Abstract: Disclosed are intermediates and a process of making an anticholesterolemic compound of the formula ##STR1## the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
June 23, 1992
Date of Patent:
September 28, 1993
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Abstract: Compounds of formula: ##STR1## in which R.sub.1 represents a polyfluoroalkoxy radical and R.sub.2 represents an alkylthio, alkylsulphinyl or alkylsulphonyl radical, their salts, their preparation and the medicaments containing them.
Type:
Grant
Filed:
January 29, 1991
Date of Patent:
August 31, 1993
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Abstract: This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one and a sterically hindered dialkylated borane to form a complex at about -50.degree. C. to about 0.degree. C., and reducing the complex with hydride at about -25.degree. C. to about 50.degree. C.
Type:
Grant
Filed:
September 2, 1992
Date of Patent:
June 8, 1993
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Abstract: Disclosed are methods of inactivating pyrogen producing organisms and pyrogenic substances in immobilized solid matrices which are used in the production and/or purification of biomedical and pharmaceutical products and materials by contacting the solid matrices with pyrogen inactivating solutions.
Type:
Grant
Filed:
November 18, 1991
Date of Patent:
April 13, 1993
Assignee:
Armour Pharmaceutical Company
Inventors:
Robert Kruse, Sudhish Chandra, Fred Feldman
Abstract: Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.
Type:
Grant
Filed:
November 27, 1990
Date of Patent:
July 21, 1992
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Abstract: Disclosed are novel aryl-substituted benzocycloalkyl-derived 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## their corresponding dihydroxy acids, and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
January 5, 1990
Date of Patent:
May 19, 1992
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Abstract: Cyclodextrins can be coupled to biorecognition molecules such as antibodies. The cyclodextrins so coupled provide a cavity or complexation zone into which active agents such as labels, drugs and the like may be incorporated. The active agent forms a noncovalently bonded inclusion complex within the cavity of the cyclodextrin. It remains associated with the cyclodextrin and the coupled biorecognition molecule and thus can be delivered to the other half of the biospecific recognition pair. A process for producing these materials is also disclosed. The process includes the steps of activating a primary hydroxyl site on a cyclodextrin; linking a biorecognition molecule to the activated primary hydroxyl site on the cyclodextrin in either a direct covalent linkage or through a covalently linked spacer; and introducing a guest molecule (active agent) into the cavity of the derivatized cyclodextrin to form an inclusion complex.