Patents Represented by Attorney Richard E. Vila
  • Patent number: 5034949
    Abstract: Single domain crack-free and striation-free KNbO.sub.3 crystals having a maximum iron content of 15 ppm, a process for the synthesis of such crystals and laser systems comprising single domain crack-free and striation-free KNbO.sub.3 crystals which systems convert green light of wavelength 500-540 nm into blue light of wavelength 430-470 nm.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: July 23, 1991
    Assignee: Sandoz Ltd.
    Inventor: Peter Gunter
  • Patent number: 5032142
    Abstract: Trichromatic dye mixtures containing(i) as the orange componentat least one dye of the formula ##STR1## or a salt thereof, or, as the yellow component,at least one dye of the formula ##STR2## or a salt thereof, whereinR.sub.1 is hydrogen or C.sub.1-4 alkyl,R.sub.2 is hydrogen, C.sub.1-4 alkyl or substituted C.sub.1-4 alkyl,each of R.sub.3 and R.sub.4 is independently hydrogen, C.sub.1-6 alkyl or substituted C.sub.1-6 alkyl,R.sub.10 is hydrogen or C.sub.2-3 hydroxyalkyl, andR.sub.11 is C.sub.2-3 hydroxyalkyl or 2-(2'-hydroxyethoxy)ethyl, with the proviso that when R.sub.11 is 2-(2'-hydroxyethoxy)ethyl, R.sub.10 must be hydrogen,(ii) as the red component,at least one dye of the formula ##STR3## or a salt thereof, wherein each of D and D' is independently ##STR4## wherein m is 1 or 2, each R.sub.5 is independently hydrogen or C.sub.1-4 alkyl,each R.sub.6 is independently hydrogen, C.sub.1-4 alkyl or C.sub.2-4 hydroxyalkyl, andx is linear or branched C.sub.2-6 alkylene, linear or branched C.sub.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: July 16, 1991
    Assignee: Sandoz Ltd.
    Inventors: Walter B. Egger, Ernst Schnider
  • Patent number: 5030248
    Abstract: Cellulosic substrates are dyed by a continuous dyeing method with dispersed sulfur dyes using a reducing sugar, especially glucose, as the reducing agent for the dye.
    Type: Grant
    Filed: August 16, 1989
    Date of Patent: July 9, 1991
    Assignee: Sandoz Ltd.
    Inventor: Laszlo A. Meszaros
  • Patent number: 5030670
    Abstract: An aqueous dispersion comprising one or more 2,2,6,6-tetraalkylpiperidine compounds having a molecular weight 2000 or less than 2000 and a melting point of 100.degree. C. or more, one or more cationic, non-ionic and/or anionic dispersing agents and an aqueous medium. These dispersions are suitable for use as light stabilizers in aqueous systems.
    Type: Grant
    Filed: October 6, 1988
    Date of Patent: July 9, 1991
    Assignee: Sandoz Ltd.
    Inventors: Erwin Hess, Rainer Wolf
  • Patent number: 5030247
    Abstract: Mixtures of azo pigments of the formulae ##STR1## wherein each R.sub.1 is independently C.sub.1-4 alkyl, andeach R.sub.2 is independently 1,4-phenylene; 1,4-phenylene substituted by 1 or 2 substituents independently selected from chloro, bromo, methyl, methoxy, trifluoromethyl (maximum of one) and nitro (maximum of one); 4,4'-diphenylene substituted by 1 or 2 substituents independently selected from chloro, bromo, methyl and methoxy, each substituent being in the 3- or 3'-position; 1,4-naphthylene or 1,5-naphthylene, the mixture containing from 8 to 20% mole of benzoic acid ester residues and from 92 to 80% mole of terephthalic acid ester residues, useful for pigmenting in the mass synthetic polymers, for example, polyethylene, polypropylene, polystyrene, polyvinyl chloride, synthetic leather and rubber latices.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: July 9, 1991
    Assignee: Sandoz Ltd.
    Inventor: Jurgen Goldmann
  • Patent number: 5030625
    Abstract: The invention relates to novel homopropargylamines of formula I ##STR1## wherein n is 2 or 3,R.sub.1 is a group of formula IIa, IIb or IIc ##STR2## in which R.sub.6 and R.sub.7 indpendently are H, halogen, CF.sub.3, lower alkyl or lower alkoxy,s is a number of 3 to 5,X is O, S, OCH.sub.2, SCH.sub.2 CH.sub.2 or NR.sub.8, andR.sub.8 is H or lower alkyl,R.sub.2 is H or lower alkyl, eitherR.sub.3 and R.sub.4, independently, are H or lower alkyl, orR.sub.3 and R.sub.4 together are (CH.sub.2).sub.u,in which u is a number of 3 to 5, andR.sub.5 is H, alkenyl or is a group selected from alkyl, trialkylsilyl, dialkylphenylsilyl, phenyl, phenylalkyl and cycloalkyl, in which alkyl, phenyl and cycloalkyl groups or moieties are unsubstituted or substituted by OH, lower alkyl, lower alkoxy, phenyl or halogen,in free base form or acid addition salt form thereof, their preparation, their chemotherapeutical and agricultural use and to compositions comprising such novel compounds and suitable for such use.
    Type: Grant
    Filed: August 14, 1989
    Date of Patent: July 9, 1991
    Assignee: Sandoz Ltd.
    Inventor: Anton Stuetz
  • Patent number: 5024786
    Abstract: An aqueous, isotropic liquid detergent composition comprising an aqueous solution of:a) an anionic surfactant; andb) an optical brightener of formula I ##STR1## in which X is hydrogen, NH.sub.4.sup..sym., or a cation of an alkali metal, an alkaline earth metal or an organic amine;R.sub.1 is selected from morpholino or anilino unsubstituted or substituted by 1, 2 or 3 groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy and halogen; piperidinyl, unsubstituted or substituted by 1 or 2 C.sub.1-4 alkyl groups; hexamethyleneimino, pyrrolidino, C.sub.1-8 alkylamino; C.sub.1-8 dialkylamino; or a 2,2,6,6-tetramethylpiperidinyl residue;R.sub.2 has a significance of R.sub.1 independently of R.sub.1 ;provided that when both groups R.sub.1 (or R.sub.2) are morpholino or unsubstituted anilino, the other groups R.sub.2 (or R.sub.1 respectively), are not both unsubstituted anilino.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: June 18, 1991
    Assignee: Sandoz Ltd.
    Inventors: John M. Farrar, Mark D. Graham
  • Patent number: 5023324
    Abstract: Disazo and trisazo compounds free of sulfo groups which contain 6-hydroxy-4-methyl-3-N-pyridiniumpyridone-2 coupling component radicals, the preferred compounds being of the formula ##STR1## wherein R is a tetrazo component radical,each R.sub.1 is independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 hydroxyalkyl the hydroxy group of which is in other than the 1-position or --NR.sub.3 R.sub.4, wherein each of R.sub.3 and R.sub.4 is independently n-C.sub.1-4 alkyl,each R.sub.2 is independently hydrogen, n-C.sub.1-4 alkyl, n-C.sub.1-4 hydroxyalkyl or C.sub.1-4 alkoxy, andeach A.sup..crclbar. is an anion,and liquid and granulated dye compositions comprising such compounds, are useful for dyeing paper and basically dyeable substrates such as polymers and copolymers of acrylonitrile and dicyanoethylene and synthetic polyesters and polyamides modified to contain acid groups. Dyeings on paper are brilliant and possess good light fastness and good fastness to water and alcohol.
    Type: Grant
    Filed: July 29, 1986
    Date of Patent: June 11, 1991
    Assignee: Sandoz Ltd.
    Inventor: Helmut Moser
  • Patent number: 5021573
    Abstract: A compound of formula I ##STR1## in which each R.sub.1 independently is selected from oxygen, .dbd.NH or .dbd.N--R.sub.2 where R.sub.2 is an aromatic or heteroaromatic group, provided not more than two groups R.sub.1 are selected from oxygen and .dbd.NH.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: June 4, 1991
    Assignee: Sandoz Ltd.
    Inventors: Peter Bitterli, Bansi L. Kauh
  • Patent number: 5021132
    Abstract: A process is disclosed for electrochemically treating p-nitrotoluene-2-sulfonic acid salts under oxidizing conditions to form 4,4'-dinitrostilbene-2,2'-disulfonic acid or the salts thereof. The process provides satisfactory yields of the stilbene compound while enabling substantial recycling of reaction materials. Substantial benefits are obtained when lithium hydroxide is employed in the reaction medium, including recovery of product of high purity, and improved recovery and recycling of lithium to the process.
    Type: Grant
    Filed: August 7, 1990
    Date of Patent: June 4, 1991
    Assignee: Sandoz Ltd.
    Inventor: Baldev K. Bandlish
  • Patent number: 5017633
    Abstract: A filled polyolefin, particularly polypropylene, containing a sterically hindered phenol antioxidant and a compound of formula I and/or II ##STR1## in which R is unsubstituted phenyl or phenyl substituted by 1 or 2 C.sub.1-12 alkyl groupsn is 0 or 1 andA is a monofunctional or difunctional residue of a phenyl, diphenyl, diphenyl ether, diphenylmethane or dibenzofuran,as processing stabilizer has good long-term stability even in the absence of conventional sulphur-containing co-stabilizers.
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: May 21, 1991
    Assignee: Sandoz Ltd.
    Inventor: Guenther Tscheulin
  • Patent number: 5013328
    Abstract: A substrate to which a dyestuff or optical brightener has been applied is aftertreated with a cationic or protonatable polymeric Product P selected from:(A) a polymeric reaction product, Product A, of a monofunctional or polyfunctional amine having one or more primary and/or secondary and/or tertiary amino groups with cyanamide, dicyanamide, guanidine or bisguanidine in which up to 50 mole percent of the cyanamide, dicyanamide, guanidine or bisguanidine may be replaced by a dicarboxylic acid or a mono- or di-ester thereof, with the splitting off ammonia, optionally in the presence of a catalyst; Product A containing at least one free hydrogen atom linked to a nitrogen atom; or(B) the polymeric reaction product, Product B, of Product A with(a) epichlorohydrin or a precursor thereof; or(b) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amine optionally in the presence of a catalyst for crosslinking N-methylol compounds; or(c) a water-soluble homo- or co-polymer, Pr
    Type: Grant
    Filed: November 15, 1989
    Date of Patent: May 7, 1991
    Assignee: Sandoz Ltd.
    Inventors: Oskar Annen, Bernhard Schlick
  • Patent number: 5008379
    Abstract: Water-soluble, anionic, chromium complexes of disazo compounds, at least one of the complex-forming disazo compounds being of the formula, ##STR1## in which ##STR2## is the radical of a carboxy group-containing diazo component of the benzene or naphthalene series, the carboxy group being ortho to the azo group and the diazo component being free from other metallizable groups, andB-- is the radical of a diazo component of the benzene or naphthalene series free from metallizable substituents,which complexes contain at least one water-solubilizing group, are in free acid or salt form and are useful for dyeing and printing substrates such as natural and synthetic polyamides, polyurethanes and anodized aluminum, particularly fur-lined leather.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: April 16, 1991
    Assignee: Sandoz Ltd.
    Inventor: Herbert Holliger
  • Patent number: 5006128
    Abstract: Compounds of the formula ##STR1## and salts thereof, whereinR.sub.1 is hydrogen or methyl,R.sub.2 is hydrogen, methyl or acetamido,R.sub.3 is hydrogen, methyl or methoxy,R.sub.4 is hydrogen, C.sub.1-4 alkyl or hydroxy(C.sub.2-4 alkyl),R.sub.5 is hydroxy(C.sub.2-4 alkyl) or hydroxy(C.sub.2-4 alkoxy)C.sub.2-4 alkyl, or--NR.sub.4 R.sub.5 is a 5- or 6-membered ring containing 1 to 3 hetero atoms which ring is unsubstituted or substituted by 1 to 3 substituents selected from C.sub.1-4 alkyl and C.sub.2-4 alkyl monosubstituted by hydroxy or amino, andthe two naphthyl-2 groups are identically substituted, with the proviso that when R.sub.3 is methoxy, R.sub.1 and R.sub.2 are different, solid and aqueous liquid dye compositions and printing inks comprising such compounds and salts and the use of such compounds and salts for dyeing and printing substrates, especially hydroxy group- and nitrogen-containing organic substrates.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: April 9, 1991
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 5006644
    Abstract: Complexes of the formula ##STR1## and salts thereof, wherein each of R.sub.1 -R.sub.4 is independently hydrogen, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --NHCOR.sub.8, --COX or --SO.sub.2 Z,wherein R.sub.8 is C.sub.1-4 alkyl or phenyl,X is hydroxy, C.sub.1-4 alkoxy, phenoxy, substituted phenoxy, phenyl(C.sub.1-4 alkoxy), substituted phenyl(C.sub.1-4 alkoxy), C.sub.1-4 alkyl, phenyl, substituted phenyl, cyclohexyl, cyclohexyl substituted by 1 to 3 C.sub.1-4 alkyl groups, amino or substituted amino, andZ is --CH.sub.2 CH.sub.2 OSO.sub.3 H, --CH.dbd.CH.sub.2 or a significance of X with the exception of C.sub.1-4 alkyl,with the proviso that 1 to 3 of R.sub.1 -R.sub.4 are --SO.sub.2 Z or at least two of R.sub.1 -R.sub.4 are --COOH,each R.sub.5 is independently hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, chloro or cyano,R.sub.6 is halo, hydroxy, C.sub.1-4 alkoxy, phenoxy, amino or substituted amino, andeach R.sub.
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: April 9, 1991
    Assignee: Sandoz Ltd.
    Inventor: Friedrich Lehr
  • Patent number: 5002586
    Abstract: A process for the dyeing or printing of leather with anionic metal complex dyes wherein the metal complex dyes are metal complexes of metallizable monoazo dyes or metallizable monoazomethine dyes or both metallizable monoazo and monoazo methine dyes and before the application of the dye or after the application of the dye or both before and after the application of the dye the leather is treated with a product (P) or a mixture of products (P) or an acid addition product thereof, product (P) being a polymer obtainable by reaction of(.alpha.) a mono-functional or poly-functional amine containing one or more amino groups of the group consisting of primary, secondary and tertiary amino groupswith(.beta.) cyanamide, dicyanodiamide, guanidine or biguanide or a mixture in which up to 50 mole percent of the cyanamide, dicyanodiamide, guanidine or biguanide are replaced by a di-carboxylic acid or a mono- or diester thereofwith cleavage of ammonia or a further reaction product thereof with reactant(.gamma.
    Type: Grant
    Filed: August 5, 1988
    Date of Patent: March 26, 1991
    Assignee: Sandoz Ltd.
    Inventors: Michel Dien, Willi Egli
  • Patent number: 5002702
    Abstract: A composition, for stabilizing a polymeric material, (hereinafter defined as a stabilizing composition) comprising(a) a thiophosphate compound; and(b) an organo tin compound.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: March 26, 1991
    Assignee: Sandoz Ltd.
    Inventors: Rainer Wolf, Jean-Paul Kehrli
  • Patent number: 5001255
    Abstract: Compounds of the formula ##STR1## the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
    Type: Grant
    Filed: July 1, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Pharm. Corp.
    Inventors: Faizulla G. Kathawala, Sompong Wattanasin
  • Patent number: 5001226
    Abstract: Compounds of the formula ##STR1## 1:1 and 1:2 metal complexes thereof, salts of such compounds and metal complexes and mixture thereof, whereineach of B.sub.1 and B.sub.2 is independently hydroxy or amino,each D is independently ##STR2## wherein R is hydrogen, C.sub.1-4 alkyl, C.sub.5-6 cycloalkyl, phenyl, benzyl or phenylethyl,R.sub.1 is hydrogen, cyano, --COOR.sub.4, --CONR.sub.5 R.sub.6, --SO.sub.2 NR.sub.5 R.sub.6, ##STR3## wherein each R.sub.3 is independently hydrogen, C.sub.1-4 alkyl, --NR.sub.5 R.sub.6 or --CONR.sub.5 R.sub.6,R.sub.4 is C.sub.1-6 alkyl or phenyl(C.sub.1-3 alkyl),R.sub.7 is C.sub.1-4 alkyl,R.sub.8 is hydrogen or C.sub.1-4 alkyl, andR.sub.9 is --S--, --O-- or --NR.sub.5 --,R.sub.2 is hydrogen, hydroxy or C.sub.1-4 alkoxy,R.sub.2a is hydrogen, C.sub.1-4 alkyl or halo,M is hydrogen; C.sub.1-8 alkyl; (C.sub.1-4 alkoxy)C.sub.1-4 alkyl; C.sub.2-4 hydroxyalkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyls; phenyl(C.sub.1-3 alkyl); phenyl (C.sub.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventors: Helmut A. Moser, Roland Wald
  • Patent number: 5000874
    Abstract: Concentrated aqueous compositions containing(a) a hydroxy- or amino-alkanephosphonic acid(b) a polyaminocarboxylic acid(c) glucoheptonic acid and optionally(d) magnesium chloride, -sulfate and/or -acetateare eminently suitable as stabilizing additives for peroxide-containing alkaline liquors which are employed in the bleach of cellulosic fibrous material.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventor: Achim Wiedemann