Patents Represented by Attorney, Agent or Law Firm Richard E. Brown
  • Barrier coating on blood contacting devices
    Patent number: 5067491
    Abstract: A blood pressure monitoring device includes a pressure sensing element mounted or a probe tip or in a catheter tip adapted for insertion into a patient's blood stream. The element includes a pressure transducer having a micromachined diaphragm which flexes in response to pressure changes. The flexes are converted by the transducer to electrical signals which pass back through the catheter to a display. The element and the catheter are conformally coated with a thin layer of parylene which insulates the device from the deleterious effects which blood components such as water and ions would otherwise have on various components of the device.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: November 26, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Maylon S. Taylor, II, Joel L. Williams
  • Method for applying a lubricious coating to an article
    Patent number: 5061424
    Abstract: A composition which includes polyvinylpyrrolidone and a polyurethane is melt processed to give a shaped article. The melt processing may be a coextrusion with a substrate polymer to give a shaped article having the composition coated on the surface thereof. The article surface is lubricious when contacted with water.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: October 29, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Houshang Karimi, Mutlu Karakelle, Robert A. Taller
  • Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter
    Patent number: 5061254
    Abstract: A melt extruded catheter of thermoplastic elastomeric hydrophilic polyurethane synthesized from a diisocyanate, polyethyleneoxide glycol of high molecular weight and a chain extender expands to a larger lumen size when contacted with an aqueous liquid. The catheter may include an antithrombogenic agent, antiinfective agent and radiopaque agent. The hydrophilic polyurethane may be synthesized by one-shot bulk polymerization, and may be melt extruded into the catheter tubing, and may encapsulate a stripe of a stiffening polyurethane.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: October 29, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Mutlu Karakelle, Donald D. Solomon
  • Blood compatible, lubricious article and composition and method therefor
    Patent number: 5061738
    Abstract: A leach resistant composition includes a quaternary ammonium complex of heparin and a silicone. A method for applying a coating of the composition to a surface of a medical article is within the purview of the present invention. Medical articles having surfaces which are both lubricious and antithrombogenic, are produced in accordance with the method hereof.
    Type: Grant
    Filed: January 11, 1991
    Date of Patent: October 29, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Donald D. Solomon, Robert A. Taller, Victor A. Williamitis
  • Method of making an article having a hemocompatible surface
    Patent number: 5059269
    Abstract: An article has a blood-contacting hemocompatible surface layer of a urethane-siloxane copolymer on a thermoplastic polymeric base material. The copolymer has siloxane segments prepared from hydroxyalkyl terminated polysiloxane glycols. The article is prepared by coextrusion of the base material and the copolymer.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: October 22, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Can B. Hu, Donald D. Solomon, Stanley C. Wells
  • Fluorogenic trypotophanase substrates
    Patent number: 5055594
    Abstract: A fluorogenic substrate for tryptophanase useful for identifying an unknown microorganism is a fluorescent dye linked to an amino acid by a carbamate or thiocarbamate group. In preferred substrates, the dye is fluorescein or 7-amino-4-methyl coumarin and the amino acid linked thereto is cysteine, threonine or serine.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: October 8, 1991
    Assignee: Becton, Dickinson and Company
    Inventor: Patrick D. Mize
  • Process for uniform coating of polymer particles with an additive
    Patent number: 5041310
    Abstract: A process for coating polymer particles with an additive includes preparing a liquid composition comprising one or more desired additives and a gelling agent in an oil. The composition is coated onto the polymer particle by any convenient procedure. On cooling the coated particle below the gelling point, the composition gels providing a polymer particle having a uniform coating of the additives which is suitable for direct introduction into a mold.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: August 20, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Joel L. Williams, Jane C. Graper
  • Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface
    Patent number: 5032666
    Abstract: A thermoplastic polyurethaneurea having free amino groups is the reaction product of a diisocyanate, a fluorinated polyol, a non-fluorinated polyol and a polyamine. The invention includes a shaped polymeric support structure having the thermoplastic polyurethaneurea coated thereon and a medical article comprising the coated support and heparin covalently bonded to the free amino groups of the coated support. In another aspect of the invention, a method for preparing the heparinized medical article is provided.
    Type: Grant
    Filed: June 19, 1989
    Date of Patent: July 16, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Can B. Hu, Donald D. Solomon
  • Chlamydia assay using amidine modified supports or particles
    Patent number: 5030561
    Abstract: A method for assaying of Chlamydia includes adhering Chlamydia antigen to amidine modified latex particles, binding of adhered antigen to an anti-Chlamydia antibody conjugated to an enzyme, separating the particles from the liquid phase of the assay and detecting bound enzyme by color development when the separated particles are contacted with a substrate for the enzyme. The invention includes a kit of materials for preforming an assay in accordance with the method of the invention.
    Type: Grant
    Filed: December 27, 1988
    Date of Patent: July 9, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: James P. Mapes, Catherine S. Donahue
  • Ultraviolet cured peelable film and method therefor
    Patent number: 5030665
    Abstract: Radiation cured peelable film useful as a surgical drape or wound dressing includes a copolymer of a vinyl monomer and an acrylate capped polyurethane prepolymer. The cured film may be prepared by casting a mixture of the vinyl monomer, prepolymer and a photoinitiator onto a surface as a liquid film and exposing the liquid film to ultraviolet light.
    Type: Grant
    Filed: April 8, 1988
    Date of Patent: July 9, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Min-Shiu Lee, John Gleason, Robert A. Taller
  • Petri dish
    Patent number: 5021351
    Abstract: In accordance with the invention there is provided a Petri dish comprising a container for the growth of microorganism cultures and a lid for the container. The construction of the lid and the container provides an improved stacking feature when a plurality of Petri dishes are stacked. The container has improved features which provide a uniform media bed with more uniform depth and improved retention of the media.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: June 4, 1991
    Assignee: Becton, Dickinson and Company
    Inventor: Klon R. Ervin
  • Homogeneous chemiluminescence immunoassay using a light absorbing material
    Patent number: 5017473
    Abstract: A method for separation-free solid phase immunoassay of an analyte includes contacting an antianalyte attached to the surface of a solid support with the analyte, a light absorbing material and a tracer for the analyte which includes a label. The resulting mixture is incubated and chemiluminescence is generated. All of the chemiluminescence is absorbed by the light absorbing material except that associated with the bound tracer whereby the only emission detected is due to the bound tracer. Since emission from free tracer in the fluid phase of the assay medium is not detected, separation of the bound and free fractions is unnecessary. The invention includes a kit of materials useful in performing an immunoassay in accordance with the method of the invention.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: May 21, 1991
    Assignee: Becton, Dickinson and Company
    Inventor: Daniel B. Wagner
  • Expandable obturator and catheter assembly including same
    Patent number: 5015238
    Abstract: An oburator includes a solid substantially stiff rod of a nonhydrophilic polymer coated with a layer of a hydrophilic polyurethane which may have an antithrombogenic agent bulk distributing therein. When the hydrophilic polyurethane comes into contact with an aqueous liquid such as water, saline or a body fluid, it absorbs the liquid and expands thereby enlarging the diameter of the obturator. Another aspect of the invention is an assembly of a catheter and the obturator of the invention. When the obturator is emplaced in the catheter and brought into contact with a liquid, it expands, releases the antithrombogenic agent and contacts the lumen wall of the catheter thereby forming a seal which prevents backflow of a body fluid.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: May 14, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Donald D. Solomon, Mutlu Karakelle, Richard W. Beck
  • Blood compatible, lubricious article and composition and method therefor
    Patent number: 5013717
    Abstract: A leach resistant composition includes a quaternary ammonium complex of heparin and a silicone. A method for applying a coating of the composition to a surface of a medical article is within the purview of the present invention. Medical articles having surfaces which are both lubricious and antithrombogenic, are produced in accordance with the method hereof.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: May 7, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Donald D. Solomon, Robert A. Taller, Victor A. Williamitis
  • Anti-infective and antithrombogenic medical articles and method for their preparation
    Patent number: 5013306
    Abstract: An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: May 7, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Donald D. Solomon, M. Parke Byron
  • Method for monitoring glucose
    Patent number: 5001054
    Abstract: A method for monitoring the glucose level in a body fluid uses an apparatus which includes a conjugate of glucose oxidase and a fluorescent dye coated onto an optical fiber in contact with the body fluid, a source of excitation light and a fluorescence emission detector. Glucose is oxidized by oxygen in the body fluid causing a decrease in oxygen concentration at the enzyme. The fluorescent dye is sensitive to oxygen quenching so that, when the oxygen concentration decreases, fluorescence emission increases in direct proportion to the glucose concentration in the fluid.
    Type: Grant
    Filed: July 31, 1990
    Date of Patent: March 19, 1991
    Assignee: Becton, Dickinson and Company
    Inventor: Daniel B. Wagner
  • Anti-infective and antithrombogenic medical articles and method for their preparation
    Patent number: 4999210
    Abstract: An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine, an antibiotic, or an antithrombogenic agent permeated into the surface or it may be a polymeric surface layer having bulk distributed chlorhexidine laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine. The article may then be laminated by dipping into a solution of chlorhexidine and a substantially hydrophilic polymer in a solvent.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: March 12, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Donald D. Solomon, M. Parke Byron
  • High clarity radiation stable polymeric composition and articles therefrom
    Patent number: 4994552
    Abstract: A high clarity polymeric composition which is stable toward sterilizing radiation includes a semicrystalline polyolefin of narrow molecular weight distribution having incorporated therein a liquid mobilizing additive, a radiation stabilizing amount of a hindered amine and a clarifying agent. The invention includes a sterilized article fabricated from the composition and a method to radiation sterilize the article.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: February 19, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Joel L. Williams, George R. Titus
  • Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings
    Patent number: 4990357
    Abstract: A coating composition for an article surface includes a uniform blend of an elastomeric segmented hydrophilic polyetherurethane and a hydrophilic polymer, such as polyvinylpyrrolidone. The invention includes a method for rendering an article surface lubricious which includes coating the composition onto the article surface and contacting the coated surface with an aqueous liquid.
    Type: Grant
    Filed: May 4, 1989
    Date of Patent: February 5, 1991
    Assignee: Becton, Dickinson and Company
    Inventors: Mutlu Karakelle, Houshang Karimi, Min-Shui Lee, Robert A. Taller
  • Apparatus for monitoring glucose
    Patent number: 4981779
    Abstract: A method for monitoring the glucose level in a body fluid uses an apparatus which includes a conjugate of glucose oxidase with a fluorescent dye coated onto an optical fiber in contact with the body fluid, a source of excitation light and a fluorescence emission detector. Glucose is oxidized by oxygen in the body fluid causing a decrease in oxygen concentration at the enzyme. The fluorescent dye is sensitive to oxygen quenching so that, when the oxygen concentration decreases, fluorescence emission increases in direct proportion to the glucose concentration in the fluid.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: January 1, 1991
    Assignee: Becton, Dickinson and Company
    Inventor: Daniel B. Wagner