Patents Represented by Attorney Richard E. Vila
  • Patent number: 4992078
    Abstract: Improved sulfur dye dispersions are obtained by subjecting an aqueous suspension of oxidized sulfur dye particles to membrane separation. The oxidized sulfur dye is obtained by controlled aeration whereby the content of sulfides, polysulfur and inorganic salts is significantly decreased.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 12, 1991
    Assignee: Sandoz Ltd.
    Inventor: Laszlo A. Meszaros
  • Patent number: 4980087
    Abstract: The invention relates to novel ether sulfates based on a mixture of branched 1-decanols and to their use as surface active agents. The novel ether sulfates are especially useful as the essential surfactant component in shampoo compositions, which compositions exhibit good foaming properties with little or no irritation potential.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: December 25, 1990
    Assignee: Sandoz Ltd.
    Inventors: Anthony Latella, Robert V. Casciani
  • Patent number: 4973427
    Abstract: Process for the fatting and hydrophobizing of tanned leather and pelts, wherein the tanned leather or pelt is fatted with an aqueous dispersion containing a natural optionally chemically modified leather fatting agent and a surface-active phosphoric acid partial ester and optionally a nonionic and/or an anionic carboxy group and/or sulfo group containing surfactant and subsequently treating the fatted leather or pelt in aqueous medium with a plyvalent metal cation; the treated substrates and the dispersions suitable for carrying out the process.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: November 27, 1990
    Assignee: Sandoz Ltd.
    Inventors: Werner Amati, Markus Badertscher
  • Patent number: 4973767
    Abstract: The invention provides a process for the preparation of a compound of the general formula (I): ##STR1## wherein X, Y and R.sup.1 to R.sup.7 are as defined. In the process, the olefinic analog of the compound of general formula (I) is treated with a halogen-bearing compound in the presence of metallic zinc.
    Type: Grant
    Filed: December 12, 1988
    Date of Patent: November 27, 1990
    Assignee: Sandoz Ltd.
    Inventors: Patrick J. Crowley, Christopher J. Urch, Paul A. Worthington
  • Patent number: 4973704
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR2## wherein R.sub.5, R.sub.6 and R.sub.7 are as defined below, R.sub.2 is C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR3## wherein R.sub.8, R.sub.9 and R.sub.10 are as defined below, R.sub.3 is hydrogen, C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR4## wherein R.sub.11, R.sub.12 and R.sub.13 are as defined below, R.sub.4 is hydrogen, C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR5## wherein R.sub.14, R.sub.15 and R.sub.16 are as defined below, X is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CH.dbd.CH--CH.sub.2 --or --CH.sub.2 --CH.dbd.CH--, wherein m is 0, 1, 2 or 3, andZ is ##STR6## wherein R.sub.17 is hydrogen or C.sub.1-3 alkyl, andR.sub.18 is hydrogen, R.sub.19 or M,whereinR.sub.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: November 27, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventor: James R. Wareing
  • Patent number: 4954133
    Abstract: Compounds of the formula ##STR1## wherein each A, independently, is a ##STR2## wherein R.sub.1 is hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,R.sub.2 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --NHCONH.sub.2 or --NHCOC.sub.1-4 alkyl,R.sub.3 is hydrogen or methoxy, andm is 0, 1 or 2,each B, independently, is a radical of a diazo or coupling component, and a and each b, independently, are 0 or 1,and metal complexes thereof, which compounds or complexes are in free acid or salt form, and mixtures thereof with a compound of the formula ##STR3## or a metal complex thereof, wherein A and b are as defined above and D is a radical of a diazo or coupling component of the benzene or 1-naphthalene series are useful for dyeing and printing hydroxy group- or nitrogen-containing organic substrates, especially cellulose fibre-containing textiles (e.g., cotton), paper and leather.
    Type: Grant
    Filed: February 12, 1986
    Date of Patent: September 4, 1990
    Assignee: Sandoz Ltd.
    Inventor: Max Oppliger
  • Patent number: 4941983
    Abstract: A fluid loss additive for oil-based well-working fluids, the fluid loss additive comprisingthe product of mixing in an oil or oil based liquid,(i) lignite or humic acid(ii) (a) an oil soluble or oil dispersible amine or amine salt;(b) an aliphatic amide or hydroxyamide, or a cyclic derivative thereof, containing no primary or secondary amine or amine salt groups; and/or(c) an oil soluble or oil dispersible amine salt containing at least one C.sub.1-22 alkyl, C.sub.2-22 alkenyl or C.sub.1-22 acyl group partially or fully salted with phosphoric acid; and(iii) a dimer and/or trimer fatty acid.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: July 17, 1990
    Assignee: Sandoz Ltd.
    Inventors: Jacqueline A. Coates, John M. Farrar, Margaret H., all of Graham
  • Patent number: 4939159
    Abstract: Compounds of the formula I: ##STR1## wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom;R.sup.1 is C.sub.1-6 primary alkyl (free of asymmetric carbon atoms), or isopropyl;R.sup.2 is substituted or unsubstituted phenyl, primary or secondary C.sub.1-6 alkyl (free of asymmetric carbons),C.sub.3-6 cycloalkyl or phenalkyl as defined in the Specification ##STR2## in which R.sup.8 is hydrogen, R.sup.9 or M, whereinR.sup.9 is a physiologically acceptable and hydrolyzable ester group, andM is a pharmaceutically acceptable cation;are obtained by multi-step processes and are useful as cholesterol biosynthesis inhibitors.
    Type: Grant
    Filed: March 8, 1989
    Date of Patent: July 3, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventors: Paul L. Anderson, Faizulla G. Kathawala, Nicholas A. Paolella, Sompong Wattanasin
  • Patent number: 4927851
    Abstract: Compounds of the formula ##STR1## in which Y is ##STR2## X is O or S; Z is --CHOH--CH.sub.2 --CHOH--CH.sub.2 --COOH, an ester or salt thereof or the lactone thereof; andeach of R.sup.1 R.sup.2 and R.sup.3 can be alkyl, cycloalkyl; or substituted or unsubstituted phenyl; and additionally R.sup.3 can be hydrogen, are obtained by a multi-step process and are useful in the treatment of atherosclerosis, e.g. sodium (E)-7-(4-phenyl-2-isopropyl-5-phenylthien-3-yl)-3,5-dihydroxyhept-6-enoate .
    Type: Grant
    Filed: September 12, 1988
    Date of Patent: May 22, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventors: Robert E. Damon, II, James R. Wareing
  • Patent number: 4927823
    Abstract: The invention relates to synergistic mixtures comprising as active ingredients(a) a compound of formula I ##STR1## wherein R.sub.1 and R.sub.2 are both H or together form a covalent bond,R.sub.3 is H, Cl or BrX is CH or N andY is CH.sub.2 OCH.sub.3, 2-furyl, benzyl or CH.sub.2 Cl in association with(b) the compound of formula II ##STR2## in a fungicidally effective aggregate amount, and the use of such mixtures.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: May 22, 1990
    Assignee: Sandoz Ltd.
    Inventor: Ulrich Gisi
  • Patent number: 4921893
    Abstract: both R.sub.1 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;both R.sub.2 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;R.sub.3 has a significance of R, independently of R, except for oxygen;X is --O--, --NH-- or ##STR2## m is an integer from 1 to 4 inclusive; R.sub.4 is a saturated or unsaturated aliphatic group unsubstituted or substituted by one or two groups selected from --OH and C.sub.1-4 alkoxy and which can be interrupted by an oxygen or sulphur atom; or an aromatic group unsubstituted or substituted by one or two groups selected from --OH, C.sub.1-4 alkyl and C.sub.1-4 alkoxy are useful as U.V. light stabilizers in polymeric organic compounds.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: May 1, 1990
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4920169
    Abstract: A compound of formula I ##STR1## in which each R.sub.1, independently is selected from hydrogen, C.sub.1-12 alkyl, C.sub.1-12 alkoxy and halogen;R.sub.2 has a significance of R.sub.1, independently of R.sub.1, or is --OH;R.sub.20 is --CO--OR.sub.6 or, when each R.sub.1 is hydrogen and R.sub.2 is 2-C.sub.1-4 alkoxy, R.sub.20 is additionally --OH;R.sub.3 is hydrogen or methyl (more preferably hydrogen); andR.sub.6 is hydrogen; unsubstituted C.sub.6-22 alkyl, uninterrupted or interrupted by 1 or 2 oxygen atoms or C.sub.1-22 alkyl mono- or di-substituted by OH and uninterrupted or interrupted by 1 or 2 oxygen atoms;provided when each RF.sub.1 and R.sub.2 is hydrogen, then R.sub.6 is not hydrogen.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: April 24, 1990
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4917706
    Abstract: Liquid compositions of sulfur dyes in reduced form are obtained by reducing a sulfur dye in an alkaline medium to which no sulfide reducing agent has been added, preferably employing a reducing sugar as reducing agent and a sulfur dye which has been washed to remove inorganic salts therefrom.
    Type: Grant
    Filed: February 1, 1988
    Date of Patent: April 17, 1990
    Assignee: Sandoz Ltd.
    Inventor: Laszlo A. Meszaros
  • Patent number: 4916178
    Abstract: The invention relates to the stabilization of alkaline solutions of peroxide bleaching compounds using, as stabilizing agent, a water-soluble poly-.alpha.-hydroxyacrylic acid salt which in the sodium salt form has an average molecular weight Mw from 2000 to 10,000 and to the preparation of such a salt.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: April 10, 1990
    Assignee: Sandoz Ltd.
    Inventors: Werner Amati, Jose Canela
  • Patent number: 4916175
    Abstract: Compounds are provided which are useful as light stabilizers for polymeric materials and which have the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are organic radicals, R.sub.3 and R.sub.15 are hydrogen or organic radicals and R is hydrogen, oxygen or an organic radical.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: April 10, 1990
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4913705
    Abstract: A mixed fabric of hydroxy group-containing fibers and cyano and/or carboxy group-containing fibers, the hydroxy group-containing fibers having been dyed with a reactive dye, is aftertreated with a product of reacting a mono- or polyfunctional amine having one or more primary, secondary and/or tertiary amino groups with cyanamide, dicyandiamide guanidine or bis-guanidine, said product containing at least one reactive hydrogen atom linked to a nitrogen atom, and is then dyed with a basic dye.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: April 3, 1990
    Assignee: Sandoz Ltd.
    Inventors: Bernhard Schlick, Claudio Artico
  • Patent number: 4900812
    Abstract: Compounds of the formula ##STR1## and water-soluble salts thereof each cation of which is independently a non-chromophoric cation, whereinMe is cobalt, copper or nickel,Pc is the phthalocyanine radical,each R.sub.1 and R.sub.2 is independently hydrogen or C.sub.1-6 alkyl,each R.sub.4 is independently hydrogen, halo, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, carboxy or sulfo,each R.sub.6 is hydrogen, cyano, carbamoyl or ##STR2## wherein An .crclbar. is a non-chromophoric anion,each R.sub.7 is hydrogen, C.sub.1-4 alkyl, C.sub.5-6 cycloalkyl, phenyl, benzyl, phenylethyl or carboxy,each W is linear or branched C.sub.2-6 alkylene; linear or branched C.sub.3-6 alkylene monosubstituted by hydroxy; linear or branched C.sub.2-6 alkylene interrupted by ##STR3## wherein R.sub.11 is linear or branched C.sub.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: February 13, 1990
    Assignee: Sandoz Ltd.
    Inventors: Helmut A. Moser, Roland Wald
  • Patent number: 4897427
    Abstract: The invention relates to a method of combatting pruning wound diseases in plants employing a compound of the formula ##STR1## wherein X is H or Cl and R is butyl, 1-cyclopropyl-ethyl or 1-cyclopropyl-1-methylethyl, or associations of a compound of the formula with appropriate fungicides.The invention comprises also hydrophobic compositions for combatting pruning wound diseases, comprising an effective amount of an appropriate fungicide and/or bactericide in an oily, thixotropic, hydrophobic non-phytotoxic medium.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: January 30, 1990
    Assignee: Sandoz Ltd.
    Inventors: Marc Barnavon, Philippe Dutruel, Rene Ravaux
  • Patent number: 4894065
    Abstract: The invention refers to a mixture of anionic dyestuffs having a skitteriness value at pH5 of 3-4 and a combinability value at pH5 of 4-5 and to a process for dyeing a fibre material comprising wool with such a mixture of dyestuffs. These mixtures of anionic dyestuffs give surface and fibre level dyeings.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: January 16, 1990
    Assignee: Sandoz Ltd.
    Inventors: Oskar Annen, Wolfgang Beck, Josef Frauenknecht
  • Patent number: D306670
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: March 20, 1990
    Assignee: Sandoz Ltd.
    Inventors: Terrence G. Pfleuger, Lawrence E. Morrison, Gary C. Planty