Patents Represented by Attorney, Agent or Law Firm Richard E. Brown
  • Method for lubricating articles
    Patent number: 5186972
    Abstract: In a method for lubricating articles, a liquid composition including a gelling agent dissolved in a lubricant is applied to the surface of an article and caused to gel on the article. Gelling may be induced by applying the liquid composition to an article at a temperature below the gelling temperature of the composition, or the article coated with the liquid composition may be cooled to induce gelling.
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: February 16, 1993
    Assignee: Becton, Dickinson and Company
    Inventors: Joel L. Williams, Thomas A. Shepard
  • Lubricated metal articles and assembly containing same
    Patent number: 5185006
    Abstract: A metal article has a coating of a noncuring polar lubricant. Preferred articles are of stainless steel and may be cutting devices such as needles, lancets and cannulas or sliding devices such as stylets and guidewires. Preferred noncuring polar lubricants are polysiloxanes terminated with a polar group. Particularly preferred lubricants are aminoalkyl or carboxyalkyl polysiloxanes. The lubricated metal article may be in a sliding relationship with a plastic article such as a catheter-guidewire or a catheter-cannula assembly. The plastic portion of the assembly may also include a lubricant.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: February 9, 1993
    Assignee: Becton, Dickinson and Company
    Inventors: Victor A. Williamitis, David E. Spielvogel
  • Stable iodophor in polyurethane foam
    Patent number: 5180061
    Abstract: A surgical scrub includes a polyurethane foam sponge impregnated with a composition which includes iodine, iodide and a nonionic surfactant in a polar vehicle. The scrub may be attached to a plastic handle and may be supplied along with other optional scrubbing items in a package wrapped in plastic film.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: January 19, 1993
    Assignee: Becton, Dickinson and Company
    Inventors: Mohammad A. Khan, Minh Q. Hoang
  • Method for immunoassay using lactoperoxidase, starch and iodine
    Patent number: 5166054
    Abstract: A method for immoassay includes a membrane coated with a capture antibody and starch. A solution suspected of containing an antigen is passed through the membrane. Antigen binds to the capture antibody. A conjugate of a detection antibody and lactoperoxidase is passed through the membrane to form a sandwich on the membrane. A substrate composition including peroxide and iodide is passed through. The lactoperoxidase catalyzes oxidation of iodide by the peroxide to give iodine which reacts with the starch to give a blue color. The invention includes a kit of materials for performing the assay of the invention.
    Type: Grant
    Filed: January 2, 1991
    Date of Patent: November 24, 1992
    Assignee: Becton, Dickinson and Company
    Inventor: Ali Naqui
  • Anti-infective and antithrombogenic medical articles and method for their preparation
    Patent number: 5165952
    Abstract: An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: November 24, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Donald D. Solomon, M. Parke Byron
  • Chlorhexidine composition useful in a surgical scrub
    Patent number: 5164107
    Abstract: A cleansing composition particularly useful as a surgical scrub includes chlorhexidine gluconate and a nonylphenoxypoly(ethyleneoxy)ethanol surfactant in an aqueous vehicle, and may contain other surfactants, thickeners, emollients, dyes, perfumes and the like.
    Type: Grant
    Filed: April 25, 1991
    Date of Patent: November 17, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Mohammad A. Khan, John F. Moellmer
  • Polyurethane and medical article therefrom
    Patent number: 5159050
    Abstract: A thermoplastic polyurethane has tertiary amino groups in the polymer chain. Protonation of the amino groups with an aqueous acid causes the polymer to absorb up to 1,000% by weight of water and swell. The protonated amino groups form a complex with an antithrombogenic agent to give an antithrombogenic polyurethane. The invention includes a shaped article of the polyurethane. The shaped article may be antithrombogenic.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: October 27, 1992
    Assignee: Becton, Dickinson and Company
    Inventor: Fidelis C. Onwumere
  • Biostable polyurethane
    Patent number: 5159051
    Abstract: A thermoplastic polyurethane having prolonged biostability has tertiary amino groups in the polymer chain. Protonation of the amino groups with an aqueous acid causes the polymer to absorb up to 1,700% by weight of water and swell. The protonated amino groups form a complex with an antithrombogenic agent to give an antithrombogenic polyurethane. The invention includes a shaped article of the polyurethane.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: October 27, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Fidelis C. Onwumere, Nancy L. Shields
  • Blood microsampling site preparation method
    Patent number: 5156611
    Abstract: A method for collecting blood while preserving the integrity of the blood sample is provided. The method includes the steps of applying a protective layer to the skin, lancing the skin through the protective layer, allowing blood from the subject to accumulate on the protective layer, and collecting a sample of the blood accumulated on the protective layer. The protective layer may be formed in situ or applied as a tape. In either case, the surface of the protective layer should be hydrophobic.
    Type: Grant
    Filed: February 5, 1990
    Date of Patent: October 20, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: John L. Haynes, George R. Titus
  • Method for making liquid crystalline tube having a point
    Patent number: 5151231
    Abstract: A catheter assembly includes a tubing portion and a needle portion, at least one of which is a thermoplastic liquid crystalline polymer. The tubing and needle may be integral or unitary. The invention includes a method to make the assembly in which a melt of the liquid crystalline polymer is shear thinned by passing through an orifice such as an extrusion die to make tubing. The shear thinned melt may be directed into a mold having a point to make a liquid crystalline needle.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: September 29, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: James M. Lambert, Donald D. Solomon
  • Substrate composition and method for solid phase urease immunoassay
    Patent number: 5139934
    Abstract: A method for enzyme immunoassay of a ligand includes urease as a label. A bound fraction of ligand and antiligand conjugated to urease is formed on a solid support. The urease component of the bound fraction is contacted with a substrate composition for urease which includes a compound converted to ammonia by the urease, a tetrazolium salt and a pH dependent reducing agent which reduces the tetrazolium salt when the pH of the assay medium has been raised by the ammonia. The tetrazolium salt is reduced to a colored insoluble formazan which precipitates as a detectable spot on the support. The invention includes the substrate composition and a kit of materials for performing the assay.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: August 18, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Thomas N. Stewart, Glenn P. Vonk, James P. Mapes
  • Ultraviolet cured peelable film and method therefor
    Patent number: 5135964
    Abstract: Radiation cured peelable film useful as a surgical drape or wound dressing includes a copolymer of a vinyl monomer and an acrylate capped polyurethane prepolymer. The cured film may be prepared by casting a mixture of the vinyl monomer, prepolymer and a photoinitiator onto a surface as a liquid film and exposing the liquid film to ultraviolet light.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: August 4, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Min-Shiu Lee, John Gleason, Robert A. Taller
  • Substrate composition for alkaline phosphatase and method for assay using same
    Patent number: 5135847
    Abstract: A composition contains levamisole and a substrate for alkaline phosphatase in a high pH buffer including 2-amino-2-methyl-1-propanol. The composition may be included in a kit of materials useful in performing an immunoassay in which intestinal alkaline phosphatase is the label. The invention includes a method for detection of a viral antigen by an immunoassay including intestinal alkaline phosphatase as the label and the composition of the invention to provide stabilized levamisole to inhibit nonintestinal alkaline phosphatase.
    Type: Grant
    Filed: November 18, 1988
    Date of Patent: August 4, 1992
    Assignee: Becton, Dickinson and Company
    Inventor: Randal A. Hoke
  • Expandable catheter having hydrophobic surface
    Patent number: 5102401
    Abstract: A catheter of a thermoplastic elastomeric hydrophilic polyurethane is coated on at least the outside surface with a hydrophobic polymer and expands to a larger lumen size in about 3 to 15 minutes when contacted with an aqueous liquid. The hydrophilic polyurethane may be synthesized by one-shot bulk polymerization, and may be melt extruded into a base tubing and dip coated with the hydrophobic polymer, or the hydrophilic polyurethane and hydrophobic polymer may be coextruded. The catheter may have multiple lumens and may include an antithrombogenic agent, antiinfective agent and radiopaque agent.
    Type: Grant
    Filed: August 22, 1990
    Date of Patent: April 7, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: James M. Lambert, Donald D. Solomon, Delmer R. Rhodes
  • Substrate composition for alkaline phosphatase and method for assay using same
    Patent number: 5093231
    Abstract: A composition contains levamisole and a substrate for alkaline phosphatase in a high pH buffer including 2-amino-2-methyl-1-propanol. The composition may be included in a kit of materials useful in performing an immunoassay in which intestinal alkaline phosphatase is the label. The invention includes a method for detection of a viral antigen by an immunoassay including intestinal alkaline phosphatase as the label and the composition of the invention to provide stabilized levamisole to inhibit nonintestinal alkaline phosphatase.
    Type: Grant
    Filed: January 11, 1991
    Date of Patent: March 3, 1992
    Assignee: Becton, Dickinson and Company
    Inventor: Randal A. Hoke
  • Composition for gelling liquids
    Patent number: 5091443
    Abstract: A gelling composition for an aqueous liquid includes ungellated starch which has been reacted with a silane coupling agent. In preferred compositions, the starch is a starch-polyacrylate graft copolymer and the composition includes a polyacrylate gelling agent. A disinfectant may be added to the composition for compositions intended for use with medical waste.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: February 25, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Mutlu Karakelle, Carl D. Benson, Robert A. Taller, David E. Spielvogel
  • Lubricious coatings, medical articles containing same and method for their preparation
    Patent number: 5084315
    Abstract: An article which becomes lubricious when wet includes a base polymer and a coating composition thereon. The composition includes a lubricating polymer and a matrix polymer which adheres to the base polymer and serves as a carrier for the lubricating polymer. The composition may also include a homogenizing polymer to enhance the compatibility of the matrix and lubricating polymer. The invention includes a method to make the article of the invention by coextruding the base polymer and the coating composition.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: January 28, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Houshang Karimi, Stanley C. Wells, David E. Spielvogel, Mutlu Karakelle, Robert A. Taller
  • Liquid crystalline catheter
    Patent number: 5078700
    Abstract: A catheter assembly includes a tubing portion and a needle portion, at least one of which is a thermoplastic liquid crystalline polymer. The tubing and needle may be integral or unitary. The invention includes a method to make the assembly in which a melt of the liquid crystalline polymer is shear thinned by passing through an orifice such as an extrusion die to make tubing. The shear thinned melt may be directed into a mold having a point to make a liquid crystalline needle.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: January 7, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: James M. Lambert, Donald D. Solomon
  • High sensitivity detection of peroxidase activity
    Patent number: 5079150
    Abstract: A new class of peroxidase substrates consists of o-diaminobenzenes having a substituent in the 4 position. The new substrates may be used in immunoassays in which a peroxidase is the label, or in assays for the peroxidase itself. Immunoassays using other enzyme labels which cause formation of hydrogen peroxide may be followed using the substrate of the invention by adding the substrate and a peroxidase to the assay fluid and detecting color formed as a result of oxidation of the substrate by the formed peroxide.
    Type: Grant
    Filed: November 17, 1988
    Date of Patent: January 7, 1992
    Assignee: Becton, Dickinson and Company
    Inventors: Daniel B. Wagner, Glen P. Vonk, Randy A. Hoke
  • Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface
    Patent number: 5077372
    Abstract: A thermoplastic polyurethaneurea having free amino groups is the reaction product of a diisocyanate, a fluorinated polyol, a non-fluorinated polyol and a polyamine. The invention includes a shaped polymeric support structure having the thermoplastic polyurethaneurea coated thereon and a medical article comprising the coated support and heparin covalently bonded to the free amino groups of the coated support. In another aspect of the invention, a method for preparing the heparinized medical article is provided.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: December 31, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Can B. Hu, Donald D. Solomon