Patents Represented by Attorney Raymond S. Parker

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  • Lupane derivatives, their preparation and the pharmaceutical compositions which contain them
    Patent number: 5468888
    Abstract: The present invention relates to new lupane dervivatives of the general formula: ##STR1## to their salts, to their preparation and to the pharmaceutical compositions which contain them.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: November 21, 1995
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Romaine Bouboutou, Norbert Dereu, Michel Evers, Jean-Christophe Gueguen, Claude James, Christele Poujade, Daniel Reisdorf, Yves Ribeill, Francoise Soler
  • Substituted naphthylene compounds exhibiting selective leukotriene B.sub.4 antagonist activity
    Patent number: 5468898
    Abstract: This invention relates to bicyclic aryl compounds having selective LTB.sub.4 antagonist properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a lipophilic substituent, and to methods for the treatment of disorders which result from LTB.sub.4 activity and pharmaceutical compositions including such compounds.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: November 21, 1995
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Fu-Chih Huang, Wan K. Chan, Charles A. Sutherland, Robert A. Galemmo, Jr.
  • Aliphatic amino bis-aryl squalene synthase inhibitors
    Patent number: 5455260
    Abstract: This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: October 3, 1995
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Robert A. Groneberg, John R. Regan, Kent W. Neuenschwander, Anthony C. Scotese
  • Cycloalkyl amine bis-aryl squalene synthase inhibitors
    Patent number: 5451596
    Abstract: This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: December 29, 1992
    Date of Patent: September 19, 1995
    Assignee: Rhone Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John W. Ullrich, Terence J. Kiesow, Kent W. Neuenschwander, Keith S. Learn, William P. Dankulich, Anthony C. Scotese
  • Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
    Patent number: 5409930
    Abstract: This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: April 25, 1995
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Alfred P. Spada, Martin P. Maquire, Paul E. Persons, Michael R. Myers
  • Oral spiramycin formulations and method for preparing same
    Patent number: 5403594
    Abstract: Formulations of spiramycin granules may be conducted by preparing a solution of albumin in the presence of an antifoaming agent, separately preparing a suspension of spiramycin in the presence of an antifoaming agent, granulating and drying a mixture of one or more sugars and water, mixing the albumin solution and spiramycin suspension with heating to coagulate the albumin, evaporating the solvents to obtain spiramycin granules, and mixing the sugar granules and spiramycin granules. Oral spiramycin formulations prepared according to this method are also disclosed.
    Type: Grant
    Filed: July 16, 1993
    Date of Patent: April 4, 1995
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Ana Calvo, Luis A. Del Rio, Manuel Esteban, Robert Rona
  • Oxazole derivatives, their preparation and pharmaceutical compositions containing them
    Patent number: 5403852
    Abstract: Oxazole derivatives of the formula ##STR1## wherein R and R' are each hydrogen or alkyl containing 1 or 2 carbon atoms, R.sub.1 and R.sub.2 are the same or different and represent hydrogen, halogen or straight- or branched-chain (C.sub.1-4) alkyloxy radicals, and n is 3-6; their salts their isomers and mixtures and their preparation method, are method are described. These derivatives display anti-inflammatory activity.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: April 4, 1995
    Assignee: Laboratoire Roger Bellon
    Inventors: Michel Barreau, Michel Kryvenko, Marc-Pierre Lavergne, Auguste Techer
  • Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors
    Patent number: 5395846
    Abstract: This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: March 7, 1995
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Robert L. Morris, Kent W. Neuenschwander, Keith S. Learn, Anthony C. Scotese
  • Oxathiane derivatives
    Patent number: 5389649
    Abstract: Oxathiane derivatives of formula ##STR1## in which R represents alkyl and A represents optionally substituted phenyl or a heteroaromatic group containing 1 or 2 nitrogen atoms optionally substituted by alkyl, alkoxy or halogen, and salts thereof possess pharmacological activity and are also useful in inhibiting head hair loss.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: February 14, 1995
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Iain M. McLay, Roger J. A. Walsh
  • Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
    Patent number: 5385912
    Abstract: This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.The compounds of this invention are described by the formula ##STR1## where Ar I is phenylene or naphthylene, Ar II is phenyl or naphthyl and A is 1-azabicyclo[2.2.2]octan-3-yl.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: January 31, 1995
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Kent Neuenschwander, Dilip Amin, Anthony C. Scotese, Robert L. Morris
  • Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B.sub.4 antagonist activity, their preparation and use in pharmaceutical compositions
    Patent number: 5366982
    Abstract: This invention relates to compounds having selective LTB.sub.4 antagonist properties, compositions comprising said compounds and methods for the treatment of disorders involving LTB.sub.4 agonist-mediated activity utilizing said compositions wherein the compounds are described by the general formula ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: November 22, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Norbert Dereu, Wolfram Hendel, Richard Labaudiniere
  • Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid
    Patent number: 5347039
    Abstract: This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one with a borohydride in the presence of titanium derivative.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: September 13, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Patrick Leon, Xavier Radisson, Viviane Massonneau
  • Thioformamide derivatives
    Patent number: 5342848
    Abstract: Thioformamide derivatives of formula (I): ##STR1## wherein R represents alkyl; A represents optionally substituted pyrid-4-yl; Y represents ethylene or methylene or a direct bond and X represents an optionally substituted phenyl, pyridyl, furyl or thienyl group or optionally substituted alkyl, alkenyl or cycloalkyl, and salts thereof possessing useful pharmacological properties.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: August 30, 1994
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Terance W. Hart, Bernard Y. J. Vacher
  • Azacyclic bisphosphonates as anticholesterolemic agents
    Patent number: 5317015
    Abstract: This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: May 31, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John W. Ullrich, Raymond D. Youssefyeh, Daniel L. Cheney, Christopher J. Burns
  • Pyran derivatives
    Patent number: 5304660
    Abstract: The invention provides compounds of formula (I) wherein R.sup.1 represents alkyl, R.sup.2 represents an acid-labile protecting group and X.sup.1 represents a halogen atom, which are useful in the synthesis of mevalonic acid derivatives.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: April 19, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Stanley F. Clark, Ronald H. Jones, Christopher G. Newton
  • 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides
    Patent number: 5288731
    Abstract: Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT.sub.3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D.sub.2 receptor binding affinity, therapeutic compositions and methods of treatment of disorders which result from 5-HT.sub.3 activity using said compounds. Processes for their preparation and the preparation of their intermediates are also disclosed.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: February 22, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John E. Airey, Matthew R. Powers, Walter Rodriguez, Raymond D. Youssefyeh
  • Process for preparing chiral dibenzofurans via intramolecular heck reaction
    Patent number: 5278323
    Abstract: The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by an intramolecular Heck stereospecific synthesis substantially free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydro-1-benzoxocin-10-carboxylic.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 11, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Matthew R. Powers
  • Hydrazine derivatives
    Patent number: 5276046
    Abstract: A hydrazine derivative of formula (I), ##STR1## wherein A represents an optionally substituted phenyl, naphthyl or heteroaromatic group containing one or two nitrogen atoms, and R.sup.1 represents hydrogen, optionally substituted alkyl, or optionally substituted benzyl, phenethyl, or 1-naphthylmethyl, or pyrid-3-ylmethyl group, and salts thereof, possess useful pharmaceutical properties.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: January 4, 1994
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Terance W. Hart, Brian W. Sharp, Roger J. A. Walsh
  • Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors
    Patent number: 5258544
    Abstract: Disclosed is a process for the preparation of 2-aryl-1-cyclohexene-1-carboxaldehydes from 1-arylcyclohexenes which are intermediates for trans-6-[(2-arylsubstituted cycloalkenyl and substituted cycloalkyl)alkenyl and alkyl]-3,4,5,6-tetrahydro-2H-pyran-2-ones.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: November 2, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Laurence W. Reilly, Jr., Ching T. Tsuei, Walter Rodriquez, Thomas Goetzen
  • Process for preparing dibenzofurans via catalytic heteroannulation
    Patent number: H1406
    Abstract: The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by a stereospecific catalytic heteroannulation synthesis free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydro-1-benzoxocin-10-carboxylic.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 3, 1995
    Assignee: Rhone Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Matthew R. Powers