw materials in steel making.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: June 22, 1993
    Assignee: Calgon Corporation
    Inventor: Rabindra K. Sinha
  • Antifungal agent
    Patent number: 5219985
    Abstract: A compound having the formula ##STR1## and a method of obtaining said compound is described. The compound has antifungal properties.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: June 15, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Brian R. Petuch, Byron H. Arison
  • 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
    Patent number: 5215980
    Abstract: Compounds of the formula: ##STR1## where R is hydrogen, C.sub.1 -C.sub.10 alkylcarbonyl, or C.sub.1 -C.sub.10 alkyl which can be substituted by amino or cyano, R.sup.1 and R.sup.2 are independently hydrogen, hydroxyl or amino, and the pharmaceutically aceptable salts and esters thereof. Pharmaceutical compositions and methods of their use are also provided for.
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: June 1, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Anthony B. Jones
  • 2-benzocoumarinyl-carbapenems
    Patent number: 5216146
    Abstract: Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: June 1, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Mark L. Greenlee, Thomas A. Rano
  • 2-phenanthridonyl-carbapenems
    Patent number: 5214139
    Abstract: Carbapenems of the formula ##STR1## wherein: P' is a removable protecting group for hydroxy; andM is a removable protecting group for carboxy;are useful intermediates for carbapenem antibiotics.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: May 25, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Thomas A. Rano, Mark L. Greenlee
  • Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
    Patent number: 5214130
    Abstract: New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala].sup.8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: May 25, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, David Taub, Robert T. Goegelman
  • 2-biphenyl carbapenem intermediates
    Patent number: 5208329
    Abstract: Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: May 4, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. Dininno, Thomas N. Salzmann
  • 2-phenanthridonyl carbapenem intermediates
    Patent number: 5208328
    Abstract: Carbapenems of the formula ##STR1## wherein: P' is a removable protecting group for hydroxy; and M is a removable protecting group for carboxy; are useful intermediates for carbapenem antibiotics.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: May 4, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Mark L. Greenlee, Thomas A. Rano
  • 2-(1,2,3-triazolylsubstituted)phenyl carbapenem antibacterial agents
    Patent number: 5208229
    Abstract: Carbapenems having the formula: ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: May 4, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Susan M. Schmitt