Abstract: Antibiotic A21A is produced by cultivating Stneptomyces filipinesis under aerobic conditions.

Abstract: This case relates to a novel process for aiding in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a bed of activated alumina and a bed of activated carbon, respectively. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

Abstract: Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are isolated using liquid ion exchange systems.

Abstract: This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described utilizes a non-aqueous extraction system for purifying crude extracts of the novel compounds. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

Abstract: This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a high pressure liquid chromatographic system (HPLC) for the isolation and purification of the active compound. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

Abstract: This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described utilizes a column containing a hydroxyalkylated dextran gel as a step in the separation of the desired compounds. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

Abstract: This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a hydroxypropyl Sephadex column chromatographic step in the isolation of the compounds from broth. The compounds which are isolated and purified are described generically s C-076 and have significant parasiticidal activity.

Abstract: This invention relates to a gelled explosive and a method for its preparation. More specifically, the invention relates to a gelled explosive composition containing water, at least one member selected from the group of a polysaccharide colloid and synthetic polymer; water-soluble melamine resin and a water-soluble explosive salt.

Abstract: Fermentation broths or impure solutions containing Cephamycin C, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are isolated using liquid anion exchange systems.

Abstract: A water-soluble anionic graft copolymer of xanthan gum and polyacrylamide wherein at least part of the amide function is sulfomethylated.

Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.

Abstract: There is disclosed a new antibiotic A21A which is produced by cultivating the microorganism, Streptomyces filipinensis, in aqueous nutrient medium. The antibiotic has growth-improving activity.

Abstract: An antibiotic, designated FR-02A or efrotomycin, is obtained by culturing Streptomyces lactamdurans in a fermentation broth and extracting the whole broth with a water immiscible polar organic solvent to obtain the antibiotic FR-02A.

Abstract: N-(Sulfo-lower alkyl)amides of (3-trifluoromethylphenoxy)-(4-chlorophenyl)acetic acid which are useful in the treatment of atherosclerosis. The N-(sulfo-lower alkyl)amides of (3-trifluoromethylphenoxy) (4-chlorophenyl)-acetic acid are prepared by reacting a (3-trifluoromethylphenoxy) (4-chlorophenyl)acetyl halide with an amino-lower alkanesulfonic acid.

Abstract: 4-Cyanothiazole is prepared by the catalytic vapor phase ammoxidation of .DELTA.3-4-methylthiazoline or 4-methylthiazole, using as catalyst a novel composition comprising a slurried chromium cobalt molybdate. The process affords high selectivity in the production of 4-cyanothiazole.

Abstract: 4-Cyanothiazole is prepared by the catalytic vapor phase ammoxidation of 4-methylthiazole using a novel catalyst composition comprising a cobalt molybdate catalyst wetted with different levels of potassium hydroxide. The process affords high selectivity to the desired 4-cyanothiazole.

Abstract: An improved process for preparing the compound 7.beta.-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-car boxylic acid or its esters, from the compound 7.beta.-(D-5-amino-5-carboxyvaleramido)-3-carbamoyloxymethyl-7-methoxy-3-c ephem-4-carboxylic acid, by conducting the transacylation of the latter compound in the presence of commercially available alumino-silicate zeolites, also known as "molecular sieves." The process can be employed to prepare a cephalosporin with a desired 7-acylamido group from cephalosporins having a broad range of different 7-acylamido groups without having to isolate and purify a 7-amino intermediate. The final products have utility as broad spectrum antibiotics.

Abstract: Novel compounds of the following formula: ##STR1## wherein R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.- ; and -.sup.+ is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted lines indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.

Abstract: A fermentation process for preparing 7-methoxy substituted cephalosporins. The products are useful as antibiotics and exhibit activity against gram-negative and gram-positive bacteria.

Abstract: This invention relates to a new antibiotic agent which also possesses growth promoting activity. The antibiotic is isolated from the fermentation broth of Streptomyces lactamdurans by solvent extraction and designated Efrotomycin.